The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

Chang, Lufen, Kamata, Hideaki, Solinas, Giovanni, Luo, Jun-Li, Maeda, Shin, Venuprasad, K., Liu, Yun-Cai, Karin, Michael·2006·Cell
DOI 10.1016/j.cell.2006.01.021

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  2. The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation
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  5. Targeting c-FLIP in cancer
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  6. Induction of Hepatitis by JNK-Mediated Expression of TNF-α
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  7. The bottleneck of JNK signaling: Molecular and functional characteristics of MKK4 and MKK7
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  8. Ubiquitin Makes Its Mark on Immune Regulation
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  9. Cytotoxicity of TNFα is regulated by integrin‐mediated matrix signaling
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  17. FLIP and the death effector domain family
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  18. Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis
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  42. Simplified apoptotic cascades
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  45. Cell death at the intestinal epithelial front line
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  46. CARMA1‐mediated NF‐κB and JNK activation in lymphocytes
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