Cited by 243Vitamin C and Antioxidants ResearchErythrocyte Function and PathophysiologyMetabolism, Diabetes, and Cancer

Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C

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Montel-Hagen, Amélie, Kinet, Sandrina, Manel, Nicolas, Mongellaz, Cédric, Prohaska, Rainer, Battini, Jean-Luc, Delaunay, Jean, Sitbon, Marc +1 more·2008·Cell

Abstract

Of all cells, human erythrocytes express the highest level of the Glut1 glucose transporter. However, the regulation and function of Glut1 during erythropoiesis are not known. Here, we report that glucose transport actually decreases during human erythropoiesis despite a >3-log increase in Glut1 transcripts. In contrast, Glut1-mediated transport of L-dehydroascorbic acid (DHA), an oxidized form of ascorbic acid (AA), is dramatically enhanced. We identified stomatin, an integral erythrocyte membrane protein, as regulating the switch from glucose to DHA transport. Notably though, we found that erythrocyte Glut1 and associated DHA uptake are unique traits of humans and the few other mammals that have lost the ability to synthesize AA from glucose. Accordingly, we show that mice, a species capable of synthesizing AA, express Glut4 but not Glut1 in mature erythrocytes. Thus, erythrocyte-specific coexpression of Glut1 with stomatin constitutes a compensatory mechanism in mammals that are unable to synthesize vitamin C.

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Crossref · 10.1016/j.cell.2008.01.042

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Authors
Montel-Hagen, A., Kinet, S., Manel, N., Mongellaz, C., Prohaska, R., Battini, J.-L., Delaunay, J., Sitbon, M., & Taylor, N.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Max Perutz Labs (AT)
  • Inserm (FR)
Corresponding author
Taylor, Naomi
Venue
Cell
Publisher
Elsevier BV
Published
2008-03
Volume
132
Issue
6
Pages
1039-1048
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2040716137
Cited by
243
References
57
Citations by year
2026: 5 · 2025: 4 · 2024: 12 · 2023: 8 · 2022: 14 · 2021: 10 · 2020: 13 · 2019: 13 · 2018: 12 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 20 · 2013: 17 · 2012: 17
FWCI
17.17
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R01AI059349)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
GLUT1, stomatin, erythropoiesis, scurvy, vitamin C, GLUT4, glucose transporter regulation
MeSH terms
Animals, Ascorbic Acid, Biological Transport, Cell Line, Dehydroascorbic Acid, Erythrocytes, Erythropoiesis, Humans, Mammals, Membrane Proteins, Transfection, 5' Untranslated Regions, Glucose Transporter Type 1, Glucose Transporter Type 4

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