Cellular and Molecular Mechanisms of Pain

Pain mechanisms: a new theory.

Melzack, R., & Wall, P. D. (1965) · Science · doi:10.1126/science.150.3699.971 · Cited by 11,108

The capsaicin receptor: a heat-activated ion channel in the pain pathway

Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132

Central sensitization: a generator of pain hypersensitivity by central neural plasticity

Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544

Human brain mechanisms of pain perception and regulation in health and disease

Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126

The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli

Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,086

Pain mechanisms: A new theory

Melzack, R., & Wall, P. D. (1996) · Pain Forum · doi:10.1016/s1082-3174(96)80062-6 · Cited by 2,786

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

McKemy, D. D., Neuhausser, W., & Julius, D. J. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,716

Molecular mechanisms of nociception

Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685 · cited 1×

ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures

Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,494

A TRP Channel that Senses Cold Stimuli and Menthol

Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,361

Neurotrophins and their receptors: A convergence point for many signalling pathways

Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298

Evidence for a central component of post-injury pain hypersensitivity

Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965

TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents

Bautista, D. M., Jordt, S. E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.023 · Cited by 1,921

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

Jordt, S., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. J. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,896

Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin

Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., & Patapoutian, A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00150-3 · Cited by 1,822

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

Davis, J. B., Gray, J., Gunthorpe, M. J., Hatcher, J. P., Davey, P. T., Overend, P., Harries, M. H., Latcham, J., Clapham, C. M., Atkinson, K., et al. (2000) · Nature · doi:10.1038/35012076 · Cited by 1,759

An SCN9A channelopathy causes congenital inability to experience pain

Cox, J. J., Reimann, F. M., Nicholas, A. K., Thornton, G., Roberts, E., Springell, K., Karbani, G., Jafri, H., Mannan, J., Raashid, Y., et al. (2006) · Nature · doi:10.1038/nature05413 · Cited by 1,605

A capsaicin-receptor homologue with a high threshold for noxious heat

Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. J. (1999) · Nature · doi:10.1038/18906 · Cited by 1,599

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

Tsuda, M., Shigemoto‐Mogami, Y., Koizumi, S., Mizokoshi, A., Kohsaka, S., Salter, M. W., & Inoue, K. (2003) · Nature · doi:10.1038/nature01786 · Cited by 1,567

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D. (2006) · Nature Neuroscience · doi:10.1038/nn1805 · Cited by 1,542

The menthol receptor TRPM8 is the principal detector of environmental cold

Bautista, D. M., Siemens, J., Glazer, J. M., Tsuruda, P. R., Basbaum, A. I., Stucky, C. L., Jordt, S. E., & Julius, D. J. (2007) · Nature · doi:10.1038/nature05910 · Cited by 1,392

Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor

Liedtke, W., Choe, Y., Martı́-Renom, M. A., Bell, A. M., Denis, C. S., AndrejŠali, Hudspeth, A. J., Friedman, J. M., & Heller, S. (2000) · Cell · doi:10.1016/s0092-8674(00)00143-4 · Cited by 1,391

TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction

Kwan, K. Y., Allchorne, A. J., Vollrath, M. A., Christensen, A. P., Zhang, D.-S., Woolf, C. J., & Corey, D. P. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.042 · Cited by 1,267

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

Chuang, H.-H., Prescott, E. D., Kong, H., Shields, S. D., Jordt, S. E., Basbaum, A. I., Chao, M. V., & Julius, D. J. (2001) · Nature · doi:10.1038/35082088 · Cited by 1,257

p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia

Ji, R., Samad, T. A., Jin, S., Schmoll, R., & Woolf, C. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00908-x · Cited by 1,239

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F., & Patapoutian, A. (2007) · Nature · doi:10.1038/nature05544 · Cited by 1,134

Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain

Coull, J. A. M., Boudreau, D., Bachand, K., Prescott, S. A., Nault, F., Attila Gabor, S. I. K., Koninck, P. D., & Koninck, Y. D. (2003) · Nature · doi:10.1038/nature01868 · Cited by 1,118

Heat-Evoked Activation of the Ion Channel, TRPV4

Güler, A. D., Lee, H., Iida, T., Shimizu, I., Tominaga, M., & Caterina, M. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06408.2002 · Cited by 1,033

OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

Strotmann, R., Harteneck, C., Nunnenmacher, K., Schultz, G., & Plant, T. D. (2000) · Nature Cell Biology · doi:10.1038/35036318 · Cited by 1,023

Wall and Melzack's Textbook of Pain

McMahon, S. B., & Koltzenburg, M. (2005) · Cited by 1,014

Chronic pain and medullary descending facilitation

Porreca, F. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02157-4 · Cited by 1,007

Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

Chen, L., & Huang, L.-Y. M. (1992) · Nature · doi:10.1038/356521a0 · Cited by 974

A Heat-Sensitive TRP Channel Expressed in Keratinocytes

Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M., Colley, S., Hogenesch, J. B., McIntyre, P., et al. (2002) · Science · doi:10.1126/science.1073140 · Cited by 968

TRPM8 Is Required for Cold Sensation in Mice

Dhaka, A. K., Murray, A. N., Mathur, J., Earley, T. J., Petrus, M. J., & Patapoutian, A. (2007) · Neuron · doi:10.1016/j.neuron.2007.02.024 · Cited by 934

TRP channel activation by reversible covalent modification

Hinman, A., Chuang, H.-H., Bautista, D. M., & Julius, D. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609598103 · Cited by 896

Mechanisms of sensory transduction in the skin

Lumpkin, E. A., & Caterina, M. J. (2007) · Nature · doi:10.1038/nature05662 · Cited by 860

Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord

Moore, K. A., Kohno, T., Karchewski, L. A., Scholz, J., Baba, H., & Woolf, C. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06724.2002 · Cited by 859

Tackling Pain at the Source: New Ideas about Nociceptors

Snider, W. D., & McMahon, S. B. (1998) · Neuron · doi:10.1016/s0896-6273(00)81003-x · Cited by 853

The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

Akopian, A. N., Souslova, V., England, S. G., Okuse, K., Ogata, N., Ure, J. M., Smith, A., Kerr, B. J., McMahon, S. B., Boyce, S., et al. (1999) · Nature Neuroscience · doi:10.1038/9195 · Cited by 828

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Chessell, I. P., Hatcher, J. P., Bountra, C., Michel, A. D., Hughes, J. P., Green, P., Egerton, J., Murfin, M., Richardson, J. C., Peck, W. L., et al. (2005) · Pain · doi:10.1016/j.pain.2005.01.002 · Cited by 807

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

Yang, Y., Wang, Y., Li, S., Xu, Z., Li, H., Ma, L., Fan, J., Bu, D., Liu, B., Fan, Z., et al. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.012153 · Cited by 800

Abnormal osmotic regulation in trpv4 -/- mice

Liedtke, W., & Friedman, J. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735416100 · Cited by 798

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Trevisani, M., Siemens, J., Materazzi, S., Bautista, D. M., Nassini, R., Campi, B., Imamachi, N., Andrè, E., Patacchini, R., Cottrell, G. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705923104 · Cited by 775

Attenuated Cold Sensitivity in TRPM8 Null Mice

Colburn, R. W., Lubin, M. L., Stone, D. J., Wang, Y., Lawrence, D., D’Andrea, M. R., Brandt, M. R., Liu, Y., Flores, C. M., & Qin, N. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.017 · Cited by 772

SCN9A Mutations in Paroxysmal Extreme Pain Disorder: Allelic Variants Underlie Distinct Channel Defects and Phenotypes

Fertleman, C. R., Baker, M. D., Parker, K. A., Moffatt, S. L., Elmslie, F., Abrahamsen, B., Östman, J., Klugbauer, N., Wood, J. N., Gardiner, R. M., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.006 · Cited by 765

A Diverse Family of GPCRs Expressed in Specific Subsets of Nociceptive Sensory Neurons

Dong, X., Han, S.-K., Zylka, M. J., Simon, M. I., & Anderson, D. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00483-4 · Cited by 762

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

Andersson, D. A., Gentry, C., Moss, S., & Bevan, S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5369-07.2008 · Cited by 739

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

Cavanaugh, D. J., Lee, H., Lo, L., Shields, S. D., Zylka, M. J., Basbaum, A. I., & Anderson, D. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901507106 · Cited by 706

Nociceptor-specific gene deletion reveals a major role for Na v 1.7 (PN1) in acute and inflammatory pain

Nassar, M. A., Stirling, L. C., Forlani, G., Baker, M. D., Matthews, E. A., Dickenson, A. H., & Wood, J. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404915101 · Cited by 695

Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ

Malmberg, A. B., Chen, C., Tonegawa, S., & Basbaum, A. I. (1997) · Science · doi:10.1126/science.278.5336.279 · Cited by 690

Neural KCNQ (Kv7) channels

Brown, D. A., & Passmore, G. M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00111.x · Cited by 676

Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists

Yaksh, T. L. (1989) · Pain · doi:10.1016/0304-3959(89)90160-7 · Cited by 673

Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing

Nagata, K., Duggan, A., Kumar, G., & Garcı́a-Añoveros, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0013-05.2005 · Cited by 646

The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy

Tanga, F. Y., Nutile-McMenemy, N., & DeLeo, J. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501634102 · Cited by 634

GlyR α3: An Essential Target for Spinal PGE 2 -Mediated Inflammatory Pain Sensitization

