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Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury
Open accessAbstract
Multiple lung pathogens such as chemical agents, H5N1 avian flu, or SARS cause high lethality due to acute respiratory distress syndrome. Here we report that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI). We show that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI. The oxidized phospholipid (OxPL) OxPAPC was identified to induce lung injury and cytokine production by lung macrophages via TLR4-TRIF. We observed OxPL production in the lungs of humans and animals infected with SARS, Anthrax, or H5N1. Pulmonary challenge with an inactivated H5N1 avian influenza virus rapidly induces ALI and OxPL formation in mice. Loss of TLR4 or TRIF expression protects mice from H5N1-induced ALI. Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI.
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“Macrophage activation via TLR4, a type of PRR, is also involved in gastric acid-induced ARDS and mouse ARDS models induced by SARS-CoV-1 or influenza virus H5N1 (355).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [355]
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“endogenous products such as oxidized phospholipids and matrix breakdown products also drive inflammation through TLR4 and probably other TLRs, providing a mechanism for perpetuating inflammation when microbial products are being cleared from the lungs (68,72).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [68]
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Cites
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976
Self-citationDefective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 2×
“Lung pathology were not affected in tlr3 (Yamamoto et al., 2003) or tlr9 (Hemmi et al., 2000) mutant mice (Figures S2A and S2B).”
BackgroundSelf-citationThe Acute Respiratory Distress Syndrome
Matthay, M. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605303342209 · Cited by 4,924
The Acute Respiratory Distress Syndrome
Ware, L. B., & Matthay, M. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421806 · Cited by 4,666
Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374
Self-citationRole of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
Self-citationAngiotensin-converting enzyme 2 protects from severe acute lung failure
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., et al. (2005) · Nature · doi:10.1038/nature03712 · Cited by 2,453
Self-citationTargeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358
Self-citationConditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Flagged first, then by citations
Cited by
Sorted by citations
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304
Self-citationPattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895
Self-citationIL‐6 in inflammation, immunity, and disease
Tanaka, T., Narazaki, M., & Kishimoto, T. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016295 · Cited by 5,046
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
Kawai, T., & Akira, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.006 · Cited by 3,658
Self-citationPathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
Mogensen, T. H. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00046-08 · Cited by 3,296
The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
Ye, Q., Wang, B., & Mao, J. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.03.037 · Cited by 2,761
Channappanavar, R., & Perlman, S. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0629-x · Cited by 2,524
Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
Merad, M., & Martin, J. C. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0331-4 · Cited by 2,472
Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183
Free Radical Lipid Peroxidation: Mechanisms and Analysis
Yin, H., Xu, L., & Porter, N. A. (2011) · Chemical Reviews · doi:10.1021/cr200084z · Cited by 2,031
Into the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940
The acute respiratory distress syndrome
Matthay, M. A., Ware, L. B., & Zimmerman, G. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60331 · Cited by 1,706
Emergence and pandemic potential of swine-origin H1N1 influenza virus
Neumann, G., Noda, T., & Kawaoka, Y. (2009) · Nature · doi:10.1038/nature08157 · Cited by 1,590
IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453
“Macrophage activation via TLR4, a type of PRR, is also involved in gastric acid-induced ARDS and mouse ARDS models induced by SARS-CoV-1 or influenza virus H5N1 (355).”
BackgroundInnate immunity to influenza virus infection
Iwasaki, A., & Pillai, P. S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3665 · Cited by 1,106
COVID-19 and diabetes mellitus: from pathophysiology to clinical management
Lim, S. K., Bae, J. H., Kwon, H., & Nauck, M. A. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00435-4 · Cited by 1,061
Host-directed therapies for bacterial and viral infections
Kaufmann, S. H. E., Dorhoi, A., Hotchkiss, R. S., & Bartenschlager, R. F. W. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.162 · Cited by 869
Liu, L., Wei, Q., Lin, Q., Fang, J., Wang, H., Kwok, H., Tang, H., Nishiura, K., Peng, J., Tan, Z., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123158 · Cited by 830
Self-citationFerroptosis in infection, inflammation, and immunity
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210518 · Cited by 836
The role of oxidative stress during inflammatory processes
Lugrin, J., Rosenblatt‐Velin, N., Parapanov, R., & Liaudet, L. (2013) · Biological Chemistry · doi:10.1515/hsz-2013-0241 · Cited by 766
Toll-Like Receptors in Antiviral Innate Immunity
Lester, S. N., & Li, K. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.11.024 · Cited by 759
The co-pathogenesis of influenza viruses with bacteria in the lung.
