The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

Phosphorylation meets ubiquitination: the control of NF-κB activity

Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81589-5 · Cited by 3,626

A Third-Generation Lentivirus Vector with a Conditional Packaging System

Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.

Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738

NF-κB at the crossroads of life and death

Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709

Inhibition of death receptor signals by cellular FLIP

Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.

Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., & Goldberg, A. L. (1994) · Cell · doi:10.1016/s0092-8674(94)90462-6 · Cited by 2,524

Tumor necrosis factor signaling

Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,422

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937

Rocaglamide breaks TRAIL-resistance in human multiple myeloma and acute T-cell leukemia in vivo in a mouse xenogtraft model

Wu, Y., Giaisi, M., Köhler, R., Chen, W., Krammer, P. H., & Li‐Weber, M. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.12.010 · Cited by 28

Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates TNF-α-mediated activation of NF-κB and caspase-8

Ogura, H., Tsukumo, Y., Sugimoto, H., Igarashi, M., Nagai, K., & Kataoka, T. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.01.019 · Cited by 28

Involvement of the apelin receptor APJ in Fas‐induced liver injury

Yasuzaki, H., Yoshida, S., Hashimoto, T., Shibata, W., Inamori, M., Toya, Y., Tamura, K., Maeda, S., & Umemura, S. (2012) · Liver International · doi:10.1111/liv.12006 · Cited by 27

Drugs acting on homeostasis: challenging cancer cell adaptation

Moschovi, M. A., Critselis, E., Çen, O., Adamaki, M., Lambrou, G. Ι., Chrousos, G. P., & Vlahopoulos, S. (2015) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2015.1095095 · Cited by 28

Tumor necrosis factor-: regulation of renal function and blood pressure

Ramseyer, V. D., & Garvin, J. L. (2013) · Cited by 27

ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells

Clorennec, C. L., Lazrek, Y., Dubreuil, O., Sampaio, C. S., Larbouret, C., Lanotte, R., Poul, M., Barret, J.-M. M., Prost, J.-F. F., Pèlegrin, A., et al. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0413-8 · Cited by 27

Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma

Yang, X., Zeng, Q., & Tezel, G. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105258 · Cited by 27

Role of Necroptosis in Intervertebral Disc Degeneration

Khaleque, A., Kim, J. H., Hwang, B.-J., Kang, J.-K., Quan, M., & Kim, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015292 · Cited by 27

Immune cell-mediated liver injury

Corazza, N., Badmann, A., & Lauer, C. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0168-1 · Cited by 27

The ubiquitin ligase Siah2 regulates obesity-induced adipose tissue inflammation

Kilroy, G. E., Carter, L. E., Newman, S. S., Burk, D. H., Manuel, J., Möller, A., Bowtell, D. D. L., Mynatt, R. L., Ghosh, S., & Floyd, Z. E. (2015) · Obesity · doi:10.1002/oby.21220 · Cited by 25

The Association Between Serum Gamma‐Glutamyl Transferase and Gastrointestinal Cancer Risk: A Systematic Review and Meta‐Analysis

Ramandi, A., George, J., Behnoush, A. H., Delavari, A., Mohammadi, Z., Poustchi, H., & Malekzadeh, R. (2025) · Cancer Medicine · doi:10.1002/cam4.70581 · Cited by 27

Down-regulation of AMP-activated protein kinase sensitizes DU145 carcinoma to Fas-induced apoptosis via c-FLIP degradation

Jung, S., Park, I. J., Kim, M., Kang, I., Choe, W., Kim, S. S., & Ha, J. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.05.018 · Cited by 26

The proteasome deubiquitinase inhibitor b-AP15 enhances DR5 activation-induced apoptosis through stabilizing DR5

Oh, Y.-T., Deng, L., Deng, J., & Sun, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-08424-w · Cited by 26

TNFα-induced apoptosis in human myeloid cell lines HL-60 and K562 is dependent of intracellular ROS generation

González, D., Rodríguez, A. B., & Pariente, J. A. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-1979-5 · Cited by 26

Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells

Song, X., Kim, S.-Y., Zhou, Z., Lagasse, E., Kwon, Y. T., & Lee, Y. J. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.104 · Cited by 26

c-Jun N-terminal kinase–mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks

Barkley, L. R., Palle, K., Durando, M., Day, T. A., Gurkar, A. U., Kakusho, N., Li, J., Masai, H., & Vaziri, C. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0829 · Cited by 29

Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity

Han, K.-J., Foster, D. G., Harhaj, E. W., Dzieciątkowska, M., Hansen, K. C., & Liu, C.-W. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw021 · Cited by 26

Fever-Like Hyperthermia Controls T Lymphocyte Persistence by Inducing Degradation of Cellular FLIPshort

Meinander, A., Söderström, T. S., Kaunisto, A., Poukkula, M., Sistonen, L., & Eriksson, J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3944 · Cited by 26

Targeted Deletion of MKK4 Gene Potentiates TNF-Induced Apoptosis through the Down-Regulation of NF-κB Activation and NF-κB-Regulated Antiapoptotic Gene Products

Sethi, G., Ahn, K. S., Xia, D., Kurie, J. M., & Aggarwal, B. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1926 · Cited by 26

Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma

Chen, M.-C., Huang, H.-H., Lai, C.-Y., Lin, Y.-J., Liou, J., Lai, M.-J., Li, Y., Teng, C., & Yang, C. (2015) · Oncotarget · doi:10.18632/oncotarget.6352 · Cited by 25

Ubiquitin Ligases Involved in the Regulation of Wnt, TGF-β, and Notch Signaling Pathways and Their Roles in Mouse Development and Homeostasis

Dibus, N., Liďák, T., & C̆ermák, L. (2019) · Genes · doi:10.3390/genes10100815 · Cited by 27

Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity

Zhou, J., Liu, J., Wang, B., Li, N., Liu, J., Han, Y., & Cao, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01752-0 · Cited by 25

Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors

Pietkiewicz, S., Sohn, D., Piekorz, R. P., Grether‐Beck, S., Budach, W., Sabapathy, K., & Jänicke, R. U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061438 · Cited by 25

Synthesis and biological activities of chaetocin and its derivatives

Sodeoka, M., Dodo, K., Teng, Y., Iuchi, K., Hamashima, Y., Iwasa, E., & Fujishiro, S. (2012) · Pure and Applied Chemistry · doi:10.1351/pac-con-11-10-31 · Cited by 25

Suppression of TRPM7 enhances TRAIL‐induced apoptosis in triple‐negative breast cancer cells

Song, C., Choi, S.-H., Oh, K., & Sim, T. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29820 · Cited by 25

Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma

Zhang, N., Liu, X., Liu, L., Deng, Z., Zeng, Q., Pang, W., Liu, Y., Song, D., & Deng, H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0309-3 · Cited by 24

A Model of Partnership Co-Opted by the Homeodomain Protein TGIF and the Itch/AIP4 Ubiquitin Ligase for Effective Execution of TNF-α Cytotoxicity

Demange, C., Ferrand, N., Prunier, C., Bourgeade, M., & Atfi, A. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.009 · Cited by 24

Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation

Verbrugge, I., Maas, C., Heijkoop, M., Verheij, M., & Borst, J. G. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.141 · Cited by 24

Distinct functions of JNK and c‐Jun in oxidant‐induced hepatocyte death

Amir, M., Liu, K., Zhao, E., & Czaja, M. J. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24203 · Cited by 24

New paradigms for the function of JNKK1/MKK4 in controlling growth of disseminated cancer cells

Taylor, J. L., Szmulewitz, R. Z., Lotan, T. L., Hickson, J. A., Griend, D. J. V., Yamada, S. D., Macleod, K. F., & Rinker-Schaeffer, C. W. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.012 · Cited by 23

Oxidative complexity: The role of ROS in the tumor environment and therapeutic implications

Shen, T., Wang, Y., Cheng, L., Bode, A. M., Gao, Y., Zhang, S., Chen, X., & Luo, X. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118241 · Cited by 24

Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL

Yerbes, R., & López‐Rivas, A. (2010) · Investigational New Drugs · doi:10.1007/s10637-010-9597-x · Cited by 23

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury

Zhuang, Y., Xu, H. C., Shinde, P. V., Warfsmann, J., Vasiļevska, J., Sundaram, B., Behnke, K., Huang, J., Hoell, J. I., Borkhardt, A., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318215 · Cited by 24

Titanium dioxide nanoparticles: revealing the mechanisms underlying hepatotoxicity and effects in the gut microbiota

Ma, Y., Yu, N., Lu, H., Shi, J., Zhang, Y., Chen, Z., & Jia, G. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03536-x · Cited by 23

