Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,240

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Open access
van Delft, Mark F., Wei, Andrew H., Mason, Kylie D., Vandenberg, Cassandra J., Chen, Lin, Czabotar, Peter E., Willis, Simon N., Scott, Clare L., Day, Catherine L., Cory, Suzanne, Adams, Jerry M., Roberts, Andrew W., Huang, David C.S.·2006·Cancer Cell
DOI 10.1016/j.ccr.2006.08.027
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.ccr.2006.08.027

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 7 references

Research works printed but not linked: 53

  1. Baell, 2002, Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs, Biochem. Pharmacol., 64, 851, 10.1016/S0006-2952(02)01148-6 · DOI
  2. Brummelkamp, 2002, Stable suppression of tumorigenicity by virus-mediated RNA interference, Cancer Cell, 2, 243, 10.1016/S1535-6108(02)00122-8 · DOI · Paper page
  3. Chan, 2003, Identification of chelerythrine as an inhibitor of Bcl-xL function, J. Biol. Chem., 278, 20453, 10.1074/jbc.C300138200 · DOI
  4. Chen, 2005, Differential targeting of pro-survival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function, Mol. Cell, 17, 393, 10.1016/j.molcel.2004.12.030 · DOI · Paper page
  5. Cheng, 2001, Bcl-2, Bcl-xL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis, Mol. Cell, 8, 705, 10.1016/S1097-2765(01)00320-3 · DOI
  6. Cochran, 2001, Protein-protein interfaces: Mimics and inhibitors, Curr. Opin. Chem. Biol., 5, 654, 10.1016/S1367-5931(01)00262-9 · DOI
  7. Cory, 2003, The Bcl-2 family: Roles in cell survival and oncogenesis, Oncogene, 22, 8590, 10.1038/sj.onc.1207102 · DOI
  8. Craig, 2002, Mcl-1 provides a window on the role of the Bcl-2 family in cell proliferation, differentiation and tumorigenesis, Leukemia, 16, 444, 10.1038/sj.leu.2402416 · DOI · Paper page
  9. Cuconati, 2003, DNA damage response and Mcl-1 destruction initiate apoptosis in adenovirus-infected cells, Genes Dev., 17, 2922, 10.1101/gad.1156903 · DOI
  10. Degterev, 2001, Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL, Nat. Cell Biol., 3, 173, 10.1038/35055085 · DOI
  11. Ekert, 2004, Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die, J. Cell Biol., 165, 835, 10.1083/jcb.200312031 · DOI
  12. Enyedy, 2001, Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening, J. Med. Chem., 44, 4313, 10.1021/jm010016f · DOI
  13. Fesik, 2005, Promoting apoptosis as a strategy for cancer drug discovery, Nat. Rev. Cancer, 5, 876, 10.1038/nrc1736 · DOI
  14. Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9 · DOI · Paper page
  15. Huang, 2000, BH3-only proteins—Essential initiators of apoptotic cell death, Cell, 103, 839, 10.1016/S0092-8674(00)00187-2 · DOI · Paper page
  16. Huang, 1997, Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death, Oncogene, 14, 405, 10.1038/sj.onc.1200848 · DOI
  17. Huang, 1997, The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry, EMBO J., 16, 4628, 10.1093/emboj/16.15.4628 · DOI
  18. Huang, 2000, Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways, Blood, 96, 1764, 10.1182/blood.V96.5.1764 · DOI
  19. Jeffers, 2003, Puma is an essential mediator of p53-dependent and -independent apoptotic pathways, Cancer Cell, 4, 321, 10.1016/S1535-6108(03)00244-7 · DOI
  20. Johnstone, 2002, Apoptosis: A link between cancer genetics and chemotherapy, Cell, 108, 153, 10.1016/S0092-8674(02)00625-6 · DOI
  21. Jourdan, 2003, A major role for Mcl-1 anti-apoptotic protein in the IL-6-induced survival of human myeloma cells, Oncogene, 22, 2950, 10.1038/sj.onc.1206423 · DOI
  22. Kaufmann, 2003, Alterations in the apoptotic machinery and their potential role in anticancer drug resistance, Oncogene, 22, 7414, 10.1038/sj.onc.1206945 · DOI
  23. Kitada, 2000, Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate anti-apoptosis proteins in B-cell chronic lymphocytic leukemia, Blood, 96, 393, 10.1182/blood.V96.2.393 · DOI · Paper page
  24. Kitada, 2003, Discovery, characterisation, and structure-activity relationships studies of pro-apoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins, J. Med. Chem., 46, 4259, 10.1021/jm030190z · DOI · Paper page
  25. Kozopas, 1993, mcl-1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to bcl-2, Proc. Natl. Acad. Sci. USA, 90, 3516, 10.1073/pnas.90.8.3516 · DOI · Paper page
  26. Le Gouill, 2004, VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis, Blood, 104, 2886, 10.1182/blood-2004-05-1760 · DOI
  27. Liu, 2003, The structure of a Bcl-xL/Bim fragment complex: Implications for Bim function, Immunity, 19, 341, 10.1016/S1074-7613(03)00234-6 · DOI
