Inactivity‐induced oxidative stress: A central role in age‐related sarcopenia?
Abstract
Ageing causes a progressive decline in skeletal muscle mass that may lead to decreased strength and functionality. The term sarcopenia is especially used to characterise this geriatric syndrome. Numerous conditions and behaviours are considered to accelerate the progression of sarcopenia such as chronic diseases, malnutrition and physical inactivity. As people in modern countries are more and more sedentary, the impact of physical inactivity on the prevalence of sarcopenia might be more and more important in the future. In this review, we discuss how reactive oxygen species (ROS) could mediate the effects of lifelong inactivity in the onset and progression of age‐related sarcopenia. Although the cellular mechanisms responsible for muscle ROS production are not necessarily the same, both inactivity and ageing are indeed known to increase basal ROS concentrations in skeletal muscle. New data and literature review are provided showing that chronic ROS overproduction induced by physical inactivity may exacerbate the activation of some redox‐sensitive signalling pathways involved in age‐related sarcopenia. We also address the scientific evidences implicating the role of ROS overproduction in the precocious failure of aged muscles to activate intracellular signalling responses to contractions.
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Sedentary lifestyles, characterised by inactive skeletal muscle, sarcopenia and adipose tissue accumulation, are associated with moderate-to-high levels of reactive oxygen species, which can deplete antioxidant defences resulting in oxidation of proteins, lipids and DNA.
“Sedentary lifestyles, characterised by inactive skeletal muscle, sarcopenia and adipose tissue accumulation, are associated with moderate-to-high levels of reactive oxygen species, which can deplete antioxidant defences resulting in oxidation of proteins, lipids and DNA (Bjork et al. 2012; Derbre et al. 2014; Gratas-Delamarche et al. 2014; Le Lay and Simard 2014).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Derbre et al. 2014
Regular moderate-intensity exercise stimulates optimal reactive oxygen species production above resting values, but not to the levels associated with chronic sedentary behaviour.
“Regular moderate-intensity exercise stimulates optimal reactive oxygen species production above resting values, but not to the levels associated with chronic sedentary behaviour (Bjork et al. 2012; Derbre et al. 2014; Gratas-Delamarche et al. 2014; Le Lay and Simard 2014).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Derbre et al. 2014
Cites
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Actual causes of death in the United States
McGinnis, J. M. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03510180077038 · Cited by 5,480 · see citing works
Actual Causes of Death in the United States, 2000
Mokdad, A. H. (2004) · JAMA · doi:10.1001/jama.291.10.1238 · Cited by 5,211 · see citing works
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004 · see citing works
Boveris, A., & Chance, B. (1973) · Biochemical Journal · doi:10.1042/bj1340707 · Cited by 2,626 · see citing works
Lauretani, F., Russo, C. R., Bandinelli, S., Bartali, B., Cavazzini, C., Di Iorio, A., Corsi, A. M., Rantanen, T., Guralnik, J. M., & Ferrucci, L. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00246.2003 · Cited by 1,946 · see citing works
Jones, D. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1865 · Cited by 1,726 · see citing works
Hydrogen peroxide sensing and signaling
Veal, E. A., Day, A. M., & Morgan, B. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.016 · Cited by 1,604 · see citing works
The healthcare costs of sarcopenia in the United States
Janssen, I., Shepard, D. S., Katzmarzyk, P. T., & Roubenoff, R. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52014.x · Cited by 1,546 · see citing works
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367 · see citing works
Rosenberg, I. H. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.5.1231 · Cited by 1,201 · see citing works
Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives
Rolland, Y., Czerwinski, S., van Kan, G. A., Morley, J. E., Cesari, M., Onder, G., Woo, J., Baumgartner, R., Pillard, F., Boirie, Y., et al. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982704 · Cited by 1,071 · see citing works
Hindlimb unloading rodent model: technical aspects
Morey, E. R., & Globus, R. K. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00969.2001 · Cited by 998 · see citing works
Gomez-Cabrera, M.-C., Domenech, E., Romagnoli, M., Arduini, A., Borras, C., Pallardo, F. V., Sastre, J., & Viña, J. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.142 · Cited by 844 · see citing works
Self-citationDegradation of oxidized proteins in mammalian cells
Grune, T., Reinheckel, T., & Davies, K. J. A. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.7.9212076 · Cited by 835 · see citing works
From space to Earth: Advances in human physiology from 20 years of bed rest studies (1986–2006)
Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., & Vernikos, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0474-z · Cited by 658 · see citing works
Li, Y.-P., Chen, Y., John, J., Moylan, J. S., Jin, B., Mann, D. L., & Reid, M. B. (2005) · The FASEB Journal · doi:10.1096/fj.04-2364com · Cited by 601 · see citing works
Rosenberg, I. H. (1989) · American Journal of Clinical Nutrition · Cited by 589 · see citing works
Oxidative stress: damage to intact cells and organs
Sies, H., & Cadenas, E. (1985) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1985.0168 · Cited by 551 · see citing works
Skeletal muscle satellite cells and adult myogenesis
