Cited by 258Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolismIron Metabolism and Disorders

Decreased ferritin levels in brain in Parkinson's disease

Dexter, D. T., Carayon, A., Vidailhet, M., Ruberg, M., Agid, F., Agid, Y., Lees, A. J., Wells, F. R. +2 more·1990·Journal of Neurochemistry

Abstract

Ferritin levels were measured in postmortem brain tissue from patients dying with Parkinson's disease [treated with L-3,4-dihydroxyphenylalanine (L-DOPA)] and from control patients. Ferritin levels were decreased in the substantia nigra, caudate-putamen, globus pallidus, cerebral cortex, and cerebellum when compared with age-matched control tissues. However, in CSF from L-DOPA-treated patients and in serum from L-DOPA-treated and untreated parkinsonian patients, ferritin levels were normal. Previous studies have suggested an increased total iron content in substantia nigra of parkinsonian brain. The failure of substantia nigra ferritin formation to be stimulated by increased iron levels suggests some defect in iron handling in this critical brain region in Parkinson's disease. The reason for decreased ferritin levels throughout the parkinsonian brain is not clear but does not seem to reflect a general system deficit in ferritin.

Integrity signals

Registry

Crossref · 10.1111/j.1471-4159.1990.tb08814.x

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20 of 20 references verified0 citation errors · 0 not checkable

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  • Increases of iron and a decrease of ferritin in the substantia nigra are indicative of high iron loading of ferritin.

    “Increases of iron and a decrease of ferritin in the substantia nigra101,116–119 are indicative of high iron loading of ferritin.120”

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Authors
Dexter, D. T., Carayon, A., Vidailhet, M., Ruberg, M., Agid, F., Agid, Y., Lees, A. J., Wells, F. R., Jenner, P., & Marsden, C. D.
Affiliations
  • Parkinson's UK (GB)
  • Inserm (FR)
Corresponding author
Jenner, P.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
1990-07
Volume
55
Issue
1
Pages
16-20
ISSN
  • 0022-3042 (ISSN-L)
  • 1471-4159
OpenAlex
W1999434577
Cited by
258
References
20
Citations by year
2026: 3 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 1 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 2
FWCI
14.15
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
Parkinson's disease, ferritin, brain iron metabolism, substantia nigra, L-dopa treatment, cerebrospinal fluid, serum ferritin, caudate-putamen, globus pallidus, cerebral cortex, cerebellum
MeSH terms
Brain Chemistry, Female, Ferritins, Humans, Iron, Male, Middle Aged, Parkinson Disease, Reference Values, Tissue Distribution

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