Developmental and Early Life Origins of Cardiometabolic Risk Factors: Novel Findings and Implications
Open accessAbstract
The intent of this review is to critically consider the data that support the concept of programming and its implications. Birth weight and growth trajectories during childhood are associated with cardiometabolic disease in adult life. Both extremes, low and high birth weight coupled with postnatal growth increase the early presence of cardiometabolic risk factors and vascular imprinting, crucial elements of this framework. Data coming from epigenetics, proteomics, metabolomics, and microbiota added relevant information and contribute to better understanding of mechanisms as well as development of biomarkers helping to move forward to take actions. Research has reached a stage in which sufficiently robust data calls for new initiatives focused on early life. Prevention starting early in life is likely to have a very large impact on reducing disease incidence and its associated effects at the personal, economic, and social levels.
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Obesity contributes to insulin resistance, dyslipidemia, and hyperinsulinemia, which are elements of metabolic syndrome.
“Obesity, affected by both low and high birth weights, is a significant contributor to insulin resistance, dyslipidemia, and hyperinsulinemia, all of which are elements of metabolic syndrome.”
Obesity-related metabolic syndrome factors substantially increase the risk of cardiovascular illnesses and lead to systemic metabolic disturbances.
“These factors substantially increase the risk of cardiovascular illnesses and lead to systemic metabolic disturbances [92].”
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Obesity and Cardiometabolic Risk Factors: From Childhood to Adulthood
Drożdż, D., Pitti, J. Á., Wójcik, M., Borghi, C., Gabbianelli, R., Mazur, A., Herceg-Čavrak, V., López‐Valcárcel, B. G., Brzeziński, M., Lurbe, E., et al. (2021) · Nutrients · doi:10.3390/nu13114176 · Cited by 441 · see citing works
Self-citationSocial Determinants of Health and Disparities in Hypertension and Cardiovascular Diseases
Chaturvedi, A., Zhu, A., Gadela, N. V., Prabhakaran, D., & Jafar, T. H. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21354 · Cited by 241 · see citing works
Schutte, A. E., Jafar, T. H., Poulter, N. R., Damasceno, A., Khan, N. A., Nilsson, P. M., Alsaid, J., Neupane, D., Kario, K., Beheiry, H., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac130 · Cited by 164 · see citing works
Polyploidy as a Fundamental Phenomenon in Evolution, Development, Adaptation and Diseases
Anatskaya, O. V., & Vinogradov, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073542 · Cited by 61 · see citing works
Alba‐Linares, J. J., Pérez, R. F., Tejedor, J. R., Bastante-Rodríguez, D., Ponce, F., Carbonell, N. G., Zafra, R. G., Fernández, A. F., Fraga, M. F., & Lurbe, E. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01774-y · Cited by 65 · see citing works
Self-citationLu, D., Yu, Y., Ludvigsson, J. F., Öberg, A. S., Sørensen, H. T., László, K. D., Li, J., & Cnattingius, S. (2023) · American Journal of Epidemiology · doi:10.1093/aje/kwac223 · Cited by 44 · see citing works
Visceral fat and cardiometabolic future in children and adolescents: a critical update
Marketou, M. E., Buechler, N. S., Fragkiadakis, K., Plevritaki, A., Zervakis, S., Maragkoudakis, S., Tsiavos, A., Simantirakis, E., & KOCHIADAKIS, G. E. (2023) · Pediatric Research · doi:10.1038/s41390-023-02709-9 · Cited by 43 · see citing works
Muhammed Saeed, A. A., Noreen, S., Awlqadr, F. H., Farooq, M. I., Qadeer, M., Rai, N., Farag, H. A., & Saeed, M. N. (2025) · Journal of Health, Population and Nutrition · doi:10.1186/s41043-025-00899-y · Cited by 29 · see citing works
“These factors substantially increase the risk of cardiovascular illnesses and lead to systemic metabolic disturbances [92].”