Le Grand, F., & Rudnicki, M. A. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.09.012 · Cited by 544 · see citing works
p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps
Wu, Z.-G., Woodring, P. J., Bhakta, K. S., Tamura, K., Wen, F., Feramisco, J., Karin, M., Wang, J. Y. J., & Puri, P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.3951-3964.2000 · Cited by 524 · see citing works
Li, Y., Schwartz, R. J., Waddell, I. D., Holloway, B. R., & Reid, M. B. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.10.871 · Cited by 502 · see citing works
Gómez‐Cabrera, M. C., Borrás, C., Pallardó, F. V., Sastre, J., Ji, L. L., & Viña, J. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080564 · Cited by 477 · see citing works
Self-citationThe developmental origins of sarcopenia
Sayer, A. A., Syddall, H., Martin, H., Patel, H., Baylis, D., & Cooper, C. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982703 · Cited by 450 · see citing works
Müller, F. L., Song, W., Liu, Y., Chaudhuri, A. R., Pieke-Dahl, S., Strong, R., Huang, T., Epstein, C. J., Roberts, L. J., CSETE, M. E., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.036 · Cited by 447 · see citing works
Aging and acute exercise enhance free radical generation in rat skeletal muscle
Bejma, J., & Ji, L. L. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.465 · Cited by 445 · see citing works
Muscle transplantation between young and old rats: age of host determines recovery
Carlson, B. M., & Faulkner, J. A. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.256.6.c1262 · Cited by 417 · see citing works
Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle
Lawler, J. M. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00186-2 · Cited by 370 · see citing works
Free radicals and muscle fatigue: of ROS, canaries, and the IOC
Reid, M. B. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.002 · Cited by 329 · see citing works
Regenerative potential of human skeletal muscle during aging
Renault, V. M., Thorne, L., Eriksson, P., Butler-Browne, G. S., & Mouly, V. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00017.x · Cited by 318 · see citing works
Mourkioti, F., Kratsios, P., Luedde, T., Song, Y.-H., Delafontaine, P., Adami, R., Parente, V., Bottinelli, R., Pasparakis, M., & Rosenthal, N. A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28721 · Cited by 315 · see citing works
Li, Y.-P., Chen, Y., Li, A. S., & Reid, M. B. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00129.2003 · Cited by 313 · see citing works
Reactive oxygen in skeletal muscle. III. Contractility of unfatigued muscle
Reid, M. B., Khawli, F. A., & Moody, M. R. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1081 · Cited by 297 · see citing works
Williamson, D., Gallagher, P. M., Harber, M. P., Hollon, C. J., & Trappe, S. W. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.036673 · Cited by 290 · see citing works
Leeuwenburgh, C., Fiebig, R., Chandwaney, R. H., & Ji, L. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.267.2.r439 · Cited by 289 · see citing works
Drew, B., Phaneuf, S., Dirks, A. J., Selman, C., Gredilla, R., Lezza, A. M. S., Barja, G., & Leeuwenburgh, C. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00455.2002 · Cited by 287 · see citing works
Satellite cells and myonuclei in young and elderly women and men
Kadi, F., Charifi, N., Denis, C., & Lexell, J. E. (2003) · Muscle & Nerve · doi:10.1002/mus.10510 · Cited by 283 · see citing works
Khassaf, M. B., McArdle, A., Esanu, C., Vasilaki, A., McArdle, F., Griffiths, R. D., Brodie, D. A., & Jackson, M. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040303 · Cited by 273 · see citing works
Radák, Z., Naito, H., Kaneko, T., Tahara, S., Nakamoto, H., Takahashi, R., Cardozo-Pelaez, F., & Goto, S. (2002) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-002-0918-6 · Cited by 269 · see citing works
The impact of sarcopenia and exercise training on skeletal muscle satellite cells
Snijders, T., Verdijk, L. B., & van Loon, L. J. C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.003 · Cited by 245 · see citing works
Molecular aging and rejuvenation of human muscle stem cells
Carlson, M. E., Suetta, C., Conboy, M. J., Aagaard, P., Mackey, A., Kjaer, M., & Conboy, I. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900045 · Cited by 245 · see citing works
Age-related muscle dysfunction
Thompson, L. V. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2008.05.003 · Cited by 226 · see citing works
Oxidative stress and the mitochondrial theory of aging in human skeletal muscle
Parise, G., Jan, K. J., Douglas, M. J., Phillips, S. M., & Tarnopolsky, M. A. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.002 · Cited by 223 · see citing works
Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults
Safdar, A., Hamadeh, M. J., Kaczor, J. J., Raha, S., deBeer, J., & Tarnopolsky, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010778 · Cited by 217 · see citing works
Free radical generation by skeletal muscle of adult and old mice: effect of contractile activity
Vasilaki, A., Mansouri, A., Remmen, H. V., van der Meulen, J. H., Larkin, L. M., Richardson, A. G., McArdle, A., Faulkner, J. A., & Jackson, M. J. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00198.x · Cited by 215 · see citing works
Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver
Ji, L., Dillon, D. A. R., & Wu, E. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.258.4.r918 · Cited by 215 · see citing works
Pansarasa, O., Bertorelli, L., Vecchiet, J., Felzani, G., & Marzatico, F. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00108-2 · Cited by 212 · see citing works
Exercise at Old Age: Does It Increase or Alleviate Oxidative Stress?
