An “elite hacker”: breast tumors exploit the normal microenvironment program to instruct their progression and biological diversity

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Molecular portraits of human breast tumours

Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551 · see citing works

Inflammation and cancer

Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works

Matrix elasticity directs stem cell lineage specification

Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915 · see citing works

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Sørlie, T., Perou, C., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M., van de Rijn, M., Jeffrey, S., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191367098 · Cited by 11,695 · see citing works

Gene expression profiling predicts clinical outcome of breast cancer

van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536 · see citing works

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

van de Vijver, M. J., He, Y. D., Veer, L. V. ‘., Dai, H. A., Hart, A. A. M., Voskuil, D. W., Schreiber, G. J., Peterse, J. L., Roberts, C., Marton, M. J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021967 · Cited by 6,411 · see citing works

Repeated observation of breast tumor subtypes in independent gene expression data sets

Sørlie, T., Tibshirani, R. J., Parker, J. S., Hastie, T. J., Marron, J. S., Nobel, A. B., Deng, S., Johnsen, H., Pesich, R., Geisler, S. B., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0932692100 · Cited by 5,428 · see citing works

Macrophage Diversity Enhances Tumor Progression and Metastasis

Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,208 · see citing works

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell · doi:10.1016/j.cell.2010.03.015 · Cited by 5,151 · see citing works

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

Parker, J. S., Mullins, M., Cheang, M. C. U., Leung, S. C. Y., Voduc, D. K., Vickery, T. L., Davies, S. R., Fauron, C. M. ‐., He, X., Hu, Z., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.1370 · Cited by 4,737 · see citing works

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538 · see citing works

Tumors: Wounds That Do Not Heal

Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · cited 1× · see citing works

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101 · see citing works

Tensional homeostasis and the malignant phenotype

Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941 · see citing works

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759 · see citing works

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from <i>BRCA</i> Mutation Carriers

Fong, P. C., Boss, D. S., Yap, T. A., Tutt, A., Wu, P., Mergui-Roelvink, M., Mortimer, P., Swaisland, H., Lau, A., O'Connor, M. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900212 · Cited by 3,634 · see citing works

The Extracellular Matrix: Not Just Pretty Fibrils

Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527 · see citing works

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., Richardson, A. L., Polyak, K., Tubo, R., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06188 · Cited by 3,206 · see citing works

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

Neve, R. M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F. L., Fevr, T., Clark, L., Bayani, N., Coppé, J., Tong, F. K., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.10.008 · Cited by 3,191 · see citing works

Histological Grading and Prognosis in Breast Cancer

Bloom, H. J. G., & Richardson, W. (1957) · British Journal of Cancer · doi:10.1038/bjc.1957.43 · Cited by 2,938 · see citing works

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

Wang, Y., Klijn, J. G. M., Zhang, Y., Sieuwerts, A. M., Look, M. P., Yang, F., Talantov, D., Timmermans, M. A. M., Gelder, M. E. M., Yu, J. X., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17947-1 · Cited by 2,848 · see citing works

The Collagen Family

Ricard-Blum, S. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004978 · Cited by 2,305 · see citing works

Putting tumours in context

Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180 · see citing works

Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

Prat, A., Parker, J. S., Karginova, O. A., Fan, C., Livasy, C., Herschkowitz, J. I., He, X., & Perou, C. M. (2010) · Breast Cancer Research · doi:10.1186/bcr2635 · Cited by 2,164 · see citing works

Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis

Sotiriou, C. P., Wirapati, P., Loi, S., Harris, A. L., Fox, S., Smeds, J., Nordgren, H., Farmer, P. J., Praz, V., Haibe‐Kains, B., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj052 · Cited by 2,060 · see citing works

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

Debnath, J., Muthuswamy, S. K., & Brugge, J. S. (2003) · Methods · doi:10.1016/s1046-2023(03)00032-x · Cited by 2,001 · see citing works

A tense situation: forcing tumour progression

Butcher, D. T., Alliston, T. N., & Weaver, V. M. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2544 · Cited by 1,922 · see citing works

Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy

Rouzier, R., Perou, C. M., Symmans, W. F., Ibrahim, N. K., Cristofanilli, M., Anderson, K., Hess, K. R., Stec, J. J., Ayers, M., Wagner, P., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2421 · Cited by 1,889 · see citing works

Tumor-Associated Lymphocytes As an Independent Predictor of Response to Neoadjuvant Chemotherapy in Breast Cancer

Denkert, C., Loibl, S., Noske, A., Roller, M., Müller, B. M., Komor, M., Budczies, J., Darb‐Esfahani, S., Kronenwett, R., Hanusch, C. A., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.7370 · Cited by 1,761 · see citing works

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

DeNardo, D. G., Brennan, D. J., Rexhepaj, E., Ruffell, B., Shiao, S. L., Madden, S. F., Gallagher, W. M., Wadhwani, N., Keil, S. D., Junaid, S. A., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-10-0028 · Cited by 1,715 · see citing works

Stromal gene expression predicts clinical outcome in breast cancer

Finak, G., Bertos, N., Pepin, F., Sadekova, S., Souleimanova, M., Zhao, H., Chen, H., Ömeroğlu, G., Meterissian, S. H., Ömeroğlu, A., et al. (2008) · Nature Medicine · doi:10.1038/nm1764 · Cited by 1,687 · see citing works

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

Bissell, M. J., & Hines, W. C. (2011) · Nature Medicine · doi:10.1038/nm.2328 · Cited by 1,516 · see citing works

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

kConFab, Lim, E., Vaillant, F., Wu, D., Forrest, N. C., Pal, B., Hart, A. H., Asselin-Labat, M.-L., Gyorki, D. E., Ward, T., et al. (2009) · Nature Medicine · doi:10.1038/nm.2000 · Cited by 1,492 · cited 1× · see citing works

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.231 · Cited by 1,483 · see citing works

