The Mammalian Epigenome

Bernstein, Bradley E., Meissner, Alexander, Lander, Eric S.·2007·Cell

Cited by (1,004)

Items 301–400 of 1,004

  1. Crosstalk among Epigenetic Pathways Regulates Neurogenesis
    Emily M. Jobe, Andrea L. McQuate, Xinyu Zhao · 2012 · Frontiers in Neuroscience
  2. Epigenetic marks: regulators of livestock phenotypes and conceivable sources of missing variation in livestock improvement programs
    Eveline Mengwi Ibeagha-Awemu, Xin Zhao · 2015 · Frontiers in Genetics
  3. Epigenetic Biomarker Development
    Christoph Bock · 2009 · Epigenomics
  4. Specificity of the Chromodomain Y Chromosome Family of Chromodomains for Lysine-methylated ARK(S/T) Motifs
    Wolfgang Fischle, Henriette Franz, Steven A. Jacobs, C. David Allis, Sepideh Khorasanizadeh · 2008 · Journal of Biological Chemistry
  5. Sirtuins in neurodegenerative diseases: an update on potential mechanisms
    Sang‐Won Min, Peter Sohn, Seo-Hyun Cho, Raymond A. Swanson, Li Gan · 2013 · Frontiers in Aging Neuroscience
  6. microRNA-dependent modulation of histone acetylation in Waldenström macroglobulinemia
    Aldo Maria Roccaro, Antonio Sacco, Xiaoying Jia, Abdel Kareem Azab, Patricia Maiso, Hai T. Ngo, Feda Azab, Judith M. Runnels, Phong Quang, Irene M. Ghobrial · 2010 · Blood
  7. Small-Molecule Ligands of Methyl-Lysine Binding Proteins
    J. Martin Herold, Tim J. Wigle, Jacqueline L. Norris, Robert Lam, Victoria Korneeva Korboukh, Cen Gao, Lindsey A. Ingerman, Dmitri Kireev, Guillermo A. Senisterra, Masoud Vedadi et al. · 2011 · Journal of Medicinal Chemistry
  8. CRISPR/Cas-Based Epigenome Editing: Advances, Applications, and Clinical Utility
    Jacob Goell, Isaac B. Hilton · 2021 · Trends in biotechnology
  9. DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers
    Ching-Yu Yen, Hurng‐Wern Huang, Chih‐Wen Shu, Ming‐Feng Hou, Shyng‐Shiou F. Yuan, Hui-Ru Wang, Yung-Ting Chang, Ammad Ahmad Farooqı, Jen‐Yang Tang, Hsueh‐Wei Chang · 2016 · Cancer Letters
  10. Global histone post-translational modifications and cancer: Biomarkers for diagnosis, prognosis and treatment?
    Shafqat Ali Khan · 2015 · World Journal of Biological Chemistry
  11. Epigenetic Landscape during Coronavirus Infection
    Alexandra Schäfer, Ralph Steven Baric · 2017 · Pathogens
  12. Genome-wide enhancer prediction from epigenetic signatures using genetic algorithm-optimized support vector machines
    Michael Fernández, Diego Miranda‐Saavedra · 2012 · Nucleic Acids Research
  13. Helper T-cell differentiation and plasticity: insights from epigenetics
    Kiyoshi Hirahara, Golnaz Vahedi, Kamran Ghoreschi, Xiang‐Ping Yang, Shingo Nakayamada, Yuka Kanno, John J. O’Shea, Arian D. J. Laurence · 2011 · Immunology
  14. The Impact of External Factors on the Epigenome:In Uteroand over Lifetime
    Estela G. Toraño, María G. García, Juan Luís Fernández-Morera, Pilar Niño García, Agustín F. Fernández · 2016 · BioMed Research International
  15. Epigenetic dynamics during preimplantation development
    Chelsea Marcho, Wei Cui, Jesse Mager · 2015 · Reproduction
  16. Roles of lncRNA in breast cancer
    Kounosuke Watabe · 2015 · Frontiers in Bioscience-Scholar
  17. Histone deacetylase 2 expression predicts poorer prognosis in oral cancer patients
    Hao‐Hueng Chang, Chun‐Pin Chiang, Hsin-Chia Hung, Chiao‐Ying Lin, Yiting Deng, Mark Yen‐Ping Kuo · 2008 · Oral Oncology
