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Cited by 842

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

Open access
Davis, Caleb F., Ricketts, Christopher J., Wang, Min, Yang, Lixing, Cherniack, Andrew D., Shen, Hui, Buhay, Christian, Kang, Hyojin, Kim, Sang Cheol, Fahey, Catherine C., Hacker, Kathryn E., Bhanot, Gyan, Gordenin, Dmitry A., Chu, Andy, Gunaratne, Preethi H., Biehl, Michael, Seth, Sahil, Kaipparettu, Benny A., Bristow, Christopher A., Donehower, Lawrence A., Wallen, Eric M., Smith, Angela B., Tickoo, Satish K., Tamboli, Pheroze, Reuter, Victor, Schmidt, Laura S., Hsieh, James J., Choueiri, Toni K., Hakimi, A. Ari, Chin, Lynda, Meyerson, Matthew, Kucherlapati, Raju, Park, Woong-Yang, Robertson, A. Gordon, Laird, Peter W., Henske, Elizabeth P., Kwiatkowski, David J., Park, Peter J., Morgan, Margaret, Shuch, Brian, Muzny, Donna, Wheeler, David A., Linehan, W. Marston, Gibbs, Richard A., Rathmell, W. Kimryn, Creighton, Chad J., Creighton, Chad J., Davis, Caleb F., Morgan, Margaret, Gunaratne, Preethi H., Donehower, Lawrence A., Kaipparettu, Benny A., Wheeler, David A., Gibbs, Richard A., Signoretti, Sabina, Cherniack, Andrew D., Robertson, A. Gordon, Chu, Andy, Choueiri, Toni K., Henske, Elizabeth P., Kwiatkowski, David J., Reuter, Victor, Hsieh, James J., Hakimi, A. Ari, Tickoo, Satish K., Ricketts, Christopher, Linehan, W. Marston, Schmidt, Laura S., Gordenin, Dmitry A., Bhanot, Gyan, Seiler, Michael, Tamboli, Pheroze, Rathmell, W. Kimryn, Fahey, Catherine C., Hacker, Kathryn E., Smith, Angela B., Wallen, Eric M., Shen, Hui, Laird, Peter W., Shuch, Brian, Muzny, Donna, Buhay, Christian, Wang, Min, Chao, Hsu, Dahdouli, Mike, Xi, Liu, Kakkar, Nipun, Reid, Jeffrey G., Downs, Brittany, Drummond, Jennifer, Morton, Donna, Doddapaneni, Harsha, Lewis, Lora, English, Adam, Meng, Qingchang, Kovar, Christie, Wang, Qiaoyan, Hale, Walker, Hawes, Alicia, Kalra, Divya, Walker, Kimberly, Murray, Bradley A., Sougnez, Carrie, Saksena, Gordon, Carter, Scott L., Schumacher, Steven E., Tabak, Barbara, Zack, Travis I., Getz, Gad, Beroukhim, Rameen, Gabriel, Stacey B., Meyerson, Matthew, Ally, Adrian, Balasundaram, Miruna, Birol, Inanc, Brooks, Denise, Butterfield, Yaron S.N., Chuah, Eric, Clarke, Amanda, Dhalla, Noreen, Guin, Ranabir, Holt, Robert A., Kasaian, Katayoon, Lee, Darlene, Li, Haiyan I., Lim, Emilia, Ma, Yussanne, Mayo, Michael, Moore, Richard A., Mungall, Andrew J., Schein, Jacqueline