Harvey, R. J., Depner, U. B., Wässle, H., Ahmadi, S., Heindl, C., Reinold, H., Smart, T. G., Harvey, K., Schütz, B., Abo‐Salem, O. M., et al. (2004) · Science · doi:10.1126/science.1094925 · Cited by 623

Upregulation of Dorsal Root Ganglion α 2 δ Calcium Channel Subunit and Its Correlation with Allodynia in Spinal Nerve-Injured Rats

Luo, Z. D., Chaplan, S. R., Higuera, E. S., Sorkin, L. S., Stauderman, K. A., Williams, M. E., & Yaksh, T. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01868.2001 · Cited by 616

The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice

Price, M. P., McIlwrath, S. L., Xie, J., Cheng, C., Qiao, J., Tarr, D. E. K., Sluka, K. A., Brennan, T. J., Lewin, G. R., & Welsh, M. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00547-5 · Cited by 604

TRPA1 acts as a cold sensor in vitro and in vivo

Karashima, Y., Talavera, K., Everaerts, W., Janssens, A., Kwan, K. Y., Vennekens, R., Nilius, B., & Voets, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808487106 · Cited by 588

Up-Regulation of P2X 4 Receptors in Spinal Microglia after Peripheral Nerve Injury Mediates BDNF Release and Neuropathic Pain

Ulmann, L., Hatcher, J. P., Hughes, J. P., Chaumont‐Dubel, S., Green, P. J., Conquet, F., Buell, G. N., Reeve, A. J., Chessell, I. P., & Rassendren, F. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2308-08.2008 · Cited by 572

Myelinated afferents signal the hyperalgesia associated with nerve injury

Campbell, J. N., Raja, S. N., Meyer, R. A., & Mackinnon, S. E. (1988) · Pain · doi:10.1016/0304-3959(88)90027-9 · Cited by 562

The receptors and coding logic for bitter taste

Mueller, K. L., Hoon, M. A., Erlenbach, I., Chandrashekar, J., Zuker, C. S., & Ryba, N. J. P. (2005) · Nature · doi:10.1038/nature03352 · Cited by 524

Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1

Karashima, Y., Damann, N., Prenen, J., Talavera, K., Segal, A., Voets, T., & Nilius, B. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2221-07.2007 · Cited by 521

TRPV2 Is a Component of Osmotically Sensitive Cation Channels in Murine Aortic Myocytes

Muraki, K., Iwata, Y., Katanosaka, Y., Ito, T., Ohya, S., Shigekawa, M., & Imaizumi, Y. (2003) · Circulation Research · doi:10.1161/01.res.0000097263.10220.0c · Cited by 520

The mammalian sodium channel BNC1 is required for normal touch sensation

Price, M. P., Lewin, G. R., McIlwrath, S. L., Cheng, C., Xie, J., Heppenstall, P. A., Stucky, C. L., Mannsfeldt, A. G., Brennan, T. J., Drummond, H. A., et al. (2000) · Nature · doi:10.1038/35039512 · Cited by 508

Novel classes of responsive and unresponsive C nociceptors in human skin

Schmidt, R., Schmelz, M., Forster, C., Ringkamp, M., Torebjörk, E. H., & Handwerker, H. O. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00333.1995 · Cited by 504

Direct activation of the ion channel TRPA1 by Ca2+

Zurborg, S., Yurgionas, B., Jira, J. A., Caspani, O., & Heppenstall, P. A. (2007) · Nature Neuroscience · doi:10.1038/nn1843 · Cited by 500

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

Clark, A. K., Yip, P. K., Grist, J., Gentry, C., Staniland, A. A., Marchand, F., Dehvari, M., Wotherspoon, G., Winter, J., Ullah, J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610811104 · Cited by 491

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

Abrahamsen, B., Zhao, J., Asante, C. O., Cendán, C. M., Marsh, S., Martı́nez-Barberá, J. P., Nassar, M. A., Dickenson, A. H., & Wood, J. N. (2008) · Science · doi:10.1126/science.1156916 · Cited by 483

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

Caceres, A. I., Brackmann, M., Elia, M., Bessac, B. F., del Camino, D., D’Amours, M., Witek, J. S., Fanger, C. M., Chong, J. A., Hayward, N. J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900591106 · Cited by 476

The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord

Sivilotti, L., & Woolf, C. J. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.1.169 · Cited by 468

Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain

Scherrer, G., Imamachi, N., Cao, Y. Q., Contet, C., Mennicken, F., O’Donnell, D., Kieffer, B. L., & Basbaum, A. I. (2009) · Cell · doi:10.1016/j.cell.2009.04.019 · Cited by 463

Transmission of Chronic Nociception by Spinal Neurons Expressing the Substance P Receptor

