Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326

IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

Schmitz, J., Owyang, A., Oldham, E., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,710

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,839

Protein Sensors for Membrane Sterols

Goldstein, J. L., DeBose-Boyd, R. A., & Brown, M. S. (2006) · Cell · doi:10.1016/j.cell.2005.12.022 · Cited by 1,517

Pro-inflammatory programmed cell death

Cookson, B. T., & Brennan, M. A. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01936-3 · Cited by 1,414

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

Kanneganti, T.-D., Özören, N., Body-Malapel, M., Amer, A., Park, J.-H., Franchi, L., Whitfield, J., Barchet, W., Colonna, M., Vandenabeele, P., et al. (2006) · Nature · doi:10.1038/nature04517 · Cited by 1,148

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Wang, X., Sato, R., Brown, M. S., Hua, X., & Goldstein, J. L. (1994) · Cell · doi:10.1016/0092-8674(94)90234-8 · Cited by 1,013

Crucial Step in Cholesterol Homeostasis

Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L., & Brown, M. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00872-3 · Cited by 987

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980

Alpha-toxin of Staphylococcus aureus

Bhakdi, S. C., & Tranum-Jensen, J. (1991) · Microbiological Reviews · doi:10.1128/mmbr.55.4.733-751.1991 · Cited by 885

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

Perregaux, D., & Gabel, C. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36591-2 · Cited by 758

NLRs join TLRs as innate sensors of pathogens

MARTINON, F., & TSCHOPP, J. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.06.004 · Cited by 673

Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process

Abrami, L., Liu, S., Cosson, P., Leppla, S. H., & van der Goot, F. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211018 · Cited by 475

Interleukin-18 and Interleukin-1β: Two Cytokine Substrates for ICE (Caspase-1)

Fantuzzi, G., & Dinarello, C. A. (1999) · Journal of Clinical Immunology · doi:10.1023/a:1020506300324 · Cited by 466

Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs

Rawson, R. B., Zelenski, N. G., Nijhawan, D., Ye, J., Sakai, J., Hasan, M. T., Chang, T. Y., Brown, M. S., & Goldstein, J. L. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80006-4 · Cited by 429

The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin

Shatursky, O., Heuck, A. P., Shepard, L. A., Rossjohn, J., Parker, M. W., Johnson, A. E., & Tweten, R. K. (1999) · Cell · doi:10.1016/s0092-8674(00)81660-8 · Cited by 357

Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation

Chamaillard, M., Girardin, S. E., Viala, J., & Philpott, D. J. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00304.x · Cited by 347

Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release

Kahlenberg, J. M., & Dubyak, G. R. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00494.2003 · Cited by 337

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

Morton, J. D., & Shimomura, L. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199904000-00008 · Cited by 320

Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins

Huffman, D. L., Abrami, L., Sasik, R., Corbeil, J., van der Goot, F. G., & Aroian, R. V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404073101 · Cited by 316

Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O

Walev, I., Bhakdi, S. C., Hofmann, F., Djonder, N., Valeva, A., Aktories, K., & Bhakdi, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051429498 · Cited by 292

Potassium-inhibited processing of IL-1 beta in human monocytes.

Walev, I., Reske, K., Palmer, M., Valeva, A., & Bhakdi, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07149.x · Cited by 278

Cryopyrin-induced Interleukin 1β Secretion in Monocytic Cells

Dowds, T. A., Masumoto, J., Zhu, L., Inohara, N., & Núñez, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401178200 · Cited by 235

Differential sorting and fate of endocytosed GPI-anchored proteins

Fivaz, M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf398 · Cited by 223

A Pore-forming Toxin Interacts with a GPI-anchored Protein and Causes Vacuolation of the Endoplasmic Reticulum

Abrami, L., Fivaz, M., Glauser, P.-E., Parton, R. G., & van der Goot, F. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.3.525 · Cited by 216

Pore-forming toxins

Gilbert, R. J. C. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8471-1 · Cited by 206

α-Toxin is a mediator of Staphylococcus aureus–induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling

Bantel, H., Sinha, B., Domschke, W., Peters, G., Schulze-Osthoff, K., & Jänicke, R. U. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105081 · Cited by 198

Sendai virus defective-interfering genomes and the activation of interferon-beta

Strahle, L., Garcin, D., & Kolakofsky, D. (2006) · Virology · doi:10.1016/j.virol.2006.03.022 · Cited by 197

Proteolytic Activation of Sterol Regulatory Element-binding Protein Induced by Cellular Stress through Depletion of Insig-1

Lee, J. N., & Ye, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408235200 · Cited by 186

Epithelial Cells Are Sensitive Detectors of Bacterial Pore-forming Toxins

Ratner, A. J., Hippe, K. R., Aguilar, J. L., Bender, M. H., Nelson, A. L., & Weiser, J. N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511431200 · Cited by 174

The Cytotoxic Enterotoxin of Aeromonas hydrophila Induces Proinflammatory Cytokine Production and Activates Arachidonic Acid Metabolism in Macrophages

Chopra, A. K., Xu, X.-J., Ribardo, D., Gonzalez, M., Kuhl, K., Peterson, J. W., & Houston, C. W. (2000) · Infection and Immunity · doi:10.1128/iai.68.5.2808-2818.2000 · Cited by 161

Plasma Membrane Microdomains Act as Concentration Platforms to Facilitate Intoxication by Aerolysin

Abrami, L., & BRINK, G. R. V. D. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.175 · Cited by 155

Adventures of a pore-forming toxin at the target cell surface

Abrami, L., Fivaz, M. L., & BRINK, G. R. V. D. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01722-4 · Cited by 136

