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Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer
Open accessAbstract
Aerobic exercise is associated with decreased cancer incidence and cancer-associated mortality. However, little is known about the effects of exercise on pancreatic ductal adenocarcinoma (PDA), a disease for which current therapeutic options are limited. Herein, we show that aerobic exercise reduces PDA tumor growth, by modulating systemic and intra-tumoral immunity. Mechanistically, exercise promotes immune mobilization and accumulation of tumor-infiltrating IL15Rα+ CD8 T cells, which are responsible for the tumor-protective effects. In clinical samples, an exercise-dependent increase of intra-tumoral CD8 T cells is also observed. Underscoring the translational potential of the interleukin (IL)-15/IL-15Rα axis, IL-15 super-agonist (NIZ985) treatment attenuates tumor growth, prolongs survival, and enhances sensitivity to chemotherapy. Finally, exercise or NIZ985 both sensitize pancreatic tumors to αPD-1, with improved anti-tumor and survival benefits. Collectively, our findings highlight the therapeutic potential of an exercise-oncology axis and identify IL-15 activation as a promising treatment strategy for this deadly disease.
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“Exercise restrains tumor growth5 and enhances immune checkpoint inhibitor (ICI) efficacy in various preclinical cancer models8–13”
From Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy (2025) · cites this paper as [8]
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“Exercise exerts potent antitumor effects in both preclinical models5,8–13 and cancer patients6.”
From Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy (2025) · cites this paper as [8]
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Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
Von Hoff, D. D., Ervin, T., Arena, F. P., Chiorean, E. G., Infante, J., Moore, M., Seay, T., Tjulandin, S. A., Ma, W. W., Saleh, M. N., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1304369 · Cited by 6,712
Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
Wolchok, J. D., Chiarion-Sileni, V., Gonzalez, R., Rutkowski, P., Grob, J.-J., Cowey, C. L., Lao, C. D., Wagstaff, J., Schadendorf, D., Ferrucci, P. F., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1709684 · Cited by 5,357
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
Gopalakrishnan, V., Spencer, C. N., Nezi, L., Reuben, A., Andrews, M. C., Karpinets, T. V., Prieto, P. A., Vicente, D., Hoffman, K., Wei, S. C., et al. (2018) · Science · doi:10.1126/science.aan4236 · Cited by 4,812
Self-citationLa Manno, G., Soldatov, R., Zeisel, A., Braun, E., Hochgerner, H., Petukhov, V., Lidschreiber, K., Kastriti, M. E., Lönnerberg, P., Furlan, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0414-6 · Cited by 4,118
Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
Larkin, J., Chiarion-Sileni, V., Gonzalez, R., Grob, J.-J., Rutkowski, P., Lao, C. D., Cowey, C. L., Schadendorf, D., Wagstaff, J., Dummer, R., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1910836 · Cited by 3,723
Generalizing RNA velocity to transient cell states through dynamical modeling
Bergen, V., Lange, M., Peidli, S., Wolf, F. A., & Theis, F. J. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0591-3 · Cited by 2,951
Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors
Rawla, P., Sunkara, T., & Gaduputi, V. (2019) · World Journal of Oncology · doi:10.14740/wjon1166 · Cited by 2,269
The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
Kumar, V., Patel, S., Tcyganov, E., & Gabrilovich, D. I. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.004 · Cited by 2,008
Single-cell mRNA quantification and differential analysis with Census
Qiu, X., Hill, A. J., Packer, J. S., Lin, D., Ma, Y.-A., & Trapnell, C. (2017) · Nature Methods · doi:10.1038/nmeth.4150 · Cited by 1,904
Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes
Riquelme, E., Zhang, Y., Zhang, L., Montiel, M., Zoltan, M., Dong, W., Quesada, P., Sahin, I., Chandra, V., San Lucas, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.008 · Cited by 1,577
Self-citationHiam-Galvez, K. J., Allen, B. M., & Spitzer, M. H. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00347-z · Cited by 1,400
Beltra, J., Manne, S., Abdel-Hakeem, M. S., Kurachi, M., Giles, J. R., Chen, Z., Casella, V., Ngiow, S. F., Khan, O., Huang, Y., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.014 · Cited by 1,139
IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells
Dubois, S. P., Mariner, J. M., Waldmann, T. A., & Tagaya, Y. (2002) · Immunity · doi:10.1016/s1074-7613(02)00429-6 · Cited by 912
Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Pappu, R., Schwab, S. R., Cornelissen, I., Pereira, J. P., Regard, J. B., Xu, Y., Camerer, E., Zheng, Y., Huang, Y., Cyster, J. G., et al. (2007) · Science · doi:10.1126/science.1139221 · Cited by 904
Pedersen, L., Idorn, M., Olofsson, G. H., Lauenborg, B., Nookaew, I., Hansen, R. H., Johannesen, H. H., Becker, J. C., Pedersen, K. S., Dethlefsen, C., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.011 · Cited by 888
Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor
Marigo, I., Bosio, E., Solito, S., Mesa, C., Fernández, A., Dolcetti, L., Ugel, S., Sonda, N., Bicciato, S., Falisi, E., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.010 · Cited by 854
Role of Myokines in Exercise and Metabolism
Pedersen, B. K., Åkerström, T. C. A., Nielsen, A. R., & Fischer, C. P. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00080.2007 · Cited by 841
O’Reilly, E. M., Oh, D.-Y., Dhani, N., Renouf, D. J., Lee, M. A., Sun, W., Fisher, G., Hezel, A., Chang, S.-C., Vlahovic, G., et al. (2019) · JAMA Oncology · doi:10.1001/jamaoncol.2019.1588 · Cited by 767
How Do Cytotoxic Lymphocytes Kill Cancer Cells?