Nichols, M. L., Allen, B. J., Rogers, S. D., Ghilardi, J. R., Honoré, P., Luger, N. M., Finke, M. P., Li, J., Lappi, D. A., Simone, D. A., et al. (1999) · Science · doi:10.1126/science.286.5444.1558 · Cited by 445

Reversal of pathological pain through specific spinal GABAA receptor subtypes

Knabl, J., Witschi, R., Hösl, K., Reinold, H., Zeilhofer, U. B., Ahmadi, S., Brockhaus, J., Sergejeva, M., Hess, A., Brune, K., et al. (2008) · Nature · doi:10.1038/nature06493 · Cited by 438

A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin

Cesare, P., & McNaughton, P. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15435 · Cited by 433

A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat

Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Hsieh, G. C., Zhu, C., Mikusa, J. P., Hernandez, G., Zhong, C., Gauvin, D. M., Chandran, P., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111559 · Cited by 433

Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control

Bessac, B. F., & Jordt, S. (2008) · Physiology · doi:10.1152/physiol.00026.2008 · Cited by 430

A Role of TRPA1 in Mechanical Hyperalgesia is Revealed by Pharmacological Inhibition

Petrus, M. J., Peier, A. M., Bandell, M., Hwang, S. W., Huynh, T. T., Olney, N. T., Jegla, T. J., & Patapoutian, A. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-40 · Cited by 422

Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures

Zimmermann, K., Leffler, A., Babeș, A., Cendán, C. M., Carr, R. W., Kobayashi, J.-I., Nau, C., Wood, J. N., & Reeh, P. W. (2007) · Nature · doi:10.1038/nature05880 · Cited by 420

The mechano‐activated K+ channels TRAAK and TREK‐1 control both warm and cold perception

Noël, J., Zimmermann, K., Busserolles, J., Deval, E., Alloui, A., Diochot, S., Guy, N., Borsotto, M., Reeh, P. W., Eschalier, A., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.57 · Cited by 412

Disinhibition Opens the Gate to Pathological Pain Signaling in Superficial Neurokinin 1 Receptor-Expressing Neurons in Rat Spinal Cord

Torsney, C., & MacDermott, A. B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4584-05.2006 · Cited by 407

Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

Grant, A. D., Cottrell, G. S., Amadesi, S., Trevisani, M., Nicoletti, P., Materazzi, S., Altier, C., Cénac, N., Zamponi, G. W., Bautista‐Cruz, F., et al. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.121111 · Cited by 393

Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons

Immke, D. C., & McCleskey, E. W. (2001) · Nature Neuroscience · doi:10.1038/nn0901-869 · Cited by 386

Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions

Verge, G. M., Milligan, E. D., Maier, S. F., Watkins, L. R., Naeve, G. S., & Foster, A. C. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03593.x · Cited by 386

Ionotropic and Metabotropic Receptors, Protein Kinase A, Protein Kinase C, and Src Contribute to C-Fiber-Induced ERK Activation and cAMP Response Element-Binding Protein Phosphorylation in Dorsal Horn Neurons, Leading to Central Sensitization

Kawasaki, Y., Kohno, T., Zhuang, Z.-Y., Brenner, G. J., Wang, H., Meer, C. V. D., Befort, K., Woolf, C. J., & Ji, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2396-04.2004 · Cited by 386

Neurosensory mechanotransduction

Chalfie, M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2595 · Cited by 385

Novel class of pain drugs based on antagonism of NGF

Hefti, F. F., Rosenthal, A., Walicke, P. A., Wyatt, S. L., Vergara, G., Shelton, D. L., & Davies, A. M. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.12.001 · Cited by 380

Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine

Zhuang, Z.-Y., Kawasaki, Y., Tan, P.-H., Wen, Y.-R., Huang, J., & Ji, R.-R. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.11.003 · Cited by 371

Functional biology of the α2δ subunits of voltage-gated calcium channels

Davies, A., Hendrich, J., Tran-Van-Minh, A., Wratten, J., Douglas, L. R., & DOLPHIN, A. C. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.03.005 · Cited by 359

The Perception of Pain

Melzack, R. (1961) · Scientific American · doi:10.1038/scientificamerican0261-41 · Cited by 355

Specificity of cold thermotransduction is determined by differential ionic channel expression

Viana, F., de la Peña, E., & Belmonte, C. (2002) · Nature Neuroscience · doi:10.1038/nn809 · Cited by 343

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

Gevaert, T., Vriens, J., Segal, A., Everaerts, W., Roskams, T., Talavera, K., Owsianik, G., Liedtke, W., Daelemans, D., Dewachter, I., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31766 · Cited by 331