E3 ubiquitin ligases and deubiquitinases as modulators of TRAIL-mediated extrinsic apoptotic signaling pathway

Woo, S. M., & Kwon, T. K. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.2.011 · Cited by 23

Activation-induced Degradation of FLIPL Is Mediated via the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Macrophages

Shi, B., Tran, T. M., Sobkoviak, R., & Pope, R. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807918200 · Cited by 23

Caspase-8-mediated cleavage of Bid and protein phosphatase 2A-mediated activation of Bax are necessary for Verotoxin-1-induced apoptosis in Burkitt's lymphoma cells

Garibal, J., Hollville, É., Renouf, B., Tétaud, C., & Wiels, J. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.10.018 · Cited by 23

NF-κB Regulation of c-FLIP Promotes TNFα-Mediated RAF Inhibitor Resistance in Melanoma

Shao, Y., Le, K., Cheng, H., & Aplin, A. E. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.91 · Cited by 22

Activation of CD40 with Platelet Derived CD154 Promotes Reactive Oxygen Species Dependent Death of Human Hepatocytes during Hypoxia and Reoxygenation

Bhogal, R. H., Weston, C. J., Curbishley, S. M., Adams, D., & Afford, S. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030867 · Cited by 22

Antitumor efficacy of a photodynamic therapy-generated dendritic cell glioma vaccine

Shixiang, Y., Sun, X., Li, J., Shanyi, Z., Xingke, X., Meiguang, Z., Wang, K., & Fang-cheng, L. (2010) · Medical Oncology · doi:10.1007/s12032-010-9713-y · Cited by 22

Kaempferol Improves TRAIL-Mediated Apoptosis in Leukemia MOLT-4 Cells by the Inhibition of Anti-apoptotic Proteins and Promotion of Death Receptors Expression

Hassanzadeh, A., Naimi, A., Hagh, M. F., Saraei, R., Marofi, F., & Solali, S. (2019) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520619666190731155859 · Cited by 22

Targeting apoptosis: preclinical and early clinical experience with mapatumumab, an agonist monoclonal antibody targeting TRAIL-R1

Moretto, P., & Hotte, S. J. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780902752463 · Cited by 22

NF-κB regulates the stability and activity of p73 by inducing its proteolytic degradation through a ubiquitin-dependent proteasome pathway

Kikuchi, H., Ozaki, T., Furuya, K., Hanamoto, T., Nakanishi, M., Yamamoto, H., Yoshida, K., Todo, S., & Nakagawara, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209748 · Cited by 21

Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells

Wang, Q., Sun, W., Hao, X., Li, T., Su, L., & Liu, X. (2012) · Cancer Cell International · doi:10.1186/1475-2867-12-54 · Cited by 22

FLIP: A flop for execution signals

Subramaniam, K., Hirpara, J. L., Tucker‐Kellogg, L., Tucker‐Kellogg, G., & Pervaiz, S. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.07.005 · Cited by 21

The Identification of New c-FLIP Inhibitors for Restoring Apoptosis in TRAIL-Resistant Cancer Cells

Yaacoub, K., Pedeux, R., Lafite, P., Jarry, U., Aci‐Sèche, S., Bonnet, P., Daniellou, R., & Guillaudeux, T. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46010046 · Cited by 21

FLIP: Molecular switch between apoptosis and necroptosis

Gong, J., Kumar, S. A., Graham, G., & Kumar, A. P. (2013) · Molecular Carcinogenesis · doi:10.1002/mc.22027 · Cited by 21

Nanoceria protects from alterations in oxidative metabolism and calcium overloads induced by TNFα and cycloheximide in U937 cells: pharmacological potential of nanoparticles

González, D., Nicola, M. D., Bruni, E., Caputo, F., Rodríguez, A. B., Pariente, J. A., & Ghibelli, L. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2192-2 · Cited by 21

Regulation of TRAIL-Receptor Expression by the Ubiquitin-Proteasome System

Sarhan, D., D’Arcy, P., & Lundqvist, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151018557 · Cited by 21

Caspase cleavage of Itch in chronic lymphocytic leukemia cells

Rossi, M., Inoue, S., Walewska, R. J., Knight, R. A., Dyer, M. J. S., Cohen, G. M., & Melino, G. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.154 · Cited by 21

Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL‐mediated apoptosis in Hodgkin's lymphomas

