Tensional homeostasis and the malignant phenotype

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Items 201–300 of 1,121

  1. Mechanoepigenetic regulation of extracellular matrix homeostasis via Yap and Taz
    Dakota L. Jones, Grey Hallstrom, Xi Jiang, R. C. Locke, M. Evans, E. Bonnevie, A. Srikumar, Thomas P. Leahy, Madhura P. Nijsure, J. Boerckel et al. · 2022 · bioRxiv
  2. Subpopulations of cancer-associated fibroblasts link the prognosis and metabolic features of pancreatic ductal adenocarcinoma
    Beiyuan Hu, Chuntao Wu, Huarong Mao, Haitao Gu, Hanguang Dong, Jiuliang Yan, Zihao Qi, Yuan Lin, Qiongzhu Dong, Jiang Long · 2022 · Annals of Translational Medicine
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    Yuzhen Wang, Xingyu Yuan, Bin Yao, Shuoji Zhu, Ping Zhu, Sha Huang · 2022 · Bioactive Materials
  4. Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis
    Guo, Yaru, Mei, Feng, Huang, Ying, Ma, Siqin, Wei, Yan, Zhang, Xuehui, Xu, Mingming, He, Ying, Heng, Boon Chin, Chen, Lili et al. · 2022 · Bioactive Materials
  5. 3D hydrogel-based microwell arrays as a tumor microenvironment model to study breast cancer growth
    Casey, John, Yue, Xiaoshan, Nguyen, Trung Dung, Acun, Aylin, Zellmer, Victoria R, Zhang, Siyuan, Zorlutuna, Pinar · 2017 · Biomedical Materials
  6. Exploring the Communication of the SASP: Dynamic, Interactive, and Adaptive Effects on the Microenvironment
    Joëlle Giroud, Inès Bouriez, Hugo Paulus, Albin Pourtier, Florence Debacq‐Chainiaux, Olivier Pluquet · 2023 · International Journal of Molecular Sciences
  7. The peritumor microenvironment: physics and immunity
    Sue Zhang, Kathryn Regan, Julian Najera, Mark W. Grinstaff, Meenal Datta, Hadi Tavakoli Nia · 2023 · Trends in cancer
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    Hideyuki Masuda · 2025 · Cell Death Discovery
  9. The Extracellular Matrix: A Key Accomplice of Cancer Stem Cell Migration, Metastasis Formation, and Drug Resistance in PDAC
    Dan Wang, Yuqiang Li, Heming Ge, Tarik Ghadban, Matthias Reeh, Cenap Güngör · 2022 · Cancers
  10. Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction
    Claudia Tanja Mierke · 2022 · Frontiers in Cell and Developmental Biology
  11. Mechanotransduction and Stiffness-Sensing: Mechanisms and Opportunities to Control Multiple Molecular Aspects of Cell Phenotype as a Design Cornerstone of Cell-Instructive Biomaterials for Articular Cartilage Repair
    Mischa Selig, Jasmin C. Lauer, Melanie L. Hart, Bernd Rolauffs · 2020 · International Journal of Molecular Sciences
  12. Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies
    Philip M. Graybill, Rafael V. Davalos · 2020 · Cancers
  13. Biomechanical Properties of Cancer Cells
    G. Runel, N. Lopez-Ramirez, J. Chlasta, I. Masse · 2021 · Cells
  14. Microphysiological Systems: Design, Fabrication, and Applications
    Kai Wang, Kun Man, Jiafeng Liu, Yang Liu, Qi Chen, Yong Zhou, Yong Suk Yang · 2020 · ACS Biomaterials Science & Engineering
  15. Tumor matrix stiffness provides fertile soil for cancer stem cells
    Sadegh Safaei, Roya Sajed, Ahmad Shariftabrizi, Shima Dorafshan, Leili Saeednejad Zanjani, Masoumeh Dehghan Manshadi, Zahra Madjd, Roya Ghods · 2023 · Cancer Cell International
  16. Mechanical homeostasis in tissue equivalents: a review
    Jonas F. Eichinger, Lea J. Haeusel, Daniel Paukner, Roland Can Aydin, Jay D. Humphrey, Christian Johannes Cyron · 2021 · Biomechanics and Modeling in Mechanobiology
  17. Cancer immune exclusion: breaking the barricade for a successful immunotherapy
    Sofía Bruni, Maria Florencia Mercogliano, Florencia Luciana Mauro, Rosalía I. Cordo Russo, Roxana Schillaci · 2023 · Frontiers in Oncology
  18. Extracellular Matrix Remodeling and Development of Cancer
    Koyeli Girigoswami, Devender Saini, Agnishwar Girigoswami · 2020 · Stem Cell Reviews and Reports
  19. The role of extracellular matrix viscoelasticity in development and disease
    Olivia Courbot, Alberto Elósegui-Artola · 2025 · npj Biological Physics and Mechanics.