Peripheral mechanisms of cutaneous nociception

Meyer, R. A., Ringkamp, M., Campbell, J. N., & Raja, S. N. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50006-0 · Cited by 324

TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons

Kwan, K. Y., Glazer, J. M., Corey, D. P., Rice, F. L., & Stucky, C. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5380-08.2009 · Cited by 322

A Critical Role of Toll-like Receptor 2 in Nerve Injury-induced Spinal Cord Glial Cell Activation and Pain Hypersensitivity

Kim, D., Kim, M. A., Cho, I., Kim, M. S., Lee, S., Jo, E., Choi, S., Park, K., Kim, J. S., Akira, S., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607277200 · Cited by 315

Parallel “Pain” Pathways Arise from Subpopulations of Primary Afferent Nociceptor

Braz, J. M., Nassar, M. A., Wood, J. N., & Basbaum, A. I. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.015 · Cited by 309

Warm Temperatures Activate TRPV4 in Mouse 308 Keratinocytes

Chung, M., Lee, H., & Caterina, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303251200 · Cited by 297

The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+ Influx and ATP Release in Primary Urothelial Cell Cultures

Mochizuki, T., Sokabe, T., Araki, I., Fujishita, K., Shibasaki, K., Uchida, K., Naruse, K., Koizumi, S., Takeda, M., & Tominaga, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020206 · Cited by 292

Molecular genetics of migraine

de Vries, B., Frants, R. R., Ferrari, M. D., & van den Maagdenberg, A. M. J. M. (2009) · Human Genetics · doi:10.1007/s00439-009-0684-z · Cited by 292

Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats

Milligan, E. D., Zapata, V., Chacur, M., Schoeniger, D., Biedenkapp, J. C., O’Connor, K., Verge, G. M., Chapman, G. A., Green, P., Foster, A. C., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03709.x · Cited by 289

Spinal GABAAand GABABReceptor Pharmacology in a Rat Model of Neuropathic Pain

Malan, T. P., Mata, H. P., & Porreca, F. (2002) · Anesthesiology · doi:10.1097/00000542-200205000-00020 · Cited by 287

P2Y12Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury

Tozaki‐Saitoh, H., Tsuda, M., Miyata, H., Ueda, K., Kohsaka, S., & Inoue, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0323-08.2008 · Cited by 279

P2Y12Receptor Upregulation in Activated Microglia Is a Gateway of p38 Signaling and Neuropathic Pain

Kobayashi, K., Yamanaka, H., Fukuoka, T., Dai, Y., Obata, K., & Noguchi, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5589-07.2008 · Cited by 275

Nociceptors Lacking TRPV1 and TRPV2 Have Normal Heat Responses

Woodbury, C. J., Zwick, M., Wang, S., Lawson, J. J., Caterina, M. J., Koltzenburg, M., Albers, K. M., Koerber, H. R., & Davis, B. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1421-04.2004 · Cited by 272

Neuron–glia crosstalk gets serious: role in pain hypersensitivity

Ren, K., & Dubner, R. A. (2008) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32830edbdf · Cited by 271

TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP

Mandadi, S., Sokabe, T., Shibasaki, K., Katanosaka, K., Mizuno, A., Moqrich, A., Patapoutian, A., Fukumi‐Tominaga, T., Mizumura, K., & Tominaga, M. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0703-x · Cited by 268

A stomatin-domain protein essential for touch sensation in the mouse

Wetzel, C., Hu, J., Riethmacher, D., Benckendorff, A., Behrmann, L., Eilers, A., Moshourab, R. A., Kozlenkov, A., Łabuz, D., Caspani, O., et al. (2006) · Nature · doi:10.1038/nature05394 · Cited by 268

General anesthetics activate a nociceptive ion channel to enhance pain and inflammation

Matta, J. A., Cornett, P. M., Miyares, R. L., Abe, K., Sahibzada, N., & Ahern, G. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711038105 · Cited by 265

Transformation of the Output of Spinal Lamina I Neurons After Nerve Injury and Microglia Stimulation Underlying Neuropathic Pain

Keller, A. F., Beggs, S., Salter, M. W., & Koninck, Y. D. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-27 · Cited by 262

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

Bautista, D. M., Sigal, Y. M., Milstein, A. D., Garrison, J. L., Zorn, J. A., Tsuruda, P. R., Nicoll, R. A., & Julius, D. J. (2008) · Nature Neuroscience · doi:10.1038/nn.2143 · Cited by 260

Acid‐sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones

Drew, L., Rohrer, D. K., Price, M. P., Blaver, K. E., Cockayne, D. A., Cesare, P., & Wood, J. N. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058693 · Cited by 256

Ideas about pain, a historical view

Perl, E. R. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2042 · Cited by 249

Sustained Currents Through ASIC3 Ion Channels at the Modest pH Changes That Occur During Myocardial Ischemia