Martínez‐Lostao, L., Anel, A., & Pardo, J. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-0685 · Cited by 766
Tuck, M. K., Chan, D. W., Chia, D., Godwin, A. K., Grizzle, W. E., Krueger, K. E., Rom, W. N., Sanda, M. G., Sorbara, L. R., Stass, S. A., et al. (2008) · Journal of Proteome Research · doi:10.1021/pr800545q · Cited by 742
TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision
Chen, Z., Ji, Z., Ngiow, S. F., Manne, S., Cai, Z., Huang, A. C., Johnson, J., Staupe, R. P., Bengsch, B., Xu, C., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.09.013 · Cited by 709
Challenges and Opportunities for Pancreatic Cancer Immunotherapy
Bear, A. S., Vonderheide, R. H., & O'Hara, M. H. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.08.004 · Cited by 674
Yáñez, A., Coetzee, S. G., Olsson, A., Muench, D. E., Berman, B. P., Hazelett, D. J., Salomonis, N., Grimes, H. L., & Goodridge, H. S. (2017) · Immunity · doi:10.1016/j.immuni.2017.10.021 · Cited by 470
Winograd, R., Byrne, K. T., Evans, R. A., Odorizzi, P. M., Meyer, A. R. L., Bajor, D. L., Clendenin, C., Stanger, B. Z., Furth, E. E., Wherry, E. J., et al. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0215 · Cited by 459
Self-citationBroadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities
Balachandran, V. P., Beatty, G. L., & Dougan, S. K. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.038 · Cited by 444
Wrangle, J. M., Velcheti, V., Patel, M. R., Garrett-Mayer, E. S., Hill, E. G., Ravenel, J. G., Miller, J. S., Farhad, M. E., Anderton, K., Lindsey, K., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30148-7 · Cited by 422
Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer
Das, S., Shapiro, B., Vucic, E., Vogt, S., & Bar‐Sagi, D. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-2080 · Cited by 369
Self-citationYang, A., Herter-Sprie, G., Zhang, H., Lin, E. Y., Biancur, D., Wang, X., Deng, J., Hai, J., Yang, S., Wong, K.-K., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0952 · Cited by 349
IL-15 Promotes the Survival of Naive and Memory Phenotype CD8+ T Cells
Berard, M., Brandt, K., Bulfone‐Paus, S., & Tough, D. F. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5018 · Cited by 343
Chiba, K. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.05.002 · Cited by 323
Systemic dysfunction and plasticity of the immune macroenvironment in cancer models
Allen, B. M., Hiam-Galvez, K. J., Burnett, C. E., Venida, A. C., DeBarge, R., Tenvooren, I., Marquez, D. M., Cho, N. W., Carmi, Y., & Spitzer, M. H. (2020) · Nature Medicine · doi:10.1038/s41591-020-0892-6 · Cited by 320
Combining microenvironment normalization strategies to improve cancer immunotherapy
Mpekris, F., Voutouri, C., Baish, J. W., Duda, D. G., Munn, L. L., Stylianopoulos, T., & Jain, R. K. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919764117 · Cited by 297
Frodermann, V., Rohde, D., Courties, G., Severe, N., Schloss, M. J., Amatullah, H., McAlpine, C. S., Cremer, S., Hoyer, F. F., Ji, F., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0633-x · Cited by 292
Schedlowski, M., Hosch, W. P., Oberbeck, R., Benschop, R. J., Jacobs, R., Raab, H., & Schmidt, R. E. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.1.93 · Cited by 250
Selective Mobilization of Cytotoxic Leukocytes by Epinephrine
Dimitrov, S., Lange, T., & Jan Born, A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902189 · Cited by 235
Tang, Y., Xu, X., Guo, S., Zhang, C., Tang, Y., Tian, Y., Ni, B., Lu, B., & Wang, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091551 · Cited by 233
Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients
Wu, W., Sun, H.-W., Chen, H., Liang, J., Yu, X.-J., Wu, C., Wang, Z., & Zheng, L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320753111 · Cited by 231
