Cited by 1,002Cancer, Lipids, and MetabolismLipid metabolism and biosynthesisSphingolipid Metabolism and Signaling

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

Open access

Nomura, Daniel K., Long, Jonathan Z., Niessen, Sherry, Hoover, Heather S., Ng, Shu-Wing, Cravatt, Benjamin F.·2010·Cell

DOI 10.1016/j.cell.2009.11.027PMC PMC2885975

Open this paper in CoChat — free account Open PDF

Abstract

Tumor cells display progressive changes in metabolism that correlate with malignancy, including development of a lipogenic phenotype. How stored fats are liberated and remodeled to support cancer pathogenesis, however, remains unknown. Here, we show that the enzyme monoacylglycerol lipase (MAGL) is highly expressed in aggressive human cancer cells and primary tumors, where it regulates a fatty acid network enriched in oncogenic signaling lipids that promotes migration, invasion, survival, and in vivo tumor growth. Overexpression of MAGL in nonaggressive cancer cells recapitulates this fatty acid network and increases their pathogenicity-phenotypes that are reversed by an MAGL inhibitor. Impairments in MAGL-dependent tumor growth are rescued by a high-fat diet, indicating that exogenous sources of fatty acids can contribute to malignancy in cancers lacking MAGL activity. Together, these findings reveal how cancer cells can co-opt a lipolytic enzyme to translate their lipogenic state into an array of protumorigenic signals. PAPERFLICK:

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cell.2009.11.027

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
Eng, J. K., McCormack, A. L., & Yates, J. R. (1994) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(94)80016-2 · Cited by 6,484
XCMS: Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and Identification
Smith, C. A., Want, E. J., O’Maille, G., Abagyan, R. A., & Siuzdak, G. E. (2006) · Analytical Chemistry · doi:10.1021/ac051437y · Cited by 5,296
Why Do Cancers Have High Aerobic Glycolysis?
Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Calle, E. E., & Kaaks, R. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1408 · Cited by 3,613
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics
Liu, H., Sadygov, R. G., & Yates, J. R. (2004) · Analytical Chemistry · doi:10.1021/ac0498563 · Cited by 2,533

Show all 69 references

Research works printed but not linked: 6

Cociorva, D., and Yates, J.R. (2006). DTASelect 2.0: improving the confidence of peptide and protein identifications. Proceedings of the 54th Annual ASMS Meeting, American Society for Mass Spectrometry, Sante Fe, New Mexico.
Jessani, N., Liu, Y., Humphrey, M., and Cravatt, B.F. (2002). Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proc. Natl. Acad. Sci. USA 99, 10335-10340. · DOI
Jessani, N., Humphrey, M., McDonald, W.H., Niessen, S., Masuda, K., Gangadharan, B., Yates, J.R., 3rd, Mueller, B.M., and Cravatt, B.F. (2004). Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo. Proc. Natl. Acad. Sci. USA 101, 13756-13761. · DOI
Jessani, N., Niessen, S., Wei, B.Q., Nicolau, M., Humphrey, M., Ji, Y., Han, W., Noh, D.Y., Yates, J.R., 3rd, Jeffrey, S.S., et al. (2005). A streamlined platform for high-content functional proteomics of primary human specimens. Nat. Methods 2, 691-697. · DOI
Liu, H., Sadygov, R.G., and Yates, J.R., III. (2004). A model for random sampling and estimation of relative protein abundance in shotgun proteomics. Anal. Chem. 76, 4193-4201. · DOI
Seftor, E.A., Meltzer, P.S., Kirschmann, D.A., Pe'er, J., Maniotis, A.J., Trent, J.M., Folberg, R., and Hendrix, M.J. (2002). Molecular determinants of human uveal melanoma invasion and metastasis. Clin. Exp. Metastasis 19, 233-246. · DOI

