Ascorbic Acid: Its Role in Immune System and Chronic Inflammation Diseases
Abstract
Ascorbic acid (AA), also known as vitamin C, was initially identified as the factor preventing the scurvy disease, and became very popular for its antioxidant properties. It is an important co-substrate of a large class of enzymes, and regulates gene expression by interacting with important transcription factors. AA is important in all stressful conditions that are linked to inflammatory processes and involve immunity. It has been known for decades that the persistence of an inflammatory stimulus is responsible for the onset of many diseases. AA is essential to stimulate the immune system by increasing the strength and protection of the organism. Therefore, its immunostimulant, antinflammatory, antiviral and antibacterial roles are well known, we have summarized its main functions in different types of diseases related to the immune system and chronic inflammation. We can conclude that AA, due to its effects and diversity of regulated pathways, is suitable for use in various fields of medicine including immunology, toxicology, radiobiology and others. AA is not preferable to be used as an isolated mode of treatment, but it can be co-applied as an adjuvant to regulate immunity, gene expression and other important physiological processes. However, we propose that future studies will take into consideration the research of new combinations of antioxidant natural substances and drugs.
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Ascorbate influences inflammatory response and immune cell function.
“Moreover, a wealth of knowledge is emerging that highlights the influence of ascorbate in inflammatory response and immune cell function110,111, which suggests that ascorbate may have synergistic effects when combined with current immunotherapy.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [110]
Ascorbate might work synergistically with existing immunotherapy.
“Moreover, a wealth of knowledge is emerging that highlights the influence of ascorbate in inflammatory response and immune cell function110,111, which suggests that ascorbate may have synergistic effects when combined with current immunotherapy.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [110]
High-dose vitamin C improves how innate and adaptive immune cells work.
“A compelling hypothesis is offered by the utilization and combination of high-dose vitamin C, which is known to enhance the function of both innate and adaptive immune cells109,110.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [110]
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- Authors
- Sorice, A., Guerriero, E., Capone, F., Colonna, G., Castello, G., & Costantini, S.
- Affiliations
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- ORCID
- Venue
- Mini-Reviews in Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2014-05-31
- Volume
- 14
- Issue
- 5
- Pages
- 444-452
- ISSN
- 1389-5575 (ISSN-L)
- OpenAlex
- W2147061446
- Cited by
- 212
- References
- 95
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 19 · 2023: 19 · 2022: 28 · 2021: 31 · 2020: 40 · 2019: 17 · 2018: 12 · 2017: 14 · 2016: 8 · 2015: 7 · 2014: 1
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mini-Reviews in Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Keywords
- vitamin C, immune system, chronic inflammation, antioxidant activity, immunostimulation, antiviral activity, antibacterial activity, gene expression regulation, transcription factors, scurvy, adjuvant therapy, antioxidant combination
- MeSH terms
- Animals, Antioxidants, Ascorbic Acid, Chronic Disease, Humans, Immune System, Inflammation
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