McCullers, J. A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3231 · Cited by 722
Immunotherapeutic Implications of Il-6 Blockade for Cytokine Storm
Tanaka, T., Narazaki, M., & Kishimoto, T. (2016) · Immunotherapy · doi:10.2217/imt-2016-0020 · Cited by 719
van der Valk, F. M., Bekkering, S., Kroon, J., Yeang, C., den Bossche, J. V., van Buul, J. D., Ravandi, A., Nederveen, A. J., Verberne, H. J., Scipione, C. A., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.020838 · Cited by 706
A decade after SARS: strategies for controlling emerging coronaviruses
Graham, R. L., Donaldson, E., & Baric, R. S. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3143 · Cited by 689
Miller, Y. I., Choi, S.-H., Wiesner, P., Fang, L., Harkewicz, R., Hartvigsen, K., Boullier, A., Gonen, A., Diehl, C. J., Que, X., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.223875 · Cited by 672
Self-citationHammad, H., Plantinga, M., Deswarte, K., Pouliot, P., Willart, M., Kool, M., Muskens, F., & Lambrecht, B. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20101563 · Cited by 647
COVID-19: Melatonin as a potential adjuvant treatment
Zhang, R., Wang, X., Ni, L., Di, X., Ma, B., Niu, S., Liu, C., & Reiter, R. J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117583 · Cited by 629
Generation and Biological Activities of Oxidized Phospholipids
Bochkov, V. N., Oskolkova, O., Birukov, K. G., Levonen, A., Binder, C. J., & Stöckl, J. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2597 · Cited by 625
Self-citationOxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection
Delgado-Roche, L., & Mesta, F. (2020) · Archives of Medical Research · doi:10.1016/j.arcmed.2020.04.019 · Cited by 612
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications
McFadyen, J. D., Stevens, H., & Peter, K. (2020) · Circulation Research · doi:10.1161/circresaha.120.317447 · Cited by 600
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
Zanoni, I., Tan, Y., Di Gioia, M., Broggi, A., Ruan, J., Shi, J., Donado, C. A., Shao, F., Wu, H., Springstead, J. R., et al. (2016) · Science · doi:10.1126/science.aaf3036 · Cited by 583
Are Reactive Oxygen Species Always Detrimental to Pathogens?
Paiva, C. N., & Bozza, M. T. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5447 · Cited by 577
Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly
Kollmann, T. R., Levy, O., Montgomery, R. R., & Goriely, S. (2012) · Immunity · doi:10.1016/j.immuni.2012.10.014 · Cited by 591
Linking oxidative stress to inflammation: Toll-like receptors
Gill, R., Tsung, A., & Billiar, T. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.006 · Cited by 553
Pathogenesis of influenza-induced acute respiratory distress syndrome
Short, K. R., Kroeze, E. J. B. V., Fouchier, R. A. M., & Kuiken, T. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70286-x · Cited by 556
Endogenous toll‐like receptor ligands and their biological significance
Yu, L., Wang, L., & Chen, S. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01127.x · Cited by 555
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice
Que, X., Hung, M.-Y., Yeang, C., Gonen, A., Prohaska, T. A., Sun, X., Diehl, C., Määttä, A., Gaddis, D. E., Bowden, K., et al. (2018) · Nature · doi:10.1038/s41586-018-0198-8 · Cited by 529
Self-citationInfluenza virus-related critical illness: pathophysiology and epidemiology
Kalil, A. C., & Thomas, P. G. (2019) · Critical Care · doi:10.1186/s13054-019-2539-x · Cited by 524
Endogenous ligands of TLR2 and TLR4: agonists or assistants?