Sorted by citations

Items 301–400 of 1,000

Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator β-glucan in a two-case ex vivo non-small-cell lung cancer studyPreprint
Fan, T. W. ‐., Warmoes, M. O., Sun, Q., Song, H., Turchan-Cholewo, J. T., Martin, J. T., Mahan, A. L., Higashi, R. M., & Lane, A. N. (2016) · Molecular Case Studies · doi:10.1101/mcs.a000893 · Cited by 62
Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies
Mimeault, M., & Batra, S. K. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.08.001 · Cited by 65
Tissue Metabonomic Phenotyping for Diagnosis and Prognosis of Human Colorectal Cancer
Tian, Y., Xu, T., Huang, J., Zhang, L., Xu, S., Xiong, B., Wang, Y., & Tang, H. (2016) · Scientific Reports · doi:10.1038/srep20790 · Cited by 63
Effects of immunization against PCSK9 in an experimental model of breast cancer
Momtazi‐Borojeni, A. A., Nik, M. E., Jaafari, M. R., Banach, M., & Sahebkar, A. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.84734 · Cited by 63
An in vivo multiplexed small-molecule screening platform
Grüner, B. M., Schulze, C. J., Yang, D., Ogasawara, D., Dix, M. M., Rogers, Z. N., Chuang, C.-H., McFarland, C. D., Chiou, S.-H., Brown, J. M., et al. (2016) · Nature Methods · doi:10.1038/nmeth.3992 · Cited by 62
Self-citation
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease
Wit, M., Viera, J. T., Strohmeyer, A., Klingenspor, M., Hankir, M. K., & Sumara, G. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202114742 · Cited by 63
Obesity-induced changes in cancer cells and their microenvironment: Mechanisms and therapeutic perspectives to manage dysregulated lipid metabolism
Lee‐Rueckert, M., Canyelles, M., Tondo, M., Rotllán, N., Kovanen, P. T., Llorente‐Cortés, V., & Escolá‐Gil, J. C. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.05.002 · Cited by 68
Natural Compounds as Regulators of the Cancer Cell Metabolism
Cerella, C., Radogna, F., Dicato, M. A., & Diederich, M. F. (2013) · International Journal of Cell Biology · doi:10.1155/2013/639401 · Cited by 67
Identification and characterization of a new reversible MAGL inhibitor
Tuccinardi, T., Granchi, C., Rizzolio, F., Caligiuri, I., Battistello, V., Toffoli, G., Minutolo, F., Macchia, M., & Martinelli, A. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.04.057 · Cited by 62
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors
Tabrizi, M. A., Baraldi, P. G., Baraldi, S., Ruggiero, E., Stefano, L. D., Rizzolio, F., Mannelli, L. D. C., Ghelardini, C., Chicca, A., Lapillo, M., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01845 · Cited by 62
Too complex to fail? Targeting fatty acid metabolism for cancer therapy
Munir, R., Lisec, J., Swinnen, J. V., & Zaidi, N. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101143 · Cited by 61
A new role for extracellular vesicles: how small vesicles can feed tumors' big appetite
Lazar, I., Clement, E., Attané, C., Muller, C., & Nieto, L. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r083725 · Cited by 64
Cancer metabolism and intervention therapy
Zhao, H., & Li, Y. (2021) · Molecular Biomedicine · doi:10.1186/s43556-020-00012-1 · Cited by 67
Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis
Zhou, X., Huang, F., Ma, G., Wei, W., Wu, N., & Liu, Z. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01199-1 · Cited by 61
GC-MS-based metabolomic analysis of human papillary thyroid carcinoma tissue
Chen, M., Shen, M., Li, Y., Liu, C., ZHOU, K., Hu, W., Xu, B., Xia, Y., & Tang, W. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2368 · Cited by 61
Characterization of Tunable Piperidine and Piperazine Carbamates as Inhibitors of Endocannabinoid Hydrolases
Long, J. Z., Jin, X., Adibekian, A., Li, W., & Cravatt, B. F. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm9016976 · Cited by 62
Self-citation
Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells
Benjamin, D. I., Li, D. S., Lowe, W. L., Heuer, T. S., Kemble, G. W., & Nomura, D. K. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00240 · Cited by 60
Self-citation
