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Cited by 9Natural Antidiabetic Agents StudiesPhytochemicals and Antioxidant ActivitiesFood Science and Nutritional Studies

Impact of nutraceuticals on type 1 and type 2 diabetes mellitus-induced micro- and macrovasculopathies

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Mabena, Philanathi, Fasemore, Thandi M. D., Nkomozepi, Pilani·2023·Applied Sciences
DOI 10.3390/app14010064
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Abstract

Diabetes mellitus (DM), one of the most serious non-communicable diseases, has long-term negative effects on the healthcare system due to its microvascular and macrovascular manifestations, which can be fatal if left untreated. Nutraceuticals, on the other hand, are alternative therapy choices of orally consumed natural food ingredients applicable in the management of several diseases, including diabetes mellitus. Through their antioxidant capabilities and bioactive components, nutraceuticals have been clinically demonstrated to be effective in preventing a number of ailments, including cancer, diabetes, heart disease, and kidney problems. Flavonoids, which are categorized as phytochemicals, are present in several of these nutraceuticals. Cocoa, one of the flavanols engaged in the treatment of diabetes mellitus, provides an additional non-pharmaceutical intervention in the management of diabetes mellitus, which, in part, is because of its high antioxidant capacity. Additionally, flavonoids improve insulin resistance and sensitivity, dyslipidemia, endothelial function, and blood pressure, as well as lower oxidative stress and inflammatory processes. As a result, they may be able to stop the progression of long-term vascular consequences of diabetes, such as cardiovascular disease, neuropathy, nephropathy, and retinopathy. Therefore, the effects of nutraceuticals (as an alternative treatment) on diabetic-related micro- and macrovascular problems are the main focus of this review.

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Cited by

Sorted by citations

Authors
Mabena, P., Fasemore, T. M. D., & Nkomozepi, P.
Affiliations
University of Johannesburg (ZA)
Corresponding author
Mabena, Philanathi
ORCID
Venue
Applied Sciences
Publisher
MDPI AG
Published
2023-12-20
Volume
14
Issue
1
Pages
64
ISSN
2076-3417 (ISSN-L)
DOI
10.3390/app14010064
OpenAlex
W4390014145
Cited by
9
References
2
Citations by year
2026: 1 · 2025: 6 · 2024: 2
FWCI
1.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Applied Sciences (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Nelson Mandela University Research Repository (submittedVersion)
Funders
University of Johannesburg, Faculty of Health Sciences
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Nursing › Nutrition and Dietetics › Food Science and Nutritional Studies
Keywords
nutraceuticals, type 1 diabetes, type 2 diabetes, diabetic microvascular complications, diabetic macrovascular complications, flavonoids, cocoa flavanols, antioxidant capacity, insulin resistance, endothelial function, oxidative stress, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cardiovascular disease

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