SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism
Jeong, Seung Min, Xiao, Cuiying, Finley, Lydia W.S., Lahusen, Tyler, Souza, Amanda L., Pierce, Kerry, Li, Ying-Hua, Wang, Xiaoxu, Laurent, Gaëlle, German, Natalie J., Xu, Xiaoling, Li, Cuiling, Wang, Rui-Hong, Lee, Jaewon, Csibi, Alfredo, Cerione, Richard, Blenis, John, Clish, Clary B., Kimmelman, Alec, Deng, Chu-Xia, Haigis, Marcia C.·2013·Cancer Cell
Cited by (446)
Items 401–446 of 446
- NAD + -Dependent Deacetylases and Medical TherapyAshok Kumar, Louisa Ben-Aderet, Jinan Elayyan, Mona Dvir‐Ginzberg · 2016 · Elsevier eBooks
- Ligand Binding and Catalysis in Selected Sirtuin IsozymesJunru Yu · 2016 · NDSU Repository (North Dakota State University)
- Sirtuins in Cancer – Emerging Role as Modulators of Metabolic ReprogrammingJaewon James Lee, Karina N. Gonzalez Herrera, Marcia C. Haigis · 2016 · Springer eBooks
- Spatio-Temporal Control of Cellular and Organismal Physiology by SirtuinsShaunak Deota, Namrata Shukla, Ullas Kolthur‐Seetharam · 2017 · Journal of the Indian Institute of Science
- A Role for Sirtuins in Maintaining Mammalian Lifespan and HealthspanWilliam Giblin · 2017 · Deep Blue (University of Michigan)
- Energy Metabolism and EpigeneticsScott J. Bultman · 2017 · Springer eBooks
- Reactive Acyl-CoA Species and Deacylation by the Mitochondrial SirtuinsKathleen A. Hershberger, Matthew D. Hirschey · 2018 · Elsevier eBooks
- Análise da expressão gênica das sirtuínas nos somatotropinomas e adenomas hipofisários clinicamente não funcionantes e sua relação com a invasividade tumoralIsabella Pacetti Pajaro Grande · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Insights into Cellular Stress Revealed by SIRT7Yufei Liu · 2014 · eScholarship (California Digital Library)
- The antiviral mechanism and viral antagonism of host histone deacetylase 4 in influenza A virus infectionHenry D. Galvin · 2020 · Otago University Research Archive (University of Otago)
- Molecular Mechanisms Underlying the Role of Mitophagy in NeurodegenerationAbhilasha Ahlawat, Meenakshi Kaira, Vaibhav Walia, Munish Garg · 2020 · Advances in medical diagnosis, treatment, and care (AMDTC) book series
- SIRT4 Overexpression Promotes the Inhibition of Cell Proliferation and Invasion in Prostate CancerAbdul-Nazif Mahmud, Feilun Cui, Xue Bo, Jianpeng Hu, Tingjun Liu, Muslimat Kehinde Adebis, Said Abdulrahman Salim Mzee, Aaron Gia Kanton · 2020 · International Journal of Scientific Research in Science and Technology
- Sirtuins and the hallmarks of cancerTalita Helen Bombardelli Gomig, Tayana Schultz Jucoski, Érika Pereira Zambalde, Alexandre Luiz Korte de Azevedo, Daniela Fiori Gradia, Enilze M.S.F. Ribeiro · 2021 · Elsevier eBooks
- Sirtuins in mechanistic target of rapamycin complex 1 signalingJesús Burillo, Patricia Marqués, Beatriz Jiménez, Carlos González-Blanco, Manuel Benito, Carlos Guillén · 2021 · Elsevier eBooks
- Sirtuin signaling in hematologic malignanciesRyan Austin Denu · 2021 · Elsevier eBooks
- Sirtuins as key players in aging and kidney dysfunctionLuca Perico, Ariela Benigni · 2021 · Elsevier eBooks
- Uma visão estrutural sobre componentes do processo de adaptação metabólica de tumoresA.L.B. Ambrosio · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Advancing knowledge about the health issues of Australia's defence personnel and veteransSusan A. Treloar, Katherine M. Kirk, ALEXANDER COWELL McFARLANE, Peter Nasveld, Brad McCall · 2010
- Energy Metabolism and EpigeneticsScott J. Bultman · 2019 · Springer eBooks
- SIRT4 functions as a tumor suppressor in prostate cancer by inducing apoptosis and inhibiting glutamine metabolismLiangliang Cai, Zhuhui Ge, Yunqiu Xu, Pingliang Sun, Guoyu Huang · 2022 · Research Square
- SirtuinsFrank K. Huynh, Eoin McDonnell, Kristin A. Anderson, Matthew D. Hirschey · 2015 · Wiley eBooks
- SIRT4 functions as a tumor suppressor in prostate cancer by inducing apoptosis and inhibiting glutamine metabolismLiangliang Cai, Zhuhui Ge, Yunqiu Xu, Pingliang Sun, Guoyu Huang · 2022 · Research Square
- Application of nuclear magnetic resonance spectroscopy for the detection of metabolic changes in blood cells with defective DNA repairGaelle Vanderstichelen · 2022 · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)
- SIRT4 Loss Reprograms Intestinal Nucleotide Metabolism to Support Proliferation and Survival Following Perturbation of HomeostasisSarah A. Tucker, Sejal Vyas, Albert Park, Shakchhi Joshi, Aslihan Inal, Tiffany Lam, Emily Tan, Kevin M. Haigis, Marcia C. Haigis · 2022 · SSRN Electronic Journal