  18. H2A.Z and H3.3 Histone Variants Affect Nucleosome Structure: Biochemical and Biophysical Studies
    Amit Thakar, Pooja Gupta, Toyotaka Ishibashi, Ron M. Finn, Begonia Silva‐Moreno, Susumu Uchiyama, Kiichi Fukui, Miroslav Tomschik, Juan Ausió, Jordanka S. Zlatanova · 2009 · Biochemistry
  19. Epigenetics and cancer
    Rajnee Kanwal, Sanjay Gupta · 2010 · Journal of Applied Physiology
  20. Chemotherapeutic Drug-Induced ABCG2 Promoter Demethylation as a Novel Mechanism of Acquired Multidrug Resistance
    Eran E. Bram, Michal Stark, Shachar Raz, Yehuda G. Assaraf · 2009 · Neoplasia
  21. Epigenetics and human disease
    Martin Hirst, Marco A. Marra · 2008 · The International Journal of Biochemistry & Cell Biology
  22. DNMT1–MicroRNA126 Epigenetic Circuit Contributes to Esophageal Squamous Cell Carcinoma Growth via ADAM9–EGFR–AKT Signaling
    Ronghua Liu, Jie Gu, Pei Jiang, Yijie Zheng, Xiaoming Liu, Xuechao Jiang, Enyu Huang, Shudao Xiong, Fengkai Xu, Guangwei Liu et al. · 2014 · Clinical Cancer Research
  23. Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes
    Ziqing Liu, Olivia M. Chen, Michael Zheng, Li Wang, Yang Zhou, Chaoying Yin, Jiandong Liu, Qian Li · 2016 · Stem Cell Research
  24. Age-associated changes in cumulus cells and follicular fluid: the local oocyte microenvironment as a determinant of gamete quality
    Elnur Babayev, Francesca E. Duncan · 2022 · Biology of Reproduction
  25. Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain
    Basil, P, Li, Q, Dempster, E L, Mill, J, Sham, P-C, Wong, C C Y, McAlonan, G M · 2014 · Translational Psychiatry
  26. Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
    Anqi Ma, Wenyu Yu, Fengling Li, Rachel M. Bleich, J. Martin Herold, Kyle Vincent Butler, Jacqueline L. Norris, Victoria Korneeva Korboukh, Ashutosh Tripathy, William P. Janzen et al. · 2014 · Journal of Medicinal Chemistry
  27. Primary Prevention of Atherosclerosis
    Claudio Napoli A, Valeria Crudele, Andrea Soricelli, Mohammed A. Al-Omran, Nicoletta Vitale, Teresa Infante, Francesco Paolo Mancini · 2012 · Circulation
  28. Single Molecule Epigenetic Analysis in a Nanofluidic Channel
    Benjamin R. Cipriany, Ruqian Zhao, Patrick J. Murphy, Stephen L. Levy, Christine P. Tan, Harold G. Craighead, Paul D. Soloway · 2010 · Analytical Chemistry
  29. Epigenetic Control of Aging
    Ursula Muñoz-Nájar, John M. Sedivy · 2010 · Antioxidants and Redox Signaling
  30. The Histone-Like NF-Y Is a Bifunctional Transcription Factor
    Michele Ceribelli, Diletta Dolfini, Daniele Merico, Raffaella Pia Gatta, M Viganò, Giulio Pavesi, Roberto Mantovani · 2008 · Molecular and Cellular Biology
  31. Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1
    Chengmin Qian, SiDe Li, Jean Jakoncic, Lei Zeng, Martin J. Walsh, Ming‐Ming Zhou · 2008 · Journal of Biological Chemistry
  32. Epigenetic analysis of the critical region I for premature ovarian failure: demonstration of a highly heterochromatic domain on the long arm of the mammalian X chromosome
    Flavio Rizzolio, Tiziano Pramparo, Cinzia Felicita Sala, Orsetta Zuffardi, Lucia De Santis, Elisa Rabellotti, Federico Calzi, Francesco Fusi, Riccardo Bellazzi, Daniela Toniolo · 2008 · Journal of Medical Genetics