Collagen density promotes mammary tumor initiation and progression

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C., White, J. G., & Keely, P. J. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-11 · Cited by 1,364 · see citing works

Concordance among Gene-Expression–Based Predictors for Breast Cancer

Fan, C., Oh, D. S., Wessels, L. F. A., Weigelt, B., Nuyten, D. S. A., Nobel, A. B., Veer, L. J. V., & Perou, C. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052933 · Cited by 1,338 · see citing works

Molecular characterization of the tumor microenvironment in breast cancer

Allinen, M., Beroukhim, R., Cai, L., Brennan, C., Lahti-Domenici, J., Huang, H., Porter, D., Hu, M., Chin, L., Richardson, A., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.010 · Cited by 1,299 · see citing works

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

Chin, K., DeVries, S., Fridlyand, J., Spellman, P. T., Roydasgupta, R., Kuo, W.-L., Lapuk, A. V., Neve, R. M., Qian, Z., Ryder, T., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.10.009 · Cited by 1,288 · see citing works

Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer

Buyse, M. E., Loi, S., Veer, L. V., Viale, G., Delorenzi, M., Glas, A. M., Saghatchian, M., Bergh, J. C. S., Lidereau, R., Ellis, P., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj329 · Cited by 1,235 · see citing works

Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5

Giannelli, G., Falk-Marzillier, J., Schiraldi, O., Stetler-Stevenson, W. G., & Quaranta, V. (1997) · Science · doi:10.1126/science.277.5323.225 · Cited by 1,221 · see citing works

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

Montesano, R., Matsumoto, K., Nakamura, T., & Orci, L. (1991) · Cell · doi:10.1016/0092-8674(91)90363-4 · Cited by 1,147 · see citing works

Regulation of matrix biology by matrix metalloproteinases

Mott, J. D., & Werb, Z. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.07.010 · Cited by 1,104 · cited 3× · see citing works

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

PETERSEN, O. W., Rønnov‐Jessen, L., Howlett, A. R., & Bissell, M. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9064 · Cited by 1,096 · see citing works

Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice.

DeOme, K. B., Faulkin, L. J., Bern, H. A., & Blair, P. B. (1959) · PubMed · Cited by 993 · see citing works

The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells

Liu, R., Wang, X., Chen, G., Dalerba, P. D., Gurney, A. L., Hoey, T. C., Sherlock, G. J., Lewicki, J. A., Shedden, K., & Clarke, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063994 · Cited by 984 · see citing works

Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival

Chang, H. Y., Nuyten, D. S. A., Sneddon, J. B., Hastie, T., Tibshirani, R., Sørlie, T., Dai, H., He, Y. D., van't Veer, L. J., Bartelink, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409462102 · Cited by 981 · see citing works

Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

Chang, H. Y., Sneddon, J. B., Alizadeh, A. A., Sood, R., West, R. B., Montgomery, K. D., Chi, J., van de Rijn, M., Botstein, D., & Brown, P. O. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020007 · Cited by 952 · see citing works

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

Kumar, S., & Weaver, V. M. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9173-4 · Cited by 930 · see citing works

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

Hennessy, B. T., Gonzalez-Angulo, A. M., Stemke‐Hale, K., Gilcrease, M. Z., Krishnamurthy, S., Lee, J., Fridlyand, J., Şahin, A. A., Agarwal, R., Joy, C., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3441 · Cited by 874 · see citing works

A Comparison of PAM50 Intrinsic Subtyping with Immunohistochemistry and Clinical Prognostic Factors in Tamoxifen-Treated Estrogen Receptor–Positive Breast Cancer

Nielsen, T. O., Parker, J. S., Leung, S. C. Y., Voduc, D. K., Ebbert, M., Vickery, T. L., Davies, S. R., Snider, J., Stijleman, I. J., Reed, J. P., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1282 · Cited by 801 · see citing works

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

Rønnov‐Jessen, L., PETERSEN, O. W., & Bissell, M. J. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.1.69 · Cited by 797 · see citing works

BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

Molyneux, G., Geyer, F. C., Magnay, F., McCarthy, A., Kendrick, H. D., Natrajan, R., Mackay, A. G., Grigoriadis, A. E., Tutt, A. N. J., Ashworth, A., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.010 · Cited by 795 · see citing works

Identification of molecular apocrine breast tumours by microarray analysis

Farmer, P. J., Bonnefoi, H. R., Becette, V., Tubiana-Hulin, M., Fumoleau, P., Larsimont, D., MacGrogan, G. M., Bergh, J. C. S., Cameron, D., Goldstein, D., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208561 · Cited by 783 · see citing works

Ductal Carcinoma in Situ of the Breast

Burstein, H. J., Polyák, K., Wong, J. S., Lester, S. C., & Kaelin, C. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra031301 · Cited by 769 · see citing works

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasionPreprint

Gocheva, V., Wang, H., Gadea, B. B., Shree, T., Hunter, K. E., Garfall, A. L., Berman, T. A., & Joyce, J. A. (2010) · Genes & Development · doi:10.1101/gad.1874010 · Cited by 739 · see citing works

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

Barcellos‐Hoff, M. H., Aggeler, J., Ram, T. G., & Bissell, M. J. (1989) · Development · doi:10.1242/dev.105.2.223 · Cited by 713 · see citing works

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

Streuli, C. H., Bailey, N., & Bissell, M. J. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.5.1383 · Cited by 678 · see citing works

The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts

Peinado, H., Lavotshkin, S., & Lyden, D. C. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.01.002 · Cited by 657 · see citing works

Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells.

