The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair
Open accessAbstract
Summary DNA interstrand cross-links (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a novel cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, two replication forks converge on the cross-link. Subsequent lesion bypass involves advance of a nascent leading strand to within one nucleotide of the ICL, followed by incisions, translesion DNA synthesis, and extension of the nascent strand beyond the lesion. Immunodepletion experiments suggest that extension requires DNA polymeras ζ Ultimately, a significant portion of the input DNA is fully repaired, but not if DNA replication is blocked. Repair in this system is accompanied by activation of the Fanconi anemia and ATR checkpoint pathways. Our experiments establish a mechanism for ICL repair that reveals how this process is coupled to DNA replication.
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Byun, T. S., Pacek, M., Yee, M.-C., Walter, J. C., & Cimprich, K. A. (2005) · Genes & Development · doi:10.1101/gad.1301205 · Cited by 767
Self-citationEmergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins
Wang, W. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2159 · Cited by 663
Dormant origins licensed by excess Mcm2–7 are required for human cells to survive replicative stress
Ge, X. Q., Jackson, D. A., & Blow, J. J. (2007) · Genes & Development · doi:10.1101/gad.457807 · Cited by 604
Repair of DNA interstrand cross-links
Dronkert, M. L. G., & Kanaar, R. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(01)00092-1 · Cited by 555
Niedernhofer, L. J., Odijk, H., Budzowska, M., van Drunen, E., Maas, A., Theil, A. F., de Wit, J., Jaspers, N. G. J., Beverloo, H. B., Hoeijmakers, J. H. J., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5776-5787.2004 · Cited by 492
S-phase–specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51
Taniguchi, T., Garcia-Higuera, I., Andreassen, P. R., Gregory, R. C., Grompe, M., & D'Andrea, A. D. (2002) · Blood · doi:10.1182/blood-2002-01-0278 · Cited by 461
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Initiation of Eukaryotic DNA Replication
Walter, J., & Newport, J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80241-5 · Cited by 425
Self-citationTranslesion synthesis: Y-family polymerases and the polymerase switch
LEHMANN, A., NIIMI, A., OGI, T., BROWN, S., SABBIONEDA, S., WING, J., KANNOUCHE, P., & GREEN, C. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.02.003 · Cited by 389
Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance
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Cited by
Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239
Mechanisms of DNA damage, repair, and mutagenesis
Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039
DNA double-strand break repair-pathway choice in somatic mammalian cells
Scully, R., Panday, A., Elango, R., & Willis, N. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0152-0 · Cited by 1,457
Maintaining genome stability at the replication fork
Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway
Kim, H., & D'Andrea, A. D. (2012) · Genes & Development · doi:10.1101/gad.195248.112 · Cited by 508
Metadata
- Authors
- Räschle, M., Knipscheer, P., Enoiu, M., Angelov, T., Sun, J., Griffith, J. D., Ellenberger, T. E., Schärer, O. D., & Walter, J. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 134
- Issue
- 6
- Pages
- 969-980
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2034100797
- Cited by
- 511
- References
- 34
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Räschle, M., Knipscheer, P., Enoiu, M., Angelov, T., Sun, J., Griffith, J. D., Ellenberger, T. E., Schärer, O. D., & Walter, J. C. (2008). Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair. Cell. https://doi.org/10.1016/j.cell.2008.08.030
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