E., Sipahimalani, Payal, Tam, Angela, Thiessen, Nina, Wong, Tina, Jones, Steven J.M., Marra, Marco A., Auman, J. Todd, Tan, Donghui, Meng, Shaowu, Jones, Corbin D., Hoadley, Katherine A., Mieczkowski, Piotr A., Mose, Lisle E., Jefferys, Stuart R., Roach, Jeffrey, Veluvolu, Umadevi, Wilkerson, Matthew D., Waring, Scot, Buda, Elizabeth, Wu, Junyuan, Bodenheimer, Tom, Hoyle, Alan P., Simons, Janae V., Soloway, Mathew G., Balu, Saianand, Parker, Joel S., Hayes, D. Neil, Perou, Charles M., Weisenberger, Daniel J., Bootwalla, Moiz S., Triche, Timothy, Lai, Phillip H., Van Den Berg, David J., Baylin, Stephen B., Chen, Fengju, Coarfa, Cristian, Noble, Michael S., DiCara, Daniel, Zhang, Hailei, Cho, Juok, Heiman, David I., Gehlenborg, Nils, Voet, Doug, Lin, Pei, Frazer, Scott, Stojanov, Petar, Liu, Yingchun, Zou, Lihua, Kim, Jaegil, Lawrence, Michael S., Chin, Lynda, Yang, Lixing, Seth, Sahil, Bristow, Christopher A., Protopopov, Alexei, Song, Xingzhi, Zhang, Jianhua, Pantazi, Angeliki, Hadjipanayis, Angela, Lee, Eunjung, Luquette, Lovelace J., Lee, Semin, Parfenov, Michael, Santoso, Netty, Seidman, Jonathan, Xu, Andrew W., Kucherlapati, Raju, Park, Peter J., Kang, Hyojin, Lee, Junehawk, Roberts, Steven A., Klimczak, Leszek J., Fargo, David, Lang, Martin, Choi, Yoon-La, Kim, Sang Cheol, Lee, June-Koo, Park, Woong-Yang, Wang, Wenyi, Fan, Yu, Ahn, Jaeil, Akbani, Rehan, Weinstein, John N., Haussler, David, Ma, Singer, Radenbaugh, Amie, Zhul, Jingchun, Biehl, Michael, Lichtenberg, Tara M., Zmuda, Erik, Black, Aaron D., Hanf, Benjamin, Ramirez, Nilsa C., Wise, Lisa, Bowen, Jay, Leraas, Kristen M., Hall, Tracy M., Gastier-Foster, Julie M., Kaelin, William G., Thorne, Leigh, Boice, Lori, Huang, Mei, Vocke, Cathy, Peterson, James, Worrell, Robert, Merino, Maria, Czerniak, Bogdan A., Aldape, Kenneth D., Wood, Christopher G., Spellman, Paul T., Atkins, Michael B., Cheville, John, Thompson, R. Houston, Jensen, Mark A., Pihl, Todd, Wan, Yunhu, Ayala, Brenda, Baboud, Julien, Velaga, Sudhakar, Walton, Jessica, Liu, Jia, Chudamani, Sudha, Wu, Ye, Sheth, Margi, Mills Shaw, Kenna R., Demchok, John A., Davidsen, Tanja, Yang, Liming, Wang, Zhining, Tarnuzzer, Roy W., Zhang, Jiashan, Eley, Greg, Felau, Ina, Zenklusen, Jean Claude, Hutter, Carolyn M., Guyer, Mark S., Ozenberger, Bradley A., Sofia, Heidi J.·2014·Cancer Cell
DOI 10.1016/j.ccr.2014.07.014
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Abstract

