SnapShot: The Splicing Regulatory Machinery
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Canonical RBDs typically bind short single-stranded RNA sequences, but some also recognize structured RNAs.
“Canonical RBDs typically bind short, single-stranded (ss)RNA sequences3,4, but some also recognize structured RNAs5.”
From A compendium of RNA-binding motifs for decoding gene regulation (2013) · cites this paper as [4]
RBFOX1, RBFOX2, and RBFOX3 motifs are conserved in introns downstream of alternative exons, whereas PUM1 and PUM2 sites are most highly conserved in 3' UTRs.
“motifs for the alternative splicing factorsRBFOX1, RBFOX2 and RBFOX3 (ref. 4) are conserved in introns downstream of alternative exons, whereas sites for the stability/translation factors PUM1 and PUM2 are most highly conserved in 3′ UTRs24,25”
From A compendium of RNA-binding motifs for decoding gene regulation (2013) · cites this paper as [4]
Known splicing regulators, including RBFOX and PTB family members, were associated with preferential exon inclusion or exclusion in a manner correlated with the expression and binding location of the RBP.
“known splicing regulators, including RBFOX and PTB family members4, were associated with preferential exon inclusion or exclusion in a manner that correlated with the expression and binding location of the RBP”
From A compendium of RNA-binding motifs for decoding gene regulation (2013) · cites this paper as [4]
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- Authors
- Gabut, M., Chaudhry, S., & Blencowe, B. J.
- Affiliations
- University of Toronto (CA)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 133
- Issue
- 1
- Pages
- 192-192.e1
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2006616325
- Cited by
- 66
- References
- 15
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 3 · 2015: 5 · 2014: 3 · 2013: 7 · 2012: 7
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- alternative splicing, splicing regulators, RNA-binding proteins
- MeSH terms
- Animals, Humans, Gene Expression, RNA-Binding Proteins, Spliceosomes, Alternative Splicing, Mice
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