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Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury
Open accessAbstract
Multiple lung pathogens such as chemical agents, H5N1 avian flu, or SARS cause high lethality due to acute respiratory distress syndrome. Here we report that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI). We show that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI. The oxidized phospholipid (OxPL) OxPAPC was identified to induce lung injury and cytokine production by lung macrophages via TLR4-TRIF. We observed OxPL production in the lungs of humans and animals infected with SARS, Anthrax, or H5N1. Pulmonary challenge with an inactivated H5N1 avian influenza virus rapidly induces ALI and OxPL formation in mice. Loss of TLR4 or TRIF expression protects mice from H5N1-induced ALI. Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI.
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“Macrophage activation via TLR4, a type of PRR, is also involved in gastric acid-induced ARDS and mouse ARDS models induced by SARS-CoV-1 or influenza virus H5N1 (355).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [355]
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“endogenous products such as oxidized phospholipids and matrix breakdown products also drive inflammation through TLR4 and probably other TLRs, providing a mechanism for perpetuating inflammation when microbial products are being cleared from the lungs (68,72).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [68]
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Cites
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976
Self-citationDefective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 2×
“Lung pathology were not affected in tlr3 (Yamamoto et al., 2003) or tlr9 (Hemmi et al., 2000) mutant mice (Figures S2A and S2B).”
BackgroundSelf-citationThe Acute Respiratory Distress Syndrome
Matthay, M. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605303342209 · Cited by 4,924
The Acute Respiratory Distress Syndrome
Ware, L. B., & Matthay, M. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421806 · Cited by 4,666
Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374
Self-citationRole of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
Self-citationAngiotensin-converting enzyme 2 protects from severe acute lung failure
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., et al. (2005) · Nature · doi:10.1038/nature03712 · Cited by 2,453
Self-citationTargeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358
Self-citationConditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Flagged first, then by citations
Cited by
Sorted by citations
Items 701–800 of 1,000
Karki, P., & Birukov, K. G. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.794437 · Cited by 27
Lipoprotein(a), a Lethal Player in Calcific Aortic Valve Disease
Hu, J., Lei, H. C., Liu, L., & Xu, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.812368 · Cited by 28
Zhao, D., Qin, Y., Liu, J., Tang, K., Lu, S., Liu, Z., Lin, Y., Zhang, C., Huang, F., Chang, J., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2219-0 · Cited by 27
Self-citationSharawi, Z. W., Ibrahim, I. M., Abd‐alhameed, E. K., Althagafy, H. S., Jaber, F. A., Harakeh, S., & Hassanein, E. H. M. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02704-1 · Cited by 27
Ogiwara, H., Yasui, F., Munekata, K., Takagi-Kamiya, A., Munakata, T., Nomura, N., Shibasaki, F., Kuwahara, K., Sakaguchi, N., Sakoda, Y., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.10.004 · Cited by 26
Vaneker, M., Heunks, L. M. A., Joosten, L. A. B., van Hees, H. W. H., Snijdelaar, D. G., Halbertsma, F. J. J., van Egmond, J., Netea, M. G., van der Hoeven, J. G., & Scheffer, G. J. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181b76499 · Cited by 27
Appleby, S. L., Mitrofan, C., Crosby, A., Hoenderdos, K., Lodge, K. M., Upton, P. D., Yates, C. M., Nash, G. B., Chilvers, E. R., & Morrell, N. W. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601219 · Cited by 27
