The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
GTPase Cycle of Dynamin Is Coupled to Membrane Squeeze and Release, Leading to Spontaneous Fission
Open accessAbstract
SUMMARY The GTPase dynamin is critically involved in membrane fission during endocytosis. How does dynamin use the energy of GTP hydrolysis for membrane remodeling? By monitoring the ionic permeability through lipid nanotubes (NT) interacting with dynamin and GTP we detected cyclic localized squeezing and relaxation of NT, ultimately yielding leak-free fission stochastically. Our calculations revealed that critical local narrowing of NT induces cooperative lipid tilting, leading to self-merger of the inner monolayer of NT (hemi-fission), consistent with the absence of leakage. We found that dynamin pre-assembled on NT without GTP produces stable curvature which, depending upon lipid composition, approaches the hemi-fission threshold. GTP addition causes gradual disassembly of dynamin, triggering either spontaneous fission or curvature relaxation. We propose that dynamin transmits GTP’s energy to periodic curvature stress caused by an assembly of a limited curvature scaffold, which next relaxes and rewinds to its initial state upon cooperative GTP hydrolysis.
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Citations
Cites
Regulated portals of entry into the cell
Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,805
Self-citationThe dynamin superfamily: universal membrane tubulation and fission molecules?
Praefcke, G. J. K., & McMahon, H. T. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1313 · Cited by 1,377
Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding
Hinshaw, J. E., & Schmid, S. L. (1995) · Nature · doi:10.1038/374190a0 · Cited by 823
Self-citationProtein-Lipid Interplay in Fusion and Fission of Biological Membranes
Chernomordik, L. V., & Kozlov, M. M. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161504 · Cited by 782
Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals
Takei, K., McPherson, P. S., Schmid, S. L., & Camilli, P. D. (1995) · Nature · doi:10.1038/374186a0 · Cited by 767
Self-citationDynamin and Its Role in Membrane Fission
Hinshaw, J. E. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.483 · Cited by 699
Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation
Sweitzer, S. M., & Hinshaw, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81207-6 · Cited by 680
Mechanism of endophilin N‐BAR domain‐mediated membrane curvature
Gallop, J. L., Jao, C. C., Kent, H. M., Butler, P. J. G., Evans, P. R., Langen, R., & McMahon, H. T. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601174 · Cited by 617
Accessory factors in clathrin-dependent synaptic vesicle endocytosis
Slepnev, V. I., & De Camilli, P. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044540 · Cited by 517
GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission
Roux, A., Uyhazi, K., Frost, A., & De Camilli, P. (2006) · Nature · doi:10.1038/nature04718 · Cited by 490
Cited by
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
McMahon, H. T., & Boucrot, E. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3151 · Cited by 2,223
Mechanisms of clathrin-mediated endocytosis
Kaksonen, M., & Roux, A. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.132 · Cited by 1,698
Dynamin, a membrane-remodelling GTPase
Ferguson, S. M., & De Camilli, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3266 · Cited by 992
A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis
Taylor, M. J., Perrais, D., & Merrifield, C. J. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000604 · Cited by 754
Endocytosis unplugged: Multiple ways to enter the cell
Kumari, S., MG, S., & Mayor, S. (2010) · Cell Research · doi:10.1038/cr.2010.19 · Cited by 599
Metadata
- Authors
- Bashkirov, P. V., Akimov, S. A., Evseev, A. I., Schmid, S. L., Zimmerberg, J., & Frolov, V. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 135
- Issue
- 7
- Pages
- 1276-1286
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2063414626
- Cited by
- 305
- References
- 38
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bashkirov, P. V., Akimov, S. A., Evseev, A. I., Schmid, S. L., Zimmerberg, J., & Frolov, V. A. (2008). GTPase Cycle of Dynamin Is Coupled to Membrane Squeeze and Release, Leading to Spontaneous Fission. Cell. https://doi.org/10.1016/j.cell.2008.11.028
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