Skeletal muscle satellite cells and adult myogenesis
Open accessAbstract
Research focusing on the canonical adult myogenic progenitor, the skeletal muscle satellite cell, is still an ever-growing field 46 years from their initial description. Recent publications revealed numerous new aspects of satellite cell biology, starting from their developmental life to their role as the principal self-renewing myogenic stem cell in adult skeletal muscle and finally their loss during aging. The myogenic potential of satellite cells is under the molecular control of specific paired-box and bHLH transcription factors whose tightly orchestrated balance accounts for an effective skeletal muscle regeneration. New reports also demonstrate satellite cells relationships with blood vessels and the high myogenic potential of stem cell subsets related to both lineages.
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Satellite cells exit quiescence by extrinsic mechanical stretch to the fibre, generating differentiated cells and self-renewing stem cells by asymmetric division.
“Satellite cells exit quiescence by extrinsic mechanical stretch to the fibre, generating differentiated cells and self-renewing stem cells by asymmetric division [84]”
From Integrating Transwomen and Female Athletes with Differences of Sex Development (DSD) into Elite Competition: The FIMS 2021 Consensus Statement (2021) · cites this paper as [84]
Skeletal muscle repair events fall into three stages: proliferation, early differentiation, and terminal differentiation.
“Briefly, the events that occur during skeletal muscle repair are thought to fall into three well defined stages including (1) proliferation, (2) early differentiation, and (3) terminal differentiation [110].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [110]
In vitro, muscle progenitor cells proliferate, express early differentiation markers (MyoD, Myf5), and fuse into mature myotubes with a contractile phenotype without immune cells or their secreted products.
“That is, when placed into culture, muscle progenitor cells proliferate, express early markers of differentiation along a muscle phenotype (MyoD, Myf5), and then fuse and form mature myotubes with a contractile phenotype in the absence of immune cells or their secreted products [110].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [110]
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- Authors
- Le Grand, F., & Rudnicki, M. A.
- ORCID
- Rudnicki, Michael A
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 19
- Issue
- 6
- Pages
- 628-633
- ISSN
- 0955-0674 (ISSN-L)
- PMC
- PMC2215059
- OpenAlex
- W2022223340
- Cited by
- 544
- References
- 8
- Citations by year
- 2026: 14 · 2025: 28 · 2024: 21 · 2023: 24 · 2022: 29 · 2021: 39 · 2020: 25 · 2019: 30 · 2018: 33 · 2017: 30 · 2016: 19 · 2015: 31 · 2014: 34 · 2013: 26 · 2012: 43
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR044031)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- skeletal muscle satellite cells, myogenic stem cells, self-renewal, muscle aging, paired box transcription factors, bHLH transcription factors, skeletal muscle regeneration, stem cell lineage
- MeSH terms
- Adult, Cell Differentiation, Humans, Regeneration, Cell Lineage, Muscle Development, Satellite Cells, Skeletal Muscle
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