Summary We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) based on multidimensional and comprehensive characterization, including mitochondrial DNA (mtDNA) and whole genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared to other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT up-regulation in cancer distinct from previously-observed amplifications and point mutations.

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Authors
Davis, C. F., Ricketts, C. J., Wang, M., Yang, L., Cherniack, A. D., Shen, H., Buhay, C., Kang, H., Kim, S. C., Fahey, C. C., Hacker, K. E., Bhanot, G., Gordenin, D. A., Chu, A., Gunaratne, P. H., Biehl, M., Seth, S., Kaipparettu, B. A., Bristow, C. A., Donehower, L. A., Wallen, E. M., Smith, A. B., Tickoo, S. K., Tamboli, P., Reuter, V., Schmidt, L. S., Hsieh, J. J., Choueiri, T. K., Hakimi, A. A., Chin, L., Meyerson, M., Kucherlapati, R., Park, W.-Y., Robertson, A. G., Laird, P. W., Henske, E. P., Kwiatkowski, D. J., Park, P. J., Morgan, M., Shuch, B., Muzny, D., Wheeler, D. A., Linehan, W. M., Gibbs, R. A., Rathmell, W. K., Creighton, C. J., Creighton, C. J., Davis, C. F., Morgan, M., Gunaratne, P. H., Donehower, L. A., Kaipparettu, B. A., Wheeler, D. A., Gibbs, R. A., Signoretti, S., Cherniack, A. D., Robertson, A. G., Chu, A., Choueiri, T. K., Henske, E. P., Kwiatkowski, D. J., Reuter, V., Hsieh, J. J., Hakimi, A. A., Tickoo, S. K., Ricketts, C., Linehan, W. M., Schmidt, L. S., Gordenin, D. A., Bhanot, G., Seiler, M., Tamboli, P., Rathmell, W. K., Fahey, C. C., Hacker, K. E., Smith, A. B., Wallen, E. M., Shen, H., Laird, P. W., Shuch, B., Muzny, D., Buhay, C., Wang, M., Chao, H., Dahdouli, M., Xi, L., Kakkar, N., Reid, J. G., Downs, B., Drummond, J., Morton, D., Doddapaneni, H., Lewis, L., English, A., Meng, Q., Kovar, C., Wang, Q., Hale, W., Hawes, A., Kalra, D., Walker, K., Murray, B. A., Sougnez, C., Saksena, G., Carter, S. L., Schumacher, S. E., Tabak, B., Zack, T. I., Getz, G., Beroukhim, R., Gabriel, S. B., Meyerson, M., Ally, A., Balasundaram, M., Birol, I., Brooks, D., Butterfield, Y. S. N., Chuah, E., Clarke, A., Dhalla, N., Guin, R., Holt, R. A., Kasaian, K., Lee, D., Li, H. I., Lim, E., Ma, Y., Mayo, M., Moore, R. A., Mungall, A. J., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Wong, T., Jones, S. J. M., Marra, M. A., Auman, J. T., Tan, D., Meng, S., Jones, C. D., Hoadley, K. A., Mieczkowski, P. A., Mose, L. E., Jefferys, S. R., Roach, J., Veluvolu, U., Wilkerson, M. D., Waring, S., Buda, E., Wu, J., Bodenheimer, T., Hoyle, A. P., Simons, J. V., Soloway, M. G., Balu, S., Parker, J. S., Hayes, D. N., Perou, C. M., Weisenberger, D. J., Bootwalla, M. S., Triche, T., Lai, P. H., Van Den Berg, D. J., Baylin, S. B., Chen, F., Coarfa, C., Noble, M. S., DiCara, D., Zhang, H., Cho, J., Heiman, D. I., Gehlenborg, N., Voet, D., Lin, P., Frazer, S., Stojanov, P., Liu, Y., Zou, L., Kim, J., Lawrence, M. S., Chin, L., Yang, L., Seth, S., Bristow, C. A., Protopopov, A., Song, X., Zhang, J., Pantazi, A., Hadjipanayis, A., Lee, E., Luquette, L. J., Lee, S., Parfenov, M., Santoso, N., Seidman, J., Xu, A. W., Kucherlapati, R., Park, P. J., Kang, H., Lee, J., Roberts, S. A., Klimczak, L. J., Fargo, D., Lang, M., Choi, Y.-L., Kim, S. C., Lee, J.-K., Park, W.-Y., Wang, W., Fan, Y., Ahn, J., Akbani, R., Weinstein, J. N., Haussler, D., Ma, S., Radenbaugh, A., Zhul, J., Biehl, M., Lichtenberg, T. M., Zmuda, E., Black, A. D., Hanf, B., Ramirez, N. C., Wise, L., Bowen, J., Leraas, K. M., Hall, T. M., Gastier-Foster, J. M., Kaelin, W. G., Thorne, L., Boice, L., Huang, M., Vocke, C., Peterson, J., Worrell, R., Merino, M., Czerniak, B. A., Aldape, K. D., Wood, C. G., Spellman, P. T., Atkins, M. B., Cheville, J., Thompson, R. H., Jensen, M. A., Pihl, T., Wan, Y., Ayala, B., Baboud, J., Velaga, S., Walton, J., Liu, J., Chudamani, S., Wu, Y., Sheth, M., Mills Shaw, K. R., Demchok, J. A., Davidsen, T., Yang, L., Wang, Z., Tarnuzzer, R. W., Zhang, J., Eley, G., Felau, I., Zenklusen, J. C., Hutter, C. M., Guyer, M. S., Ozenberger, B. A., & Sofia, H. J.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2014-09
Volume
26
Issue
3
Pages
319-330
ISSN
1535-6108 (ISSN-L)
DOI
10.1016/j.ccr.2014.07.014
OpenAlex
W2010991736
Cited by
842
References
9
FWCI
55.73
Type
journal article
Language
en
Open access
bronze

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