Host Immune Responses to SARS Coronavirus in Humans
Li, C. K.-F., & Xu, X. (2009) · Springer eBooks · doi:10.1007/978-3-642-03683-5_16 · Cited by 26
Itch Control by Toll-Like Receptors
Taves, S., & Ji, R. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-44605-8_7 · Cited by 26
Shen, C., Lin, J.-Y., Chang, Y., Wu, S., Peng, C., Wu, C., & Huang, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02049 · Cited by 26
Withania somnifera as a potential future drug molecule for COVID-19
Kashyap, V. K., Dhasmana, A., Yallapu, M. M., Chauhan, S. C., & Jaggi, M. (2020) · Future Drug Discovery · doi:10.4155/fdd-2020-0024 · Cited by 29
Heteromeric TRP Channels in Lung Inflammation
Zergane, M., Kuebler, W. M., & Michalick, L. (2021) · Cells · doi:10.3390/cells10071654 · Cited by 26
Is It All About Endothelial Dysfunction and Thrombosis Formation? The Secret of COVID-19
Elyaspour, Z., Zibaeenezhad, M. J., Razmkhah, M., & Razeghian‐Jahromi, I. (2021) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296211042940 · Cited by 26
Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model
Cui, H. Y., Zhang, C., Zhang, C., Cai, Z., Chen, L., Chen, Z., Zhao, K., Qiao, S., Wang, Y., Meng, L., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.892864 · Cited by 26
Ischemia-Reperfusion Lung Injury Is Attenuated in MyD88-Deficient Mice
Altemeier, W. A., Liles, W. C., Villagra-Garcia, A., Matute‐Bello, G., & Glenny, R. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077123 · Cited by 26
Acute Respiratory Distress Syndrome Induced by a Swine 2009 H1N1 Variant in Mice
Zhang, Y., Sun, H., Fan, L., Ma, Y., Sun, Y., Pu, J., Yang, J., Jian, Q., Ma, G., & Liu, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029347 · Cited by 26
Self-citationHaimovich, B., Reddell, M. T., Calvano, J. E., Calvano, S. E., Macor, M., Coyle, S. M., & Lowry, S. F. (2010) · Critical Care · doi:10.1186/cc9283 · Cited by 28
Uematsu, T., Iizasa, E., Kobayashi, N., Yoshida, H., & Hara, H. (2015) · Scientific Reports · doi:10.1038/srep17577 · Cited by 26
Arita, R., Ono, R., Saito, N., Takayama, S., Namiki, T., Ito, T., & Ishii, T. (2020) · Traditional & Kampo Medicine · doi:10.1002/tkm2.1258 · Cited by 26
Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury
Dubey, P. K., Masuda, K., Nyati, K. K., Zaman, M. M.-U., Chalise, J. P., Millrine, D., Wang, K., Ripley, B., & Kishimoto, T. (2017) · International Immunology · doi:10.1093/intimm/dxx004 · Cited by 25
25‐Hydroxycholesterol protects against acute lung injury via targeting MD ‐2
Ouyang, W., Zhou, H., Liu, C., Wang, S., Yu, H., Xia, J., & Xu, F. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13820 · Cited by 26
Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection
Fujiwara, S., Hoshizaki, M., Ichida, Y., Lex, D., Kuroda, E., Ishii, K. J., Magi, S., Okada, M., Takao, H., Gandou, M., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0289-1 · Cited by 25
Self-citationSun, Y., Su, J., Yang, S., Liu, Z., Liu, D., Gan, F., Chen, X., & Huang, K. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b05829 · Cited by 25
Self-citationThrombosis and Hemostasis Issues in Cancer Patients with COVID-19
Horowitz, N. A., & Brenner, B. (2020) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0040-1714275 · Cited by 25
The Impact of Diabetes Mellitus in COVID-19: A Mechanistic Review of Molecular Interactions
Yaribeygi, H., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2020) · Journal of Diabetes Research · doi:10.1155/2020/5436832 · Cited by 29
Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein
Zhang, L., Zhang, Y., Qin, X., Jiang, X., Zhang, J., Mao, L., Jiang, Z., Jiang, Y. L., Liu, G., Qiu, J., et al. (2022) · Critical Care · doi:10.1186/s13054-022-04034-9 · Cited by 25
Vijayakumar, P., Mishra, A., Ranaware, P. B., Kolte, A. P., Kulkarni, D. D., Burt, D. W., & Raut, A. A. (2015) · Gene · doi:10.1016/j.gene.2015.01.016 · Cited by 25
