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Cited by 863

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems

Open access
da Silva, Dana, Kaduri, Maya, Poley, Maria, Adir, Omer, Krinsky, Nitzan, Shainsky-Roitman, Janna, Schroeder, Avi·2018·Chemical Engineering Journal
DOI 10.1016/j.cej.2018.01.010
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Abstract

Polylactic acid (PLA) is the most commonly used biodegradable polymer in clinical applications today. Examples range from drug delivery systems, tissue engineering, temporary and long-term implantable devices; constantly expanding to new fields. This is owed greatly to the polymer's favorable biocompatibility and to its safe degradation products. Once coming in contact with biological media, the polymer begins breaking down, usually by hydrolysis, into lactic acid (LA) or to carbon dioxide and water. These products are metabolized intracellularly or excreted in the urine and breath. Bacterial infection and foreign-body inflammation enhance the breakdown of PLA, through the secretion of enzymes that degrade the polymeric matrix. The biodegradation occurs both on the surface of the polymeric device and inside the polymer body, by diffusion of water between the polymer chains. The median half-life of the polymer is 30 weeks; however, this can be lengthened or shortened to address the clinical needs. Degradation kinetics can be tuned by determining the molecular composition and the physical architecture of the device. Using L- or D- chirality of the LA will greatly slow or lengthen the degradation rates, respectively. Despite the fact that this polymer is more than 150 years old, PLA remains a fertile platform for biomedical innovation and fundamental understanding of how artificial polymers can safely coexist with biological systems.

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Metadata

Authors
da Silva, D., Kaduri, M., Poley, M., Adir, O., Krinsky, N., Shainsky-Roitman, J., & Schroeder, A.
Venue
Chemical Engineering Journal
Publisher
Elsevier BV
Published
2018-05
Volume
340
Pages
9-14
ISSN
1385-8947 (ISSN-L)
DOI
10.1016/j.cej.2018.01.010
OpenAlex
W2781695025
Cited by
863
References
8
FWCI
15.89
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems. https://app.cochat.ai/papers/10.1016/j.cej.2018.01.010
The paper
da Silva, D., Kaduri, M., Poley, M., Adir, O., Krinsky, N., Shainsky-Roitman, J., & Schroeder, A. (2018). Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems. Chemical Engineering Journal. https://doi.org/10.1016/j.cej.2018.01.010

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.