Giaisi, M., Köhler, R., Fulda, S., Krammer, P. H., & Li‐Weber, M. (2011) · International Journal of Cancer · doi:10.1002/ijc.26458 · Cited by 21

cAMP prevents TNF-induced apoptosis through inhibiting DISC complex formation in rat hepatocytes

Bhattacharjee, R., Xiang, W., Wang, Y., Zhang, X., & Billiar, T. R. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.087 · Cited by 21

An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish

Xu, L., Yin, W., Xia, J., Peng, M., Li, S., Lin, S., Pei, D., & Shu, X. (2011) · Hepatology · doi:10.1002/hep.25560 · Cited by 20

Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor α liver injury

Wu, D., & Cederbaum, A. I. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.021 · Cited by 21

Preconditioning with death ligands FasL and TNF- protects the cirrhotic mouse liver against ischaemic injury

Jang, J.-H., Moritz, W., Graf, R., & Clavien, P. (2007) · Gut · doi:10.1136/gut.2007.137703 · Cited by 21

Nuclear Factor-κB in the Liver: Friend or Foe?

Schwabe, R. F., & Brenner, D. A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.058 · Cited by 21

α‐TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway

Yu, W., Tiwary, R., Li, J., Park, S., Li, J., Xiong, A., Simmons-Menchaca, M., Sanders, B. G., & Kline, K. A. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20681 · Cited by 21

Myeloid-restricted CD68 deficiency attenuates atherosclerosis via inhibition of ROS-MAPK-apoptosis axis

Duan, L., Zhao, Y., Jia, J., Chao, T., Wang, H., Liang, Y., Lou, Y., Zheng, Q., & Wang, H. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166698 · Cited by 20

Necroptosis in the pathophysiology of preeclampsia

Yu, H., Chen, L., & Du, B. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2229138 · Cited by 21

The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis

Holloway, J., Seeley, A., Cobbe, N., Turkington, R. C., Longley, D. B., & Evergren, E. (2024) · Cell Death and Disease · doi:10.1038/s41419-023-06417-4 · Cited by 22

Significance of Necroptosis in Cartilage Degeneration

Khaleque, M. A., Kim, J.-H., Tanvir, M. A. H., Park, J., & Kim, Y. (2024) · Biomolecules · doi:10.3390/biom14091192 · Cited by 20

Ubiquitin Ligases in Cancer: Ushers for Degradation

Newton, K., & Vucic, D. (2007) · Cancer Investigation · doi:10.1080/07357900701508041 · Cited by 20

JNK activation is required for TNFα-induced apoptosis in human hepatocarcinoma cells

Minero, V. G., Khadjavi, A., Costelli, P., Baccino, F. M., & Bonelli, G. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.05.017 · Cited by 20

Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-α-induced cell death

Wang, J., Tang, R., Lv, M., Zhang, J., & Shen, B. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-6 · Cited by 20

The Itch ubiquitin ligase is required for KSHV RTA induced vFLIP degradation

Chmura, J. C., Herold, K., Ruffin, A. T., Atuobi, T., Fabiyi, Y., Mitchell, A. E., Choi, Y. B., & Ehrlich, E. S. (2016) · Virology · doi:10.1016/j.virol.2016.11.016 · Cited by 20

Repression of NF‐κB and activation of AP‐1 enhance apoptosis in prostate cancer cells

Zhang, X., Huang, X., & Olumi, A. F. (2008) · International Journal of Cancer · doi:10.1002/ijc.24139 · Cited by 20

FLIP ing the coin? Death receptor‐mediated signals during skin tumorigenesis

Leverkus, M., Diessenbacher, P., & Geserick, P. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00728.x · Cited by 21

A Five-Year Itch in TNF-α Cytotoxicity: The Time Factor Determines JNK Action

Lin, A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.006 · Cited by 19

Oncogenic ILK, tumor suppression and all that JNK

Durbin, A. D., Hannigan, G. E., & Malkin, D. M. (2009) · Cell Cycle · doi:10.4161/cc.8.24.10093 · Cited by 19

Bclaf1 regulates c‐FLIP expression and protects cells from TNF‐induced apoptosis and tissue injury

Zhang, R., Xue, T., Shao, A., Lang, Y., Qin, C., Zhao, M., Kuang, Y., Yu, Z., Geng, Y., Zhao, C., et al. (2021) · EMBO Reports · doi:10.15252/embr.202152702 · Cited by 19