Li, Q., Tan, H.-L., Wang, Y., Cheng-yong, X., Feng, J., Li, M., & Dou, Y. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/3017571 · Cited by 25
Wang, B. S., Huang, X., Chen, L. Z., Liu, M. M., & Shi, J. B. (2019) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2019.1618291 · Cited by 25
Yang, H., Song, Z., & Hong, D. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109761 · Cited by 24
Aokage, T., Seya, M., Hirayama, T., Nojima, T., Iketani, M., Aoyama-Ishikawa, M., Terasaki, Y., Taniguchi, A., Miyahara, N., Nakao, A., et al. (2021) · BMC Pulmonary Medicine · doi:10.1186/s12890-021-01712-2 · Cited by 25
ACE2 and Innate Immunity in the Regulation of SARS-CoV-2-Induced Acute Lung Injury: A Review
Qu, L., Chen, C., Yin, T., Fang, Q., Hong, Z.-Z., Zhou, R., Tang, H., & Dong, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111483 · Cited by 23
Antiviral effects of Yinhuapinggan granule against influenza virus infection in the ICR mice model
Peng, X.-Q., Zhou, H., Zhang, Y., Yang, J., Wan, H., & He, Y. T. (2015) · Journal of Natural Medicines · doi:10.1007/s11418-015-0939-z · Cited by 24
Humberd, J., Nagy, T., Barber, J. P., Brooks, P., Tompkins, S. M., & Tripp, R. A. (2011) · Viral Immunology · doi:10.1089/vim.2010.0085 · Cited by 24
Protocatechuic Acid, a Novel Active Substance against Avian Influenza Virus H9N2 Infection
Ou, C., Shi, N., Yang, Q., Zhang, Y., Wu, Z., Wang, B., Compans, R. W., & He, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111004 · Cited by 24
Critical illness is an iatrogenic disorder
Marshall, J. C. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181f2002a · Cited by 24
Babb, R., Chen, A., Ogunniyi, A. D., Hirst, T. R., Kara, E. E., McColl, S. R., Alsharifi, M., & Paton, J. C. (2016) · Clinical Science · doi:10.1042/cs20160475 · Cited by 25
Costa, S. G., Barioni, É. D., Ignácio, A., Albuquerque, J., Câmara, N. O. S., Pavani, C., Vitoretti, L. B., Damazo, A. S., Farsky, S. H. P., & Lino‐dos‐Santos‐Franco, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-13117-5 · Cited by 24
The protective effects of Thalictrum minus L. on lipopolysaccharide-induced acute lung injury
Badamjav, R., Sonom, D., Wu, Y., Zhang, Y., Kou, J., Yu, B., & Li, F. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112355 · Cited by 24
Complex mechanism of COVID-19 development
Bolevich, S., & Bolevich, S. S. (2020) · Sechenov Medical Journal · doi:10.47093/2218-7332.2020.11.2.50-61 · Cited by 26
Yan, Y., Xin, A., Liu, Q., Huang, H., Shao, Z., Zang, Y., Chen, L., Sun, Y., & Gao, H. (2015) · BMC Veterinary Research · doi:10.1186/s12917-015-0480-z · Cited by 23
Self-citationZheng, F., Wu, X., Zhang, J., Fu, Z., & Zhang, Y. (2022) · Redox Report · doi:10.1080/13510002.2022.2096339 · Cited by 23
Karthik, S., Saraswathi, I., Alarifi, A., Al-Atram, A. A., Mickeymaray, S., Paramasivam, A., Shaikh, S., Jeraud, M., & Alothaim, A. S. (2022) · PeerJ · doi:10.7717/peerj.14227 · Cited by 23
The paradigm of prophylactic viral outbreaks measures by microbial biosurfactants
Kumari, K., Nandi, A., Sinha, A., Ghosh, A., Sengupta, S., Saha, U., Singh, P. K., Panda, P. K., Raina, V., & Verma, S. K. (2023) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2023.02.016 · Cited by 23
Hu, Z., Chen, R., Cai, Z., Yu, L., Yang, F., Weng, L., Wang, J., Ge, X., Zhu, T., Wang, J., et al. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2011.56 · Cited by 23
Qian, J., Liu, L., Chen, L., Lu, X., & Zhu, C. (2014) · Human & Experimental Toxicology · doi:10.1177/0960327114542963 · Cited by 24
Peptide Targeting and Imaging of Damaged Lung Tissue in Influenza-Infected Mice
Li, N., Yin, L., Thévenin, D., Yamada, Y., Limmon, G. V., Chen, J., Chow, V. T. K., Engelman, D. M., & Engelward, B. P. (2013) · Future Microbiology · doi:10.2217/fmb.12.134 · Cited by 23
Shoemaker, J. E., Fukuyama, S., Eisfeld, A. J., Muramoto, Y., Watanabe, S., Watanabe, T., Matsuoka, Y., Kitano, H., & Kawaoka, Y. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-117 · Cited by 22
Westphalen, K., Monma, E., Islam, M. N., & Bhattacharya, J. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00206.2011 · Cited by 23
