The DOI matches its Crossref record; 184 of the 184 references it cites were found in a registry or an index.
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway
Open accessAbstract
The maintenance of genome stability is critical for survival, and its failure is often associated with tumorigenesis. The Fanconi anemia (FA) pathway is essential for the repair of DNA interstrand cross-links (ICLs), and a germline defect in the pathway results in FA, a cancer predisposition syndrome driven by genome instability. Central to this pathway is the monoubiquitination of FANCD2, which coordinates multiple DNA repair activities required for the resolution of ICLs. Recent studies have demonstrated how the FA pathway coordinates three critical DNA repair processes, including nucleolytic incision, translesion DNA synthesis (TLS), and homologous recombination (HR). Here, we review recent advances in our understanding of the downstream ICL repair steps initiated by ubiquitin-mediated FA pathway activation.
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Metadata
- Authors
- Kim, H., & D'Andrea, A. D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-07-01
- Volume
- 26
- Issue
- 13
- Pages
- 1393-1408
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2134071049
- Cited by
- 508
- References
- 184
- Type
- posted content
- Language
- en
- Open access
- diamond
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