Erridge, C. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1209775 · Cited by 532
Air Pollution and Type 2 Diabetes
Rajagopalan, S., & Brook, R. D. (2012) · Diabetes · doi:10.2337/db12-0190 · Cited by 527
Cytokine storm intervention in the early stages of COVID-19 pneumonia
Sun, X., Wang, T., Cai, D., Hu, Z., Chen, J., Liao, H., Zhi, L., Wei, H., Zhang, Z., Qiu, Y., et al. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.04.002 · Cited by 513
The many faces of the anti-COVID immune response
Vardhana, S. A., & Wolchok, J. D. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200678 · Cited by 513
Influenza virus-induced lung injury: pathogenesis and implications for treatment
Herold, S., Becker, C., Ridge, K. M., & Budinger, G. R. S. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186214 · Cited by 517
Saturated fatty acids trigger TLR4-mediated inflammatory response
Rocha, D. M., Caldas, A. P., Oliveira, L. L., Bressan, J., & Hermsdorff, H. H. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.11.015 · Cited by 492
Nox enzymes and new thinking on reactive oxygen: A double-edged sword revisited
Lambeth, J. D., & Neish, A. S. (2014) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104651 · Cited by 495
Lucas, K., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8425-7 · Cited by 466
Gehrke, N., Mertens, C., Zillinger, T., Wenzel, J., Bald, T., Zahn, S., Tüting, T., Hartmann, G., & Barchet, W. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.004 · Cited by 485
Oxidative stress and glutathione in TGF-β-mediated fibrogenesis
Liu, R.-M., & Pravia, K. A. G. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.026 · Cited by 473
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans
Chou, M.-Y., Fogelstrand, L., Hartvigsen, K., Hansen, L. F., Woelkers, D., Shaw, P. X., Choi, J., Perkmann, T., Bäckhed, F., Miller, Y. I., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36800 · Cited by 468
Self-citationSessile alveolar macrophages communicate with alveolar epithelium to modulate immunity
Westphalen, K., Gusarova, G. A., Islam, M. N., Subramanian, M., Cohen, T. S., Prince, A. S., & Bhattacharya, J. (2014) · Nature · doi:10.1038/nature12902 · Cited by 463
Pathogenesis of Acute Respiratory Distress Syndrome
Huppert, L. A., Matthay, M. A., & Ware, L. B. (2019) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0039-1683996 · Cited by 475
The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza
Morita, M., Kuba, K., Ichikawa, A., Nakayama, M., Katahira, J., Iwamoto, R., Watanebe, T., Sakabe, S., Daidoji, T., Nakamura, S., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.027 · Cited by 466
Self-citationTotura, A. L., Whitmore, A. C., Agnihothram, S., Schäfer, A., Katze, M. G., Heise, M. T., & Baric, R. S. (2015) · mBio · doi:10.1128/mbio.00638-15 · Cited by 487
Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
Bessac, B. F., & Jordt, S. (2008) · Physiology · doi:10.1152/physiol.00026.2008 · Cited by 430
The TLR4 antagonist Eritoran protects mice from lethal influenza infection
Shirey, K. A., Lai, W., Scott, A. J., Lipsky, M., Mistry, P., Pletneva, L. M., Karp, C. L., McAlees, J. W., Gioannini, T. L., Weiss, J. P., et al. (2013) · Nature · doi:10.1038/nature12118 · Cited by 426
Lv, H., Liu, Q., Wen, Z., Feng, H., Deng, X., & Ci, X. (2017) · Redox Biology · doi:10.1016/j.redox.2017.03.001 · Cited by 424
Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms
He, Y.-Q., Zhou, C., Yu, L., Wang, L., Deng, J.-L., Tao, Y., Zhang, F., & Chen, W. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105224 · Cited by 415
Oxidative stress pathways of air pollution mediated toxicity: Recent insights