Anti-tumor pharmacological evaluation of extracts from stellera chamaejasme L based on hollow fiber assay

Liu, X., Yang, Q., Zhang, G., Li, Y., Chen, Y., Weng, X., Wang, Y., Wang, Y., & Zhu, X. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-116 · Cited by 19

Activation of c-Jun N-terminal kinase is essential for oxidative stress-induced Jurkat cell apoptosis by monochloramine

Ogino, T., Ozaki, M., Hosako, M., Omori, M., Okada, S., & Matsukawa, A. (2008) · Leukemia Research · doi:10.1016/j.leukres.2008.07.009 · Cited by 19

Programmed cell death with a necrotic-like phenotype

Morgan, M. J., & Liu, Z.-G. (2013) · BioMolecular Concepts · doi:10.1515/bmc-2012-0056 · Cited by 20

cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells

Mora-Molina, R., Stöhr, D., Rehm, M., & López‐Rivas, A. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04574-6 · Cited by 19

Cbl‐b‐dependent degradation of FLIPL is involved in ATO‐induced autophagy in leukemic K562 and gastric cancer cells

Zhang, G., Liu, J., Zhang, Y., Qu, J., Xu, L., Zheng, H., Liu, Y., & Qu, X. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.07.067 · Cited by 19

Cellular FLICE-Inhibitory Protein Regulates Tissue Homeostasis

Nakano, H., Piao, X., Shindo, R., & Komazawa‐Sakon, S. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_448 · Cited by 19

Role for IKK2 in muscle: waste not, want not

Karin, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci30268 · Cited by 19

Molecular mechanism of Mitomycin C-dependent caspase-8 regulation: implications for apoptosis and synergism with interferon-α signalling

Liedtke, C., Lambertz, D., Schnepel, N., & Trautwein, C. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0145-x · Cited by 19

Pleiotropic functions of TNF-α determine distinct IKKβ-dependent hepatocellular fates in response to LPS

Dajani, R. B., Şanlıoğlu, S., Zhang, Y., Li, Q., Monick, M. M., Lazartigues, E. D., Eggleston, T., Davisson, R. L., Hunninghake, G. W., & Engelhardt, J. F. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00043.2006 · Cited by 19

Complement-5 Inhibition Deters Progression of Fulminant Hepatitis to Acute Liver Failure in Murine Models

Kusakabe, J., Hata, K., Miyauchi, H., Tajima, T., Wang, Y., Tamaki, I., Kawasoe, J., Okamura, Y., Zhao, X., Okamoto, T., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.01.001 · Cited by 18

The Emerging Role of Deubiquitinases in Cell Death

Zhou, Z., Song, X., Kang, R., & Tang, D. (2022) · Biomolecules · doi:10.3390/biom12121825 · Cited by 20

Genomewide Expression Analysis in Zebrafish mind bomb Alleles with Pancreas Defects of Different Severity Identifies Putative Notch Responsive Genes

Hegde, A., Qiu, N. C., Qiu, X., Ho, S. H.-K., Tay, K. Q.-Y., George, J., Ng, F. S. L., Govindarajan, K. R., Gong, Z., Mathavan, S., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001479 · Cited by 18

Pentoxifylline augments TRAIL/Apo2L mediated apoptosis in cutaneous T cell lymphoma (HuT-78 and MyLa) by modulating the expression of antiapoptotic proteins and death receptors

Gahlot, S., Khan, M. A., Rishi, L., & Majumdar, S. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.08.018 · Cited by 18

Impact of JNK1, JNK2, and ligase Itch on reactive oxygen species formation and survival of prostate cancer cells treated with diallyl trisulfide

Sielicka-Dudzin, A., Borkowska, A., Herman-Antosiewicz, A., Woźniak, M., Jóźwik, A., Fedeli, D., & Antosiewicz, J. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0241-0 · Cited by 18

Cerulein-Induced Acute Pancreatitis Is Associated With c-Jun NH(2)-Terminal Kinase 1–Dependent Ferritin Degradation and Iron-Dependent Free Radicals Formation

Śledziński, M., Borkowska, A., Sielicka-Dudzin, A., Hałoń, M., Woźniak, M., Spodnik, J. H., Herman-Antosiewicz, A., & Antosiewicz, J. (2013) · Pancreas · doi:10.1097/mpa.0b013e318287d097 · Cited by 18

