The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The interferon pathway, particularly IFN-γ, accords with previous data (Marino et al, 2016;Cheng et al, 2024;Herbrich et al, 2025;Heavican-Foral et al, 2026)”
From A scalable in vitro cell competition model identifies preleukemic super competitor clones (2026) · cites this paper as Herbrich et al, 2025
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease
Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., Wu, C.-L., Sano, S., Muralidharan, S., Rius, C., et al. (2017) · Science · doi:10.1126/science.aag1381 · Cited by 1,536
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., et al. (2014) · Nature · doi:10.1038/nature13038 · Cited by 1,443
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.001 · Cited by 1,339
Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade
Wei, S. C., Levine, J. H., Cogdill, A. P., Zhao, Y., Anang, N.-A. A. S., Andrews, M. C., Sharma, P., Wang, J., Wargo, J. A., Pe’er, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.024 · Cited by 1,302
Self-citationLoss of IFN-γ pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy
Gao, J., Shi, L. Z., Zhao, H., Chen, J., Xiong, L., He, Q., Chen, T., Roszik, J., Bernatchez, C., Woodman, S. E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.069 · Cited by 1,300
Self-citationRegulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA
Steimle, V., Siegrist, C.-A., Mottet, A., Lisowska-Grospierre, B., & Mach, B. (1994) · Science · doi:10.1126/science.8016643 · Cited by 898
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
Fraietta, J. A., Nobles, C. L., Sammons, M. A., Lundh, S., Carty, S. A., Reich, T. J., Cogdill, A. P., Morrissette, J. J. D., DeNizio, J. E., Reddy, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0178-z · Cited by 862
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
Zhang, Q., Zhao, K., Shen, Q., Han, Y., Gu, Y., Li, X., Zhao, D., Liu, Y., Wang, C., Zhang, X., et al. (2015) · Nature · doi:10.1038/nature15252 · Cited by 807
Research works printed but not linked: 56
- Steensma, 2015, Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes, Blood, 126, 9, 10.1182/blood-2015-03-631747 · DOI · Paper page
- Genovese, 2014, Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence, N. Engl. J. Med., 371, 2477, 10.1056/NEJMoa1409405 · DOI · Paper page
- Jaiswal, 2014, Age-related clonal hematopoiesis associated with adverse outcomes, N. Engl. J. Med., 371, 2488, 10.1056/NEJMoa1408617 · DOI · Paper page
- Bolton, 2021, Clonal hematopoiesis is associated with risk of severe Covid-19, Nat. Commun., 12, 5975, 10.1038/s41467-021-26138-6 · DOI
- Pich, 2025, Tumor-Infiltrating Clonal Hematopoiesis, N. Engl. J. Med., 392, 1594, 10.1056/NEJMoa2413361 · DOI
- Kleppe, 2015, Somatic mutations in leukocytes infiltrating primary breast cancers, NPJ Breast Cancer, 1, 10.1038/npjbcancer.2015.5 · DOI
- Severson, 2018, Detection of clonal hematopoiesis of indeterminate potential in clinical sequencing of solid tumor specimens, Blood, 131, 2501, 10.1182/blood-2018-03-840629 · DOI
- Ptashkin, 2018, Prevalence of Clonal Hematopoiesis Mutations in Tumor-Only Clinical Genomic Profiling of Solid Tumors, JAMA Oncol., 4, 1589, 10.1001/jamaoncol.2018.2297 · DOI
- Bolton, 2020, Cancer therapy shapes the fitness landscape of clonal hematopoiesis, Nat. Genet., 52, 1219, 10.1038/s41588-020-00710-0 · DOI · Paper page
- Coombs, 2017, Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes, Cell Stem Cell, 21, 374, 10.1016/j.stem.2017.07.010 · DOI · Paper page
- Ko, 2010, Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2, Nature, 468, 839, 10.1038/nature09586 · DOI · Paper page
- Figueroa, 2010, Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation, Cancer Cell, 18, 553, 10.1016/j.ccr.2010.11.015 · DOI · Paper page
