Globular adiponectin as a complete mesoangioblast regulator: Role in proliferation, survival, motility, and skeletal muscle differentiation
Open accessAbstract
Mesoangioblasts are progenitor endowed with multipotent mesoderm differentiation ability. Despite the promising results obtained with mesoangioblast transplantation in muscle dystrophy, an improvement of their efficient engrafting and survival within damaged muscles, as well as their ex vivo activation/expansion and commitment toward myogenic lineage, is highly needed and should greatly increase their therapeutic potential. We show that globular adiponectin, an adipokine endowed with metabolic and differentiating functions for muscles, regulates vital cues of mesoangioblast cell biology. The adipokine drives mesoangioblasts to entry cell cycle and strongly counteracts the apoptotic process triggered by growth factor withdrawal, thereby serving as an activating and prosurvival stem cell factor. In addition, adiponectin provides a specific protection against anoikis, the apoptotic death due to lack of anchorage to extracellular matrix, suggesting a key protective role for these nonresident stem cells after systemic injection. Finally, adiponectin behaves as a chemoattractive factor toward mature myotubes and stimulates their differentiation toward the skeletal muscle lineage, serving as a positive regulator in mesoangioblast homing to injured or diseased muscles. We conclude that adiponectin exerts several advantageous effects on mesoangioblasts, potentially valuable to improve their efficacy in cell based therapies of diseased muscles.
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gApN can serve as a positive regulator in mesoangioblasts homing to injured or diseased muscles of mice, thus driving their commitment towards the skeletal muscle lineage.
“gApN can serve as a positive regulator in mesoangioblasts homing to injured or diseased muscles of mice , thus driving their commitment towards the skeletal muscle lineage [73] (Figure 3).”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [73]
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Gamberi, T., Magherini, F., Mannelli, M., Chrisam, M., Cescon, M., Castagnaro, S., Modesti, A., Braghetta, P., & Fiaschi, T. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01766-0 · Cited by 5 · see citing works
Smit, E. R., Romijn, M., Langerhorst, P., van der Zwaan, C., van der Staaij, H., Rotteveel, J., van Kaam, A. H., Fustolo-Gunnink, S. F., Hoogendijk, A. J., Onland, W., et al. (2024) · Pediatric Research · doi:10.1038/s41390-024-03481-0 · Cited by 5 · see citing works
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Dadson, J. K. E. (2014) · YorkSpace (York University)
Model of Muscle Injury Macrophage IL-10 for Survival in a Mouse Transplanted Mesoangioblasts Require
Rovere, P. Q., Cossu, G., Manfredi, A. A., Brunelli, S., Bosurgi, L., Corna, G., & Vezzoli, M. (2012)
Traditional Chinese Medicine for Diabetic Sarcopenia: A Review and Its Related Mechanisms
Ye, Z., Yuan, H., He, H., & Wen, W. (2026) · Journal of Diabetes Research · doi:10.1155/jdr/6655697
- Authors
- Fiaschi, T., Tedesco, F. S., Giannoni, E., Diaz-Manera, J., Parri, M., Cossu, G., & Chiarugi, P.
- Affiliations
- University of Florence (IT)
- Vita-Salute San Raffaele University (IT)
- Division of Regenerative Medicine, San Raffaele Scientific Institute, 20132 Milan, Italy;
- University of Milan (IT)
- Corresponding author
- Chiarugi, Paola
- ORCID
- Venue
- Molecular Biology of the Cell
- Published
- 2010-03-15
- Volume
- 21
- Issue
- 6
- Pages
- 848-859
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC2836966
- OpenAlex
- W2141950527
- Cited by
- 35
- References
- 64
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 6 · 2016: 2 · 2014: 2 · 2013: 5 · 2012: 5
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Biology of the Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Regione Toscana
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- globular adiponectin, mesoangioblasts, adipokines, skeletal muscle regeneration, muscular dystrophy, cell cycle entry, apoptosis, anoikis, cell survival, cell motility, myogenesis, cell homing, cell therapy, stem cells
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Cell Survival, Cells, Cultured, Humans, Mice, Inbred C57BL, Stem Cells, Mice, Knockout, Muscle, Skeletal, Coculture Techniques, Sarcoglycans, Cell Proliferation, Mice, Rats, Adiponectin
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