Fujita, T. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.20588 · Cited by 26 · see citing works
Vinther, J. L., Cadman, T., Avraam, D., Ekstrøm, C. T., Sørensen, T. I. A., Elhakeem, A., Santos, A. C., de Moira, A. P., Heude, B., Íñiguez, C., et al. (2023) · PLoS Medicine · doi:10.1371/journal.pmed.1004036 · Cited by 25 · see citing works
Lamberto, F., Peral-Sanchez, I., Muenthaisong, S., Zana, M., Willaime‐Morawek, S., & Dinnyés, A. (2021) · Genes · doi:10.3390/genes12101564 · Cited by 24 · see citing works
Primary Hypertension Beginning in Childhood and Risk for Future Cardiovascular Disease
Falkner, B. E., & Lurbe, E. (2021) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2021.08.008 · Cited by 20 · see citing works
Self-citationEducational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney
DeFreitas, M. J., Katsoufis, C. P., Benny, M., Young, K. C., Kulandavelu, S., Ahn, H., Sfakianaki, A. K., & Abitbol, C. L. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.853722 · Cited by 16 · see citing works
Zhang, X., Wang, Y., Xue, S., Gong, L., Yan, J., Zheng, Y., Yang, X., Fan, Y., Han, K., Chen, Y., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-74902-7 · Cited by 14 · see citing works
Vinther, J. L., Ekstrøm, C. T., Sørensen, T. I. A., Cederkvist, L., Lawlor, D. A., & Andersen, A. N. (2023) · Scientific Reports · doi:10.1038/s41598-023-30123-y · Cited by 13 · see citing works
Cardiovascular Health Starts in the Womb
Falkner, B. E., Alexander, B. T., Nuyt, A. M., South, A. M., & Ingelfinger, J. R. (2024) · Hypertension · doi:10.1161/hypertensionaha.124.21359 · Cited by 12 · see citing works
Self-citationGraton, M. E., Spaans, F., He, R., Chatterjee, P., Kirschenman, R. D., Quon, A., Phillips, T. J., Case, C. P., & Davidge, S. T. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00627-x · Cited by 10 · see citing works
Epigenetic mechanisms linking pregnancy complications to cardiovascular disease in offspring
Talpur, K. R., Bano, I., & Abdullah, M. W. (2024) · Exploration of Cardiology · doi:10.37349/ec.2024.00037 · Cited by 11 · see citing works
Zhang, Y., Liang, J., Liu, Q., Fan, X., Xu, C. Y., Gu, A., Zhao, W., & Hang, D. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.637437 · Cited by 9 · see citing works
Du, H., Sun, Y., Zhang, Y., Wang, S., Zhu, H., Chen, S., & Pan, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.963827 · Cited by 9 · see citing works
Du, B., Wang, H., Wu, Y., Li, Z., Niu, Y., Wang, Q., Zhang, L., Sun, C., Wu, Y., Huang, J., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-02812-y · Cited by 8 · see citing works
Sletner, L., Yajnik, C. S., Turowski, G. E., Michelsen, T. M., Sommer, C., Birkeland, K. I., Roald, B., & Jenum, A. K. (2024) · Placenta · doi:10.1016/j.placenta.2024.02.002 · Cited by 7 · see citing works
The effects of adverse and positive experiences on cardiovascular health in Australian children
Guo, S., Wijesuriya, R., O’Connor, M., Moreno‐Betancur, M., Goldfeld, S. R., Burgner, D. P., Liu, R., & Priest, N. (2024) · International Journal of Cardiology · doi:10.1016/j.ijcard.2024.132262 · Cited by 7 · see citing works
Zhu, Y., Wu, S., Qiu, W., Wang, J., Feng, Y., & Chen, C. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.51844 · Cited by 7 · see citing works
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Nutrition & Metabolism · doi:10.1186/s12986-023-00759-8 · Cited by 7 · see citing works