  20. Focal adhesion-mediated cell anchoring and migration: fromin vitrotoin vivo
    Naoya Yamaguchi, Holger Knaut · 2022 · Development
  21. Mechanical Cues Affect Migration and Invasion of Cells From Three Different Directions
    Claudia Tanja Mierke · 2020 · Frontiers in Cell and Developmental Biology
  22. Tissue mechanics in tumor heterogeneity and aggression
    Anna‐Marie Finger, Audrey M. Hendley, Diego A. Figueroa, Hugo González Velozo, Valerie Marie Weaver · 2025 · Trends in cancer
  23. Understanding Glioblastoma Signaling, Heterogeneity, Invasiveness, and Drug Delivery Barriers
    Nadin Rabah, Fatima-ezzahra Ait Mohand, Nataly Kravchenko‐Balasha · 2023 · International Journal of Molecular Sciences
  24. Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility
    Monika E. Dolega, Sylvain Monnier, Benjamin Brunel, Jean‐François Joanny, Pierre Recho, Giovanni Cappello · 2021 · eLife
  25. Extracellular matrix density regulates the formation of tumour spheroids through cell migration
    Inês G. Gonçalves, José Manuel García‐Aznar · 2021 · PLoS Computational Biology
  26. Remote Tuning of Built‐In Magnetoelectric Microenvironment to Promote Bone Regeneration by Modulating Cellular Exposure to Arginylglycylaspartic Acid Peptide
    Wenwen Liu, Fengyi Zhang, Yuanyang Yan, Chenguang Zhang, Han Zhao, Boon Chin Heng, Ying Huang, Yang Shen, Zhang Jinxing, Lili Chen et al. · 2020 · Advanced Functional Materials
  27. TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation
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  28. Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer
    Allison P. Drain, Nastaran Zahir, Jason J. Northey, Hui Zhang, Po‐Jui Huang, Ori Maller, Johnathon N. Lakins, Xinmiao Yu, Jennifer L. Leight, Brenda Alston‐Mills et al. · 2021 · The Journal of Experimental Medicine
  29. Proteoglycans as Mediators of Cancer Tissue Mechanics
    Anna Barkovskaya, Alexander Buffone, Martin Žídek, Valerie Marie Weaver · 2020 · Frontiers in Cell and Developmental Biology
  30. Advances in biofabrication techniques for collagen-based 3D in vitro culture models for breast cancer research
    John Redmond, Helen O. McCarthy, Paul Buchanan, Tanya J. Levingstone, Nicholas Dunne · 2021 · Materials Science and Engineering C
  31. Matrix Stiffness-Regulated Growth of Breast Tumor Spheroids and Their Response to Chemotherapy
    Yunfeng Li, Nancy Khuu, Elisabeth Prince, Huachen Tao, Ningtong Zhang, Zhengkun Chen, Albert Gevorkian, Alison P. McGuigan, Eugenia Kumacheva · 2020 · Biomacromolecules
  32. Mapping cellular-scale internal mechanics in 3D tissues with thermally responsive hydrogel probes
    Stephanie Mok, Sara Al Habyan, Charles Ledoux, Wontae Lee, Katherine N. MacDonald, Luke Martin McCaffrey, Christopher Moraes · 2020 · Nature Communications
  33. A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer
    Connor Stashko, Mary-Kate Hayward, Jason J. Northey, Neil Pearson, Alastair J. Ironside, Johnathon N. Lakins, Roger Oria, Marie-Anne Goyette, Lakyn N. Mayo, Hege Giercksky Russnes et al. · 2023 · Nature Communications
  34. Cancer cell mechanobiology: a new frontier for cancer research
    Weibo Yu, Shivani Sharma, Elizabeth Rao, Amy C. Rowat, James Kazimierz Gimzewski, Dong Chul Han, Jianyu Rao · 2021 · Journal of the National Cancer Center
  35. Extracellular matrix stiffness controls VEGF165 secretion and neuroblastoma angiogenesis via the YAP/RUNX2/SRSF1 axis
    Min Bao, Yi Chen, Ji-Ting Liu, Han Bao, Wenbin Wang, Ying‐Xin Qi, Fan Lv · 2021 · Angiogenesis
  36. Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications
    Hao Peng, Zheng Chao, Zefeng Wang, Xiaodong Hao, Zirui Xi, Sheng Ma, Xiangdong Guo, Junbiao Zhang, Qiang Zhou, Guanyu Qu et al. · 2025 · Experimental Hematology and Oncology