Ji, L. L. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05653.x · Cited by 205 · see citing works
Lambertucci, R. H., Levada‐Pires, A. C., Rossoni, L. V., Curi, R., & Pithon‐Curi, T. C. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.12.006 · Cited by 205 · see citing works
Kang, C., OʼMoore, K. M., Dickman, J. R., & Ji, L. L. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.08.007 · Cited by 204 · see citing works
Nitric oxide, reactive oxygen species, and skeletal muscle contraction
Reid, M. B. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200103000-00006 · Cited by 198 · see citing works
Adaptive responses of mouse skeletal muscle to contractile activity: The effect of age
Vasilaki, A., McArdle, F., Iwanejko, L. M., & McArdle, A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.08.004 · Cited by 182 · see citing works
Patel, J. C., McLeod, L. E., Vries, R. G. J., Flynn, A., Wang, X., & Proud, C. G. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02992.x · Cited by 171 · see citing works
Servais, S., Letexier, D., Favier, R. J. M., Duchamp, C., & Dominique Desplanches, C. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.001 · Cited by 170 · see citing works
Redox modulation of contractile function in respiratory and limb skeletal muscle
Smith, M. A., & Reid, M. B. (2006) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2005.12.011 · Cited by 163 · see citing works
Skeletal muscle proteolysis in aging
Combaret, L., Dardevet, D. P., Béchet, D., Taillandier, D., Mosoni, L., & Attaix, D. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831b9c31 · Cited by 152 · see citing works
Mechanical Muscle Function, Morphology, and Fiber Type in Lifelong Trained Elderly
Aagaard, P., Magnusson, S. P., Larsson, B., Kjær, M., & Krustrup, P. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31814fb402 · Cited by 149 · see citing works
Heat treatment reduces oxidative stress and protects muscle mass during immobilization
Selsby, J. T., & DODD, S. L. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00497.2004 · Cited by 147 · see citing works
Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy
Hofer, T., Marzetti, E., Xu, J., Seo, A. Y., Güleç, Ş., Knutson, M. D., Leeuwenburgh, C., & Dupont‐Versteegden, E. E. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.02.007 · Cited by 140 · see citing works
The role of hormones, cytokines and heat shock proteins during age-related muscle loss
Lee, C. E., McArdle, A., & Griffiths, R. D. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.05.005 · Cited by 138 · see citing works
Age and sex differences in human skeletal muscle: Role of reactive oxygen species
Pansarasa, O., Castagna, L., Colombi, B., Vecchiet, J., Felzani, G., & Marzatico, F. (2000) · Free Radical Research · doi:10.1080/10715760000301451 · Cited by 135 · see citing works
Goldspink, D. F., Morton, A. J., Loughna, P. T., & Goldspink, G. (1986) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00585311 · Cited by 132 · see citing works
Ardite, E., Barberà, J. A., Roca, J., & Fernández-Checa, J. C. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63335-4 · Cited by 129 · see citing works
Marzani, B., Balage, M., Vénien, A., Astruc, T., Papet, I., Dardevet, D. P., & Mosoni, L. (2008) · Journal of Nutrition · doi:10.3945/jn.108.094029 · Cited by 121 · see citing works
Bar‐Shai, M., Carmeli, E., Ljubuncic, P., & Reznick, A. Z. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.019 · Cited by 118 · see citing works
Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading
Andrianjafiniony, T., Dupré-Aucouturier, S., Letexier, D., Couchoux, H., & Dominique Desplanches, C. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00069.2010 · Cited by 115 · see citing works
Capel, F., Rimbert, V., Lioger, D., Diot, A., Rousset, P., Mirand, P. P., Boirie, Y., Morio, B., & Mosoni, L. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.11.001 · Cited by 108 · see citing works
A reducing redox environment promotes C2C12 myogenesis: Implications for regeneration in aged muscle
Hansen, J. M., Klass, M., Harris, C., & CSETE, M. E. (2006) · Cell Biology International · doi:10.1016/j.cellbi.2006.11.027 · Cited by 100 · see citing works
Neurogenesis of Excitation-Contraction Uncoupling in Aging Skeletal Muscle
Payne, A. M., & Delbono, O. (2004) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200401000-00008 · Cited by 97 · see citing works
