Coronary Artery Disease and Diabetes Mellitus

Aronson, Doron; Edelman, Elazer R.

doi:10.1016/j.ccl.2014.04.001

Cited by 222Coronary Interventions and DiagnosticsCardiac Imaging and DiagnosticsDiabetes, Cardiovascular Risks, and Lipoproteins

Coronary Artery Disease and Diabetes Mellitus

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Aronson, Doron, Edelman, Elazer R.·2014·Cardiology Clinics

DOI 10.1016/j.ccl.2014.04.001PMC PMC4672945

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Abstract

Diabetes mellitus (DM) is a major risk factor for cardiovascular disease. Near-normal glycemic control does not reduce cardiovascular events. For many patients with 1- or 2-vessel coronary artery disease, there is little benefit from any revascularization procedure over optimal medical therapy. For multivessel coronary disease, randomized trials demonstrated the superiority of coronary artery bypass grafting over multivessel percutaneous coronary intervention in patients with treated DM. However, selection of the optimal myocardial revascularization strategy requires a multidisciplinary team approach ('heart team'). This review summarizes the current evidence regarding the effectiveness of various medical therapies and revascularization strategies in patients with DM.

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Dysfunction of multiple organ systems manifests similarly in diabetes as during normal chronological ageing, but in diabetes this frequently occurs at a younger age.
“Dysfunction of multiple organ systems manifests similarly in diabetes as it does during normal chronological ageing, but in diabetes this frequently occurs at a younger age [2–4].”
From Cellular senescence: at the nexus between ageing and diabetes (2019) · cites this paper as [2]

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Self-citation
Weighty Matters
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Nrf2 at the heart of oxidative stress and cardiac protection
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Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics
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Impact of diabetes mellitus on mortality rates and outcomes in myocardial infarction
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Association between the Non‐high‐Density Lipoprotein Cholesterol to High‐Density Lipoprotein Cholesterol Ratio and the Risk of Coronary Artery Disease
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Selective deletion of endothelial cell calpain in mice reduces diabetic cardiomyopathy by improving angiogenesis
Teng, X.-M., Ji, C., Zhong, H., Zheng, D., Ni, R., Hill, D. J., Xiong, S., Fan, G., Greer, P. A., Shen, Z., et al. (2019) · Diabetologia · doi:10.1007/s00125-019-4828-y · Cited by 49 · see citing works
The Role of Epicardial Adipose Tissue in the Development of Atrial Fibrillation, Coronary Artery Disease and Chronic Heart Failure in the Context of Obesity and Type 2 Diabetes Mellitus: A Narrative Review
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NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co‐expression network analysis
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Age Stratification and Stroke Severity in the Telestroke Network
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Recent Highlights of Research on miRNAs as Early Potential Biomarkers for Cardiovascular Complications of Type 2 Diabetes Mellitus
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Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives
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The impact of financial crisis on coronary artery disease burden in Greece
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The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop
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The relationship between carotid intima-media thickness and serum secreted frizzled-related protein-4 and dipeptidyl peptidase-4 in diabetic patients with cardiovascular diseases
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Contribution of Circulating Mfge8 to Human T2DM and Cardiovascular Disease
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AUTOMATED DIAGNOSIS OF DIABETES USING ENTROPIES AND DIABETIC INDEX
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A Lean Pork-Containing Breakfast Reduces Hunger and Glycemic Response Compared to a Refined Carbohydrate-Containing Breakfast in Adults with Prediabetes
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A Computing System for Discovering Causal Relationships Among Human Genes to Improve Drug Repositioning
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The C allele of the reactive oxygen species modulator 1 (ROMO1) polymorphism rs6060566 is a biomarker predicting coronary artery stenosis in Slovenian subjects with type 2 diabetes mellitus
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Admission hyperglycemia is associated with reperfusion failure in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis.
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Somatic Versus Cognitive Depressive Symptoms as Predictors of Coronary Artery Disease Among Women with Suspected Ischemia
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Stroke Severity among Men and Women Acute Ischemic Stroke Patients in the Telestroke Network
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Clinical Conditions and Their Impact on Utility of Genetic Scores for Prediction of Acute Coronary Syndrome
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Epicardial Fat Thickness as a Marker of Coronary Artery Disease in Diabetics: A Single Center Study
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Five-year trajectories of gait speed and hand grip strength in older adults with cardiometabolic multimorbidity: a national retrospective cohort study
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Cardiovascular Health in the Shadow of Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease: An Emerging Paradigm
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Circulating levels of C1q/TNF-α‐related protein 6 (CTRP6) in coronary artery disease and its correlation with inflammatory markers
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Shexiang Tongxin Dropping Pill Promotes Angiogenesis through VEGF/eNOS Signaling Pathway on Diabetic Coronary Microcirculation Dysfunction
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Aloin reduces advanced glycation end products, decreases oxidative stress, and enhances structural stability in glycated low-density lipoprotein
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Role of CABG in the management of obstructive coronary arterial disease in patients with diabetes mellitus
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Self-citation
Optimal treatment of the diabetic patient with multivessel disease
Bansilal, S., Farkouh, M. E., & Fuster, V. (2008) · Current Cardiology Reports · doi:10.1007/s11886-008-0045-x · Cited by 3 · see citing works
Weighing Coronary Revascularization Options in Patients With Type 2 Diabetes Mellitus
Godoy, L. C., Tavares, C. A. M., & Farkouh, M. E. (2019) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2019.08.002 · Cited by 9 · see citing works
Diabetes and Coronary Artery Disease
Sethi, S. S., & Farkouh, M. E. (2015) · Springer eBooks · doi:10.1007/978-3-319-20415-4_4
Diabetes and multivessel disease
Godoy, L. C., Rao, V. A., & Farkouh, M. E. (2018) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000550 · Cited by 10 · see citing works

Authors: Aronson, D., & Edelman, E. R.
Affiliations: Technion – Israel Institute of Technology (IL)
Brigham and Women's Hospital (US)
ORCID: Aronson, Doron
Edelman, Elazer R.
Venue: Cardiology Clinics
Publisher: Elsevier BV
Published: 2014-08
Volume: 32
Issue: 3
Pages: 439-455
ISSN: 0733-8651 (ISSN-L)
DOI: 10.1016/j.ccl.2014.04.001
PMC: PMC4672945
OpenAlex: W2103962300
Cited by: 222
References: 125
Citations by year: 2026: 9 · 2025: 30 · 2024: 24 · 2023: 27 · 2022: 29 · 2021: 27 · 2020: 23 · 2019: 19 · 2018: 12 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 1
FWCI: 1.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cardiology Clinics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM049039)
Topics: Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: coronary artery disease, diabetes mellitus, glycemic control, cardiovascular risk, coronary revascularization, coronary artery bypass grafting, percutaneous coronary intervention, multivessel coronary artery disease, heart team, optimal medical therapy
MeSH terms: Coronary Artery Disease, Diabetes Mellitus, Humans, Hypoglycemic Agents, Myocardial Revascularization, Risk Factors, Global Health, Incidence, Prevalence, Glycemic Index

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Coronary Artery Disease and Diabetes Mellitus

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