Cited by 109Birth, Development, and HealthPregnancy and preeclampsia studiesGestational Diabetes Research and Management

Developmental and Early Life Origins of Cardiometabolic Risk Factors: Novel Findings and Implications

Open access
Lurbe, Empar, Ingelfinger, Julie·2021·Hypertension

Abstract

The intent of this review is to critically consider the data that support the concept of programming and its implications. Birth weight and growth trajectories during childhood are associated with cardiometabolic disease in adult life. Both extremes, low and high birth weight coupled with postnatal growth increase the early presence of cardiometabolic risk factors and vascular imprinting, crucial elements of this framework. Data coming from epigenetics, proteomics, metabolomics, and microbiota added relevant information and contribute to better understanding of mechanisms as well as development of biomarkers helping to move forward to take actions. Research has reached a stage in which sufficiently robust data calls for new initiatives focused on early life. Prevention starting early in life is likely to have a very large impact on reducing disease incidence and its associated effects at the personal, economic, and social levels.

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Crossref · 10.1161/hypertensionaha.120.14592

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90 of 90 references verified0 citation errors · 0 not checkable

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Authors
Lurbe, E., & Ingelfinger, J.
Affiliations
  • Universitat de València (ES)
  • Harvard University (US)
Venue
Hypertension
Published
2021-02
Volume
77
Issue
2
Pages
308-318
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
OpenAlex
W3120874154
Cited by
106
References
90
Citations by year
2026: 18 · 2025: 26 · 2024: 19 · 2023: 26 · 2022: 13 · 2021: 4
FWCI
4.00
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
developmental origins of health and disease, cardiometabolic risk factors, birth weight, epigenetics, microbiota, metabolomics, proteomics, biomarkers
MeSH terms
Adverse Childhood Experiences, Adolescent, Adult, Aging, Birth Weight, Cardiovascular Diseases, Cardiovascular System, Child, Child, Preschool, Female, Forecasting, Gestational Age, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Male, Metabolic Diseases, Middle Aged, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Proteomics, Epigenesis, Genetic, Metabolomics, Precision Medicine, Epigenomics, Microbiota

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