The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.
High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer
Open accessAbstract
Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with diverse immune cell infiltration patterns, which has been linked to both, therapy sensitivity and resistance. However, full understanding of how immune cell phenotypes vary across different patient and tumor subgroups is lacking. Here, we dissect the NSCLC tumor microenvironment at high resolution by integrating 1,212,463 single-cells from 538 samples and 309 patients across 29 datasets, including our own dataset capturing cells with low mRNA content. Based on the cellular composition we stratified patients into immune deserted, B cell, T cell, and myeloid cell subtypes. Using bulk samples with genomic and clinical information, we identified specific cellular components associated with tumor histology and genotypes. Analysis of cells with low mRNA content uncovered distinct subpopulations of tissue-resident neutrophils (TRNs) that acquire new functional properties in the tissue microenvironment, providing evidence for the plasticity of TRNs. TRN-derived gene signature was associated with anti-PD-L1 treatment failure in a large NSCLC cohort.
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Metadata
- Authors
- Salcher, S., Sturm, G., Horvath, L., Untergasser, G., Kuempers, C., Fotakis, G., Panizzolo, E., Martowicz, A., Trebo, M., Pall, G., Gamerith, G., Sykora, M., Augustin, F., Schmitz, K., Finotello, F., Rieder, D., Perner, S., Sopper, S., Wolf, D., Pircher, A., & Trajanoski, Z.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 40
- Issue
- 12
- Pages
- 1503-1520.e8
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W4308834549
- Cited by
- 477
- References
- 159
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Salcher, S., Sturm, G., Horvath, L., Untergasser, G., Kuempers, C., Fotakis, G., Panizzolo, E., Martowicz, A., Trebo, M., Pall, G., Gamerith, G., Sykora, M., Augustin, F., Schmitz, K., Finotello, F., Rieder, D., Perner, S., Sopper, S., Wolf, D., . . . Trajanoski, Z. (2022). High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer. Cancer Cell. https://doi.org/10.1016/j.ccell.2022.10.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
