The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
The Mammalian Epigenome
Open accessAbstract
Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and environment. With the sequencing of the human genome completed, investigators now seek a comprehensive view of the epigenetic changes that determine how genetic information is made manifest across an incredibly varied background of developmental stages, tissue types, and disease states. Here we review current research efforts, with an emphasis on large-scale studies, emerging technologies, and challenges ahead.
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“Epigenetic adaptation is the biological process through which the ecology of relationships, experiences, perceptions, and physical and chemical toxins get”
From Malleability, plasticity, and individuality: How children learn and develop in context1 (2019) · cites this paper as Bernstein, Meissner, & Lander, 2007
Citations
Cites
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Self-citationJenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Genome sequencing in microfabricated high-density picolitre reactors
Margulies, M., Egholm, M., Altman, W. E., Attiya, S., Bader, J. S., Bemben, L. A., Berka, J., Braverman, M. S., Chen, Y.-J., Chen, Z., et al. (2005) · Nature · doi:10.1038/nature03959 · Cited by 7,693
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
The fundamental role of epigenetic events in cancer
Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Self-citationTargeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
CpG Islands in vertebrate genomes
Gardiner‐Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,417
Epigenetic Reprogramming in Mammalian Development
Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078
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Bearer, E. L., & Mulligan, B. S. (2018) · Current Genomics · doi:10.2174/1389202919666180307150508 · Cited by 19
DNA methylation in adolescents with anxiety disorder: A longitudinal study
Bortoluzzi, A., Salum, G. A., da Rosa, E. D., Chagas, V. D. S., Castro, M. A. A., & Manfro, G. G. (2018) · Scientific Reports · doi:10.1038/s41598-018-32090-1 · Cited by 16
Zhang, Q., Lei, X., & Lu, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084925 · Cited by 16
Epigenome overlap measure (EPOM) for comparing tissue/cell types based on chromatin states
Li, W. V., Razaee, Z. S., & Li, J. J. (2016) · BMC Genomics · doi:10.1186/s12864-015-2303-9 · Cited by 10
Commensal microbiota-derived signals regulate host immune system through epigenetic modifications
Takahashi, D., & Hase, K. (2015) · Inflammation and Regeneration · doi:10.2492/inflammregen.35.129 · Cited by 3
Metadata
- Authors
- Bernstein, B. E., Meissner, A., & Lander, E. S.
- Affiliations
- Broad Institute (US)
- Whitehead Institute for Biomedical Research (US)
- Corresponding author
- Bernstein, Bradley E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 128
- Issue
- 4
- Pages
- 669-681
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2134087142
- Cited by
- 2,086
- References
- 97
- Citations by year
- 2026: 16 · 2025: 50 · 2024: 53 · 2023: 55 · 2022: 62 · 2021: 94 · 2020: 78 · 2019: 89 · 2018: 108 · 2017: 111 · 2016: 127 · 2015: 128 · 2014: 135 · 2013: 150 · 2012: 157
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Massachusetts General Hospital
- Boehringer Ingelheim Fonds
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- DNA methylation, histone modifications, chromatin structure, epigenetic regulation, epigenetic inheritance
- MeSH terms
- Animals, Histones, Humans, Mammals, Gene Expression Regulation, Developmental, CpG Islands, DNA Methylation, Chromatin Assembly and Disassembly, Genomic Instability, Epigenesis, Genetic
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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