Gangwar, R. S., Bevan, G. H., Palanivel, R., Das, L. M., & Rajagopalan, S. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101545 · Cited by 428
Wicherska‐Pawłowska, K., Wróbel, T., & Rybka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413397 · Cited by 451
Innate sensing of oxidation-specific epitopes in health and disease
Binder, C. J., Papac-Milicevic, N., & Witztum, J. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.63 · Cited by 403
Self-citationKellner, M., Noonepalle, S. K. R., Lü, Q., Srivastava, A., Zemskov, E. A., & Black, S. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_8 · Cited by 411
The role of oxidized phospholipids in atherosclerosis
Berliner, J. A., Leitinger, N., & Tsimikas, S. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800074-jlr200 · Cited by 404
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections
Zou, Z., Yan, Y., Shu, Y., Gao, R., Sun, Y., Li, X., Ju, X., Liang, Z., Liu, Q., Zhao, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms4594 · Cited by 397
Self-citationSARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression
Cecchini, R., & Cecchini, A. L. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110102 · Cited by 406
Detection of Viral Infections by Innate Immunity
Carty, M., Guy, C., & Bowie, A. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114316 · Cited by 427
Disease tolerance and immunity in host protection against infection
Soares, M. P., Teixeira, L., & Moita, L. F. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2016.136 · Cited by 376
Redox Biology of Respiratory Viral Infections
Khomich, O. A., Kochetkov, S. N., Bartosch, B., & Ivanov, A. V. (2018) · Viruses · doi:10.3390/v10080392 · Cited by 396
Oldham, J. M., Ma, S.-F., Martinez, F. J., Anstrom, K. J., Raghu, G., Schwartz, D. A., Valenzi, E., Witt, L., Lee, C., Vij, R., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201505-1010oc · Cited by 341
Baskin, C. R., Bielefeldt-Ohmann, H., Tumpey, T. M., Sabourin, P. J., Long, J. P., García-Sastre, A., Tolnay, A.-E., Albrecht, R., Pyles, J. A., Olson, P. H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813234106 · Cited by 361
Effect of Particulate Matter Air Pollution on Cardiovascular Oxidative Stress Pathways
Rao, X., Zhong, J., Brook, R. D., & Rajagopalan, S. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7394 · Cited by 368
Epidemiology and Immune Pathogenesis of Viral Sepsis
Lin, G.-L., McGinley, J. P., Drysdale, S. B., & Pollard, A. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02147 · Cited by 351
Kampfrath, T., Maiseyeu, A., Ying, Z., Shah, Z., Deiuliis, J. A., Xu, X., Kherada, N. I., Brook, R. D., Reddy, K. M., Padture, N. P., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.237560 · Cited by 362
Programming dendritic cells to induce TH2 and tolerogenic responses
Pulendran, B., Tang, H., & Manicassamy, S. (2010) · Nature Immunology · doi:10.1038/ni.1894 · Cited by 358
An overview of inflammation: mechanism and consequences
Ahmed, A. U. (2011) · Frontiers in Biology · doi:10.1007/s11515-011-1123-9 · Cited by 376
Critical Role of IL-17RA in Immunopathology of Influenza Infection
Crowe, C. R., Chen, K., Pociask, D. A., Alcorn, J. F., Krivich, C., Enelow, R. I., Ross, T. M., Witztum, J. L., & Kolls, J. K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900995 · Cited by 353
Aboudounya, M. M., & Heads, R. J. (2021) · Mediators of Inflammation · doi:10.1155/2021/8874339 · Cited by 359
Regulation and Repair of the Alveolar-Capillary Barrier in Acute Lung Injury
Bhattacharya, J., & Matthay, M. A. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183756 · Cited by 348
Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)?