Yagi, J., Wenk, H. N., Naves, L. A., & McCleskey, E. W. (2006) · Circulation Research · doi:10.1161/01.res.0000238388.79295.4c · Cited by 249

Caenorhabditis elegans TRPA-1 functions in mechanosensation

Kindt, K. S., Viswanath, V., Macpherson, L. J., Quast, K. B., Hu, H., Patapoutian, A., & Schafer, W. R. (2007) · Nature Neuroscience · doi:10.1038/nn1886 · Cited by 238

Protons Open Acid-Sensing Ion Channels by Catalyzing Relief of Ca2+ Blockade

Immke, D. C., & McCleskey, E. W. (2003) · Neuron · doi:10.1016/s0896-6273(02)01130-3 · Cited by 233

A Transient Receptor Potential Vanilloid 4-Dependent Mechanism of Hyperalgesia Is Engaged by Concerted Action of Inflammatory Mediators

Alessandri‐Haber, N., Dina, O. A., Joseph, E. K., Reichling, D. B., & Levine, J. D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5385-05.2006 · Cited by 228

Role of voltage-gated calcium channels in ascending pain pathways

Zamponi, G. W., Lewis, R. J., Todorovic, S. M., Arnerić, S. P., & Snutch, T. P. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.021 · Cited by 226

Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex

Liu, X. J., Gingrich, J. R., Vargas‐Caballero, M., Dong, Y., Sengar, A. S., Beggs, S., Wang, S., Ding, H. K., Frankland, P. W., & Salter, M. W. (2008) · Nature Medicine · doi:10.1038/nm.1883 · Cited by 225

The Effect of Menthol on the Thermoreceptors

Hensel, H., & Zotterman, Y. (1951) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1951.tb00824.x · Cited by 221

Induction of CX3CL1 Expression in Astrocytes and CX3CR1 in Microglia in the Spinal Cord of a Rat Model of Neuropathic Pain

Lindia, J. A., McGowan, E., Jochnowitz, N., & Abbadie, C. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.02.001 · Cited by 211

Neuropathic Pain Develops Normally in Mice Lacking both Nav1.7 and Nav1.8

Nassar, M. A., Levato, A., Stirling, L. C., & Wood, J. N. (2005) · Molecular Pain · doi:10.1186/1744-8069-1-24 · Cited by 210

Glycine Inhibitory Dysfunction Turns Touch into Pain through PKCgamma Interneurons

Miraucourt, L. S., Dallel, R., & Voisin, D. L. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001116 · Cited by 208

Thermal hyperalgesia as a marker of oxaliplatin neurotoxicity: A prospective quantified sensory assessment study

Attal, N., Bouhassira, D., Gautron, M., Vaillant, J.-N., Mitry, E., Lepère, C., Rougier, P. R., & Guirimand, F. (2009) · Pain · doi:10.1016/j.pain.2009.03.024 · Cited by 196

Distinct Mechanosensitive Properties of Capsaicin-Sensitive and -Insensitive Sensory Neurons

Drew, L., Wood, J. N., & Cesare, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-j0001.2002 · Cited by 193

Variable Threshold of Trigeminal Cold-Thermosensitive Neurons Is Determined by a Balance between TRPM8 and Kv1 Potassium Channels

Madrid, R., de la Peña, E., Donovan-Rodríguez, T., Belmonte, C., & Viana, F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4778-08.2009 · Cited by 185

In vivo silencing of the CaV3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy

Messinger, R. B., Naik, A. K., Jagodic, M. M., Nelson, M. T., Lee, W. Y., Choe, W. J., Orestes, P., Latham, J. R., Todorovic, S. M., & Jevtović‐Todorović, V. (2009) · Pain · doi:10.1016/j.pain.2009.06.012 · Cited by 183

Cold current in thermoreceptive neurons

Reid, G., & Flonta, M. (2001) · Nature · doi:10.1038/35097164 · Cited by 180

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Materazzi, S., Nassini, R., Andrè, E., Campi, B., Amadesi, S., Trevisani, M., Bunnett, N. W., Patacchini, R., & Geppetti, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802354105 · Cited by 178

Innocuous, Not Noxious, Input Activates PKCγ Interneurons of the Spinal Dorsal Horn via Myelinated Afferent Fibers

Neumann, S., Braz, J. M., Skinner, K., Llewellyn‐Smith, I. J., & Basbaum, A. I. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1259-08.2008 · Cited by 175

Sodium Channel Blockade May Contribute to the Analgesic Efficacy of Antidepressants

Dick, I. E., Brochu, R. M., Purohit, Y., Kaczorowski, G. J., Martin, W. J., & Priest, B. T. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.10.001 · Cited by 174