  33. Dynamic changes in DNA methylation during thermal control establishment affect CREB binding to the brain‐derived neurotrophic factor promoter
    M. Yossifoff, Tatiana Kisliouk, Noam Meiri · 2008 · European Journal of Neuroscience
  34. The chromatin-remodeling enzyme BRG1 coordinates CIITA induction through many interdependent distal enhancers
    Zuyao Ni, Mohamed Abou El Hassan, Zhaodong Xu, Yu Tao, Rod Bremner · 2008 · Nature Immunology
  35. Transcriptional Control of Inflammatory Responses
    Stephen T. Smale, Gioacchino Natoli · 2014 · Cold Spring Harbor Perspectives in Biology
  36. Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation
    Jia Zhou, Renee Sears, Xiaoyun Xing, Bo Zhang, Daofeng Li, Nicole B. Rockweiler, H. Josh Jang, Mayank N. K. Choudhary, Hyung Joo Lee, Rebecca F. Lowdon et al. · 2017 · BMC Genomics
  37. Reconciling the positive and negative roles of histone H2A.Z in gene transcription
    Maud Marques, Liette Laflamme, Alain L. Gervais, Luc R. Gaudreau · 2010 · Epigenetics
  38. The role of promoter hypermethylation in fibroblast activation and fibrogenesis
    Elisabeth Maria Zeisberg, Michael Zeisberg · 2012 · The Journal of Pathology
  39. Mechanisms of Stress-induced Visceral Pain
    Beverley Greenwood–Van Meerveld, Anthony C. Johnson · 2018 · Journal of Neurogastroenterology and Motility
  40. LSD2/KDM1B and Its Cofactor NPAC/GLYR1 Endow a Structural and Molecular Model for Regulation of H3K4 Demethylation
    Rui Fang, Fei Chen, Zhenghong Dong, Di Hu, Andrew J. Barbera, Erin Clark, Jian Fang, Ying Yang, Pinchao Mei, Michael Scott Rutenberg et al. · 2012 · Molecular Cell
  41. The dynamic epigenetic program in male germ cells: Its role in spermatogenesis, testis cancer, and its response to the environment
    Maren Godmann, Romain Lambrot, Sarah Kimmins · 2009 · Microscopy Research and Technique
  42. Epigenetic-related therapeutic challenges in cardiovascular disease
    Concetta Schiano, Maria Teresa Vietri, Vincenzo Grimaldi, Antonietta Picascia, Maria Rosaria De Pascale, Claudio Napoli A · 2015 · Trends in Pharmacological Sciences
  43. Predicting chromatin organization using histone marks
    Jialiang Huang, Eugenio Marco, Luca Pinello, Guo‐Cheng Yuan · 2015 · Genome biology
  44. A Distinct DNA-Methylation Boundary in the 5′- Upstream Sequence of the FMR1 Promoter Binds Nuclear Proteins and Is Lost in Fragile X Syndrome
    Naumann, Anja, Hochstein, Norbert, Weber, Stefanie, Fanning, Ellen, Doerfler, Walter · 2009 · The American Journal of Human Genetics
  45. Quantitative DNA-methylation in Daphnia magna and effects of multigeneration Zn exposure
    M. Vandegehuchte, Filip Lemière, Colin Janssen · 2009 · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology
  46. Beyond Genetics: What Causes Type 1 Diabetes
    Zhen Wang, Zhiguo Xie, Qianjin Lu, Christopher Chang, Zhiguang Zhou · 2016 · Clinical Reviews in Allergy & Immunology
  47. Epigenetics and cancer metabolism
    Christelle Johnson, Marc O. Warmoes, Xiling Shen, Jason W. Locasale · 2013 · Cancer Letters
  48. Epigenetic Changes in the Myelodysplastic Syndrome
    Jean‐Pierre J. Issa · 2010 · Hematology/Oncology Clinics of North America
  49. The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP)
    Sofia Leka-Emiri, George Panagiotis Chrousos, Christina Kanaka‐Gantenbein · 2017 · Journal of Endocrinological Investigation
