The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair
Open accessAbstract
Summary Structure-specific endonucleases mediate repair of DNA structures formed from replication fork collapse or during double-strand break (DSB) repair. Here we identify BTBD12 as the human ortholog of the budding yeast DNA repair factor Slx4p and D. melanogaster MUS312. Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. Depletion of SLX4 causes sensitivity to mitomycin C and camptothecin, and reduces the efficiency of DSB repair in vivo. SLX4 complexes cleave 3’-flap, 5’-flap and replication fork structures; yet unlike other endonucleases associated with SLX4, the SLX1-SLX4 module promotes symmetrical cleavage of static and migrating Holliday junctions (HJs), identifying SLX1-SLX4 as a HJ resolvase. Thus, SLX4 assembles a modular tool-kit for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure.
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Metadata
- Authors
- Svendsen, J. M., Smogorzewska, A., Sowa, M. E., O'Connell, B. C., Gygi, S. P., Elledge, S. J., & Harper, J. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 138
- Issue
- 1
- Pages
- 63-77
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2079185082
- Cited by
- 450
- References
- 33
- FWCI
- 15.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Svendsen, J. M., Smogorzewska, A., Sowa, M. E., O'Connell, B. C., Gygi, S. P., Elledge, S. J., & Harper, J. W. (2009). Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair. Cell. https://doi.org/10.1016/j.cell.2009.06.030
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