Ml, L., Aggeler, J., Farson, D. A., Hatier, C., Hassell, J. R., & Bissell, M. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.1.136 · Cited by 620 · see citing works

Gene expression profiling of the tumor microenvironment during breast cancer progression

Ma, X., Dahiya, S. M., Richardson, E., Erlander, M. G., & Sgroi, D. C. (2009) · Breast Cancer Research · doi:10.1186/bcr2222 · Cited by 618 · see citing works

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

Farmer, P. J., Bonnefoi, H. R., Anderle, P., Cameron, D., Wirapati, P., Becette, V., André, S., Piccart, M. J., Campone, M., Brain, E. G. C., et al. (2009) · Nature Medicine · doi:10.1038/nm.1908 · Cited by 618 · see citing works

Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks

Liu, S., Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-0538 · Cited by 611 · see citing works

An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen

Doane, A. S., Danso, M. A., Lal, P., Donaton, M., Zhang, L., Hudis, C. A., & Gerald, W. L. (2006) · Oncogene · doi:10.1038/sj.onc.1209415 · Cited by 604 · see citing works

Incidence of and Treatment for Ductal Carcinoma In Situ of the Breast

Ernster, V. L. (1996) · JAMA · doi:10.1001/jama.1996.03530360023033 · Cited by 600 · see citing works

Tenascin interferes with fibronectin action

Chiquet‐Ehrismann, R., Kalla, P., Pearson, C. A., Beck, K., & Chiquet, M. (1988) · Cell · doi:10.1016/0092-8674(88)90158-4 · Cited by 596 · see citing works

Refinement of breast cancer classification by molecular characterization of histological special types

Weigelt, B., Horlings, H. M., Kreike, B., Hayes, M., Hauptmann, M., Wessels, L. F. A., de Jong, D., van de Vijver, M. J., Veer, L. V., & Peterse, J. L. (2008) · The Journal of Pathology · doi:10.1002/path.2407 · Cited by 560 · see citing works

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

Shree, T., Olson, O. C., Elie, B. T., Kester, J. C., Garfall, A. L., Simpson, K., Bell-McGuinn, K. M., Zabor, E. C., Brogi, E., & Joyce, J. A. (2011) · Genes &amp; Development · doi:10.1101/gad.180331.111 · Cited by 541 · see citing works

Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition

Guðjónsson, Þ., Rønnov‐Jessen, L., Villadsen, R., Rank, F. E., Bissell, M. J., & PETERSEN, O. W. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.1.39 · Cited by 518 · see citing works

Regulation of In Situ to Invasive Breast Carcinoma Transition

Hu, M., Yao, J., Carroll, D. K., Weremowicz, S., Chen, H., Carrasco, D. R., Richardson, A. L., Violette, S. M., Nikolskaya, T., Nikolsky, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.03.007 · Cited by 497 · see citing works

Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Trier, S. M., & Keely, P. J. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.133116 · Cited by 493 · see citing works

Converting a breast cancer microarray signature into a high-throughput diagnostic test

Glas, A. M., Floore, A. N., Delahaye, L. J. M. J., Witteveen, A. T., Pover, R., Bakx, N., Lahti‐Domenici, J., Bruinsma, T. J., Warmoes, M. O., Bernards, R., et al. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-278 · Cited by 493 · see citing works

Pathological prognostic factors in breast cancer. II. Histological type. Relationship with survival in a large study with long‐term follow‐up

Ellis, I. O., Galea, M., BROUGHTON, N., Locker, A. P., Blamey, R. W., & Elston, C. W. (1992) · Histopathology · doi:10.1111/j.1365-2559.1992.tb01032.x · Cited by 486 · see citing works

Pregnancy-associated breast cancer and metastasis

Schedin, P. S. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1839 · Cited by 467 · see citing works

Postnatal mammary gland development requires macrophages and eosinophils

Gouon–Evans, V., Rothenberg, M. E., & Pollard, J. W. (2000) · Development · doi:10.1242/dev.127.11.2269 · Cited by 463 · see citing works

Clinical Application of the 70-Gene Profile: The MINDACT Trial

Cardoso, F., Veer, L. V., Rutgers, E. J. T., Loi, S., Mook, S., & Piccart, M. J. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.3222 · Cited by 462 · see citing works

Histological and molecular types of breast cancer: is there a unifying taxonomy?

Weigelt, B., & Reis-Filho, J. S. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.166 · Cited by 461 · see citing works

Syndecans

Tkachenko, E., Rhodes, J., & Simons, M. (2005) · Circulation Research · doi:10.1161/01.res.0000159708.71142.c8 · Cited by 457 · see citing works

Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast

Leek, R., Landers, R. J., Harris, A. L., & Lewis, C. E. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690158 · Cited by 450 · see citing works

The tumor microenvironment is a dominant force in multidrug resistance

Correia, A. L., & Bissell, M. J. (2012) · Drug Resistance Updates · doi:10.1016/j.drup.2012.01.006 · Cited by 443 · see citing works

An Atlas of Mouse Mammary Gland Development

Richert, M. M., Schwertfeger, K. L., Ryder, J. W., et al. (2000) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1026499523505 · Cited by 442 · see citing works

Evidence for a stem cell hierarchy in the adult human breast

Villadsen, R., Fridriksdottir, A. J., Rønnov‐Jessen, L., Guðjónsson, Þ., Rank, F. E., LaBarge, M. A., Bissell, M. J., & PETERSEN, O. W. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200611114 · Cited by 418 · see citing works

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

Sympson, C. J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.3.681 · Cited by 400 · see citing works

The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells

Simian, M., Hirai, Y., Navre, M., Werb, Z., Lochter, A., & Bissell, M. J. (2001) · Development · doi:10.1242/dev.128.16.3117 · Cited by 392 · see citing works

Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome

Bergamaschi, A., Tagliabue, E., Sørlie, T., Naume, B., Triulzi, T., Orlandi, R., Russnes, H., Nesland, J. M., Tammi, R., Auvinen, P., et al. (2007) · The Journal of Pathology · doi:10.1002/path.2278 · Cited by 387 · see citing works

Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2

Lyons, T. R., O’Brien, J., Borges, V. F., Conklin, M. W., Keely, P. J., Eliceiri, K. W., Marusyk, A., Tan, A. C., & Schedin, P. S. (2011) · Nature Medicine · doi:10.1038/nm.2416 · Cited by 381 · see citing works

Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657)

The I-SPY 1 TRIAL Investigators, Esserman, L. J., Berry, D. A., Cheang, M. C. U., Yau, C. S. F., Perou, C. M., Carey, L., DeMichele, A. M., Gray, J. W., Conway‐Dorsey, K., et al. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1895-2 · Cited by 362 · see citing works

Breast cancer molecular profiling with single sample predictors: a retrospective analysis

Weigelt, B., Mackay, A. G., A’Hern, R., Natrajan, R., Tan, D. S. P., Dowsett, M., Ashworth, A., & Reis-Filho, J. S. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70008-5 · Cited by 360 · see citing works

Mesenchyme-Dependent Morphogenesis and Epithelium-Specific Cytodifferentiation in Mouse Mammary Gland

Sakakura, T., Nishizuka, Y., & Dawe, C. J. (1976) · Science · doi:10.1126/science.827022 · Cited by 357 · see citing works

Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer

Jänicke, F., Schmitt, M., Pache, L., Ulm, K., Harbeck, N., Höfler, H., & Graeff, H. (1993) · Breast Cancer Research and Treatment · doi:10.1007/bf01833260 · Cited by 354 · see citing works

Endorepellin, a Novel Inhibitor of Angiogenesis Derived from the C Terminus of Perlecan

Mongiat, M., Sweeney, S. M., Antonio, J. D. S., Fu, J., & Iozzo, R. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210445200 · Cited by 341 · see citing works

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

Weigelt, B., Lo, A. T., Park, C. C., Gray, J. W., & Bissell, M. J. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0502-2 · Cited by 336 · see citing works

A clinically relevant gene signature in triple negative and basal-like breast cancer

Rody, A., Karn, T., Liedtke, C., Pusztai, L., Ruckhaeberle, E., Hanker, L., Gaetje, R., Solbach, C., Ahr, A., Metzler, D., et al. (2011) · Breast Cancer Research · doi:10.1186/bcr3035 · Cited by 332 · see citing works

Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype

Park, S. Y., Gönen, M., Kim, H. J., Franziska Michor, A., & Polyák, K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40724 · Cited by 324 · see citing works

The secretory function of adipocytes in the physiology of white adipose tissue

Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318 · see citing works

Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices

Xu, R., Boudreau, A., & Bissell, M. J. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9178-z · Cited by 312 · see citing works

Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution

Schenk, S., Hintermann, E., Bilban, M., Koshikawa, N., Hojilla, C., Khokha, R., & Quaranta, V. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200208145 · Cited by 309 · see citing works

Identification of molecular apocrine breast tumours by microarray analysis

Farmer, P. J., Bonnefoi, H. R., Becette, V., Tubiana-Hulin, M., Fumoleau, P., Larsimont, D., MacGrogan, G. M., Bergh, J. C. S., Cameron, D., Goldstein, D. R., et al. (2005) · Breast Cancer Research · doi:10.1186/bcr1122 · Cited by 307 · see citing works

The Role of the Microenvironment in Mammary Gland Development and CancerPreprint

Polyak, K., & Kalluri, R. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003244 · Cited by 306 · see citing works

Hormonal and local control of mammary branching morphogenesis

Sternlicht, M. D., Kouros‐Mehr, H., Lu, P., & Werb, Z. (2006) · Differentiation · doi:10.1111/j.1432-0436.2006.00105.x · Cited by 303 · see citing works

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis

Wiseman, B. S., Sternlicht, M. D., Lund, L. R., Alexander, C. M., Mott, J., Bissell, M. J., Soloway, P. D., Itohara, S., & Werb, Z. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302090 · Cited by 301 · see citing works

Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression

Ioachim, E. E., Charchanti, A. V., Briasoulis, E. C., Karavasilis, V., Tsanou, H., Arvanitis, D. L., Agnantis, N. J., & Pavlidis, N. A. (2002) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00210-1 · Cited by 301 · see citing works

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.

Yang, Y., Spitzer, E., Meyer, D., et al. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.1.215 · Cited by 300 · see citing works

Alternatively Activated Macrophages and Collagen Remodeling Characterize the Postpartum Involuting Mammary Gland across Species

O’Brien, J., Lyons, T. R., Monks, J., Lucia, M. S., Wilson, R. S., Hines, L. M., Man, Y.-G., Borges, V. F., & Schedin, P. S. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090735 · Cited by 288 · see citing works

In situforce mapping of mammary gland transformation

Lopez, J. I., Kang, I., You, W., McDonald, D. M., & Weaver, V. M. (2011) · Integrative Biology · doi:10.1039/c1ib00043h · Cited by 284 · see citing works

Myoepithelial Cells: Their Origin and Function in Breast Morphogenesis and Neoplasia

Guðjónsson, Þ., Adriance, M. C., Sternlicht, M. D., PETERSEN, O. W., & Bissell, M. J. (2005) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-005-9586-4 · Cited by 282 · see citing works

The α2 Integrin Subunit-Deficient Mouse

Chen, J., Diacovo, T. G., Grenache, D. G., Santoro, S. A., & Zutter, M. M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64185-5 · Cited by 277 · see citing works

Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland

Ingman, W. V., Wyckoff, J., Gouon–Evans, V., Condeelis, J. S., & Pollard, J. W. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20972 · Cited by 273 · see citing works

β1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cells

Hosseraye, I. T.-D. L., Deugnier, M., Faraldo, M. M., Petit, V., Bouvard, D., Medina, D., Fässler, R., Thiery, J. P., & Glukhova, M. A. (2008) · Nature Cell Biology · doi:10.1038/ncb1734 · Cited by 264 · see citing works

Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo

Mailleux, A., Spencer‐Dene, B., Dillon, C., Ndiaye, D., Savona‐Baron, C., Itoh, N., Kato, S., Dickson, C., Thiery, J. P., & Bellusci, S. (2002) · Development · doi:10.1242/dev.129.1.53 · Cited by 256 · see citing works