Influenza, evolution, and the next pandemic
Fedson, D. S. (2018) · Evolution Medicine and Public Health · doi:10.1093/emph/eoy027 · Cited by 24
Monji, F., Siddiquee, A. A.-M., & Hashemian, F. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173561 · Cited by 21
Cao, L., Du, M., Cai, M., Feng, Y., Miao, J., Sun, J., Song, J., & Du, B. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124960 · Cited by 23
Seixas, M. L., Mitre, L. P., Shams, S., Lanzuolo, G. B., Bartolomeo, C. S., Silva, E. A., Prado, C. M., Ureshino, R. P., & Stilhano, R. S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.825629 · Cited by 24
Hofstetter, A. R., Cruz, J. A. D. L., Cao, W., Patel, J. R., Belser, J. A., McCoy, J. W., Liepkalns, J. S., Amoah, S., Cheng, G., Ranjan, P., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149864 · Cited by 22
We do not need mechanical ventilation any more
Sorbo, L. D., & Ranieri, V. M. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181f20d5b · Cited by 22
Role for phospholipid acyl chains and cholesterol in pulmonary infections and inflammation
Shaikh, S. R., Fessler, M. B., & Gowdy, K. M. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4vmr0316-103r · Cited by 23
Influence of alpha-lipoic acid on nicotine-induced lung and liver damage in experimental rats
Ateyya, H., Nader, M. A., Attia, G. M., & El-Sherbeeny, N. A. (2016) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0366 · Cited by 22
Prantner, D., Shirey, K. A., Lai, W., Lu, W., Cole, A. M., Vogel, S. N., & Demo, A. G. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.2a1215-567rr · Cited by 22
Mao, M., & Huang, M. (2018) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v16i11.3 · Cited by 22
Perspective: Nutritional Strategies Targeting the Gut Microbiome to Mitigate COVID-19 Outcomes
Daoust, L., Pilon, G., & Marette, A. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab031 · Cited by 21
Roussel, L., Martel, G., Bérubé, J., & Rousseau, S. (2010) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2010.11.005 · Cited by 22
Innate immune role of IL-6 in influenza a virus pathogenesis
Li, X., Huang, C., Rai, K. R., & Xu, Q. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1605446 · Cited by 26
Pang, C., Neubauer, N., Boyles, M. S. P., Brown, D., Kanase, N., Hristozov, D. R., Fernandes, T. F., Stone, V., Wohlleben, W., & Marcomini, A. (2017) · NanoImpact · doi:10.1016/j.impact.2017.06.002 · Cited by 21
Li, Q., Ran, Q., Sun, L., Yin, J., Luo, T. L., Liu, L., Zhao, Z., Yang, Q., Li, Y., Chen, Y., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.522729 · Cited by 20
Cyclic 68 Ga-Labeled Peptides for Specific Detection of Human Angiotensin-Converting Enzyme 2
Parker, M. F. L., Blecha, J. E., Rosenberg, O. S., Ohliger, M. A., Flavell, R. R., & Wilson, D. M. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.120.261768 · Cited by 23
Lodhi, N., Singh, R., Rajput, S., & Saquib, Q. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168660 · Cited by 21
Toll-like Receptors in Viral Encephalitis
Gern, O. L., Mulenge, F., Pavlou, A., Ghita, L., Steffen, I., Stangel, M., & Kalinke, U. (2021) · Viruses · doi:10.3390/v13102065 · Cited by 24
Zhang, H., Zeng, J., Li, J., Gong, H., Chen, M., Li, Q., Liu, S., Luo, S., Dong, H., Xu, Y., et al. (2023) · Biomolecules and Biomedicine · doi:10.17305/bb.2022.8549 · Cited by 22
An, W., Lakhina, S., Leong, J., Rawat, K., & Husain, M. (2024) · Pathogens · doi:10.3390/pathogens13070561 · Cited by 23
Ren, W., Hu, L., Hua, F., Jin, J., Wang, Y., & Zhu, L. (2011) · Immunology Letters · doi:10.1016/j.imlet.2011.07.010 · Cited by 21
Wu, F., Liu, Y., Lv, X., Miao, X., Sun, Y., & Yu, W. (2012) · BioMed Research International · doi:10.1155/2012/406435 · Cited by 21
Self-citationLow levels of a natural IgM antibody are associated with vein graft stenosis and failure
Sobel, M., Moreno, K. I., Yagi, M., Kohler, T. R., Tang, G. L., Clowes, A. W., Zhou, X., & Eugenio, E. C. (2013) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2013.04.042 · Cited by 21
