The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Microtubule-organizing centers: from the centrosome to non-centrosomal sites
Open accessAbstract
The process of cellular differentiation requires the distinct spatial organization of the microtubule cytoskeleton, the arrangement of which is specific to cell type. Microtubule patterning does not occur randomly, but is imparted by distinct subcellular sites called microtubule-organizing centers (MTOCs). Since the discovery of MTOCs fifty years ago, their study has largely focused on the centrosome. All animal cells use centrosomes as MTOCs during mitosis. However in many differentiated cells, MTOC function is reassigned to non-centrosomal sites to generate non-radial microtubule organization better suited for new cell functions, such as mechanical support or intracellular transport. Here, we review the current understanding of non-centrosomal MTOCs (ncMTOCs) and the mechanisms by which they form in differentiating animal cells.
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Cites
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Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase
Hernández-Vega, A., Braun, M., Scharrel, L., Jahnel, M., Wegmann, S., Hyman, B. T., Alberti, S., Diez, S., & Hyman, A. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.042 · Cited by 395
“Although there is considerable knowledge about how neurons use microtubule bundles for microtubule-based transport, we have less knowledge about how microtubule bundles form (Baas et al., 2005; Chen et al., 2017; Sanchez and Feldman, 2017; Tanaka and Kirschner, 1991).”
BackgroundIntegrin and microtubule crosstalk in the regulation of cellular processes
LaFlamme, S. E., Mathew-Steiner, S., Singh, N., Colello-Borges, D., & Nieves, B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2913-x · Cited by 84
Peela, N., Barrientos, E. S., Truong, D., Mouneimne, G., & Nikkhah, M. (2017) · Integrative Biology · doi:10.1039/c7ib00180k · Cited by 29
Tillery, M. M. L., Zheng, C., Zheng, Y., & Megraw, T. L. (2024) · Molecular Biology of the Cell · doi:10.1091/mbc.e23-06-0245 · Cited by 9
Tubulin and GTP Are Crucial Elements for Postsynaptic Density Construction and Aggregation
Suzuki, T., Fujii, T., Kametani, K., Li, W., & Tabuchi, K. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70085 · Cited by 2
Metadata
- Authors
- Sanchez, A. D., & Feldman, J. L.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 44
- Pages
- 93-101
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2522470354
- Cited by
- 285
- References
- 75
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
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