The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
A C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory
Open accessAbstract
Recently it has been proposed that di-methylation of histone H3 on lysine 4 (H3K4me2) acts as an epigenetic memory to maintain transcriptional patterns in developing tissues. This model suggests that there may be a requirement to reprogram this modification in the germline to prevent transcriptional memory from being inappropriately transmitted to the next generation. We asked if SPR-5, the C. elegans ortholog of the H3K4me2 demethylase LSD1/KDM1, plays a role in epigenetically reprogramming H3K4me2. We show that spr-5 mutants exhibit progressive sterility over many generations due to defects in oogenesis and spermatogenesis. These defects correlate with a progressive failure to erase H3K4me2 in the primordial germ cells, resulting in the misregulation of spermatogenesis-expressed genes due to the transgenerational accumulation of H3K4me2 at these loci. These results suggest that H3K4me2 can serve as an epigenetic memory and that LSD1/KDM1 demethylases play a critical role in the reprogramming of this memory in the germline, preventing inappropriate epigenetic information from being propagated from one generation to the next.
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Cited by
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piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans
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Metadata
- Authors
- Katz, D. J., Edwards, T. M., Reinke, V., & Kelly, W. G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 137
- Issue
- 2
- Pages
- 308-320
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2091232875
- Cited by
- 344
- References
- 42
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Katz, D. J., Edwards, T. M., Reinke, V., & Kelly, W. G. (2009). A C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory. Cell. https://doi.org/10.1016/j.cell.2009.02.015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
