Cited by 2,086Epigenetics and DNA MethylationGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

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The Mammalian Epigenome

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Bernstein, Bradley E., Meissner, Alexander, Lander, Eric S.·2007·Cell

DOI 10.1016/j.cell.2007.01.033

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Abstract

Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and environment. With the sequencing of the human genome completed, investigators now seek a comprehensive view of the epigenetic changes that determine how genetic information is made manifest across an incredibly varied background of developmental stages, tissue types, and disease states. Here we review current research efforts, with an emphasis on large-scale studies, emerging technologies, and challenges ahead.

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Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Self-citation
Translating the Histone Code
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Genome sequencing in microfabricated high-density picolitre reactors
Margulies, M., Egholm, M., Altman, W. E., Attiya, S., Bader, J. S., Bemben, L. A., Berka, J., Braverman, M. S., Chen, Y.-J., Chen, Z., et al. (2005) · Nature · doi:10.1038/nature03959 · Cited by 7,693
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
The fundamental role of epigenetic events in cancer
Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Self-citation
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
CpG Islands in vertebrate genomes
Gardiner‐Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,417
Epigenetic Reprogramming in Mammalian Development
Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078

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Authors: Bernstein, B. E., Meissner, A., & Lander, E. S.
Affiliations: Broad Institute (US)
Whitehead Institute for Biomedical Research (US)
Corresponding author: Bernstein, Bradley E.
ORCID: Bernstein, Bradley E.
Meissner, Alexander
Lander, Eric S.
Venue: Cell
Publisher: Elsevier BV
Published: 2007-02
Volume: 128
Issue: 4
Pages: 669-681
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2007.01.033
OpenAlex: W2134087142
Cited by: 2,086
References: 97
Citations by year: 2026: 16 · 2025: 50 · 2024: 53 · 2023: 55 · 2022: 62 · 2021: 94 · 2020: 78 · 2019: 89 · 2018: 108 · 2017: 111 · 2016: 127 · 2015: 128 · 2014: 135 · 2013: 150 · 2012: 157
FWCI: 13.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2358 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Massachusetts General Hospital
Boehringer Ingelheim Fonds
National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: DNA methylation, histone modifications, chromatin structure, epigenetic regulation, epigenetic inheritance
MeSH terms: Animals, Histones, Humans, Mammals, Gene Expression Regulation, Developmental, CpG Islands, DNA Methylation, Chromatin Assembly and Disassembly, Genomic Instability, Epigenesis, Genetic

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The Mammalian Epigenome

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