A Cell Proliferation Signature Is a Marker of Extremely Poor Outcome in a Subpopulation of Breast Cancer Patients

Dai, H. A., Veer, L. V., Lamb, J. R., He, Y. D., Mao, M., Fine, B. M., Bernards, R., van de Vijver, M. J., Deutsch, P., Sachs, A. B., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3953 · Cited by 250 · see citing works

Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells

Soriano, J. V., Pepper, M. S., Nakamura, T., et al. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.2.413 · Cited by 235 · see citing works

Wounding and Its Role in RSV-Mediated Tumor Formation

Dolberg, D. S., Hollingsworth, R. E., Hertle, M., & Bissell, M. J. (1985) · Science · doi:10.1126/science.2996144 · Cited by 230 · see citing works

Molecular Anatomy of Breast Cancer Stroma and Its Prognostic Value in Estrogen Receptor–Positive and –Negative Cancers

Bianchini, G., Qi, Y., Álvarez, R. H., Iwamoto, T., Coutant, C., Ibrahim, N. K., Valero, V., Cristofanilli, M., Green, M. C., Radvanyi, L. G., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.2419 · Cited by 227 · see citing works

Inflammatory breast carcinoma incidence and survival: the surveillance, epidemiology, and end results program of the National Cancer Institute, 1975-1992.

Chang, S., Parker, S. L., Pham, T. H., et al. (1998) · PubMed · Cited by 226 · see citing works

Ablation of β1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation

Naylor, M. J., Li, N., Cheung, J., Lowe, E. T., Lambert, E., Marlow, R., Wang, P., Schatzmann, F., Wintermantel, T. M., Schüetz, G., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200503144 · Cited by 225 · see citing works

Prognostic Breast Cancer Signature Identified from 3D Culture Model Accurately Predicts Clinical Outcome across Independent Datasets

Martin, K. J., Patrick, D. R., Bissell, M. J., & Fournier, M. V. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002994 · Cited by 225 · see citing works

Elucidation of a Role for Stromal Steroid Hormone Receptors in Mammary Gland Growth and Development Using Tissue Recombinants

Cunha, G. R., Young, P., Hom, Y. K., et al. (1997) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1026303630843 · Cited by 221 · see citing works

Candidate regulators of mammary branching morphogenesis identified by genome‐wide transcript analysis

Kouros‐Mehr, H., & Werb, Z. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20978 · Cited by 220 · see citing works

Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development

Gouon-Evans, V., Lin, E. Y., & Pollard, J. W. (2002) · Breast Cancer Research · doi:10.1186/bcr441 · Cited by 217 · see citing works

Identification of Extracellular and Intracellular Signaling Components of the Mammary Adipose Tissue and Its Interstitial Fluid in High Risk Breast Cancer Patients

Celis, J. E., Moreira, J. M. A., Cabezón, T., Gromov, P., Friis, E., Rank, F. E., & Gromova, I. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500030-mcp200 · Cited by 216 · see citing works

Tales from the crypt[ic] sites of the extracellular matrix

Schenk, S., & Quaranta, V. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00129-6 · Cited by 213 · see citing works

Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer

Casey, T., Bond, J. P., Tighe, S. W., Hunter, T., Lintault, L., PATEL, O. V., Eneman, J. D., Crocker, A. M., White, J. H., Tessitore, J., et al. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-9982-8 · Cited by 210 · see citing works

Mediation of Wound-Related Rous Sarcoma Virus Tumorigenesis by TGF-β

Sieweke, M. H., Thompson, N. L., Sporn, M. B., & Bissell, M. J. (1990) · Science · doi:10.1126/science.2163544 · Cited by 207 · see citing works

Inability of Rous sarcoma virus to cause sarcomas in the avian embryo

Dolberg, D. S., & Bissell, M. J. (1984) · Nature · doi:10.1038/309552a0 · Cited by 206 · see citing works

Cell-Matrix Interactions in Mammary Gland Development and Breast CancerPreprint

Muschler, J. L., & Streuli, C. H. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003202 · Cited by 200 · see citing works

Mammary Gland Development in Adult Mice Requires Epithelial and Stromal Estrogen Receptor α

Mueller, S. O., Clark, J. A., Myers, P., & Korach, K. S. (2002) · Endocrinology · doi:10.1210/endo.143.6.8836 · Cited by 195 · see citing works

Expression and functional properties of transforming growth factor alpha and epidermal growth factor during mouse mammary gland ductal morphogenesis.

Snedeker, S. M., Brown, C. F., & DiAugustine, R. P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.276 · Cited by 194 · see citing works

Determination of Stromal Signatures in Breast Carcinoma

West, R. B., Nuyten, D. S. A., Subramanian, S., Nielsen, T. O., Corless, C. L., Rubin, B. P., Montgomery, K. D., Zhu, S., Patel, R. M., Hernandez‐Boussard, T., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030187 · Cited by 194 · see citing works

Patterning Mechanisms of Branched Organs

Lu, P., & Werb, Z. (2008) · Science · doi:10.1126/science.1162783 · Cited by 189 · see citing works

Diverse and Active Roles for Adipocytes During Mammary Gland Growth and Function

Hovey, R. C., & Aimo, L. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9187-8 · Cited by 188 · see citing works

The MAPKERK-1,2 pathway integrates distinct and antagonistic signals from TGFα and FGF7 in morphogenesis of mouse mammary epithelium

Fata, J. E., Mori, H., Ewald, A. J., Zhang, H., Yao, E. S., Werb, Z., & Bissell, M. J. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.03.013 · Cited by 187 · see citing works

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments

LaBarge, M. A., Nelson, C. M., Villadsen, R., Fridriksdottir, A. J., Ruth, J. R., Stampfer, M. R., PETERSEN, O. W., & Bissell, M. J. (2008) · Integrative Biology · doi:10.1039/b816472j · Cited by 177 · see citing works