  50. Choline Nutrition Programs Brain Development Via DNA and Histone Methylation
    Jan Krzysztof Blusztajn, Tiffany J. Mellott · 2012 · Central Nervous System Agents in Medicinal Chemistry
  51. Our changing view of the genomic landscape of cancer
    Daphne W. Bell · 2009 · The Journal of Pathology
  52. Epigenetic therapies for chemoresensitization of epithelial ovarian cancer
    Daniela Elena Matei, Kenneth P. Nephew · 2009 · Gynecologic Oncology
  53. Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis
    Efthimia Karantzali, Herbert Schulz, Oliver Hummel, Norbert Hübner, AK Hatzopoulos, Androniki Kretsovali · 2008 · Genome biology
  54. Epigenetic memory and priming in plants
    Neslihan Turgut Kara, Burcu Arıkan, Haluk Çelik · 2020 · Genetica
  55. Epigenetic reprogramming of the male genome during gametogenesis and in the zygote
    Sophie Rousseaux, Nicolas Reynoird, Emmanuelle Escoffier, Julien Thévenon, Cécile Caron, Saadi Khochbin · 2008 · Reproductive BioMedicine Online
  56. Modeling the relationship of epigenetic modifications to transcription factor binding
    Liang Liu, G. Jin, Xiao-Bo Zhou · 2015 · Nucleic Acids Research
  57. Emerging EZH2 Inhibitors and Their Application in Lymphoma
    Jennifer Kimberly Lue, Jennifer Effie Amengual · 2018 · Current Hematologic Malignancy Reports
  58. Engineering Epigenetic Regulation Using Synthetic Read-Write Modules
    Minhee Park, Nikit Patel, Albert J. Keung, Ahmad S. Khalil · 2018 · Cell
  59. Nuclear receptor coregulators merge transcriptional coregulation with epigenetic regulation
    Shigeaki Kato, Atsushi Yokoyama, Ryoji Fujiki · 2011 · Trends in Biochemical Sciences
  60. Epigenetics and arterial hypertension: the challenge of emerging evidence
    Simonetta Friso, Cristián A. Carvajal, Carlos Fardella, Oliviero Olivieri · 2014 · Translational research
  61. DNA Methylation of Specific CpG Sites in the Promoter Region Regulates the Transcription of the Mouse Oxytocin Receptor
    Shimrat Mamrut, Hala Harony‐Nicolas, Rapita Sood, Hadar Shahar-Gold, Harold Gainer, Yi-Jun Shi, Liza Barki‐Harrington, Shlomo Wagner · 2013 · PLoS ONE
  62. Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development
    Samir Kumar Patra, Aditi Patra, Federica Rizzi, Tapash Chandra Ghosh, Saverio Bettuzzi · 2008 · Cancer and Metastasis Reviews
  63. Computational Oncology in the Multi-Omics Era: State of the Art
    Guillermo de Anda‐Jáuregui, Enrique Hernandez Lemus · 2020 · Frontiers in Oncology
  64. Transcriptional control of erythropoiesis: emerging mechanisms and principles
    S-I Kim, Emery H. Bresnick · 2007 · Oncogene
  65. Zinc restriction during different periods of life: Influence in renal and cardiovascular diseases
    Analía Lorena Tomat, María A. Costa, Cristina Teresa Arranz · 2010 · Nutrition
  66. A tumor suppressor role for C/EBPα in solid tumors: more than fat and blood
    Ana Rita Lourenço, Paul James Coffer · 2017 · Oncogene
  67. The myelodysplastic syndrome as a prototypical epigenetic disease
    Jean‐Pierre J. Issa · 2013 · Blood
  68. Global DNA hypomethylation in cancer: review of validated methods and clinical significance
    Estela G. Toraño, Sandra Petrus-Reurer, Agustín F. Fernández, Mario F. Fraga · 2012 · Clinical Chemistry and Laboratory Medicine (CCLM)