  28. MacCallum, 2005, Seliciclib (CYC202, R-roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1, Cancer Res., 65, 5399, 10.1158/0008-5472.CAN-05-0233 · DOI · Paper page
  29. Nijhawan, 2003, Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation, Genes Dev., 17, 1475, 10.1101/gad.1093903 · DOI · Paper page
  30. O'Connor, 1998, Bim: A novel member of the Bcl-2 family that promotes apoptosis, EMBO J., 17, 384, 10.1093/emboj/17.2.384 · DOI
  31. Oltersdorf, 2005, An inhibitor of Bcl-2 family proteins induces regression of solid tumours, Nature, 435, 677, 10.1038/nature03579 · DOI · Paper page
  32. Opferman, 2005, Obligate role of anti-apoptotic Mcl-1 in the survival of hematopoietic stem cells, Science, 307, 1101, 10.1126/science.1106114 · DOI
  33. Petros, 2000, Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies, Protein Sci., 9, 2528, 10.1017/S096183680000331X · DOI
  34. Rahmani, 2005, Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation, J. Biol. Chem., 280, 35217, 10.1074/jbc.M506551200 · DOI · Paper page
  35. Raje, 2005, Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma, Blood, 106, 1042, 10.1182/blood-2005-01-0320 · DOI
  36. Ranger, 2001, Mouse models of cell death, Nat. Genet., 28, 113, 10.1038/88815 · DOI · Paper page
  37. Rutledge, 2002, A view to a kill: Ligands for Bcl-2 family proteins, Curr. Opin. Chem. Biol., 6, 479, 10.1016/S1367-5931(02)00352-6 · DOI
  38. Sattler, 1997, Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis, Science, 275, 983, 10.1126/science.275.5302.983 · DOI · Paper page
  39. Schmitt, 2000, Genetic analysis of chemoresistance in primary murine lymphomas, Nat. Med., 6, 1029, 10.1038/79542 · DOI · Paper page
  40. Shibue, 2003, Integral role of Noxa in p53-mediated apoptotic response, Genes Dev., 17, 2233, 10.1101/gad.1103603 · DOI · Paper page
  41. Strasser, 1990, Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2, Nature, 348, 331, 10.1038/348331a0 · DOI · Paper page
  42. Su, 2002, Large-scale analysis of the human and mouse transcriptomes, Proc. Natl. Acad. Sci. USA, 99, 4465, 10.1073/pnas.012025199 · DOI · Paper page
  43. Tsujimoto, 1985, Involvement of the bcl-2 gene in human follicular lymphoma, Science, 228, 1440, 10.1126/science.3874430 · DOI
  44. Tzung, 2001, Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3, Nat. Cell Biol., 3, 183, 10.1038/35055095 · DOI · Paper page
  45. Vaux, 1988, Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells, Nature, 335, 440, 10.1038/335440a0 · DOI · Paper page
  46. Wang, 2000, Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells, Proc. Natl. Acad. Sci. USA, 97, 7124, 10.1073/pnas.97.13.7124 · DOI · Paper page
  47. Waterhouse, 2004, Assaying cytochrome c translocation during apoptosis, Methods Mol. Biol., 284, 307
  48. Willis, 2005, Pro-apoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins, Genes Dev., 19, 1294, 10.1101/gad.1304105 · DOI · Paper page
  49. Yu, 2005, The role of Mcl-1 down-regulation in the pro-apoptotic activity of the multikinase inhibitor BAY 43-9006, Oncogene, 24, 6861, 10.1038/sj.onc.1208841 · DOI
  50. Zhai, 2006, Comparison of chemical inhibitors of anti-apoptotic Bcl-2-family proteins, Cell Death Differ., 13, 1419, 10.1038/sj.cdd.4401937 · DOI
  51. Zhang, 2002, Myeloid cell factor-1 is a critical survival factor for multiple myeloma, Blood, 99, 1885, 10.1182/blood.V99.6.1885 · DOI
  52. Zhong, 2005, Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis, Cell, 121, 1085, 10.1016/j.cell.2005.06.009 · DOI
  53. Zong, 2001, BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak, Genes Dev., 15, 1481, 10.1101/gad.897601 · DOI

Cited by

See all 1,240

Metadata

Authors
van Delft, M. F., Wei, A. H., Mason, K. D., Vandenberg, C. J., Chen, L., Czabotar, P. E., Willis, S. N., Scott, C. L., Day, C. L., Cory, S., Adams, J. M., Roberts, A. W., & Huang, D. C. S.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2006-11
Volume
10
Issue
5
Pages
389-399
ISSN
1535-6108 (ISSN-L)
DOI
10.1016/j.ccr.2006.08.027
OpenAlex
W2027395744
Cited by
1,240
References
7
FWCI
24.43
Type
journal article
Language
en
Open access
bronze
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. https://app.cochat.ai/papers/10.1016/j.ccr.2006.08.027
The paper
van Delft, M. F., Wei, A. H., Mason, K. D., Vandenberg, C. J., Chen, L., Czabotar, P. E., Willis, S. N., Scott, C. L., Day, C. L., Cory, S., Adams, J. M., Roberts, A. W., & Huang, D. C. S. (2006). The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. https://doi.org/10.1016/j.ccr.2006.08.027

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.