A Population of Myogenic Stem Cells That Survives Skeletal Muscle Aging
Abstract
Age-related decline in integrity and function of differentiated adult tissues is widely attributed to reduction in number or regenerative potential of resident stem cells. The satellite cell, resident beneath the basal lamina of skeletal muscle myofibers, is the principal myogenic stem cell. Here we have explored the capacity of satellite cells within aged mouse muscle to regenerate skeletal muscle and to self-renew using isolated myofibers in tissue culture and in vivo. Satellite cells expressing Pax7 were depleted from aged muscles, and when aged myofibers were placed in culture, satellite cell myogenic progression resulted in apoptosis and fewer total differentiated progeny. However, a minority of cultured aged satellite cells generated large clusters of progeny containing both differentiated cells and new cells of a quiescent satellite-cell-like phenotype characteristic of self-renewal. Parallel in vivo engraftment assays showed that, despite the reduction in Pax7+ cells, the satellite cell population associated with individual aged myofibers could regenerate muscle and self-renew as effectively as the larger population of satellite cells associated with young myofibers. We conclude that a minority of satellite cells is responsible for adult muscle regeneration, and that these stem cells survive the effects of aging to retain their intrinsic potential throughout life. Thus, the effectiveness of stem-cell-mediated muscle regeneration is determined by both extrinsic environmental influences and diversity in intrinsic potential of the stem cells themselves. Disclosure of potential conflicts of interest is found at the end of this article.
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A subset of MuSCs identified by inducible Mx1-Cre lineage tracing is particularly resistant to stress, perhaps representing a population protected from ageing.
“Another subset of MuSCs (identified by inducible Mx1–Cre lineage tracing) is particularly resistant to stress36, perhaps also representing a population that is protected from ageing37.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [37]
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- Authors
- Collins, C. A., Zammit, P. S., Ruiz, A. P., Morgan, J. E., & Partridge, T. A.
- Affiliations
- Hammersmith Hospital (GB)
- King's College London (GB)
- Children's National (US)
- Corresponding author
- Zammit, Peter S.
- Morgan, Jennifer E.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-01-11
- Volume
- 25
- Issue
- 4
- Pages
- 885-894
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1977233815
- Cited by
- 320
- References
- 46
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 12 · 2021: 28 · 2020: 13 · 2019: 11 · 2018: 12 · 2017: 20 · 2016: 23 · 2015: 25 · 2014: 21 · 2013: 26 · 2012: 34
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Stem Cells (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- satellite cells, myogenic stem cells, skeletal muscle aging, muscle regeneration, self-renewal, Pax7, stem cell heterogeneity, engraftment, apoptosis, quiescent stem cells
- MeSH terms
- Aging, Animals, Cell Survival, Disease Models, Animal, Immunohistochemistry, Stem Cells, Muscle, Skeletal, Muscle Fibers, Skeletal, Cell Culture Techniques, Mice, PAX7 Transcription Factor
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