  69. Alcohol Exposure Decreases CREB Binding Protein Expression and Histone Acetylation in the Developing Cerebellum
    Guo, Weixiang, Crossey, Erin L., Zhang, Li, Zucca, Stefano, George, Olivia L., Valenzuela, C. Fernando, Zhao, Xinyu · 2011 · PLoS ONE
  70. Epigenetic Regulation of BMP7 in the Regenerative Response to Ischemia
    Takeshi Marumo, Keiichi Hishikawa, Masahiro Yoshikawa, Toshiro Fujita · 2008 · Journal of the American Society of Nephrology
  71. Effects of BPA on female reproductive function: The involvement of epigenetic mechanism
    Stefania Santangeli, Francesca Maradonna, Ike Olivotto, Chiara Carla Piccinetti, Giorgia Gioacchini, Oliana Carnevali · 2016 · General and Comparative Endocrinology
  72. The Role of piRNA and its Potential Clinical Implications in Cancer
    Carolina Baraúna Assumpção, Danielle Queiroz Calcagno, Taíssa Maíra Thomaz Araújo, Sidney Emanuel Batista dos Santos, Ândrea Kely Campos Ribeiro dos Santos, Gregory Joseph Riggins, Rommel Mário Rodríguez Burbano, Paulo Pimentel de Assumpção · 2015 · Epigenomics
  73. Impacts of Epigenetic Processes on the Health and Productivity of Livestock
    Mengqi Wang, Eveline Mengwi Ibeagha-Awemu · 2021 · Frontiers in Genetics
  74. Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy
    Takako Iida Jones, Oliver D. King, Charis L. Himeda, Sachiko T. Homma, Jennifer C. J. Chen, Mary Lou Beermann, Chi Wing Yan, Charles P. Emerson, Jeffrey B. Miller, Kathryn R. Wagner et al. · 2015 · Clinical Epigenetics
  75. Epigenetics, miRNAs, and human cancer: a new chapter in human gene regulation
    Nicola Valeri, Ivan Vannini, Francesca Fanini, Federica Calore, Brett Adair, Muller Fabbri · 2009 · Mammalian Genome
  76. Stress-Induced Chronic Visceral Pain of Gastrointestinal Origin
    Beverley Greenwood–Van Meerveld, Anthony C. Johnson · 2017 · Frontiers in Systems Neuroscience
  77. Retinol saturase promotes adipogenesis and is downregulated in obesity
    Michael Schupp, Martina I. Lefterova, Jürgen Janke, Kirstin Leitner, Ana G. Cristancho, Shannon E. Mullican, Mohammed Qatanani, Nava R. Szwergold, David J. Steger, Joshua C. Curtin et al. · 2009 · Proceedings of the National Academy of Sciences
  78. Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cells
    Warren C. Fiskus, Kate Buckley, Rekha Rao, Aditya Mandawat, Yonghua Yang, Rajeshree Joshi, Yongchao Wang, Ramesh Balusu, Jianguang Chen, Sanjay Koul et al. · 2009 · Cancer Biology & Therapy
  79. Lysine Methylation and Functional Modulation of Androgen Receptor by Set9 Methyltransferase
    Soyoung Ko, Jungmi Ahn, Chung Seog Song, So-Young Kim, Katarzyna Knapczyk‐Stwora, Bandana Chatterjee · 2011 · Molecular Endocrinology
  80. The Histone Modification Code in the Pathogenesis of Autoimmune Diseases
    Yasuto Araki, Toshihide Mimura · 2017 · Mediators of Inflammation
  81. Current Insights into Oral Cancer Epigenetics
    Alexandra Iulia Irimie, Cristina Alexandra Ciocan, Diana Gulei, Nikolay Hristov Mehterov, Atanas G. Atanasov, Diana Dudea, Ioana Berindan‐Neagoe · 2018 · International Journal of Molecular Sciences
  82. MicroRNA epigenetic alterations in human cancer: One step forward in diagnosis and treatment
    Nuo Yang, George Coukos, Lin Zhang · 2007 · International Journal of Cancer