- Calcagno, 2020, The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages, Sci. Immunol., 5, 10.1126/sciimmunol.aaz1974 · DOI
- Pan, 2017, The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression, Immunity, 47, 284, 10.1016/j.immuni.2017.07.020 · DOI
- Nguyen, 2021, Tet2 deficiency in immune cells exacerbates tumor progression by increasing angiogenesis in a lung cancer model, Cancer Sci., 112, 4931, 10.1111/cas.15165 · DOI
- Chisolm, 2019, Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses, Immunity, 51, 155, 10.1016/j.immuni.2019.05.006 · DOI
- Grasso, 2020, Conserved Interferon-gamma Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma, Cancer Cell, 38, 500, 10.1016/j.ccell.2020.08.005 · DOI · Paper page
- Ishida, 2008, Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function, J. Immunol., 180, 569, 10.4049/jimmunol.180.1.569 · DOI · Paper page
- Nalio Ramos, 2022, Tissue-resident FOLR2(+) macrophages associate with CD8(+) T cell infiltration in human breast cancer, Cell, 185, 1189, 10.1016/j.cell.2022.02.021 · DOI
- Seyfried, 2021, CCR5 maintains macrophages in the bone marrow and drives hematopoietic failure in a mouse model of severe aplastic anemia, Leukemia, 35, 3139, 10.1038/s41375-021-01219-z · DOI
- Lancien, 2021, Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4(+) T Cells, J. Immunol., 207, 421, 10.4049/jimmunol.2000498 · DOI
- Jenkins, 2025, TET2-loss enhances immediate and time-resolved interferon-gamma signaling responses across myeloid differentiation, Exp. Hematol., 144, 10.1016/j.exphem.2025.104727 · DOI
- Plattner, 2020, Deconvoluting tumor-infiltrating immune cells from RNA-seq data using quanTIseq, Methods Enzymol., 636, 261, 10.1016/bs.mie.2019.05.056 · DOI
- Ott, 2019, T-Cell-Inflamed Gene-Expression Profile, Programmed Death Ligand 1 Expression, and Tumor Mutational Burden Predict Efficacy in Patients Treated With Pembrolizumab Across 20 Cancers: KEYNOTE-028, J. Clin. Oncol., 37, 318, 10.1200/JCO.2018.78.2276 · DOI · Paper page
- Ayers, 2017, IFN-gamma-related mRNA profile predicts clinical response to PD-1 blockade, J. Clin. Investig., 127, 2930, 10.1172/JCI91190 · DOI · Paper page
- Xu, 2019, Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy, J. Clin. Investig., 129, 4316, 10.1172/JCI129317 · DOI
- Peng, 2022, Ascorbic acid induced TET2 enzyme activation enhances cancer immunotherapy efficacy in renal cell carcinoma, Int. J. Biol. Sci., 18, 995, 10.7150/ijbs.67329 · DOI
- Castro, 2018, Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion, Front. Immunol., 9, 847, 10.3389/fimmu.2018.00847 · DOI · Paper page
- Dimitri, 2024, TET2 regulates early and late transitions in exhausted CD8(+) T cell differentiation and limits CAR T cell function, Sci. Adv., 10, 10.1126/sciadv.adp9371 · DOI
- Jain, 2023, TET2 guards against unchecked BATF3-induced CAR T cell expansion, Nature, 615, 315, 10.1038/s41586-022-05692-z · DOI
- Lee, 2021, Tet2 Inactivation Enhances the Antitumor Activity of Tumor-Infiltrating Lymphocytes, Cancer Res., 81, 1965, 10.1158/0008-5472.CAN-20-3213 · DOI
- Heimlich, 2024, Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation, Blood Adv., 8, 3665, 10.1182/bloodadvances.2023011445 · DOI
- Niroula, 2021, Distinction of lymphoid and myeloid clonal hematopoiesis, Nat. Med., 27, 1921, 10.1038/s41591-021-01521-4 · DOI
- Rauch, 2023, Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes, Nat. Cardiovasc. Res., 2, 805
- Sano, 2018, Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1beta/NLRP3 Inflammasome, J. Am. Coll. Cardiol., 71, 875, 10.1016/j.jacc.2017.12.037 · DOI · Paper page
- Fuster, 2020, TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity, Cell Rep., 33, 10.1016/j.celrep.2020.108326 · DOI · Paper page
- Ito, 2019, Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis, Cell Rep., 28, 2480, 10.1016/j.celrep.2019.07.094 · DOI · Paper page