  37. Matrix-Stiffness–Regulated Inverse Expression of Krüppel-Like Factor 5 and Krüppel-Like Factor 4 in the Pathogenesis of Renal Fibrosis
    Chen, Wan-Chun, Lin, Hsi-Hui, Tang, Ming-Jer · 2015 · The American Journal of Pathology
  38. Environmental Particulate (PM2.5) Augments Stiffness-Induced Alveolar Epithelial Cell Mechanoactivation of Transforming Growth Factor Beta
    Dysart, Marilyn M., Galvis, Boris R., Russell, Armistead G., Barker, Thomas H. · 2014 · PLoS ONE
  39. Natural killer cell immune synapse formation and cytotoxicity are controlled by tension of the target interface
    Daniel Friedman, Poppy Simmonds, Alexander James Hale, Leoma D. Bere, Nigel W. Hodson, Michael White, Daniel M. Davis · 2021 · Journal of Cell Science
  40. Self‐Strengthening Adhesive Force Promotes Cell Mechanotransduction
    Leixiao Yu, Yong Xia Hou, Wenyan Xie, Jose Luis Cuellar‐Camacho, Qiang Wei, Rainer Haag · 2020 · Advanced Materials
  41. Talin‑1 interaction network in cellular mechanotransduction (Review)
    Ye Zhao, Nikita Lykov, Chi‐Meng Tzeng · 2022 · International Journal of Molecular Medicine
  42. Mapping Tumor Spheroid Mechanics in Dependence of 3D Microenvironment Stiffness and Degradability by Brillouin Microscopy
    Vaibhav Mahajan, Timon Beck, Paulina Gregorczyk, André Ruland, Simon Alberti, Jochen R. Guck, Carsten Werner, Raimund Schlüßler, Anna Verena Taubenberger · 2021 · Cancers
  43. Protein Hydrogels: The Swiss Army Knife for Enhanced Mechanical and Bioactive Properties of Biomaterials
    Carla Huerta-López, Jorge Alegre‐Cebollada · 2021 · Nanomaterials
  44. Degradable porous drug-loaded polymer scaffolds for localized cancer drug delivery and breast cell/tissue growth
    John David Obayemi, S. M. Jusu, Ali Azeko Salifu, S. Ghahremani, M. Tadesse, Vanessa O. Uzonwanne, Winston Oluwole Soboyejo · 2020 · Materials Science and Engineering C
  45. Tumor spheroids under perfusion within a 3D microfluidic platform reveal critical roles of cell-cell adhesion in tumor invasion
    Yu Huang, Yujie Ma, Cindy Wu, Carina Shiau, Jeffrey E. Segall, Mingming Wu · 2020 · Scientific Reports
  46. Probing the physical hallmarks of cancer
    Hadi Tavakoli Nia, Lance L. Munn, Rakesh K. Jain · 2025 · Nature Methods
  47. Matrix stiffening facilitates the collective invasion of breast cancer through the periostin-integrin mechanotransduction pathway
    Tiantian Wu, Shanshan Xiong, Mimi Chen, Bjorn T. Tam, Wei Chen, Ke Dong, Zhenling Ma, Zhe Wang, Gaoliang Ouyang · 2023 · Matrix Biology
  48. A Review of Single-Cell Adhesion Force Kinetics and Applications
    Ashwini Surendra Shinde, Kavitha Illath, Pallavi Gupta, Pallavi Shinde, Ki‐Taek Lim, Moeto Nagai, Tuhin Subhra Santra · 2021 · Cells
  49. Extracellular Matrix-Mediated Breast Cancer Cells Morphological Alterations, Invasiveness, and Microvesicles/Exosomes Release
    Marco Franchi, Zoi Piperigkou, Konstantinos-Athanasios Karamanos, Leonardo Franchi, Valentina Masola · 2020 · Cells
  50. A Complex and Evolutive Character: Two Face Aspects of ECM in Tumor Progression
    Margaux Sala, Manon Ros, Frédéric Saltel · 2020 · Frontiers in Oncology
  51. Interplay Between Extracellular Matrix Remodeling and Angiogenesis in Tumor Ecosystem
    Rohit Siddhartha, Minal Garg · 2023 · Molecular Cancer Therapeutics
  52. CAR T Cell Locomotion in Solid Tumor Microenvironment
    Duy Nguyen, Elizabeth Ogando‐Rivas, Ruixuan Liu, Theodore Wang, Jacob A. Rubin, Linchun Jin, Haipeng Tao, William W. Sawyer, Héctor R. Méndez‐Gómez, Matthew Cascio et al. · 2022 · Cells
  53. Cytoskeletal prestress: The cellular hallmark in mechanobiology and mechanomedicine
    Farhan Chowdhury, Bo Huang, Ning Wang · 2021 · Cytoskeleton
  54. Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids
    Eóin McEvoy, Yu Han, Ming Guo, Vivek B. Shenoy · 2020 · Nature Communications