Chian, C., Chiang, C., Yuan-Jung, C., Chuang, C., Liu, S.-L., Jheng, Y., Zhang, H., & Ryu, J. H. (2012) · Shock · doi:10.1097/shk.0b013e31825a1982 · Cited by 21
Ventilator-induced lung injury
Ngiam, N. S. P., & Kavanagh, B. P. (2011) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e32834e7d00 · Cited by 21
Suzuki, E., Sugimoto, M., Kawaguchi, K., Pu, F., Uozumi, R., Yamaguchi, A., Nishie, M., Tsuda, M., Kotake, T., Morita, S., et al. (2018) · Breast Cancer · doi:10.1007/s12282-018-0920-2 · Cited by 21
Host Detection and the Stealthy Phenotype in Influenza Virus Infection
Dash, P., & Thomas, P. G. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_412 · Cited by 21
The Role of the Nrf2 Pathway in Airway Tissue Damage Due to Viral Respiratory Infections
Kombe, A. J. K., Abadi, L. F., Nanduri, R., Gerasimova, Y. V., Δάσκου, Μ., Gain, C., Sharma, E., Wong, M., & Kelesidis, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137042 · Cited by 20
Oxidized phospholipid damage signals as modulators of immunity
Choi, J. H., & Kagan, J. C. (2025) · Open Biology · doi:10.1098/rsob.240391 · Cited by 22
Role of innate immunity in primary graft dysfunction after lung transplantation
Diamond, J. M., & Wigfield, C. H. (2013) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e3283651994 · Cited by 21
Rojatti, M., Regli, I. B., Zanforlin, A., Ferretti, E., Falk, M., Strapazzon, G., Gamper, M., Zanon, P., Böck, M., & Rauch, S. (2020) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-020-00536-1 · Cited by 20
SARS-CoV-2 and Acute Cerebrovascular Events: An Overview
Ghasemi, M., Umeton, R. P., Keyhanian, K., Mohit, B., Rahimian, N., Eshaghhosseiny, N., & Davoudi, V. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153349 · Cited by 20
Geochemistry and oxidative potential of the respirable fraction of powdered mined Chinese coals
Trechera, P., Moreno, T., Córdoba, P., Moreno, N., Amato, F., Cortés, J., Zhuang, X., Li, B., Li, J., Shangguan, Y., et al. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.149486 · Cited by 21
Jia, X.-H., Zhang, K., Feng, S., Li, Y., Yao, D., Liu, Q., Liu, D., Li, X., Huang, J. M., Wang, H., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114186 · Cited by 20
Self-citationMabrey, F. L., Nian, H., Yu, C., Barnes, E. M., Malhotra, U., Mikacenic, C. R., Goldstein, J., O’Mahony, D. S., Garcia‐Diaz, J., Finn, P. W., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104667 · Cited by 22
Olavarría, V. H., Valdivia, S., Salas, B., Villalba, M., Sandoval, R., Oliva, H., Valdebenito, S., & Yáñez, A. J. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.07.016 · Cited by 20
Experimental immunotherapeutic approaches for atherosclerosis
Amir, S., & Binder, C. J. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.07.009 · Cited by 20
Self-citationSpecific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice
Tchitchek, N., Eisfeld, A. J., Tisoncik-Go, J., Josset, L., Gralinski, L. E., Bécavin, C., Tilton, S. C., Webb‐Robertson, B., Ferris, M. T., Totura, A. L., et al. (2013) · BMC Systems Biology · doi:10.1186/1752-0509-7-69 · Cited by 20
Gonçalves-de-Albuquerque, C. F., Burth, P., Silva, A. R., de Moraes, I. M. M., Oliveira, F. M. D. J., Santelli, R. E., Freire, A. S., de Lima, G. S., da Silva, E. D., da Silva, C. I., et al. (2014) · Respiratory Research · doi:10.1186/s12931-014-0093-2 · Cited by 20
Uematsu, T., Fujita, T., Nakaoka, H. J., Hara, T., Kobayashi, N., Murakami, Y., Seiki, M., & Sakamoto, T. (2016) · Scientific Reports · doi:10.1038/srep37815 · Cited by 20
Garcia, C. C., Tavares, L. P., Dias, A. C. F., Kehdy, F. S. G., Alvarado-Arnez, L. E., Queiroz‐Junior, C. M., Galvão, I., Lima, B. H. F., Matos, A. D. R., Gonçalves, A. P., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00975 · Cited by 19
Ouabain Protects Mice Against Lipopolysaccharide-Induced Acute Lung Injury
Wang, C., Meng, Y., Wang, Y., Jiang, Z., Xu, M., Bo, L., & Deng, X. (2018) · Medical Science Monitor · doi:10.12659/msm.908627 · Cited by 20
