Cited by 2,452Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer and biochemical research

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Cancer Cell Metabolism: Warburg and Beyond

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Hsu, Peggy P., Sabatini, David M.·2008·Cell

DOI 10.1016/j.cell.2008.08.021

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Abstract

Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.

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“It is well established that AMP-kinase senses the AMP/ATP ratio (reviewed in Hardie, 2007), whereas mTOR (the mammalian target of rapamycin) senses cellular amino acid concentrations (Kim et al., 2008; Sancak et al., 2008).”
BackgroundSelf-citation
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
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BackgroundInfluential

Authors: Hsu, P. P., & Sabatini, D. M.
Affiliations: Broad Institute (US)
Corresponding author: Sabatini, David M.
ORCID: Hsu, Peggy P.
Sabatini, David M.
Venue: Cell
Publisher: Elsevier BV
Published: 2008-09
Volume: 134
Issue: 5
Pages: 703-707
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2008.08.021
OpenAlex: W2022101765
Semantic Scholar: eb48a9ee1047d39abd15070d0ffa0430d74d5d8a
Cited by: 2,452
References: 41
Citations by year: 2026: 62 · 2025: 113 · 2024: 162 · 2023: 153 · 2022: 191 · 2021: 160 · 2020: 232 · 2019: 160 · 2018: 147 · 2017: 166 · 2016: 151 · 2015: 141 · 2014: 148 · 2013: 121 · 2012: 119
FWCI: 25.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1780 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA129105)
National Institute of General Medical Sciences (T32GM007753)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: cancer metabolism, Warburg effect, aerobic glycolysis, metabolic reprogramming
MeSH terms: Animals, Energy Metabolism, Glycolysis, Humans, Neoplasms, Cell Respiration, Biosynthetic Pathways

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Cancer Cell Metabolism: Warburg and Beyond

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