Mechanosensitive currents in the neurites of cultured mouse sensory neurones

Hu, J., & Lewin, G. R. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117648 · Cited by 174

Functional role of unmyelinated tactile afferents in human hairy skin: sympathetic response and perceptual localization

Olausson, H., Cole, J. D., Rylander, K., McGlone, F. P., Lamarre, Y., Wallin, B. G., Krämer, H. H., Wessberg, J., Elam, M., Bushnell, M. C., et al. (2007) · Experimental Brain Research · doi:10.1007/s00221-007-1175-x · Cited by 169

NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders

Estación, M., Dib‐Hajj, S. D., Benke, P. J., Morsche, R. H. M. T., Eastman, E. M., Macala, L. J., Drenth, J. P. H., & Waxman, S. G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3443-08.2008 · Cited by 166

Loss of Neurons from Laminas I-III of the Spinal Dorsal Horn Is Not Required for Development of Tactile Allodynia in the Spared Nerve Injury Model of Neuropathic Pain

Polgár, E., Hughes, D. I., Arham, A. Z., & Todd, A. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1490-05.2005 · Cited by 161

Autoimmunity and Anti-TNF-α Agents

Atzeni, F., Turiel, M., CAPSONI, F., Doria, A., Meroni, P. L., & Sarzi‐Puttini, P. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.100 · Cited by 159

TRPV1 Unlike TRPV2 Is Restricted to a Subset of Mechanically Insensitive Cutaneous Nociceptors Responding to Heat

Lawson, J. J., McIlwrath, S. L., Woodbury, C. J., Davis, B. M., & Koerber, H. R. (2008) · Journal of Pain · doi:10.1016/j.jpain.2007.12.001 · Cited by 158

The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function

Page, A. J., Brierley, S. M., Martin, C. M., Martínez‐Salgado, C., Wemmie, J. A., Brennan, T. J., Symonds, E. L., Omari, T. I., Lewin, G. R., Welsh, M. J., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.061 · Cited by 154

Inflammatory mediators and modulators of pain

McMahon, S. B., Bennett, D., & Bevan, S. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50008-4 · Cited by 152

TRESK two‐pore‐domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones

Dobler, T., Springauf, A., Tovornik, S., Weber, M., Schmitt, A. G., Sedlmeier, R., Wischmeyer, E., & Döring, F. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.145649 · Cited by 151

Noxious heat activates all capsaicin-sensitive and also a sub-population of capsaicin-insensitive dorsal root ganglion neurons

Nagy, I., & Rang, H. P. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00535-1 · Cited by 147

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

Honoré, P., Chandran, P., Hernandez, G., Gauvin, D. M., Mikusa, J. P., Zhong, C., Joshi, S. K., Ghilardi, J. R., Sevcik, M. A., Fryer, R. M., et al. (2009) · Pain · doi:10.1016/j.pain.2008.11.004 · Cited by 146

Cutaneous Nociception Evoked by 15-delta PGJ2 via Activation of Ion Channel TRPA1

Cruz‐Orengo, L., Dhaka, A., Heuermann, R. J., Young, T. J., Montana, M. C., Cavanaugh, E. J., Kim, D., & Story, G. M. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-30 · Cited by 134

Localization of mechanosensitive channel TRPV4 in mouse skin

Suzuki, M., Watanabe, Y., Oyama, Y., Mizuno, A., Kusano, E., Hirao, A., & Ookawara, S. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.041 · Cited by 124

Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing

Roza, C., Puel, J., Kress, M., Baron, A., Diochot, S., Lazdunski, M., & Waldmann, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.066001 · Cited by 123

Alkylamides that produce tingling paresthesia activate tactile and thermal trigeminal neurons

Bryant, B. P., & Mezine, I. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01878-8 · Cited by 123

Glia in pathological pain: A role for fractalkine

Milligan, E. D., Sloane, E. M., & Watkins, L. R. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.04.011 · Cited by 123

Mechanosensitive Ion Channels in Cultured Sensory Neurons of Neonatal Rats

Cho, H., Shin, J.-E., Shin, C. Y., Lee, S.-Y., & Oh, U. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01238.2002 · Cited by 117

Pungent Qualities of Sanshool-Related Compounds Evaluated by a Sensory Test and Activation of Rat TRPV1

SUGAI, E., Morimitsu, Y., Iwasaki, Y., Morita, A., Watanabe, T., & Kubota, K. (2005) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.69.1951 · Cited by 117

Intrathecal Ziconotide for Neuropathic Pain: A Review

Rauck, R. L., Wallace, M. S., Burton, A. W., Kapural, L., & North, J. M. (2009) · Pain Practice · doi:10.1111/j.1533-2500.2009.00303.x · Cited by 104