Transient reflecting grating spectroscopy for defect analysis of surface region of semiconductors
Donen, H., Katayama, K., & Sawada, T. (2002) · Journal of Applied Physics · doi:10.1063/1.1492860 · Cited by 95 · see citing works
Superoxide dismutase gene expression in skeletal muscle: fiber-specific effect of age
Hollander, J. M., Bejma, J., Ookawara, T., et al. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00130-5 · Cited by 95 · see citing works
Regulation of C2C12 myogenic terminal differentiation by MKK3/p38α pathway
Cabane, C., Englaro, W., Yeow, K., Ragno, M., & Dérijard, B. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00078.2002 · Cited by 95 · see citing works
Ryan, M. J., Jackson, J. R., Hao, Y., Leonard, S. S., & Alway, S. E. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.002 · Cited by 94 · see citing works
Ljubicic, V., & Hood, D. A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00483.x · Cited by 87 · see citing works
Vitamin E and the Oxidative Stress of Exercise
Jackson, M. J., Khassaf, M. B., Vasilaki, A., McArdle, F., & McArdle, A. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1331.015 · Cited by 86 · see citing works
Kim, J.-H., Kwak, H., Leeuwenburgh, C., & Lawler, J. M. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.12.012 · Cited by 79 · see citing works
Feng, J., Xie, H., Meany, D. L., Thompson, L. V., Arriaga, E. A., & Griffin, T. J. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.11.1137 · Cited by 78 · see citing works
Effects of Age and Sedentary Lifestyle on Skeletal Muscle NF- B Signaling in Men
Buford, T. W., Cooke, M. B., Manini, T. M., Leeuwenburgh, C., & Willoughby, D. S. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp196 · Cited by 78 · see citing works
Habitual exercise program protects murine intestinal, skeletal, and cardiac muscles against aging
Rosa, E. F., Silva, A. C., Ihara, S. S. M., Mora, O. A., Aboulafia, J., & Nouailhetas, V. L. A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00417.2005 · Cited by 77 · see citing works
Oh‐ishi, S., Kizaki, T., Yamashita, H., et al. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01637-f · Cited by 74 · see citing works
Age-related increase in xanthine oxidase activity in human plasma and rat tissues
Aranda, R., Domènech, E. B., Rus, A. D., Real, J. T., Sastre, J., Viña, J., & Pallardó, F. V. (2007) · Free Radical Research · doi:10.1080/10715760701481461 · Cited by 72 · see citing works
Self-citationMarzetti, E., Groban, L., Wohlgemuth, S. E., Lees, H. A., Lin, M., Jobe, H., Giovannini, S., Leeuwenburgh, C., & Carter, C. S. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00620.2007 · Cited by 72 · see citing works
Thompson, D. D. M. (2008) · PubMed · Cited by 70 · see citing works
Impact of Lifelong Sedentary Behavior on Mitochondrial Function of Mice Skeletal Muscle
Figueiredo, P., Powers, S. K., Ferreira, R. M., Amado, F. M. L., Appell, H.-J., & Duarte, J. A. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp066 · Cited by 67 · see citing works
Huang, J. H., & Hood, D. A. (2009) · IUBMB Life · doi:10.1002/iub.164 · Cited by 66 · see citing works
Human muscle aging: ROS-mediated alterations in rectus abdominis and vastus lateralis muscles
Marzani, B., Felzani, G., Bellomo, R. G., Vecchiet, J., & Marzatico, F. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.08.010 · Cited by 65 · see citing works
Capel, F., Buffière, C., Mirand, P. P., & Mosoni, L. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.02.005 · Cited by 65 · see citing works
Antioxidant enzyme systems in skeletal muscle atrophied by immobilization
Kondo, H., Miura, M., & Itokawa, Y. (1993) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00374299 · Cited by 63 · see citing works
Vasilaki, A., van der Meulen, J. H., Larkin, L. M., Harrison, D. C., Pearson, T., Remmen, H. V., Richardson, A., Brooks, S. V., Jackson, M. J., & McArdle, A. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00635.x · Cited by 60 · see citing works
Spangenburg, E. E. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-010 · Cited by 60 · see citing works
Indication of in vivo xanthine oxidase activity in human skeletal muscle during exercise
Hellsten, Y., AHLBORG, G., Jensen‐Urstad, M., & Sjödin, B. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08475.x · Cited by 53 · see citing works
Are antioxidants useful for treating skeletal muscle atrophy?