Alveolar Macrophage Chemokine Secretion Mediates Neutrophilic Lung Injury in Nox2-Deficient Mice
Potera, R. M., Cao, M., Jordan, L. F., Hogg, R. T., Hook, J. S., & Moreland, J. G. (2018) · Inflammation · doi:10.1007/s10753-018-0883-7 · Cited by 21
Oxidative Stress and Its Association with COVID-19: A Narrative Review
Baqi, H. R., Farag, H. A. M., Bilbeisi, A. H. E., Askandar, R. H., & Afifi, A. M. E. (2020) · Kurdistan Journal of Applied Research · doi:10.24017/covid.11 · Cited by 20
Antinociception by the anti‐oxidized phospholipid antibody E06
Mohammadi, M., Oehler, B., Kloka, J. A., Martin, C., Brack, A., Blum, R., & Rittner, H. L. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14340 · Cited by 19
Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin
Doustimotlagh, A. H., & Eftekhari, M. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.02.021 · Cited by 19
Liu, X., Guan, P., Yu, C. T., Yang, H., Shan, A. S., & Feng, X. J. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12027 · Cited by 19
Ren, J., Li, X., Zhu, S., Yin, B., Guo, Z., Cui, Q., Song, J., Pei, H., & Ma, Y. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c02470 · Cited by 19
ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection
Zhu, X., Trimarco, J. D., Williams, C. A., Barrera, A., Reddy, T. E., & Heaton, N. S. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111540 · Cited by 16
Scavenger receptor BI attenuates oxidized phospholipid-induced pulmonary inflammation
Dunigan, K., Yaeger, M. J., Hodge, M. X., Kilburg-Basnyat, B. J., Reece, S. W., Birukova, A., Guttenberg, M. A., Novak, C. M., Chung, S., Ehrmann, B. M., et al. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116381 · Cited by 20
Avian influenza H5N1: an update on molecular pathogenesis
Wang, H., & Jiang, C. (2009) · Science in China Series C Life Sciences · doi:10.1007/s11427-009-0059-7 · Cited by 19
Self-citation
Metadata
- Authors
- Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., Liu, H., Sun, Y., Pasparakis, M., Kopf, M., Mech, C., Bavari, S., Peiris, J. S. M., Slutsky, A. S., Akira, S., Hultqvist, M., Holmdahl, R., Nicholls, J., Jiang, C., Binder, C. J., & Penninger, J. M.
- Affiliations
- Institute of Molecular Biotechnology (AT)
- Austrian Academy of Sciences (AT)
- University of Cologne (DE)
- Western University (CA)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- United States Army Medical Research Institute of Infectious Diseases (US)
- St. Michael's Hospital (CA)
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- Karolinska Institutet (SE)
- University of Hong Kong (HK)
- Corresponding author
- Imai, Yumiko
- Penninger, Josef M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 133
- Issue
- 2
- Pages
- 235-249
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC7112336
- OpenAlex
- W2156613610
- Cited by
- 1,356
- References
- 60
- Citations by year
- 2026: 34 · 2025: 53 · 2024: 56 · 2023: 76 · 2022: 105 · 2021: 143 · 2020: 152 · 2019: 47 · 2018: 69 · 2017: 64 · 2016: 80 · 2015: 65 · 2014: 82 · 2013: 68 · 2012: 53
- FWCI
- 29.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1933 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- University of Pittsburgh
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (100233)
- Defense Threat Reduction Agency
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- acute lung injury, TLR4, TRIF, TRAF6, oxidized phospholipids, OxPAPC, oxidative stress, reactive oxygen species, NCF1, lung macrophages, H5N1 avian influenza, SARS, anthrax, innate immunity, respiratory distress syndrome
- MeSH terms
- Animals, Humans, Influenza, Human, Lung, Mice, Inbred C57BL, Orthomyxoviridae Infections, Phospholipids, Respiratory Distress Syndrome, Signal Transduction, Interleukin-6, NF-kappa B, Oxidative Stress, NADPH Oxidases, Adaptor Proteins, Vesicular Transport, Severe Acute Respiratory Syndrome, Toll-Like Receptor 4, Mice
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