- Yeaton, 2022, The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation, Cancer Discov., 12, 2392, 10.1158/2159-8290.CD-21-1146 · DOI · Paper page
- Hsiehchen, 2022, Clonal hematopoiesis and differential outcomes after immune checkpoint blockade, Cancer Cell, 40, 1071, 10.1016/j.ccell.2022.08.024 · DOI
- Diplas, 2023, Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers, JAMA Netw. Open, 6, 10.1001/jamanetworkopen.2022.54221 · DOI
- Svensson, 2022, TET2-Driven Clonal Hematopoiesis and Response to Canakinumab: An Exploratory Analysis of the CANTOS Randomized Clinical Trial, JAMA Cardiol., 7, 521, 10.1001/jamacardio.2022.0386 · DOI · Paper page
- Boj, 2015, Organoid models of human and mouse ductal pancreatic cancer, Cell, 160, 324, 10.1016/j.cell.2014.12.021 · DOI · Paper page
- Bian, 2021, Intratumoral SIRPalpha-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy, Nat. Commun., 12, 3229, 10.1038/s41467-021-23442-z · DOI
- Chaib, 2023, Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer, Sci. Adv., 9, 10.1126/sciadv.add3231 · DOI
- Borcherding, 2021, Mapping the immune environment in clear cell renal carcinoma by single-cell genomics, Commun. Biol., 4, 122, 10.1038/s42003-020-01625-6 · DOI
- Tirosh, 2016, Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq, Science, 352, 189, 10.1126/science.aad0501 · DOI · Paper page
- Chen, 2016, Cytofkit: A Bioconductor Package for an Integrated Mass Cytometry Data Analysis Pipeline, PLoS Comput. Biol., 12, 10.1371/journal.pcbi.1005112 · DOI
- Hahne, 2009, flowCore: a Bioconductor package for high throughput flow cytometry, BMC Bioinf., 10, 106, 10.1186/1471-2105-10-106 · DOI
- Van Gassen, 2015, FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data, Cytometry. A., 87, 636, 10.1002/cyto.a.22625 · DOI
- Becht, 2018, Dimensionality reduction for visualizing single-cell data using UMAP, Nat. Biotechnol.
- Nikolayeva, 2014, edgeR for differential RNA-seq and ChIP-seq analysis: an application to stem cell biology, Methods Mol. Biol., 1150, 45, 10.1007/978-1-4939-0512-6_3 · DOI
- Diboun, 2006, Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma, BMC Genom., 7, 252, 10.1186/1471-2164-7-252 · DOI
- Love, 2014, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2, Genome Biol., 15, 550, 10.1186/s13059-014-0550-8 · DOI · Paper page
- Barbie, 2009, Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1, Nature, 462, 108, 10.1038/nature08460 · DOI
- Finotello, 2019, Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data, Genome Med., 11, 34, 10.1186/s13073-019-0638-6 · DOI
- Cristescu, 2018, Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy, Science, 362, 10.1126/science.aar3593 · DOI · Paper page
Cited by
A scalable in vitro cell competition model identifies preleukemic super competitor clones
Cabrera-Cosme, L., Rubio-Lara, J. A., Bennett, E., Miłek, J., Baldreki, C., Dowle, A., Vijayabaskar, M. S., Davies, S. J., Taylor-Smith, E., Bain, F. M., et al. (2026) · doi:10.64898/2026.10.21.760611
Metadata
- Authors
- Herbrich, S., Chaib, M., Anandhan, S., Andrewes, S. W., Nagarajan, A., Guan, B., Gandhi, N., Gilliam, J., Radovich, M., & Sharma, P.
- ORCID
- Herbrich, Shelley
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2026-01
- Volume
- 44
- Issue
- 1
- Pages
- 187-202.e7
- ISSN
- 1535-6108
- PMC
- PMC13746248
- Cited by
- 30
- References
- 12
- Language
- en
- Licence
- Funders
- National Institutes of Health (1S10OD024977-01)
- Parker Institute for Cancer Immunotherapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors. https://app.cochat.ai/papers/10.1016/j.ccell.2025.09.011
- The paper
- Herbrich, S., Chaib, M., Anandhan, S., Andrewes, S. W., Nagarajan, A., Guan, B., Gandhi, N., Gilliam, J., Radovich, M., & Sharma, P. (2026). TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors. Cancer Cell. https://doi.org/10.1016/j.ccell.2025.09.011