The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Signaling pathway cooperation in TGF-β-induced epithelial–mesenchymal transition
Open accessAbstract
Transdifferentiation of epithelial cells into cells with mesenchymal properties and appearance, i.e. epithelial-mesenchymal transition (EMT), is essential during development, and occurs in pathological contexts, such as in fibrosis and cancer progression. Although EMT can be induced by many extracellular ligands, TGF-β and TGF-β-related have emerged as major inducers of this transdifferentiation process in development and cancer. Additionally, it is increasingly apparent that signaling pathways cooperate in the execution of EMT. This update summarizes the current knowledge of the coordination of TGF-β-induced Smad and non-Smad signaling pathways in EMT, and the remarkable ability of Smads to cooperate with other transcription-directed signaling pathways in the control of gene reprogramming during EMT.
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Cites
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Molecular mechanisms of epithelial–mesenchymal transition
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Self-citationWnt/β-catenin signaling and disease
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Regulatory networks defining EMT during cancer initiation and progression
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SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
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Self-citationEMT, the cytoskeleton, and cancer cell invasion
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Cited by
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876
TGFβ biology in cancer progression and immunotherapy
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Self-citationTGF-β1 Signaling and Tissue Fibrosis
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Specificity, versatility, and control of TGF-β family signaling
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Self-citationTargeting TGFβ signal transduction for cancer therapy
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“TGFβ can induce different states of EMP and the cellular response to TGFβ is context-dependent; inflammatory factors, Wnt, Notch, Hippo, and Hedgehog interplay with TGFβ to orchestrate the EMP response.(126) In Fig.”
Background
Metadata
- Authors
- Derynck, R., Muthusamy, B. P., & Saeteurn, K. Y.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 31
- Pages
- 56-66
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W1966701340
- Cited by
- 374
- References
- 116
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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