Meyer, M. A., Baer, J. M., Knolhoff, B. L., Nywening, T. M., Panni, R. Z., Su, X., Weilbaecher, K. N., Hawkins, W. G., Ma, C. X., Fields, R. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03600-6 · Cited by 228
Exercise-Dependent Regulation of NK Cells in Cancer Protection
Idorn, M., & Højman, P. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.05.007 · Cited by 223
Exercise-induced redistribution of T lymphocytes is regulated by adrenergic mechanisms
Krüger, K., Lechtermann, A., Fobker, M., Völker, K., & Mooren, F. C. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.008 · Cited by 221
Ashcraft, K. A., Peace, R. M., Betof, A. S., Dewhirst, M. W., & Jones, L. W. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0887 · Cited by 217
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth
Rundqvist, H., Veliça, P., Barbieri, L., Gameiro, P. A., Bargiela, D., Gojkovic, M., Mijwel, S., Reitzner, S. M., Wulliman, D., Ahlstedt, E., et al. (2020) · eLife · doi:10.7554/elife.59996 · Cited by 216
Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy
Schadler, K. L., Thomas, N. J., Galie, P. A., Bhang, D. H., Roby, K. C., Addai, P., Till, J. E., Sturgeon, K., Zaslavsky, A., Chen, C. S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11748 · Cited by 199
Self-citationLi, H. Y., McSharry, M. V., Bullock, B., Nguyen, T. T., Kwak, J., Poczobutt, J. M., Sippel, T. R., Heasley, L. E., Weiser-Evans, M. C. M., Clambey, E. T., et al. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0365 · Cited by 193
Gomes-Santos, I. L., Amoozgar, Z., Kumar, A. S., Ho, W. W., Roh, K., Talele, N. P., Curtis, H., Kawaguchi, K., Jain, R. K., & Fukumura, D. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0499 · Cited by 181
Lack of immunoediting in murine pancreatic cancer reversed with neoantigen
Evans, R. A., Diamond, M. S., Rech, A. J., Chao, T., Richardson, M. W., Lin, J., Bajor, D. L., Byrne, K. T., Stanger, B. Z., Riley, J. L., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88328 · Cited by 181
Self-citationType 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis
Lin, J. H., Huffman, A. P., Wattenberg, M. M., Walter, D. M., Carpenter, E. L., Feldser, D. M., Beatty, G. L., Furth, E. E., & Vonderheide, R. H. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190673 · Cited by 175
Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer
Wang, L., Simons, D. L., Lu, X., Tu, T. Y., Solomon, S. T., Wang, R., Rosario, A., Avalos, C., Schmolze, D. B., Yim, J. H., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0429-7 · Cited by 174
Wainberg, Z. A., Höchster, H. S., Kim, E. J.-H., George, B., Kaylan, A., Chiorean, E. G., Waterhouse, D. M., Guiterrez, M., Parikh, A. R., Jain, R., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-0099 · Cited by 162
Mechanisms of T-Cell Exhaustion in Pancreatic Cancer
Saka, D., Gökalp, M., Piyade, B., Çevik, N. C., Sever, E. A., Unutmaz, D., Ceyhan, G. O., Demir, İ. E., & Asimgil, H. (2020) · Cancers · doi:10.3390/cancers12082274 · Cited by 160
Foucher, E. D., Ghigo, C., Chouaı̈b, S., Galon, J., Iovanna, J., & Olive, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01044 · Cited by 145
Bessard, A., Solé-Jamault, V., Bouchaud, G., Quéméner, A., & Jacques, Y. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0275 · Cited by 138
Increased regulatory B cells are involved in immune evasion in patients with gastric cancer
Murakami, Y., Saito, H., Shimizu, S., Kono, Y., Shishido, Y., Miyatani, K., Matsunaga, T., Fukumoto, Y., Ashida, K., Sakabe, T., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49581-4 · Cited by 133
Grasselly, C., Denis, M., Bourguignon, A., Talhi, N., Mathé, D., Tourette, A., Serre, L., Jordheim, L. P., Matera, E. L., & Dumontet, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02100 · Cited by 129
Exercise reduces immune suppression and breast cancer progression in a preclinical model
Wennerberg, E., Lhuillier, C., Rybstein, M. D., Dannenberg, K., Rudqvist, N.-P., Koelwyn, G. J., Jones, L. W., & Demaria, S. (2020) · Oncotarget · doi:10.18632/oncotarget.27464 · Cited by 129