  55. Stiffness-mediated mesenchymal stem cell fate decision in 3D-bioprinted hydrogels
    Yufan Liu, Zhao Li, Jianjun Li, Siming Yang, Yijie Zhang, Bin Yao, Wei Song, Xiaobing Fu, Sha Huang · 2020 · Burns & Trauma
  56. Changes in Tissue Fluidity Predict Tumor Aggressiveness In Vivo
    Frank Sauer, Steffen Grosser, Mehrgan Shahryari, Alexander Hayn, Jing Guo, Jürgen Braun, Susanne Briest, Benjamin Wolf, Bahriye Aktas, Lars‐Christian Horn et al. · 2023 · Advanced Science
  57. The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?
    Carole Luthold, Tarek Hallal, David P. Labbé, François Bordeleau · 2022 · Cancers
  58. A Hydrogel-Integrated Culture Device to Interrogate T Cell Activation with Physicochemical Cues
    Matthew H.W. Chin, Michael D. A. Norman, Eileen Gentleman, Marc‐Olivier Coppens, Richard M. Day · 2020 · ACS Applied Materials & Interfaces
  59. Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening
    Wen-Jun Wang, Lauren A. Hapach, Lauren A. Griggs, Kyra Smart, Yusheng Wu, Paul V. Taufalele, Matthew M Rowe, Katherine M. Young, Madison E Bates, Andrew C Johnson et al. · 2022 · Science Advances
  60. The role of matrix stiffness in cancer stromal cell fate and targeting therapeutic strategies
    Jiayun Wei, Jia Yao, Mengchao Yan, Ye Xie, Pinyan Liu, Yongcui Mao, Xun Li · 2022 · Acta Biomaterialia
  61. Can’t handle the stress? Mechanobiology and disease
    Noam Zuela-Sopilniak, Jan Lammerding · 2022 · Trends in Molecular Medicine
  62. Engineering hydrogels for personalized disease modeling and regenerative medicine
    Ian M. Tayler, Ryan S. Stowers · 2021 · Acta Biomaterialia
  63. Adhesion strength and contractility enable metastatic cells to become adurotactic
    Benjamin Yeoman, G. Shatkin, Pranjali Beri, Afsheen Banisadr, P. Katira, A. Engler · 2020 · Cell Reports
  64. Pancreatic Cancer and Cellular Senescence: Tumor Microenvironment under the Spotlight
    Michela Cortesi, Michele Zanoni, Francesca Pirini, Maria Maddalena Tumedei, Sara Ravaioli, Ilario Giovanni Rapposelli, Giovanni Luca Frassineti, Sara Bravaccini · 2021 · International Journal of Molecular Sciences
  65. Phenotypic Heterogeneity and Metastasis of Breast Cancer Cells
    Lauren A. Hapach, Shawn P. Carey, Samantha C. Schwager, Paul Taufalele, Wenjun Wang, Jenna A. Mosier, Nerymar Ortiz-Otero, Tanner J. McArdle, Zachary E. Goldblatt, Marsha C. Lampi et al. · 2021 · Cancer Research
  66. Recent advances in tumor microenvironment-targeted nanomedicine delivery approaches to overcome limitations of immune checkpoint blockade-based immunotherapy
    Jaehyun Kim, Juhyeong Hong, Jieun Lee, Shayan Fakhraei Lahiji, Yong‐Hee Kim · 2021 · Journal of Controlled Release
  67. Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment
    Christina H. Stuelten, Ying E. Zhang · 2021 · Frontiers in Cell and Developmental Biology
  68. Obesity‐Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling
    Ling Lu, Jeffrey A. Mulligan, Yunxin Ouyang, Adrian A. Shimpi, Rebecca M. Williams, Garrett F. Beeghly, Benjamin David Hopkins, Jason A. Spector, Steven G. Adie, Claudia Fischbach · 2020 · Advanced Functional Materials
  69. Epithelial-to-Mesenchymal Transition in the Light of Plasticity and Hybrid E/M States
    Laura Bornes, Guillaume Belthier, Jacco van Rheenen · 2021 · Journal of Clinical Medicine
  70. Collagenase-mediated extracellular matrix targeting for enhanced drug penetration and therapeutic efficacy in nanoscale delivery systems for cancer therapy
    Pengyu Gong, Fei Wang, Yixin Hua, Jie Ying, Jianxiang Chen, Yiting Qiao · 2025 · Journal of Nanobiotechnology
  71. The role of matrix stiffness in breast cancer progression: a review
    Ruoxi Xu, Peng Yin, Jifu Wei, Qiang Ding · 2023 · Frontiers in Oncology