Validation of 70-gene prognosis signature in node-negative breast cancer

Bueno-de-Mesquita, J. M., Linn, S., Keijzer, R., Wesseling, J., Nuyten, D. S. A., van Krimpen, C., Meijers, C., de Graaf, P. W., Bos, M. M. E. M., Hart, A. A. M., et al. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0191-2 · Cited by 177 · see citing works

Interleukin 6 mediated recruitment of mesenchymal stem cells to the hypoxic tumor milieu

Rattigan, Y. I., Hsu, J., Mishra, P. J., Glod, J. W., & Banerjee, D. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.07.002 · Cited by 176 · see citing works

A stromal gene signature associated with inflammatory breast cancer

Boersma, B. J., Reimers, M., Yi, M., Ludwig, J. A., Luke, B. T., Stephens, R. M., Yfantis, H. G., Lee, D. H., Weinstein, J. N., & Ambs, S. (2007) · International Journal of Cancer · doi:10.1002/ijc.23237 · Cited by 174 · see citing works

Effects of inhibition of basement membrane collagen deposition on rat mammary gland development

Wicha, M. S., Liotta, L. A., Vonderhaar, B. K., et al. (1980) · Developmental Biology · doi:10.1016/0012-1606(80)90402-9 · Cited by 171 · see citing works

HGF/SF: a potent cytokine for mammary growth, morphogenesis and development

Niranjan, B., Buluwela, L., Yant, J., Perusinghe, N. P., Atherton, A. J., Phippard, D., Dale, T. C., Gusterson, B. A., & Kamalati, T. (1995) · Development · doi:10.1242/dev.121.9.2897 · Cited by 170 · see citing works

Concordance of clinical and molecular breast cancer subtyping in the context of preoperative chemotherapy response

de Ronde, J. J., Hannemann, J., Halfwerk, H., Mulder, L., Straver, M. E., Peeters, M.-J. T. F. D. V., Wesseling, J., van de Vijver, M. J., Wessels, L. F. A., & Rodenhuis, S. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0499-6 · Cited by 167 · see citing works

Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues

Kaczmarek, J., Castellani, P., Nicolò, G., et al. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910590104 · Cited by 159 · see citing works

Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo

Boulanger, C. A., Mack, D. L., Booth, B. W., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611637104 · Cited by 157 · see citing works

Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling

Kristensen, V. N., Vaske, C. J., Ursini‐Siegel, J., Loo, P. V., Nord, S., Sachidanandam, R., Sørlie, T., Wärnberg, F., Haakensen, V. D., Helland, Å., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108781108 · Cited by 149 · see citing works

Analysis of the MammaPrint Breast Cancer Assay in a Predominantly Postmenopausal Cohort

Wittner, B. S., Sgroi, D. C., Ryan, P. D., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4723 · Cited by 146 · see citing works

The MINDACT trial: The first prospective clinical validation of a genomic tool

Cardoso, F., Piccart, M. J., Veer, L. V., et al. (2007) · Molecular Oncology · doi:10.1016/j.molonc.2007.10.004 · Cited by 145 · see citing works

Epimorphin Functions as a Key Morphoregulator for Mammary Epithelial Cells

Hirai, Y., Lochter, A., Galosy, S. S., Koshida, S., Niwa, S., & Bissell, M. J. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.1.159 · Cited by 141 · see citing works

Syndecan-1 in Breast Cancer Stroma Fibroblasts Regulates Extracellular Matrix Fiber Organization and Carcinoma Cell Motility

Yang, N., Mosher, R., Seo, S., Beebe, D. J., & Friedl, A. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.039 · Cited by 139 · see citing works

Biological Functions of the Genes in the Mammaprint Breast Cancer Profile Reflect the Hallmarks of Cancer

Tian, S., Roepman, P., Veer, L. J. V., Bernards, R., Snoo, F. D., & Glas, A. M. (2010) · Biomarker Insights · doi:10.4137/bmi.s6184 · Cited by 137 · see citing works

Stroma in breast development and disease

Arendt, L. M., Rudnick, J. A., Keller, P. J., & Kuperwasser, C. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.10.003 · Cited by 134 · see citing works

Activation of Host Wound Responses in Breast Cancer Microenvironment

Troester, M. A., Lee, M. H., Carter, M. J., Fan, C., Cowan, D. W., Perez, E. R., Pirone, J. R., Perou, C. M., Jerry, D. J., & Schneider, S. S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1126 · Cited by 134 · see citing works

The mammary microenvironment alters the differentiation repertoire of neural stem cells

Booth, B. W., Mack, D. L., Androutsellis‐Theotokis, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803214105 · Cited by 133 · see citing works

PIK3CA Mutations in In situ and Invasive Breast Carcinomas

Miron, A., Varadi, M., Carrasco, D. R., Li, H., Luongo, L., Kim, H. J., Park, S. Y., Cho, E. Y., Lewis, G., Kehoe, S. M., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-08-2660 · Cited by 133 · see citing works

Myoepithelial Cells: Autocrine and Paracrine Suppressors of Breast Cancer Progression

Barsky, S. H., & Karlin, N. J. (2005) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-005-9585-5 · Cited by 132 · see citing works

Reconstitution of Mammary Gland Development In Vitro: Requirement of c-met and c-erbB2 Signaling for Branching and Alveolar Morphogenesis

Niemann, C., Brinkmann, V., Spitzer, E., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.533 · Cited by 131 · see citing works

Magnetic Resonance Imaging Captures the Biology of Ductal Carcinoma In Situ

Esserman, L. J., Kumar, A. S., Herrera, A. F., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.5518 · Cited by 130 · see citing works

Breast Cancer: Induction of Differentiation by Embryonic Tissue

DeCosse, J. J., Gossens, C. L., Kuzma, J. F., & Unsworth, B. R. (1973) · Science · doi:10.1126/science.181.4104.1057 · Cited by 129 · see citing works

Gene Expression Signature in Organized and Growth-Arrested Mammary Acini Predicts Good Outcome in Breast Cancer

Fournier, M. V., Martin, K. J., Kenny, P. A., Xhaja, K., Bosch, I., Yaswen, P., & Bissell, M. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0515 · Cited by 129 · see citing works

Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms

Hancox, R. A., Allen, M. D., Holliday, D. L., Edwards, D. R., Pennington, C. J., Guttery, D. S., Shaw, J., Walker, R. A., Pringle, J. H., & Jones, J. L. (2009) · Breast Cancer Research · doi:10.1186/bcr2251 · Cited by 127 · see citing works

Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus.