Sakurai, K., Takeba, Y., Yosuke, O., Mizuno, M., Tsuzuki, Y., Aso, K., Kida, K., Ohta, Y., Ootaki, M., Iiri, T., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710186 · Cited by 6 · see citing works
Prediction of atherosclerotic cardiovascular risk in early childhood
Ferraro, S., Benedetti, S., Mannarino, S., Marcovina, S. M., Biganzoli, E. M., & Zuccotti, G. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117684 · Cited by 6 · see citing works
Anatskaya, O. V., Runov, A. L., Ponomartsev, S. V., Vonsky, M. S., Elmuratov, A. U., & Vinogradov, A. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087063 · Cited by 6 · see citing works
Lozano, M., Vallejo-Ortega, J., Marín, N., González, L., Esplugues, A., López-Espinosa, M.-J., Beneíto, A., González‐Palacios, S., Llop, S., & Soler-Blasco, R. (2025) · Pediatric Research · doi:10.1038/s41390-025-04273-w · Cited by 5 · see citing works
Coordination of cardiogenesis in vivo and in vitro
Mendjan, S., Deyett, A., & Yelon, D. L. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00878-5 · Cited by 5 · see citing works
Fisher, J. J., Grace, T., Castles, N. A., Jones, E. A., Delforce, S. J., Peters, A. E., Crombie, G. K., Hoedt, E. C., Warren, K. E., Kahl, R. G. S., et al. (2024) · JMIR Research Protocols · doi:10.2196/63562 · Cited by 5 · see citing works
Early Life Programming of Vascular Aging and Cardiometabolic Events: The McDonald Lecture 2022
Nilsson, P. M. (2023) · Artery Research · doi:10.1007/s44200-023-00031-7 · Cited by 5 · see citing works
Invited Commentary: Beyond Barker—Mothers Are the Ones at Risk
Wilcox, A. J. (2023) · American Journal of Epidemiology · doi:10.1093/aje/kwad056 · Cited by 5 · see citing works
Akinola, I. J., Ubuane, P. O., Dada, A. O., Chionuma, J. O., Kuye-Kuku, T. O., & Olalere, F. D. H. (2024) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2346136.068 · Cited by 4 · see citing works
Ma, X., Jian, S., Hou, E., Wei, Y., & Tu, S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0322654 · Cited by 4 · see citing works
He, F., Liu, J., Yu, D., Huang, Z., Chen, H., Wang, C., & Tang, T. (2025) · BMC Medicine · doi:10.1186/s12916-025-04470-8 · Cited by 3 · see citing works
Wang, X., Wang, Q., Li, M., Zhao, Y., Song, Q., Fu, C., Hao, W., & Zhu, D. (2024) · Preventive Medicine · doi:10.1016/j.ypmed.2024.108060 · Cited by 3 · see citing works
Shakya, D., Ng, N., Oli, N., Vaidya, A., & Krettek, A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0323698 · Cited by 3 · see citing works
Bongers‐Karmaoui, M. N., Hirsch, A., Budde, R. P. J., Roest, A. A. W., Jaddoe, V. W. V., & Gaillard, R. (2023) · The International Journal of Cardiovascular Imaging · doi:10.1007/s10554-023-02950-7 · Cited by 3 · see citing works
Maternal betel quid use during pregnancy and child growth: a cohort study from rural Bangladesh
Islam, M. R., Aktar, S., Pervin, J., Rahman, S. M., Rahman, M., Rahman, A. M., & Ekström, E. (2024) · Global Health Action · doi:10.1080/16549716.2024.2375829 · Cited by 3 · see citing works
Tong, J., Wang, X., Gan, H., Gao, H., Lu, M., Zhou, J., Liang, C., Tao, S., Geng, M., Yan, S., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.037887 · Cited by 3 · see citing works
Childhood Primary Hypertension: Not Uncommon, Not Benign
Halbach, S. M., & Flynn, J. T. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21041 · Cited by 3 · see citing works
MOORE, L. G., Wesolowski, S. R., Lorca, R. A., & Julian, C. G. (2025) · Acta Physiologica · doi:10.1111/apha.70093 · Cited by 2 · see citing works
Benzene-induced growth restriction and compensatory rebound in mouse fetuses and placentas
