Decreased ferritin levels in brain in Parkinson's disease
Abstract
Ferritin levels were measured in postmortem brain tissue from patients dying with Parkinson's disease [treated with L-3,4-dihydroxyphenylalanine (L-DOPA)] and from control patients. Ferritin levels were decreased in the substantia nigra, caudate-putamen, globus pallidus, cerebral cortex, and cerebellum when compared with age-matched control tissues. However, in CSF from L-DOPA-treated patients and in serum from L-DOPA-treated and untreated parkinsonian patients, ferritin levels were normal. Previous studies have suggested an increased total iron content in substantia nigra of parkinsonian brain. The failure of substantia nigra ferritin formation to be stimulated by increased iron levels suggests some defect in iron handling in this critical brain region in Parkinson's disease. The reason for decreased ferritin levels throughout the parkinsonian brain is not clear but does not seem to reflect a general system deficit in ferritin.
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Increases of iron and a decrease of ferritin in the substantia nigra are indicative of high iron loading of ferritin.
“Increases of iron and a decrease of ferritin in the substantia nigra101,116–119 are indicative of high iron loading of ferritin.120”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [116]
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- Authors
- Dexter, D. T., Carayon, A., Vidailhet, M., Ruberg, M., Agid, F., Agid, Y., Lees, A. J., Wells, F. R., Jenner, P., & Marsden, C. D.
- Affiliations
- Parkinson's UK (GB)
- Inserm (FR)
- Corresponding author
- Jenner, P.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1990-07
- Volume
- 55
- Issue
- 1
- Pages
- 16-20
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1999434577
- Cited by
- 258
- References
- 20
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 1 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 2
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- Parkinson's disease, ferritin, brain iron metabolism, substantia nigra, L-dopa treatment, cerebrospinal fluid, serum ferritin, caudate-putamen, globus pallidus, cerebral cortex, cerebellum
- MeSH terms
- Brain Chemistry, Female, Ferritins, Humans, Iron, Male, Middle Aged, Parkinson Disease, Reference Values, Tissue Distribution
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