Cited by 198Acute Lymphoblastic Leukemia researchHematopoietic Stem Cell TransplantationCancer Cells and Metastasis

Leukemia Propagating Cells Rebuild an Evolving Niche in Response to Therapy

Open access
Duan, Cai-Wen, Shi, Jun, Chen, Jing, Wang, Bo, Yu, Ye-Hua, Qin, Xia, Zhou, Xiang-Cheng, Cai, Yi-Jun +9 more·2014·Cancer Cell

Abstract

Residence of cancer-propagating cells (CPCs) within preferential microenvironmental niches has a major part in evading therapy. However, the nature of niches involved and the mechanisms protecting CPCs remain largely unknown. We addressed these issues in mouse transplantation models of acute lymphoblastic leukemia (ALL). When the engrafted leukemic cells substantially damaged adjacent microenvironment in the bone marrow (BM), after chemotherapy small foci of CPCs were retained, surrounded by sheaths of supporting cells that comprise a protective niche. We investigated patients' BM biopsies and found evidence of a similar process in patients receiving induction therapy. The efficacy of chemotherapy was enhanced by interfering with the niche formation or function. We therefore identified a therapy-induced niche that protects CPCs.

Integrity signals

Registry

Crossref · 10.1016/j.ccr.2014.04.015

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • These altered cells are difficult to eliminate by conventional antitumoral agents because drugs do not reach the bone marrow at the required concentration, and because the stem cell niche changes/adapts after chemotherapy, protecting altered cells.

    “These altered cells are difficult to eliminate by conventional antitumoral agents because drugs do not reach the bone marrow at the required concentration, and because the stem cell niche (a physical and functional entity that supports the self-renewal and differentiation of stem cells) changes/adapts after chemotherapy, protecting altered cells97.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Duan, C.-W., Shi, J., Chen, J., Wang, B., Yu, Y.-H., Qin, X., Zhou, X.-C., Cai, Y.-J., Li, Z.-Q., Zhang, F., Yin, M.-Z., Tao, Y., Mi, J.-Q., Li, L.-H., Enver, T., Chen, G.-Q., & Hong, D.-L.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • University College London (GB)
Corresponding author
Enver, Tariq
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2014-06
Volume
25
Issue
6
Pages
778-793
ISSN
1535-6108 (ISSN-L)
OpenAlex
W2094470615
Cited by
198
References
36
Citations by year
2026: 4 · 2025: 14 · 2024: 9 · 2023: 18 · 2022: 16 · 2021: 16 · 2020: 17 · 2019: 13 · 2018: 30 · 2017: 22 · 2016: 16 · 2015: 18 · 2014: 5
FWCI
20.14
Type
journal article
Language
en
Open access
Locations
  • Cancer Cell (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Cancer Research UK (12796)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
acute lymphoblastic leukemia, leukemia microenvironment, bone marrow microenvironment, chemoresistance, niche formation, supporting cells, induction therapy, mouse transplantation model
MeSH terms
Animals, Antineoplastic Combined Chemotherapy Protocols, Biopsy, Bone Marrow Cells, Cytarabine, Daunorubicin, Disease Models, Animal, Humans, Neoplastic Stem Cells, Mice, SCID, Mice, Inbred NOD, Xenograft Model Antitumor Assays, Mice, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Stem Cell Niche, Tumor Microenvironment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review