O’Neil, B. H., Scott, A. J., Ma, W. W., Cohen, S. J., Aisner, D. L., Menter, A. R., Tejani, M. A., Cho, J. K., Granfortuna, J. M., Coveler, L., et al. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv264 · Cited by 129
Ngo‐Huang, A., Parker, N. H., Bruera, E. D., Lee, R. E., Simpson, R. J., O’Connor, D. P., Petzel, M. Q. B., Fontillas, R. C., Schadler, K., Xiao, L., et al. (2019) · Integrative Cancer Therapies · doi:10.1177/1534735419894061 · Cited by 120
Self-citationBlockade of β-Adrenergic Receptors Improves CD8+ T-cell Priming and Cancer Vaccine Efficacy
Daher, C., Vimeux, L., Stoeva, R., Peranzoni, E., Bismuth, G., Wieduwild, É., Lucas, B., Donnadieu, E., Bercovici, N., Trautmann, A., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0833 · Cited by 111
Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy
Kim, S. R., Puranik, A. S., Jiang, K., Chen, X., Zhu, X., Taylor, I., Khodadadi‐Jamayran, A., Lerman, A., Hickson, L. J., Childs, B. G., et al. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020091373 · Cited by 108
Self-citationIsolation of Mononuclear Cells from Human Cord Blood by Ficoll‐Paque Density Gradient
Jaatinen, T., & Laine, J. T. (2007) · Current Protocols in Stem Cell Biology · doi:10.1002/9780470151808.sc02a01s1 · Cited by 99
Myeloid-Derived Suppressor Cells and Pancreatic Cancer: Implications in Novel Therapeutic Approaches
Thyagarajan‐Sahu, A., Alshehri, M. S. A., Miller, K. L., Sherwin, C. M. T., Travers, J. B., & Sahu, R. P. (2019) · Cancers · doi:10.3390/cancers11111627 · Cited by 95
Exercise during preoperative therapy increases tumor vascularity in pancreatic tumor patients
Bedoya, C. A. F., Cardoso, A. C. F., Parker, N. H., Ngo‐Huang, A., Petzel, M. Q. B., Kim, M. P., Fogelman, D. R., Romero, S. G., Wang, H., Park, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49582-3 · Cited by 77
Self-citationLiu, C., Yang, Y., Chen, C., Li, L., Li, J., Wang, X., Chu, Q., Qiu, L., Ba, Q., Li, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25967-9 · Cited by 74
Lu, J., Giuntoli, R. L., Omiya, R., Kobayashi, H., Kennedy, R. B., & Celis, E. (2002) · PubMed · Cited by 69
Desbois, M., Vu, P. L., Coutzac, C., Marcheteau, E., Béal, C., Terme, M., Gey, A., Morisseau, S., Teppaz, G., Boselli, L., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600019 · Cited by 65
Delayed leukocytosis after hard strength and endurance exercise: Aspects of regulatory mechanisms
Risøy, B. A., Raastad, T., Hallén, J., Lappegård, K. T., Bæverfjord, K., Kravdal, A., Siebke, E. M., & Benestad, H. B. (2003) · BMC Physiology · doi:10.1186/1472-6793-3-14 · Cited by 61
Home-based exercise during preoperative therapy for pancreatic cancer
Ngo‐Huang, A., Parker, N. H., Wang, X., Petzel, M. Q. B., Fogelman, D. R., Schadler, K., Bruera, E. D., Fleming, J. B., Lee, J. E., & Katz, M. H. G. (2017) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-017-1599-0 · Cited by 60
Self-citationA map of the distribution of sphingosine 1-phosphate in the spleen
Ramos-Pérez, W. D., Fang, V., Escalante‐Alcalde, D., Cammer, M., & Schwab, S. R. (2015) · Nature Immunology · doi:10.1038/ni.3296 · Cited by 59
Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males
Sand, K. L. (2013) · World Journal of Experimental Medicine · doi:10.5493/wjem.v3.i1.11 · Cited by 58
Han, X., Shi, H., Sun, Y., Shang, C., Luan, T., Wang, D., Ba, X., & Zeng, X. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1837-1 · Cited by 56
Skeletal muscle antagonizes antiviral CD8 + T cell exhaustion
Wu, J., Weisshaar, N., Hotz‐Wagenblatt, A., Madi, A., Ma, S., Mieg, A., Hering, M., Möhr, K., Schlimbach, T., Borgers, H., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba3458 · Cited by 55
Alterations in the innate immune system due to exhausting exercise in intensively trained rats
