Metal based neurodegenerative diseases—From molecular mechanisms to therapeutic strategies
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Copper, iron, and zinc ions affect Aβ aggregation and lead to formation of reactive oxygen species.
“These metal ions have been shown to affect Aβ aggregation, as well as lead to the formation of reactive oxygen species (ROS).12−16”
From Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity (2014) · cites this paper as [16]
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- Authors
- Crichton, R. R., Dexter, D. T., & Ward, R. J.
- Affiliations
- UCLouvain (BE)
- Imperial College London (GB)
- University of Florence (IT)
- Corresponding author
- Crichton, Robert R.
- Venue
- Coordination Chemistry Reviews
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 252
- Issue
- 10-11
- Pages
- 1189-1199
- ISSN
- 0010-8545 (ISSN-L)
- OpenAlex
- W2034919415
- Cited by
- 252
- References
- 62
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 10 · 2023: 13 · 2022: 14 · 2021: 15 · 2020: 7 · 2019: 19 · 2018: 16 · 2017: 15 · 2016: 20 · 2015: 20 · 2014: 23 · 2013: 19 · 2012: 13
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Coordination Chemistry Reviews (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- metal homeostasis, iron, copper, reactive oxygen species, protein carbonylation, protein aggregation, ubiquitin-proteasome system, Parkinson's disease, Alzheimer's disease, chelation therapy, redox-active metals
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