Platelet-derived Growth Factor Stimulates Membrane Lipid Synthesis Through Activation of Phosphatidylinositol 3-Kinase and Sterol Regulatory Element-binding Proteins

Demoulin, J., Ericsson, J., Kallin, A., Rorsman, C., Rönnstrand, L., & Heldin, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405924200 · Cited by 127

Analysis of circadian liver gene expression by ADDER, a highly sensitive method for the display of differentially expressed mRNAs

Kornmann, B. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.11.e51 · Cited by 119

Marker exchange mutagenesis of the aerolysin determinant in Aeromonas hydrophila demonstrates the role of aerolysin in A. hydrophila-associated systemic infections

Chakraborty, T., Huhle, B., Hof, H., Bergbauer, H., & Goebel, W. (1987) · Infection and Immunity · doi:10.1128/iai.55.9.2274-2280.1987 · Cited by 112

Aeromonas hydrophila Cytotoxic Enterotoxin Activates Mitogen-activated Protein Kinases and Induces Apoptosis in Murine Macrophages and Human Intestinal Epithelial Cells

Galindo, C. L., Fadl, A. A., Sha, J., Gutierrez, C., Popov, V. L., Boldogh, I. R., Aggarwal, B. B., & Chopra, A. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404641200 · Cited by 107

A rivet model for channel formation by aerolysin‐like pore‐forming toxins

Iacovache, I., Paumard, P., Scheib, H., Lesieur, C., Sakai, N., Matile, S., Parker, M. W., & van der Goot, F. G. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600959 · Cited by 107

Isolation of Cholesterol-requiring Mutant Chinese Hamster Ovary Cells with Defects in Cleavage of Sterol Regulatory Element-binding Proteins at Site 1

Rawson, R. B., Cheng, D., Brown, M. S., & Goldstein, J. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28261 · Cited by 95

Potassium Regulates IL-1β Processing Via Calcium-Independent Phospholipase A2

Walev, I., Klein, J., Husmann, M., Valeva, A., Strauch, S., Wirtz, H., Weichel, O., & Bhakdi, S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.10.5120 · Cited by 94

Type III secretion: The bacteria-eukaryotic cell express

Mota, L. J., Sorg, I., & Cornelis, G. R. (2005) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2005.08.036 · Cited by 93

Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins

Castoreno, A. B., Wang, Y., Stockinger, W., Jarzylo, L. A., Du, H., Pagnon, J. C., Shieh, E. C., & Nohturfft, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506716102 · Cited by 82

Channels formed by subnanomolar concentrations of the toxin aerolysin trigger apoptosis of T lymphomas

Nelson, K. L., Brodsky, R. A., & Buckley, J. T. (1999) · Cellular Microbiology · doi:10.1046/j.1462-5822.1999.00009.x · Cited by 77

Aerolysin Induces G-protein Activation and Ca2+Release from Intracellular Stores in Human Granulocytes

Krause, K., Fivaz, M. L., Monod, A., & van der Goot, F. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18122 · Cited by 75

Recovery of human fibroblasts from attack by the pore-forming α-toxin of Staphylococcus aureus

Walev, I., Palmer, M., Martin, E., Jonas, D., Weller, U., Höhn-Bentz, H., Husmann, M., & Bhakdi, S. (1994) · Microbial Pathogenesis · doi:10.1006/mpat.1994.1065 · Cited by 74

Caspase-2, a Novel Lipid Sensor under the Control of Sterol Regulatory Element Binding Protein 2

Logette, E., Jossic-Corcos, C. L., Masson, D., Solier, S., Sequeira-Legrand, A., Dugail, I., Lemaire‐Ewing, S., Desoche, L., Solary, É., & Corcos, L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9621-9631.2005 · Cited by 54

Insulin Regulation of Sterol Regulatory Element-binding Protein-1 Expression in L-6 Muscle Cells and 3T3 L1 Adipocytes

Nadeau, K. J., Leitner, J. W., Gurerich, I., & Draznin, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403596200 · Cited by 48

Early cell signaling by the cytotoxic enterotoxin of Aeromonas hydrophila in macrophages

Ribardo, D. A., Kuhl, K. R., Boldogh, I., Peterson, J. W., Houston, C. W., & Chopra, A. K. (2002) · Microbial Pathogenesis · doi:10.1006/mpat.2001.0490 · Cited by 42

Partial C-terminal Unfolding Is Required for Channel Formation by Staphylococcal -toxin

Vécsey-Semjén, B., Möllby, R., & van der Goot, F. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8655 · Cited by 38

Pneumolysin-mediated activation of NFκB in human neutrophils is antagonized by docosahexaenoic acid

Fickl, H., Cockeran, R., Steel, H. C., Feldman, C. H., Cowan, G. J. M., Mitchell, T. J., & Anderson, R. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02757.x · Cited by 37

Microarray Analysis of Aeromonas hydrophila Cytotoxic Enterotoxin-Treated Murine Primary Macrophages

Galindo, C. L., Fadl, A. A., Sha, J., & Chopra, A. K. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.5439-5445.2004 · Cited by 19

Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene

Logette, E., Solary, É., & Corcos, L. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.11.006 · Cited by 16

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Swanson, K. V., Deng, M., & Ting, J. P.-Y. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0165-0 · Cited by 4,884

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

Franchi, L., Eigenbrod, T., Muñoz-Planillo, R., & Nuñez, G. (2009) · Nature Immunology · doi:10.1038/ni.1703 · Cited by 1,834

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

Davis, B. K., Wen, H., & Ting, J. P.-Y. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101405 · Cited by 1,618

Cholesterol, inflammation and innate immunity.

Tall, A. R., & Yvan-Charvet, L. (2015) · Nature Reviews Immunology · doi:10.1038/nri3793 · Cited by 1,479