Voltage-gated calcium channels and pain

Cao, Y. Q. (2006) · Pain · doi:10.1016/j.pain.2006.10.019 · Cited by 99

TRPA1 Is Differentially Modulated by the Amphipathic Molecules Trinitrophenol and Chlorpromazine

Hill, K., & Schaefer, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609600200 · Cited by 94

Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons

Bhattacharya, M. R. C., Bautista, D. M., Wu, K. C., Haeberle, H., Lumpkin, E. A., & Julius, D. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810801105 · Cited by 85

A high‐threshold heat‐activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium

Leffler, A., Babeș, R.-M., Nau, C., Reeh, P. W., & Babeș, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05643.x · Cited by 82

Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons

Kirschstein, T., Büsselberg, D., & Treede, R. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00533-8 · Cited by 79

Immune and glial regulation of pain

Watkins, L. R. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.001 · Cited by 78

Long-Term Potentiation at C-Fibre Synapses by Low-Level Presynaptic Activity in vivo

Drdla-Schutting, R., & Sandkühler, J. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-18 · Cited by 73

Chapter 4 Genetics and Molecular Pathophysiology of Nav1.7‐Related Pain Syndromes

Dib‐Hajj, S. D., Yang, Y., & Waxman, S. G. (2008) · Advances in genetics · doi:10.1016/s0065-2660(08)01004-3 · Cited by 69

Understanding Sensory Nerve Mechanotransduction through Localized Elastomeric Matrix Control

Lin, Y., Cheng, C., LeDuc, P. R., & Chen, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004293 · Cited by 68

Heat Sensitization in Skin and Muscle Nociceptors Expressing Distinct Combinations of TRPV1 and TRPV2 Protein

Rau, K. K., Jiang, N., Johnson, R. D., & Cooper, B. Y. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00840.2006 · Cited by 63

Science of pain

Basbaum, A. I., & Bushnell, M. C. (2009) · Elsevier eBooks · Cited by 58

Marked Attenuation of Inflammatory Mediator-Induced C-Fiber Sensitization for Mechanical and Hypotonic Stimuli in TRPV4 −/− Mice

Chen, X., Alessandri‐Haber, N., & Levine, J. D. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-31 · Cited by 58

NaV1.7 Gain-of-function Mutations As A Continuum: A1632E Displays Physiological Changes Associated With Erythromelalgia And Paroxysmal Extreme Pain Disorder Mutations And Produces Symptoms Of Both Disorders

Estación, M., Dib‐Hajj, S. D., Benke, P. J., Morsche, R. H. M. T., Eastman, E. M., Macala, L. J., Drenth, J. P. H., & Waxman, S. G. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.12.960 · Cited by 53

A novel mechanosensitive channel identified in sensory neurons

Cho, H., Koo, J. Y., Kim, S., Park, S. P., Yang, Y., & Oh, U. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04802.x · Cited by 34

Voltage-gated calcium channels in chronic pain: emerging role of alternative splicing

Swayne, L. A., & Bourinet, E. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0390-4 · Cited by 32

Mechanosensitive whole-cell currents in cultured rat somatosensory neurons

Takahashi, A., & Gotoh, H. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02366-0 · Cited by 22

Immune System, Pain and Analgesia

Rittner, H. L., Machelska, H., & Stein, C. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00172-9 · Cited by 17

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

Coste, B., Mathur, J., Schmidt, M., Earley, T. J., Ranade, S., Petrus, M. J., Dubin, A. E., & Patapoutian, A. (2010) · Science · doi:10.1126/science.1193270 · Cited by 3,316

Inflammation 2010: New Adventures of an Old Flame

Medzhitov, R. M. (2010) · Cell · doi:10.1016/j.cell.2010.03.006 · Cited by 1,928

The Sensory Neurons of Touch

Abraira, V. E., & Ginty, D. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.051 · Cited by 1,648

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

Ji, R.-R., Nackley, A., Huh, Y., Terrando, N., & Maixner, W. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002130 · Cited by 1,630

Nociceptors: the sensors of the pain pathway

Dubin, A. E., & Patapoutian, A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42843 · Cited by 1,418

Leading Edge Review Cellular and Molecular Mechanisms of Pain

Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. J. (2014)

Mechanisms of Physiologic Pain

Chan, S. F., Hayek, S. M., & Veizi, E. (2018) · Springer eBooks · doi:10.1007/978-3-319-64922-1_3

Molecular mechanisms of pain: a basis for chronic pain and therapeutic approaches based on the cell and the gene.

Riley, J. P., & Boulis, N. M. (2006) · PubMed · Cited by 12

Molecular mechanisms of nociception

Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685

Genetic Analysis of Pain Mechanisms

Robinson, D. A., & Zhuo, M. (2002) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v12.i4.30 · Cited by 2