Cull, M. E., Brown, L. M., Grant, P. M., Xue, L., & Winn, L. M. (2026) · Reproductive Toxicology · doi:10.1016/j.reprotox.2026.109231 · Cited by 2 · see citing works
Methods for Modeling Early Life Stress in Rodents
Choe, J. Y., & Jones, H. P. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-4200-9_11 · Cited by 2 · see citing works
Fleury, E. S., Papandonatos, G. D., Manz, K. E., Pennell, K. D., Hall, A. M., Chen, A., Buckley, J. P., Yolton, K. A., Cecil, K. M., Lanphear, B. P., et al. (2025) · Pediatric Research · doi:10.1038/s41390-025-04322-4 · Cited by 2 · see citing works
Brandimonte‐Hernández, M., Ruiz‐Ojeda, F. J., Blaauwendraad, S. M., Kamphuis, A. S. J., Ventura, E. F., Berkeveld, M. A., Collado, M. C., van Diepen, J. A., Iozzo, P., Knipping, K., et al. (2024) · medRxiv · doi:10.1101/2024.06.14.24308770 · Cited by 2 · see citing works
Lim, B. S. Y., & Li, L. (2024) · Maternal-Fetal Medicine · doi:10.1097/fm9.0000000000000222 · Cited by 1 · see citing works
Evolving Concepts in Cardiometabolic Risk: A Review of Recent Evidence
Elsaka, O. (2025) · Research in Cardiovascular Medicine · doi:10.4103/rcm.rcm_15_24 · Cited by 1 · see citing works
Onakomaiya, D. O., Bubu, O. M., & Schoenthaler, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-23750-8.00014-x · Cited by 1 · see citing works
Evsevyeva, M. E., Eremin, M. V., Сергеева, О. В., Guseva, A. V., Zvyagintseva, E. M., Дмитриевна, К. В., Kryuchkov, M. S., Fursova, E. N., Mazharov, V. N., & Khodzhayan, A. (2025) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2025-3219 · Cited by 1 · see citing works
Overview of exosomal non-coding RNAs in cardiovascular disease using high throughput sequencing
Eivazi, M., Abkhooie, L., Hosseini, K., Mobasheran, P., Ebrahimi, T., Tarhriz, V., & Lazartigues, E. D. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178277 · Cited by 1 · see citing works
Obradovic, M. M., Radovanović, J., Stanimirović, J., Zarić, B. L., & Isenović, E. R. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025255 · Cited by 1 · see citing works
TIGAR deficiency enhances cardiac resilience through epigenetic programming of Parkin expression
Tang, Y., Jankauskas, S. S., Liu, L., Wang, X., Xiaoli, A. M., Yang, F., Santulli, G., Feng, D., & Pessin, J. E. (2026) · JCI Insight · doi:10.1172/jci.insight.200105 · Cited by 1 · see citing works
Tapio, J., Sakko, S., Kettunen, J., Tulppo, M. P., & Koivunen, P. (2026) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00542.2025 · Cited by 1 · see citing works
Maternal Body Mass Index, Gestational Weight Gain, and Cardiovascular Disease in Offspring
Wang, H., Möller, J., Liang, Y., Janszky, I., & László, K. D. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2026.31324 · Cited by 1 · see citing works
Does ethnic concentration buffer effects of neighborhood deprivation on early childhood growth?
Andrea, S. B., Booman, A., O'Malley, J. P., Tillotson, C. J., Marino, M., Chung‐Bridges, K., DeVoe, J. E., & Boone‐Heinonen, J. (2024) · Health & Place · doi:10.1016/j.healthplace.2024.103378 · Cited by 1 · see citing works
Neurocognition in Childhood Hypertension
Lande, M. B., & Kupferman, J. C. (2023) · Springer eBooks · doi:10.1007/978-3-031-06231-5_30 · Cited by 1 · see citing works
Early Vascular Aging in Pediatric Hypertension Patients
Litwin, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-06231-5_59 · Cited by 1 · see citing works
Birth weight and hypertension: nature or nurture?
