The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration
Open accessAbstract
Growth cone guidance and synaptic plasticity involve dynamic local changes in proteins at axons and dendrites. The Dual Leucine zipper MAPKKK (DLK) has been previously implicated in synaptogenesis and axon outgrowth in C. elegans and other animals. Here we show that in C. elegans DLK-1 regulates not only proper synapse formation and axon morphology, but also axon regeneration, by influencing mRNA stability. DLK-1 kinase signals via a MAPKAP kinase, MAK-2, to stabilize the mRNA encoding CEBP-1, a bZip protein related to CCAAT/enhancer binding proteins, via its 3′ UTR. Inappropriate upregulation of cebp-1 in adult neurons disrupts synapses and axon morphology. CEBP-1 and the DLK-1 pathway are essential for axon regeneration after laser axotomy in adult neurons, and that axotomy induces translation of CEBP-1 in axons. Our findings identify the DLK-1 pathway as a regulator of mRNA stability in synapse formation and maintenance and also in adult axon regeneration.
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Cites
Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127
RIBEYE, a Component of Synaptic Ribbons
Schmitz, F., Königstorfer, A., & Südhof, T. C. (2000) · Neuron · doi:10.1016/s0896-6273(00)00159-8 · Cited by 581
MAPKAP kinases — MKs — two's company, three's a crowd
Gaestel, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1834 · Cited by 413
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Huang, Y.-W. A., Zhou, B., Wernig, M., & Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2016.12.044 · Cited by 528
Neuronal Intrinsic Mechanisms of Axon Regeneration
Liu, K., Tedeschi, A., Park, K. K., & He, Z. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113723 · Cited by 458
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Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
A toolkit for GFP-mediated tissue-specific protein degradation in C. elegans
Wang, S., Tang, N. H., Lara-Gonzalez, P., Zhao, Z., Cheerambathur, D. K., Prevo, B., Chisholm, A. D., Desai, A., & Oegema, K. (2017) · Development · doi:10.1242/dev.150094 · Cited by 119
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Hamilton, A. M., & Zito, K. (2013) · Neural Plasticity · doi:10.1155/2013/196848 · Cited by 110
Metadata
- Authors
- Yan, D., Wu, Z., Chisholm, A. D., & Jin, Y.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 138
- Issue
- 5
- Pages
- 1005-1018
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2114638395
- Cited by
- 352
- References
- 3
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yan, D., Wu, Z., Chisholm, A. D., & Jin, Y. (2009). The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration. Cell. https://doi.org/10.1016/j.cell.2009.06.023
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