- SIRT4 enhances the sensitivity of colorectal cancer cells to 5-FU by inhibiting ammonia-mediated autophagyBo Xu, Liangliang Cai, Hua Xiao, Guohao Cai, Pingliang Sun, Guoyu Huang · 2023 · Research Square
- SIRT4 Overcomes 5-Fluorouracil Associated Chemoresistance by Inhibiting Autophagy through Inhibition of ammonia productionBo Xu, Xiaojing Cai, Hua Xiao, Guoyu Huang · 2023 · Research Square
- Osteoclast-Cancer Cell Metabolic Symbiosis Renders PARP Inhibitor Therapy Resistance in Bone MetastasisHuijuan Fan, Zhanao Xu, Ke Yao, Bingxin Zheng, Yuan Zhang, Xuxiang Wang, Tengjiang Zhang, Xuan Li, Haitian Hu, Bin Yue et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Identification of SIRT4 as a novel paralog-specific interactor and candidate suppressor of C-RAF kinase in MAPK signalingMehrnaz Mehrabipour, Radovan Dvorský, Saeideh Nakhaei‐Rad, Alexander Lang, Patrick Verhülsdonk, Mohammad Reza Ahmadian, Roland P. Piekorz · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- In silico analysis of sirtuin-type histone deacetylase genes in sugar beet (Beta vulgaris L.)Seher Yolcu · 2024 · Frontiers in Life Sciences and Related Technologies
- SIRTifying intestinal nucleotide metabolismShweta Tiwary, Cristina D. Guerena, Jenna L. Jewell · 2024 · Trends in Endocrinology and Metabolism
- The Role of NAD+-Dependent Signal Mechanisms in Cancer Development and TreatmentTing Lu, Zheng‐Hong Qin, Junchao Wu · 2025 · Springer eBooks
- Associations of Midlife Leukocyte Telomere Length With Measures of Left Atrial Function in Community‐Dwelling Older Adults: The ARIC StudyRomil R Parikh, Nathan Pankratz, John Lane, Dan E. Arking, Anne A. Eaton, Lin Y. Chen, Pamela L. Lutsey, Weihong Tang · 2025 · Journal of the American Heart Association
- CREB3L4 upregulates SIRT4 expression to increase GABA/glutamate ratio and mitochondrial homeostasis for epilepsy suppressionHaoyu Liu, Qiannan Song, Jiayi Jin, Hong Chen · 2025 · Epilepsy Research
- Sirtuins as a Double-Edged Sword in Cancer: From Molecular Mechanisms to Therapeutic OpportunitiesNúria Sima, Laia Bosch‐Presegué, Alejandro Vaquero · 2014 · Springer eBooks
- Additional file 1 of HIF-1α-dependent miR-424 induction confers cisplatin resistance on bladder cancer cells through down-regulation of pro-apoptotic UNC5B and SIRT4Yu Meng, Toshinori Ozaki, Sun, Dan, Haotian Xing, Wei, Baojun, Jun An, Yang, Jieping, Gao, Ying, Liu, Shuangjie, Kong, Chuize et al. · 2020 · Figshare
- An integrated bioinformatics and multi-omics investigation of the sirtuin family to identify their prognostic importance in human cancersMd. Shahedur Rahman, Rizone Al Hasib, Md Rezanur Rahman, Polash Kumar Biswas, Abu Reza, Munzura Khatun, Mohammad Abu Hena Mostofa Jamal · 2025 · Tumor Biology
- Etude des modifications épigénétiques en fonction de l'agressivité du cancer sporadique du sein : l'implication de l'histone désacétylase SIRT1 dans la progression tumoraleKhaldoun T Rifai · 2018 · theses.fr (ABES)
- ATGL-catalyzed lipid catabolism promotes DNA double-strand break repairMahima Devarajan, Rachel K. Meyer, Gavin Fredrickson, William A. Hofstadter, Mara T. Mashek, Mari V. Reid, Evan W. Kerr, Anna Bartelt, Peter Gutenberger, Simone Intriago et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Carvacrol-Based Formulations Modulate Sirtuins and Exert Cytotoxic and Antimicrobial Effects in Lung Cancer ModelsSelin Aktar Kiremitci, Ayşe Simay Metin, İmren Hasoğlu, Mert Gecim, Didem Demir, Hande Karagedik, Pınar Yurdakul, Öykü Gönül Geyik · 2026 · Antioxidants
- Sirtuin proteins: structure, functions, and evolutionary insightsNeetu Sachan, P. K. Varshney, Phool Chandra, Pradeep Singh · 2026 · Elsevier eBooks
- Bone marrow mesenchymal stem cell-derived CHI3L1 protected against Helicobacter pylori-induced gastric mucosal damage by promoting DNA damage repair via regulating CTCF/CPT1AWang Qianqian, Xiaoxiao Wang, Yongbin Wang, Chen Jing, Hu Zhang · 2026 · Journal of Biological Chemistry
- Sirtuin 4 is downregulated in oral carcinogenesisTanatat Apiwessa, Paranin Chaicharncheep, Somchai Yodsanga, Theerapat Chanamuangkon, Ekarat Phattarataratip · 2026 · Odontology
- The sirtuin family: from mechanisms to therapyJiaying Xiao, Yiling Li, Yuyao Xie, Yuan Chen, Qihan Liu, Hao Li, Rui Sun · 2026 · Molecular Biomedicine
- BindingDB Entry 50021643: Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50010551: An overview of Sirtuins as potential therapeutic target: Structure, function and modulators.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50020903: Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy.BindingDB · 2025 · UC San Diego