Nilsson, P. M. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003443 · Cited by 1 · see citing works
Arora, A., Vacy, K., Marques, C., Degeratu, M.-O., Mastropasqua, F., Humphrey, J., Ye, X., Oksanen, M., the Barwon Infant Study Investigator Group, Vuillermin, P., et al. (2025) · medRxiv · doi:10.1101/2025.05.30.25328657 · Cited by 1 · see citing works
Early Vascular Aging in Pediatric Hypertension Patients
Litwin, M. (2022) · Springer eBooks · doi:10.1007/978-3-319-31420-4_59-1
Early vascular aging; before-from-after conception and during childhood
(2022) · Hypertension News · doi:10.30824/2204-5
Vinther, J. L., Cadman, T., Avraam, D., Ekstrøm, C. T., Sørensen, T. I. A., Elhakeem, A., Santos, A. C., de Moira, A. P., Heude, B., Íñiguez, C., et al. (2022) · medRxiv · doi:10.1101/2022.06.01.22275859
Alba‐Linares, J. J., Fernández-Pérez, R., Ponce-Zanon, F., García-Carbonell, N., Zafra, R. G., Fernandez-Fraga, M., & Lurbe, E. (2022) · Journal of Hypertension · doi:10.1097/01.hjh.0000835704.94772.0b
Self-citationNeurocognition in Childhood Hypertension
Lande, M. B., & Kupferman, J. C. (2022) · Springer eBooks · doi:10.1007/978-3-319-31420-4_30-2
Small-for-gestational-age and determinants of HOMA indices, leptin and adiponectin in infancyPreprint
Huang, R., He, H., Nuyt, A. M., Julien, P., Marc, I., Levy, E. H., Fraser, W. D., & Luo, Z. (2022) · Research Square · doi:10.21203/rs.3.rs-1912833/v1
Prävention ungünstiger metabolischer Prägung bei intrauteriner Wachstumsrestriktion
Nüsken, K., Tauscher, A., Dötsch, J., Stepan, H., & Nüsken, E. (2023) · Die Diabetologie · doi:10.1007/s11428-023-01079-4
a. Cardiovascular Prevention Strategies in a Life Course Perspective
Nilsson, P. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15512-3.00018-0
Alba‐Linares, J. J., Pérez, R. F., Tejedor, J. R., Bastante-Rodríguez, D., Ponce, F., Carbonell, N. G., Zafra, R. G., Fernández, A. F., Fraga, M. F., & Lurbe, E. (2023) · Figshare · doi:10.6084/m9.figshare.22623118
Self-citationAlba‐Linares, J. J., Pérez, R. F., Tejedor, J. R., Bastante-Rodríguez, D., Ponce, F., Carbonell, N. G., Zafra, R. G., Fernández, A. F., Fraga, M. F., & Lurbe, E. (2023) · Figshare · doi:10.6084/m9.figshare.22623115
Self-citationAlba‐Linares, J. J., Pérez, R. F., Tejedor, J. R., Bastante-Rodríguez, D., Ponce, F., Carbonell, N. G., Zafra, R. G., Fernández, A. F., Fraga, M. F., & Lurbe, E. (2023) · Figshare · doi:10.6084/m9.figshare.22623124
Self-citationAlba‐Linares, J. J., Pérez, R. F., Tejedor, J. R., Bastante-Rodríguez, D., Ponce, F., Carbonell, N. G., Zafra, R. G., Fernández, A. F., Fraga, M. F., & Lurbe, E. (2023) · Figshare · doi:10.6084/m9.figshare.22623121
Self-citationPerinatal Factors and its Association with Cardiometabolic Profile in SchoolchildrenPreprint
Mansour, K. M. K., Tornquist, L., Pfeiffer, K. A., Paiva, D. N., & Reuter, C. P. (2024) · Research Square · doi:10.21203/rs.3.rs-4438298/v1
HyperChildNET COST Action CA19115: report of the task force
Lurbe, E., Mancia, G., Drożdż, D., Erdine, S. E., Fernández‐Aranda, F., Litwin, M., Sinha, M. D., Simonetti, G. D., Stabouli, S., & Wühl, E. (2024) · Blood Pressure · doi:10.1080/08037051.2024.2421214
Self-citationCord Blood Metabolite Profiles and Childhood Cardio-Metabolic Outcomes in a Population-Based Cohort
Kaupper, C. S., Blaauwendraad, S. M., Gaillard, R., Koletzko, B. V., & Jaddoe, V. W. V. (2025) · Annals of Nutrition and Metabolism · doi:10.1159/000543697
From life history theory to clinical practice: potential markers of fast life strategy
Kim, O. T., & Drapkina, O. M. (2025) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2024-4198
Huang, J. V., & Dehghan, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-32046-0_9-1
Okube, O. T., Aketch, V., Kitur, N., Njoroge, J. K., Oyagi, N. A. M., & Gary, L. P. (2025) · medRxiv · doi:10.1101/2025.09.04.25335098
Chen, L., Zheng, S., Tahir, M. F., Wang, Y., Luo, S., Zhong, H., Huang, D., Chen, L., An, X., & Liang, X. (2025) · Research Square · doi:10.21203/rs.3.rs-6437199/v1
