The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

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  71. Signaling Pathways
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  72. TNF signaling
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  73. FLICE-Inhibitory Protein
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  74. Research Highlights
    2006 · Nature Immunology
  75. FLICE Inhibitory Protein
    Xiangguo Liu, Shi‐Yong Sun · 2008 · Springer eBooks
  76. FLIP
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  77. FLICE-Inhibitory Protein
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  78. FLIP
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  79. FLICE Inhibitory Protein
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