  72. Fibroblasts as Turned Agents in Cancer Progression
    Robert Wieder · 2023 · Cancers
  73. Lose the Stress: Viscoelastic Materials for Cell Engineering
    Emily M. Carvalho, Sanjay Kumar · 2021 · Acta Biomaterialia
  74. The extracellular matrix in breast cancer predicts prognosis through composition, splicing, and crosslinking
    Robertson, Claire · 2016 · Experimental Cell Research
  75. 3D Cancer Models: Depicting Cellular Crosstalk within the Tumour Microenvironment
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  76. Advances on colorectal cancer 3D models: The needed translational technology for nanomedicine screening
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  77. Lymph Node Subcapsular Sinus Microenvironment-On-A-Chip Modeling Shear Flow Relevant to Lymphatic Metastasis and Immune Cell Homing
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  78. Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages
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  79. Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing
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  80. Implications of Cellular Mechanical Memory in Bioengineering
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  81. Substratum stiffness regulates Erk signaling dynamics through receptor-level control
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  82. Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review)
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  83. Compliant Substrates Enhance Macrophage Cytokine Release and NLRP3 Inflammasome Formation During Their Pro-Inflammatory Response
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  84. The Mechanical Microenvironment in Breast Cancer
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  87. Tissue-scale tensional homeostasis in skin regulates structure and physiological function
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  88. Increased Stiffness Inhibits Invadopodia Formation and Cell Migration in 3D.
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  89. Cancer-associated fibroblasts in the tumor microenvironment: heterogeneity, crosstalk mechanisms, and therapeutic implications
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  90. Regulation of Tumor Invasion by the Physical Microenvironment: Lessons from Breast and Brain Cancer
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  91. Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration
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  93. Rapid fabrication of collagen bundles mimicking tumor-associated collagen architectures
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  95. Rethinking liquid biopsy: Microfluidic assays for mobile tumor cells in human body fluids
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  96. Radiotherapy-induced tumor physical microenvironment remodeling to overcome immunotherapy resistance
    Jianfeng Peng, Xiaoyan Yin, Wenhua Yun, Xiangjiao Meng, Zhaoqin Huang · 2023 · Cancer Letters
  97. The Effects of Stiffness, Fluid Viscosity, and Geometry of Microenvironment in Homeostasis, Aging, and Diseases: A Brief Review
    Seungman Park, Wei‐Hung Jung, Matthew Pittman, Junjie Chen, Yun Chen · 2020 · Journal of Biomechanical Engineering
  98. Matrix Stiffness Regulates Chemosensitivity, Stemness Characteristics, and Autophagy in Breast Cancer Cells.
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  99. Leveraging microenvironmental synthetic lethalities to treat cancer
    Metcalf, Kevin J., Alazzeh, Alaa, Werb, Zena, Weaver, Valerie M. · 2021 · Journal of Clinical Investigation
  100. Getting physical: Material mechanics is an intrinsic cell cue
    Hamza Atcha, Yu Suk Choi, Ovijit Chaudhuri, Adam Jeffrey Engler · 2023 · Cell stem cell