Estruel‐Amades, S., Camps‐Bossacoma, M., Massot‐Cladera, M., Pérez-Cano, F. J., & Castell, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-57783-4 · Cited by 36
Physical activity delays accumulation of immunosuppressive myeloid-derived suppressor cells
Garritson, J. D., Krynski, L. M., Simon, L. H., Haughian, J. M., Pullen, N., & Hayward, R. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234548 · Cited by 34
Zhan, B., Shi, W., Lu, J., Shen, G., Lin, X., Feng, J., & Huang, H. (2017) · Oncotarget · doi:10.18632/oncotarget.18057 · Cited by 31
Barnstorf, I., Borsa, M., Baumann, N. S., Pallmer, K., Yermanos, A., Joller, N., Spörri, R., Welten, S. P. M., Kräutler, N. J., & Oxenius, A. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181589 · Cited by 22
O’Neil, B. H., Scott, A. J., Ma, W. W., Cohen, S. J., Aisner, D. L., Menter, A. R., Tejani, M. A., Cho, J. K., Granfortuna, J. M., Coveler, A. L., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw095 · Cited by 16
IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models
Guo, S., Smeltz, R. B., Nanajian, A., & Heller, R. F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.614667 · Cited by 15
IL-15 Promotes the Survival of Naive and Memory Phenotype CD8+ T Cells
Berard, M., Brandt, K., Bulfone‐Paus, S., & Tough, D. F. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.4.2170-a · Cited by 13
Coveler, A. L., Bajor, D. L., Masood, A., Yilmaz, E., Shields, A. F., Javle, M. M., Paluri, R. K., Vaccaro, G. M., Zalupski, M. M., Grilley‐Olson, J. E., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.2020.38.15_suppl.tps4671 · Cited by 8
Better Together: B7S1 Checkpoint Blockade Synergizes with anti-PD1
Meyer, M. A., & DeNardo, D. G. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.029 · Cited by 6
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Metadata
- Authors
- Kurz, E., Hirsch, C. A., Dalton, T., Shadaloey, S. A., Khodadadi-Jamayran, A., Miller, G., Pareek, S., Rajaei, H., Mohindroo, C., Baydogan, S., Ngo-Huang, A., Parker, N., Katz, M. H. G., Petzel, M., Vucic, E., McAllister, F., Schadler, K., Winograd, R., & Bar-Sagi, D.
- Affiliations
- New York University (US)
- Columbia University Irving Medical Center (US)
- Trinity Health (US)
- The University of Texas MD Anderson Cancer Center (US)
- Moffitt Cancer Center (US)
- NYU Langone Health (US)
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 40
- Issue
- 7
- Pages
- 720-737.e5
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC9280705
- OpenAlex
- W4282010758
- Cited by
- 258
- References
- 81
- Citations by year
- 2026: 58 · 2025: 69 · 2024: 62 · 2023: 48 · 2022: 21
- FWCI
- 21.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 375 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Cancer Prevention and Research Institute of Texas (RP200173)
- National Institutes of Health (CA210263, T32- GM136573, T32CA193111, F30 CA243205)
- Novartis
- National Center for Advancing Translational Sciences
- Stanford Genome Technology Center
- Green Templeton College, University of Oxford
- The University of Texas MD Anderson Cancer Center Duncan Family Institute for Cancer Prevention and Risk Assessment
- National Cancer Institute (/ NCI 5 P30CA16087, S10 OD021747, NIZ985)
- Canadian Institutes of Health Research (146792, R21CA218732, P30CA016672, R37CA237384\u201301A1, RP170259)
- New York University (T32CA193111, F30 CA243205, T32- GM136573)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- aerobic exercise, pancreatic ductal adenocarcinoma, antitumor immunity, CD8+ T cells, tumor-infiltrating lymphocytes, anti-PD-1 therapy, chemosensitivity, exercise oncology
- MeSH terms
- Antineoplastic Agents, Humans, Immunotherapy, Pancreatic Neoplasms, CD8-Positive T-Lymphocytes, Interleukin-15, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Receptors, Interleukin-15, Tumor Microenvironment
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