Martins‐Green, M. M., Boudreau, N. J., & Bissell, M. J. (1994) · PubMed · Cited by 120 · see citing works

Extracellular Matrix Composition Reveals Complex and Dynamic Stromal-Epithelial Interactions in the Mammary Gland

Maller, O., Martinson, H. A., & Schedin, P. S. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9189-6 · Cited by 120 · see citing works

Role of cancer-associated fibroblasts in breast cancer development and prognosis

Aboussekhra, A. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113362aa · Cited by 119 · see citing works

Changes in tenascin-C isoform expression in invasive and preinvasive breast disease.

Adams, M., Jones, J. L., Walker, R. A., Pringle, J. H., & Bell, S. C. (2002) · PubMed · Cited by 117 · see citing works

The spatial and temporal expression of the α2β1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morphogenesis

Keely, P. J., Wu, J. E., & Santoro, S. A. (1995) · Differentiation · doi:10.1046/j.1432-0436.1995.5910001.x · Cited by 117 · see citing works

Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis

Lilla, J. N., & Werb, Z. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.021 · Cited by 115 · see citing works

Stem Cells in the Human BreastPreprint

PETERSEN, O. W., & Polyák, K. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003160 · Cited by 115 · see citing works

Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity

Kim, J., Villadsen, R., Sørlie, T., Fogh, L., Grønlund, S. Z., Fridriksdottir, A. J., Kuhn, I., Rank, F. E., Wielenga, V. T., Solvang, H. K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203203109 · Cited by 114 · see citing works

Necrosis and Hypoxia in Invasive Breast Carcinoma

Tomes, L., Emberley, E. D., Niu, Y., Troup, S., Pastorek, J., Strange, K. S., Harris, A. L., & Watson, P. H. (2003) · Breast Cancer Research and Treatment · doi:10.1023/a:1025476722493 · Cited by 113 · see citing works

Hormonal requirements for basement membrane collagen deposition by cultured rat mammary epithelium.

Liotta, L. A., Wicha, M. S., Foidart, J., et al. (1979) · PubMed · Cited by 108 · see citing works

Analysis of stromal signatures in the tumor microenvironment of ductal carcinoma in situ

Sharma, M., Beck, A. H., Webster, J. A., Espinosa, Í., Montgomery, K. D., Varma, S., van de Rijn, M., Jensen, K. C., & West, R. B. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0654-0 · Cited by 107 · see citing works

Persistence of responsiveness of adult mouse mammary gland to induction by embryonic mesenchyme

Sakakura, T., Sakagami, Y., & Nishizuka, Y. (1979) · Developmental Biology · doi:10.1016/0012-1606(79)90111-8 · Cited by 105 · see citing works

Fibroblast Hepatocyte Growth Factor Promotes Invasion of Human Mammary Ductal Carcinoma <i>In situ</i>

Jedeszko, C., Victor, B. C., Podgorski, I., & Sloane, B. F. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1043 · Cited by 104 · see citing works

Transcriptional and spatiotemporal regulation of prolactin receptor mRNA and cooperativity with progesterone receptor function during ductal branch growth in the mammary gland

Hovey, R. C., Trott, J. F., Ginsburg, E., et al. (2001) · Developmental Dynamics · doi:10.1002/dvdy.1179 · Cited by 102 · see citing works

Reprogramming Human Cancer Cells in the Mouse Mammary Gland

Bussard, K. M., Boulanger, C. A., Booth, B. W., Bruno, R. D., & Smith, G. H. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0591 · Cited by 100 · see citing works

Prolactin Expression and Secretion by Human Breast Glandular and Adipose Tissue Explants

Zinger, M., McFarland-Mancini, M. M., & Ben‐Jonathan, N. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021255 · Cited by 97 · see citing works

Informed consent in the childrens cancer group

Childrens Cancer Group, Kodish, E. D., Pentz, R. D., Noll, R. B., Ruccione, K., Buckley, J. D., & Lange, B. J. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980615)82:12 · Cited by 91 · see citing works

The Mammary Gland: A Model for Development

Daniel, C. W., & Smith, G. H. (1999) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1018796301609 · Cited by 90 · see citing works

Impact of mammographic screening on the detection of good and poor prognosis breast cancers

Esserman, L. J., Shieh, Y., Rutgers, E. J. T., et al. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1748-z · Cited by 86 · see citing works

Morphogenesis of the developing mammary gland: Stage-dependent impact of adipocytes

Landskroner-Eiger, S., Park, J.-Y., Israel, D. D., Pollard, J. W., & Scherer, P. E. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.06.019 · Cited by 81 · see citing works

Transforming growth factor-β and breast cancer: Mammary gland development

Barcellos‐Hoff, M. H., & Ewan, K. (2000) · Breast Cancer Research · doi:10.1186/bcr40 · Cited by 80 · see citing works

Functional Significance of MMP-9 in Tumor Necrosis Factor-Induced Proliferation and Branching Morphogenesis of Mammary Epithelial Cells

Lee, P.-P. H., Hwang, J.-J., Murphy, G., & Ip, M. M. (2000) · Endocrinology · doi:10.1210/endo.141.10.7697 · Cited by 80 · see citing works

Exosome signaling in mammary gland development and cancer

Hendrix, A., & Hume, A. N. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113391ah · Cited by 79 · see citing works

