Cited by 212Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative StressFlavonoids in Medical Research

Ascorbic Acid: Its Role in Immune System and Chronic Inflammation Diseases

Sorice, Angela, Guerriero, Eliana, Capone, Francesca, Colonna, Giovanni, Castello, Giuseppe, Costantini, Susan·2014·Mini-Reviews in Medicinal Chemistry

Abstract

Ascorbic acid (AA), also known as vitamin C, was initially identified as the factor preventing the scurvy disease, and became very popular for its antioxidant properties. It is an important co-substrate of a large class of enzymes, and regulates gene expression by interacting with important transcription factors. AA is important in all stressful conditions that are linked to inflammatory processes and involve immunity. It has been known for decades that the persistence of an inflammatory stimulus is responsible for the onset of many diseases. AA is essential to stimulate the immune system by increasing the strength and protection of the organism. Therefore, its immunostimulant, antinflammatory, antiviral and antibacterial roles are well known, we have summarized its main functions in different types of diseases related to the immune system and chronic inflammation. We can conclude that AA, due to its effects and diversity of regulated pathways, is suitable for use in various fields of medicine including immunology, toxicology, radiobiology and others. AA is not preferable to be used as an isolated mode of treatment, but it can be co-applied as an adjuvant to regulate immunity, gene expression and other important physiological processes. However, we propose that future studies will take into consideration the research of new combinations of antioxidant natural substances and drugs.

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Crossref · 10.2174/1389557514666140428112602

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95 of 95 references verified0 citation errors · 0 not checkable

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  • Ascorbate influences inflammatory response and immune cell function.

    “Moreover, a wealth of knowledge is emerging that highlights the influence of ascorbate in inflammatory response and immune cell function110,111, which suggests that ascorbate may have synergistic effects when combined with current immunotherapy.”

    From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [110]

  • Ascorbate might work synergistically with existing immunotherapy.

    “Moreover, a wealth of knowledge is emerging that highlights the influence of ascorbate in inflammatory response and immune cell function110,111, which suggests that ascorbate may have synergistic effects when combined with current immunotherapy.”

    From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [110]

  • High-dose vitamin C improves how innate and adaptive immune cells work.

    “A compelling hypothesis is offered by the utilization and combination of high-dose vitamin C, which is known to enhance the function of both innate and adaptive immune cells109,110.”

    From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [110]

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Authors
Sorice, A., Guerriero, E., Capone, F., Colonna, G., Castello, G., & Costantini, S.
Affiliations
  • Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
  • University of Campania "Luigi Vanvitelli" (IT)
Venue
Mini-Reviews in Medicinal Chemistry
Published
2014-05-31
Volume
14
Issue
5
Pages
444-452
ISSN
1389-5575 (ISSN-L)
OpenAlex
W2147061446
Cited by
212
References
95
Citations by year
2026: 8 · 2025: 8 · 2024: 19 · 2023: 19 · 2022: 28 · 2021: 31 · 2020: 40 · 2019: 17 · 2018: 12 · 2017: 14 · 2016: 8 · 2015: 7 · 2014: 1
FWCI
9.31
Type
journal article
Language
en
Open access
closed
Locations
  • Mini-Reviews in Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
Keywords
vitamin C, immune system, chronic inflammation, antioxidant activity, immunostimulation, antiviral activity, antibacterial activity, gene expression regulation, transcription factors, scurvy, adjuvant therapy, antioxidant combination
MeSH terms
Animals, Antioxidants, Ascorbic Acid, Chronic Disease, Humans, Immune System, Inflammation

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