Huertas, A., Montani, D., Savale, L., Pichon, J., Tu, L., Parent, F., Guignabert, C., & Humbert, M. J. C. (2020) · European Respiratory Journal · doi:10.1183/13993003.01634-2020 · Cited by 336
Oxidative Stress and Inflammation in Acute and Chronic Lung Injuries
Bezerra, F. S., Lanzetti, M., Nesi, R. T., Nagato, A. C., Silva, C. P. E., Kennedy-Feitosa, E., Melo, A. C., Cattani‐Cavalieri, I., Pôrto, L. C., & Valença, S. S. (2023) · Antioxidants · doi:10.3390/antiox12030548 · Cited by 373
Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity
Suurmond, J., & Diamond, B. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78084 · Cited by 335
Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates
Smits, S. L., de Lang, A., van den Brand, J. M. A., Leijten, L. M. E., van IJcken, W. F. J., Eijkemans, M. J. C., van Amerongen, G., Kuiken, T., Andeweg, A. C., Osterhaus, A. D. M. E., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000756 · Cited by 332
Inflammasome activation at the crux of severe COVID-19
Vora, S. M., Lieberman, J., & Wu, H. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00588-x · Cited by 332
Anka, A. U., Tahir, M. I., Abubakar, S. D., Alsabbagh, M. Y., Zian, Z., Hamedifar, H., Sabzevari, A., & Azizi, G. (2020) · Scandinavian Journal of Immunology · doi:10.1111/sji.12998 · Cited by 365
Particulate matter, air pollution, and blood pressure
Brook, R. D., & Rajagopalan, S. (2009) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2009.08.005 · Cited by 315
Tang, H., Cao, W., Kasturi, S. P., Ravindran, R., Nakaya, H. I., Kundu, K., Murthy, N., Kepler, T. B., MALISSEN, B., & Pulendran, B. (2010) · Nature Immunology · doi:10.1038/ni.1883 · Cited by 319
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Zahedipour, F., Hosseini, S. A., Sathyapalan, T., Majeed, M. A., Jamialahmadi, T., Al‐Rasadi, K., Banach, M., & Sahebkar, A. (2020) · Phytotherapy Research · doi:10.1002/ptr.6738 · Cited by 328
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Metadata
- Authors
- Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., Liu, H., Sun, Y., Pasparakis, M., Kopf, M., Mech, C., Bavari, S., Peiris, J. S. M., Slutsky, A. S., Akira, S., Hultqvist, M., Holmdahl, R., Nicholls, J., Jiang, C., Binder, C. J., & Penninger, J. M.
- Affiliations
- Institute of Molecular Biotechnology (AT)
- Austrian Academy of Sciences (AT)
- University of Cologne (DE)
- Western University (CA)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- United States Army Medical Research Institute of Infectious Diseases (US)
- St. Michael's Hospital (CA)
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- Karolinska Institutet (SE)
- University of Hong Kong (HK)
- Corresponding author
- Imai, Yumiko
- Penninger, Josef M.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 133
- Issue
- 2
- Pages
- 235-249
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC7112336
- OpenAlex
- W2156613610
- Cited by
- 1,356
- References
- 60
- Citations by year
- 2026: 34 · 2025: 53 · 2024: 56 · 2023: 76 · 2022: 105 · 2021: 143 · 2020: 152 · 2019: 47 · 2018: 69 · 2017: 64 · 2016: 80 · 2015: 65 · 2014: 82 · 2013: 68 · 2012: 53
- FWCI
- 29.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1933 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- University of Pittsburgh
- European Commission
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (100233)
- Defense Threat Reduction Agency
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- acute lung injury, TLR4, TRIF, TRAF6, oxidized phospholipids, OxPAPC, oxidative stress, reactive oxygen species, NCF1, lung macrophages, H5N1 avian influenza, SARS, anthrax, innate immunity, respiratory distress syndrome
- MeSH terms
- Animals, Humans, Influenza, Human, Lung, Mice, Inbred C57BL, Orthomyxoviridae Infections, Phospholipids, Respiratory Distress Syndrome, Signal Transduction, Interleukin-6, NF-kappa B, Oxidative Stress, NADPH Oxidases, Adaptor Proteins, Vesicular Transport, Severe Acute Respiratory Syndrome, Toll-Like Receptor 4, Mice
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