Identification of a low-risk subgroup of HER-2-positive breast cancer by the 70-gene prognosis signature

Knauer, M., Cardoso, F., Wesseling, J., et al. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605916 · Cited by 78 · see citing works

Tenascin-c inhibits extracellular matrix-dependent gene expression in mammary epithelial cells: localization of active regions using recombinant tenascin fragments

Jones, P. L., Boudreau, N. J., Myers, C. A., Erickson, H., & Bissell, M. J. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.2.519 · Cited by 74 · see citing works

Transforming Growth Factor-βs and Mammary Gland Involution; Functional Roles and Implications for Cancer Progression

Flanders, K. C., & Wakefield, L. M. (2009) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-009-9122-z · Cited by 71 · see citing works

Accelerating Identification and Regulatory Approval of Investigational Cancer Drugs

Esserman, L. J., & Woodcock, J. (2011) · JAMA · doi:10.1001/jama.2011.1837 · Cited by 69 · see citing works

Roles of Hepatocyte Growth Factor/Scatter Factor and Transforming Growth Factor-β1 in Mammary Gland Ductal Morphogenesis

Soriano, J. V., Pepper, M. S., Orci, L., et al. (1998) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1018790705727 · Cited by 68 · see citing works

Early Dysregulation of Cell Adhesion and Extracellular Matrix Pathways in Breast Cancer Progression

Emery, L. A., Tripathi�, A., King, C., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090115 · Cited by 68 · see citing works

Regulation of Mammary Gland Branching Morphogenesis by EphA2 Receptor Tyrosine Kinase

Vaught, D., Chen, J., & Brantley‐Sieders, D. M. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-04-0378 · Cited by 67 · see citing works

Mammary Gland Reprogramming: Metalloproteinases Couple Form with FunctionPreprint

Khokha, R., & Werb, Z. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004333 · Cited by 65 · see citing works

Embryonic Inductive Tissues That Cause Histologic Differentiation of Murine Mammary Carcinoma In Vitro 2

DeCosse, J. J., Gossens, C. L., Kuzma, J. F., & Unsworth, B. R. (1975) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/54.4.913 · Cited by 60 · see citing works

The assessment of angiogenesis and fibroblastic stromagenesis in hyperplastic and pre-invasive breast lesions

Pavlakis, K., Messini, I., Vrekoussis, T., Yiannou, P., Keramopoullos, D., Louvrou, N., Liakakos, T., & Stathopoulos, E. N. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-88 · Cited by 59 · see citing works

The biological and clinical characteristics of breast carcinoma with mixed ductal and lobular morphology

Rakha, E. A., Gill, M. S., El‐Sayed, M. E., et al. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0007-4 · Cited by 59 · see citing works

Overexpression of the Matrix Metalloproteinase Matrilysin Results in Premature Mammary Gland Differentiation and Male Infertility

Rudolph‐Owen, L. A., Cannon, P., & Matrisian, L. M. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.2.421 · Cited by 57 · see citing works

Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling

Garner, O. B., Bush, K. T., Nigam, K. B., Yamaguchi, Y., Xu, D., Esko, J. D., & Nigám, S. K. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.04.035 · Cited by 55 · see citing works

Unexpected Deposition of Brown Fat in Mammary Gland During Postnatal Development

Gouon–Evans, V., & Pollard, J. W. (2002) · Molecular Endocrinology · doi:10.1210/me.2001-0337 · Cited by 53 · see citing works

Gene expression meta-analysis supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB family

Sanga, S., Broom, B. M., Vittorio Cristini, C., & Edgerton, M. E. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-59 · Cited by 53 · see citing works

The Impact of Preoperative Magnetic Resonance Imaging on Surgical Treatment and Outcomes for Ductal Carcinoma In Situ

Itakura, K., Lessing, J. N., Sakata, T., et al. (2011) · Clinical Breast Cancer · doi:10.3816/cbc.2011.n.006 · Cited by 43 · see citing works

Clinical Utility of the 70-gene MammaPrint Profile in a Japanese Population

Ishitobi, M., Goranova, T., Komoike, Y., et al. (2010) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyp195 · Cited by 38 · see citing works

Mammary Gland Development in Adult Mice Requires Epithelial and Stromal Estrogen Receptor

Mueller, S. O. (2002) · Endocrinology · doi:10.1210/en.143.6.2357 · Cited by 37 · see citing works

Intratumoral microvessel density and expression of ED-A/ED-B sequences of fibronectin in breast carcinoma

D’Ovidio, M. C., Mastracchio, A., Marzullo, A., et al. (1998) · European Journal of Cancer · doi:10.1016/s0959-8049(98)00041-0 · Cited by 35 · see citing works

Breast cancer

Harbeck, N., Penault-Llorca, F., Cortes, J., Gnant, M., Houssami, N., Poortmans, P., Ruddy, K., Tsang, J., & Cardoso, F. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0111-2 · Cited by 3,024 · see citing works

The hypoxic tumor microenvironment: A driving force for breast cancer progression

Semenza, G. L. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.05.036 · Cited by 535 · see citing works

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Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

Technological Paradox of Hackers Begetting Hackers: A Case of Ethical and Unethical Hackers and their Subtle Tools

Banda, R., Phiri, J., Nyirenda, M., et al. (2019) · Zambia ICT Journal · doi:10.33260/zictjournal.v3i1.74 · Cited by 8 · see citing works

Hacking Hollywood: discussing hackers' reactions to three popular films

Jecan, V., & Babeş-Bolyai, U. (2011) · Cited by 1 · see citing works

Hacker Taggers: A new type of hackers

Warren, M. J., & Leitch, S. (2009) · Information Systems Frontiers · doi:10.1007/s10796-009-9203-y · Cited by 14 · see citing works

Using social network analysis to identify key hackers for keylogging tools in hacker forums

Samtani, S., & Chen, H. (2016) · doi:10.1109/isi.2016.7745500 · Cited by 38 · see citing works