Implication of cytokines: Roles of tumor necrosis factor‐α in liver injury

Nagaki, M., & Moriwaki, H. (2008) · Hepatology Research · doi:10.1111/j.1872-034x.2008.00422.x · Cited by 18

Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner

Park, E., Min, K., Choi, K. S., & Kwon, T. K. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.01.009 · Cited by 18

Protein Kinase-Mediated Decision Between the Life and Death

Engin, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-49844-3_1 · Cited by 20

Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule

Agrahari, A. K., Dikshit, M., & Asthana, S. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.07.008 · Cited by 18

Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1

Zou, Y., Zheng, Q., Jiang, B., Liu, Y., Xu, Y., Ma, L., Hu, Z., Wu, M., & Song, H. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05076-1 · Cited by 18

The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response

Lu, X., Xu, H., Xu, J., Lu, S., You, S., Huang, X., Zhang, N., & Zhang, L. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.968927 · Cited by 17

Apoptosis Induced by Cytoskeletal Disruption Requires Distinct Domains of MEKK1

Tricker, E. M., Arvand, A., Kwan, R., Chen, G. Y., Gallagher, E. D., & Cheng, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017310 · Cited by 17

Genetic Delineation of the Pathways Mediated by Bid and JNK in Tumor Necrosis Factor-α-induced Liver Injury in Adult and Embryonic Mice

Ni, H., Chen, X., Shi, Y., Liao, Y., Beg, A. A., Fan, J., & Yin, X. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807259200 · Cited by 17

Si‐Wu‐Tang Alleviates Nonalcoholic Fatty Liver Disease via Blocking TLR4‐JNK and Caspase‐8‐GSDMD Signaling Pathways

Zhang, Y., Zhou, G., Chen, Z., Guan, W., Zhang, J., Bi, M., Wang, F., You, X., Liao, Y., Zheng, S., et al. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/8786424 · Cited by 20

The emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance

Meng, Y., Qiu, L., Zhang, S., & Han, J. (2021) · Cancer Drug Resistance · doi:10.20517/cdr.2020.115 · Cited by 19

Transgene-enforced co-stimulation of CD4+ T cells leads to enhanced and sustained anti-tumor effector functioning

Chang, L., Chang, W. C., McNamara, G. T., Aguilar, B., Ostberg, J. R., & Jensen, M. C. (2007) · Cytotherapy · doi:10.1080/14653240701656079 · Cited by 15

Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation

Gehrke, N., Nagel, M., Straub, B. K., Wörns, M., Schuchmann, M., Galle, P. R., & Schattenberg, J. M. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00097.2017 · Cited by 17

The role of JNK2 in toxic liver injury

Liedtke, C., & Trautwein, C. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.08.004 · Cited by 17

On the role of IRS2 in the regulation of functional β-cell mass

Nießen, M. (2006) · Archives of Physiology and Biochemistry · doi:10.1080/13813450600711409 · Cited by 17

Osteocalcin reduces fat accumulation and inflammatory reaction by inhibiting ROS-JNK signal pathway in chicken embryonic hepatocytes

Zhang, M., Tu, W. J., Zhang, Q., Wu, X. L., Zou, X., & Jiang, S. (2022) · Poultry Science · doi:10.1016/j.psj.2022.102026 · Cited by 17

Research Highlights

(2006) · Nature Immunology · doi:10.1038/ni0406-373

An antiapoptotic protein, c‐FLIPL, directly binds to MKK7 and inhibits the JNK pathway

Nakajima, A., Komazawa‐Sakon, S., Takekawa, M., Sasazuki, T., Yeh, W., Yagita∥, H., Okumura, K., & Nakano, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601423 · Cited by 94

Tumor Necrosis Factor (TNF) Receptor-associated Factor 7 Is Required for TNFα-induced Jun NH2-terminal Kinase Activation and Promotes Cell Death by Regulating Polyubiquitination and Lysosomal Degradation of c-FLIP Protein

Scudiero, I., Zotti, T., Ferravante, A., Vessichelli, M., Reale, C., Masone, M. C., Leonardi, A., Vito, P., & Stilo, R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.300137 · Cited by 48

A Five-Year Itch in TNF-α Cytotoxicity: The Time Factor Determines JNK Action

Lin, A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.006 · Cited by 19

The Absence of NF-κB-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis

Tang, F., Tang, G., Xiang, J., Dai, Q., Rosner, M. R., & Lin, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8571-8579.2002 · Cited by 145