  83. Short-term memory of danger signals and environmental stimuli in immune cells
    Silvia Monticelli, Gioacchino Natoli · 2013 · Nature Immunology
  84. Cognition, Information Fields and Hologenomic Entanglement: Evolution in Light and Shadow
    William B. Miller · 2016 · Biology
  85. Synthesizing the role of epigenetics in the response and adaptation of species to climate change in freshwater ecosystems
    Guilherme Jeremias, João Barbosa, Sérgio Miguel Marques, Jana Asselman, Fernando J.M. Gonçalves, Joana Luísa Pereira · 2018 · Molecular Ecology
  86. Epigenetics in epilepsy
    Katja Kobow, Ingmar Blümcke · 2017 · Neuroscience Letters
  87. Primers on nutrigenetics and nutri(epi)genomics: Origins and development of precision nutrition
    Laura Bordoni, Rosita Gabbianelli · 2019 · Biochimie
  88. Multimodal deep learning approaches for single-cell multi-omics data integration
    Tasbiraha Athaya, Rony Chowdhury Ripan, Xiaoman Li, Haiyan Hu · 2023 · Briefings in Bioinformatics
  89. Prediction of regulatory elements in mammalian genomes using chromatin signatures
    Kyoung‐Jae Won, Iouri Chepelev, Bing Ren, Wei Wang · 2008 · BMC Bioinformatics
  90. Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells
    Tzutzuy Ramı́rez, Jan Brocher, Helga Stopper, Robert Hock · 2007 · Chromosoma
  91. Fetal muscle development, mesenchymal multipotent cell differentiation, and associated signaling pathways1,2
    ‬Min Du, Junxing Zhao, Xu Yan, Yan Huang, L. V. Nicodemus, W. Yue, R. J. McCormick, Maobi Zhu · 2010 · Journal of Animal Science
  92. Epigenetic control of autoimmune diseases: From bench to bedside
    Antonietta Picascia, Vincenzo Grimaldi, Orlando Pignalosa, Maria Rosaria De Pascale, Concetta Schiano, Claudio Napoli A · 2015 · Clinical Immunology
  93. Third Report on Chicken Genes and Chromosomes 2015
    Michael Schmid, Jacqueline Smith, David W. Burt, Bronwen L. Aken, Parker B. Antin, Alan L. Archibald, Christopher M. Ashwell, Perry J. Blackshear, Clarissa Boschiero, C. Titus Brown et al. · 2015 · Cytogenetic and Genome Research
  94. H3K27 Demethylase JMJD3 Employs the NF-κB and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis
    Woo‐Yong Park, Beom-Jin Hong, Jungsul Lee, Chulhee Choi, Mi‐Young Kim · 2016 · Cancer Research
  95. Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma
    Jessica Tomé-García, Parsa Erfani, German Nudelman, Alexander M. Tsankov, Igor Katsyv, Rut Tejero, Bin Zhang, Martin J. Walsh, Roland H. Friedel, Elena Zaslavsky et al. · 2018 · Nature Communications
  96. Genetic Landscape of Nonobstructive Azoospermia and New Perspectives for the Clinic
    Miriam Cerván‐Martín, José Antonio Castilla, Rogelio Palomino‐Morales, F. David Carmona · 2020 · Journal of Clinical Medicine
  97. Effects of Prenatal Hypoxia on Nervous System Development and Related Diseases
    Bin Wang, Hongtao Zeng, Jingliu Liu, Miao Sun · 2021 · Frontiers in Neuroscience
  98. Unlocking epigenetic codes in neurogenesis
    Bing Yao, Peng Jin · 2014 · Genes & Development
  99. Epigenetic control of gene expression in the alcoholic brain
    Igor Ponomarev · 2013 · Alcohol research
  100. Chromatin Topology and the Regulation of Antigen Receptor Assembly
    Claudia Bossen, Robert Månsson, Cornelis Murre · 2012 · Annual Review of Immunology