Huang, J. V., & Dehghan, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-73363-5_9
Dillard, J., Royse, E. X., & Hillman, N. H. (2025) · Pediatric Research · doi:10.1038/s41390-025-04373-7
Stop using “former”: preterm birth and cardiometabolic risk to future health
Kelly, M. M. (2025) · Pediatric Research · doi:10.1038/s41390-025-04472-5
Reflexiones sobre los orígenes del riesgo de obesidad infantil
Lurbe, E., Álvarez‐Pitti, J., Sastre, J. M., & Aguilar, F. (2025) · Anales de Pediatría · doi:10.1016/j.anpedi.2025.504037
Self-citationTaking a closer look at the early onset of childhood obesity risk
Lurbe, E., Álvarez‐Pitti, J., Sastre, J. M., & Aguilar, F. (2025) · Anales de Pediatría (English Edition) · doi:10.1016/j.anpede.2025.504037
Self-citationBengtson, A. M., Pellowski, J. A., Botha, M., Burd, T., Workman, L., Goddard, E., Stein, D. J., Burgner, D. P., Mansell, T., & Zar, H. J. (2025) · medRxiv · doi:10.64898/2025.12.03.25341573
Alba‐Linares, J. J., Pérez, R. F., Tejedor, J. R., Bastante-Rodríguez, D., Ponce, F., Carbonell, N. G., Zafra, R. G., Fernández, A. F., Fraga, M. F., & Lurbe, E. (2023) · Figshare · doi:10.6084/m9.figshare.22623112
Self-citationCallanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089071
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089062
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089068
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089050
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089056
Du, B., Wang, H., Wu, Y., Li, Z., Niu, Y., Wang, Q., Zhang, L., Chen, S., Wu, Y., Huang, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22625834
Callanan, S., Killeen, S. L., Delahunt, A., Cooney, N., Cushion, R., McKenna, M. J., Crowley, R. K., Twomey, P. J., Kilbane, M. T., McDonnell, C. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24089065
Cheng, B., Pan, C., Wei, W., Cheng, S., Zhao, B., Feng, J., & Zhang, F. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.181283
García, C., Xu, Y., & Parella, M. A. (2026) · The Journals of Gerontology Series A · doi:10.1093/gerona/glag051
Placental secretome: uncovering the vast signals shaping fetal metabolic health trajectory
Jo, S., Alejandro, E. U., & Beetch, M. (2026) · Current Opinion in Physiology · doi:10.1016/j.cophys.2026.100944
Perinatal factors and their association with cardiometabolic profile in schoolchildren
Mansour, K. M. K., Tornquist, L., Mortensen, N., Pfeiffer, K. A., Paiva, D. N., & Reuter, C. P. (2026) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-026-02253-2
Arora, A., Vacy, K., Marques, C., Degeratu, M.-O., Mastropasqua, F., Humphrey, J., Ye, X., Oksanen, M., Vuillermin, P., Ponsonby, A., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106291 · Cited by 1 · see citing works
Disrupting the heart-brain axis: the combined impact of parental obesity and Alzheimer disease
Speretta, G. F. F. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00418.2026
- Authors
- Lurbe, E., & Ingelfinger, J.
- Affiliations
- Universitat de València (ES)
- Harvard University (US)
- Venue
- Hypertension
- Published
- 2021-02
- Volume
- 77
- Issue
- 2
- Pages
- 308-318
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W3120874154
- Cited by
- 106
- References
- 90
- Citations by year
- 2026: 18 · 2025: 26 · 2024: 19 · 2023: 26 · 2022: 13 · 2021: 4
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- developmental origins of health and disease, cardiometabolic risk factors, birth weight, epigenetics, microbiota, metabolomics, proteomics, biomarkers
- MeSH terms
- Adverse Childhood Experiences, Adolescent, Adult, Aging, Birth Weight, Cardiovascular Diseases, Cardiovascular System, Child, Child, Preschool, Female, Forecasting, Gestational Age, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Male, Metabolic Diseases, Middle Aged, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Proteomics, Epigenesis, Genetic, Metabolomics, Precision Medicine, Epigenomics, Microbiota
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