Bonetto, A., Penna, F., Muscaritoli, M., Minero, V. G., Fanelli, F. R., Baccino, F. M., & Costelli, P. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.002 · Cited by 52 · see citing works
Nutrition, diet, physical activity, smoking, and longevity
Walker, A. R. P., Walker, B. F., & Adam, F. I. (2003) · Nutrition · doi:10.1016/s0899-9007(02)00948-6 · Cited by 47 · see citing works
Wu, M., Desai, D. H., Kakarla, S. K., Katta, A., Paturi, S., Gutta, A. K., Rice, K. M., Walker, E. M., & Blough, E. R. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.932 · Cited by 43 · see citing works
Oxidative stress during recovery from muscle atrophy
Kondo, H., Kodama, J., Kishibe, T., et al. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81788-2 · Cited by 41 · see citing works
Effects of hindlimb unweighting and aging on rat semimembranosus muscle and myosin
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Myofibrillar myosin ATPase activity in hindlimb muscles from young and aged rats
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Acetaminophen Improves Protein Translational Signaling in Aged Skeletal Muscle
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Seynnes, O., Maffiuletti, N. A., Maganaris, C. N., Boer, M. D. D., Pensini, M., di Prampero, P. E., & Narici, M. V. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01874.x · Cited by 25 · see citing works
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Sedentary individuals as “controls” in human studies: The correct approach?
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Xu, X. M., Chen, C., Arriaga, E. A., & Thompson, L. V. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00174.2010 · Cited by 14 · see citing works
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Oxidative stress and frailty: A systematic review and synthesis of the best evidence
Soysal, P., Isik, A. T., Carvalho, A. F., Fernandes, B. S., Solmi, M., Schofield, P., Veronese, N., & Stubbs, B. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.01.006 · Cited by 252 · see citing works
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Cytokine Signaling in Skeletal Muscle Wasting
Zhou, J., Liu, B., Liang, C., Li, Y., & Song, Y.-H. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.03.002 · Cited by 172 · see citing works
Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study
Liu, C. K., Lyass, A., Larson, M. G., Massaro, J. M., Wang, N., D’Agostino, R. B., Benjamin, E. J., & Murabito, J. M. (2016) · AGE · doi:10.1007/s11357-015-9864-z · Cited by 157 · see citing works
Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention
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Is immunosenescence influenced by our lifetime “dose” of exercise?
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Muller, G. C., Gottlieb, M. G. V., Luz Correa, B., Filho, I. G., Moresco, R. N., & Bauer, M. E. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.05.006 · Cited by 55 · see citing works
Andreani, C., Bartolacci, C., Guescini, M., Battistelli, M., Stocchi, V., Orlando, F., Provinciali, M., Amici, A., Marchini, C., Tiano, L., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8936251 · Cited by 37 · see citing works
- Authors
- Derbré, F., Gratas‐Delamarche, A., Gómez‐Cabrera, M. C., & Viña, J.
- Affiliations
- Laboratoire Movement, Sport and Health Sciences (M2S) University Rennes II‐ENS Cachan, UFR APS Rennes France
- École Normale Supérieure Paris-Saclay (FR)
- Universitat de València (ES)
- Venue
- European Journal of Sport Science
- Publisher
- Wiley
- Published
- 2012-03
- Volume
- 14
- Issue
- S1
- Pages
- S98-108
- ISSN
- 1536-7290 (ISSN-L)
- 1746-1391
- OpenAlex
- W2161640220
- Cited by
- 89
- References
- 103
- Citations by year
- 2025: 3 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 5 · 2017: 5 · 2016: 9 · 2015: 9 · 2014: 4
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Sport Science (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Federación Española de Enfermedades Raras
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- age-related sarcopenia, physical inactivity, oxidative stress, reactive oxygen species, skeletal muscle aging, sedentary lifestyle, muscle mass loss
- MeSH terms
- Aged, Aged, 80 and over, Humans, Motor Activity, Muscular Atrophy, Signal Transduction, Oxidative Stress, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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