The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Microbiology of Dental Plaque Biofilms and Their Role in Oral Health and Caries
Abstract
Dental plaque is the biofilm found naturally on teeth. Dental plaque is also implicated in dental caries, which is associated with shifts in the microbial balance of the biofilm resulting in increased proportions of acid producing and acid tolerating bacteria, especially (but not exclusively) mutans streptococci and lactobacilli. The regular intake of fermentable dietary sugars, or impaired saliva flow, produces persistent conditions of low pH within the biofilm, which selects for these cariogenic bacteria. Clinicians should prevent this disruption to the natural microbial balance of the biofilm (relevant approaches are described) rather than merely treating its consequences by restoring cavities.
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In the citing paper
“The Industrial Revolution saw the production of refined grain and concentrated sugar from processed sugar beet and cane9, generating mono- and disaccharides, which are the main substrates for microbial fermentation that lowers plaque pH and cause enamel demineralization26.”
From Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions (2013) · cites this paper as [26]
In the citing paper
“Caries and periodontal disease are both polymicrobial, plaque-mediated infections, thought to result from perturbation of a healthy, ecologically balanced oral biofilm23,24 that can occur from dietary changes, such as the increased consumption of fermentable carbohydrates25,26.”
From Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions (2013) · cites this paper as [26]
In the citing paper
“This is thought to be caused by increased amounts of soft carbohydrate foods compared with hunter-gatherer diets26.”
From Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions (2013) · cites this paper as [26]
Citations
Cites
Bacterial biofilms: from the Natural environment to infectious diseases
Hall‐Stoodley, L., Costerton, J. W., & Stoodley, P. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro821 · Cited by 7,133
Antibiotic resistance of bacteria in biofilms
Stewart, P. S., & Costerton, J. W. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05321-1 · Cited by 4,596
Role of Streptococcus mutans in human dental decay
Loesche, W. J. (1986) · Microbiological Reviews · doi:10.1128/mr.50.4.353-380.1986 · Cited by 3,360
Biofilms as Complex Differentiated Communities
Stoodley, P., Sauer, K., Davies, D. G., & Costerton, J. W. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.160705 · Cited by 3,151
Defining the normal bacterial flora of the oral cavity
Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5721-5732.2005 · Cited by 3,092
Role of Streptococcus mutans in human dental decay.
Loeshe, W. J. (1986) · Medical Entomology and Zoology · Cited by 1,346
Microbial ecology of dental plaque and its significance in health and disease
Marsh, P. D. (1994) · Advances in Dental Research · doi:10.1177/08959374940080022001 · Cited by 1,278
Self-citationDental biofilms: difficult therapeutic targets
SOCRANSKY, S. S., & HAFFAJEE, A. D. (2002) · Periodontology 2000 · doi:10.1034/j.1600-0757.2002.280102.x · Cited by 1,273
Are dental diseases examples of ecological catastrophes?
Marsh, P. D. (2003) · Microbiology · doi:10.1099/mic.0.26082-0 · Cited by 1,256
Self-citationEvolving concepts in biofilm infections
Hall‐Stoodley, L., & Stoodley, P. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01323.x · Cited by 1,138
Flagged first, then by citations
Research works printed but not linked: 1
- Marsh, 1989, Host defenses and microbial homeostasis: role of microbial interactions, J Dent Res, 68, 1567
Cited by
Sorted by citations
Adler, C. J., Dobney, K., Weyrich, L. S., Kaidonis, J., Walker, A. W., Haak, W., Bradshaw, C. J. A., Townsend, G., Sołtysiak, A., Alt, K. W., et al. (2013) · Nature Genetics · doi:10.1038/ng.2536 · Cited by 621
The oral metagenome in health and disease
Belda‐Ferre, P., Alcaraz, L. D., Cabrera‐Rubio, R., Romero, H., Simón‐Soro, Á., Pignatelli, M., & Mira, Á. (2011) · The ISME Journal · doi:10.1038/ismej.2011.85 · Cited by 540
Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia
Shi, Z., Xie, H., Wang, P., Zhang, Q., Wu, X., Chen, E., Ng, L., Worthington, H. V., Needleman, I. G., & Furness, S. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008367.pub2 · Cited by 390
Freires, I. A., Denny, C., Benso, B., de Alencar, S. M., & Rosalen, P. L. (2015) · Molecules · doi:10.3390/molecules20047329 · Cited by 328
Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia
Hua, F., Xie, H., Worthington, H. V., Furness, S., Zhang, Q., & Li, C. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008367.pub3 · Cited by 312
Metadata
- Authors
- Marsh, P. D.
- Affiliations
- Health Protection Agency (GB)
- Corresponding author
- Marsh, Philip D.
- ORCID
- Marsh, Philip D.
- Venue
- Dental Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 54
- Issue
- 3
- Pages
- 441-454
- ISSN
- 0011-8532 (ISSN-L)
- OpenAlex
- W1983606482
- Cited by
- 372
- References
- 62
- Citations by year
- 2026: 17 · 2025: 25 · 2024: 30 · 2023: 32 · 2022: 28 · 2021: 31 · 2020: 24 · 2019: 35 · 2018: 34 · 2017: 20 · 2016: 22 · 2015: 18 · 2014: 15 · 2013: 16 · 2012: 18
- FWCI
- 15.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dental Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- dental plaque, biofilm, dental caries, oral microbiota, mutans streptococci, lactobacilli, acidogenic bacteria, dietary sugar, salivary flow, biofilm pH, dental caries prevention, oral health
- MeSH terms
- Bacteria, Dental Caries, Dental Plaque, Humans, Mouth, Oral Health, Biofilms, Microbial Interactions
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