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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Stable suppression of tumorigenicity by virus-mediated RNA interference

Brummelkamp, Thijn R, Bernards, René, Agami, Reuven·2002·Cancer Cell
DOI 10.1016/s1535-6108(02)00122-8
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Crossref · 10.1016/s1535-6108(02)00122-8

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3 of 3 references verified0 citation errors · 0 not checkable

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  • Continued reliance on mutant RAS signaling is required for tumor maintenance after neoplastic initiation.

    “the continued reliance on mutant RAS signaling for tumor maintenance”

    From A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution (2017) · cites this paper as Brummelkamp et al., 2002

    The Significance passage reports that suppressing mutant K-RAS V12 in human pancreatic carcinoma cells caused loss of tumorigenicity, indicating that this oncogene remained necessary late in tumorigenesis. The Abstract reports the same result. These passages support continued dependence in that setting, but not an unqualified requirement for mutant RAS signaling in tumors generally. (LLM, conf=0.84)

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Citations

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Research works printed but not linked: 18

  1. Agami, 2000, Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage, Cell, 102, 55, 10.1016/S0092-8674(00)00010-6 · DOI
  2. Barbacid, 1987, ras genes, Annu. Rev. Biochem., 56, 779, 10.1146/annurev.bi.56.070187.004023 · DOI · Paper page
  3. Bos, 1989, ras oncogenes in human cancer, Cancer Res., 49, 4682
  4. Brummelkamp, 2002, A System for stable expression of short interfering RNAs in mammalian cells, Science, 296, 550, 10.1126/science.1068999 · DOI
  5. Chin, 1999, Essential role for oncogenic Ras in tumour maintenance, Nature, 400, 468, 10.1038/22788 · DOI
  6. Gitlin, 2002, Short interfering RNA confers intracellular antiviral immunity in human cells, Nature, 418, 430, 10.1038/nature00873 · DOI
  7. Hahn, 2002, Modelling the molecular circuitry of cancer, Nat. Rev. Cancer, 2, 331, 10.1038/nrc795 · DOI
  8. Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9 · DOI · Paper page
  9. Jackson, 2001, Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras, Genes Dev., 15, 3243, 10.1101/gad.943001 · DOI
  10. Jacque, 2002, Modulation of HIV-1 replication by RNA interference, Nature, 418, 435, 10.1038/nature00896 · DOI
  11. Johnson, 1997, K-ras is an essential gene in the mouse with partial functional overlap with N-ras, Genes Dev., 11, 2468, 10.1101/gad.11.19.2468 · DOI
  12. Johnson, 2001, Somatic activation of the K-ras oncogene causes early onset lung cancer in mice, Nature, 410, 1111, 10.1038/35074129 · DOI · Paper page
  13. Lewis, D.L., Hagstrom, J.E., Loomis, A.G., Wolff, J.A., and Herweijer, H. (2002). Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat. Genet. Published online July 29, 2002. 10.1038/ng944 · DOI
  14. McCaffrey, 2002, RNA interference in adult mice, Nature, 418, 38, 10.1038/418038a · DOI
  15. McCormick, 1989, ras GTPase activating protein, Cell, 56, 5, 10.1016/0092-8674(89)90976-8 · DOI
  16. McCormick, 1990, GTP binding and growth control, Curr. Opin. Cell Biol., 2, 181, 10.1016/0955-0674(90)90004-X · DOI
  17. Novina, 2002, siRNA-directed inhibition of HIV-1 infection, Nat. Med., 8, 681, 10.1038/nm725 · DOI
  18. Tuschl, 2002, Expanding small RNA interference, Nat. Biotechnol., 20, 446, 10.1038/nbt0502-446 · DOI

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Metadata

Authors
Brummelkamp, T. R., Bernards, R., & Agami, R.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2002-09
Volume
2
Issue
3
Pages
243-247
ISSN
1535-6108
DOI
10.1016/s1535-6108(02)00122-8
Cited by
886
References
3
Language
en
Licence

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