Cancer Chemoprevention With Nuts
Falasca, M., Casari, I., & Maffucci, T. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju238 · Cited by 61
Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors
Granchi, C., Rizzolio, F., Palazzolo, S., Carmignani, S., Macchia, M., Saccomanni, G., Manera, C., Martinelli, A., Minutolo, F., & Tuccinardi, T. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01459 · Cited by 59
Inhibitors of lipogenic enzymes as a potential therapy against cancer
Montesdeoca, N., López, M., Ariza, X., Herrero, L., & Makowski, K. (2020) · The FASEB Journal · doi:10.1096/fj.202000705r · Cited by 58
From cancer metabolism to new biomarkers and drug targets
Chiaradonna, F., Moresco, R. M., Airoldi, C., Gaglio, D., Palorini, R., Nicotra, F., Messa, C., & Alberghina, L. (2011) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.07.006 · Cited by 61
Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile
Oliveras‐Ferraros, C., Vázquez‐Martín, A., Cuyàs, E., Corominas-Faja, B., Rodríguez‐Gallego, E., Fernández‐Arroyo, S., Martı́n-Castillo, B., Joven, J., & Menéndez, J. A. (2014) · Cell Cycle · doi:10.4161/cc.27982 · Cited by 60
Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered
Kinlaw, W. B., Baures, P. W., Lupien, L. E., Davis, W. L., & Kuemmerle, N. B. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25332 · Cited by 59
Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens
Ellermann, M., Pacheco, A. R., Jimenez, A. G., Russell, R. M., Cuesta, S., Kumar, A., Zhu, W., do Vale, G. D., Martin, S. A., Raj, P., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.022 · Cited by 62
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence
Jiang, M., Huizenga, M. C. W., Wirt, J. L., Pálóczi, J., Amedi, A., van den Berg, R. J. B. H. N., Benz, J., Collin, L., Deng, H., Di, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43606-3 · Cited by 63
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer
Kohnz, R. A., Mulvihill, M. M., Chang, J. W., Hsu, K., Sorrentino, A., Cravatt, B. F., Bandyopadhyay, S., Goga, A., & Nomura, D. K. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00053 · Cited by 58
Self-citation
Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition
Zhu, W., Zhao, Y., Zhou, J., Wang, X., Pan, Q., Zhang, N., Wang, L., Wang, M., Zhan, D.-H., Liu, Z., et al. (2016) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0361-3 · Cited by 58
Detection of Metastatic Breast and Thyroid Cancer in Lymph Nodes by Desorption Electrospray Ionization Mass Spectrometry Imaging
Zhang, J., Feider, C. L., Nagi, C. S., Yu, W., Carter, S. A., Suliburk, J. W., Cao, H. S. T., & Eberlin, L. S. (2017) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-016-1570-2 · Cited by 58
Forcing ATGL expression in hepatocarcinoma cells imposes glycolytic rewiring through PPAR-α/p300-mediated acetylation of p53
Leo, L. D., Vegliante, R., Ciccarone, F., Salvatori, I., Scimeca, M., Bonanno, E., Sagnotta, A., Grazi, G. L., Aquilano, K., & Ciriolo, M. R. (2018) · Oncogene · doi:10.1038/s41388-018-0545-0 · Cited by 58
Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached
Wilcock, D. J., Badrock, A. P., Wong, C. W., Owen, R., Guerin, M., Southam, A. D., Johnston, H. R., Telfer, B. A., Fullwood, P., Watson, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110995 · Cited by 58
Targeting lipid metabolism for ferroptotic cancer therapy
Luo, M., Yan, J., Hu, X., Li, H., Li, H., Liu, Q., Chen, Y., & Zou, Z. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01795-0 · Cited by 62
Metabolic Profiling Reveals PAFAH1B3 as a Critical Driver of Breast Cancer Pathogenicity
Mulvihill, M. M., Benjamin, D. I., Ji, X., Scolan, E. L., Louie, S. M., Shieh, A., Green, M., Narasimhalu, T., Morris, P. J., Luo, K., et al. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.05.008 · Cited by 57
Self-citation
Analysis of genomic and transcriptomic variations as prognostic signature for lung adenocarcinoma
Zengin, T., & Önal-Süzek, T. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-03691-3 · Cited by 56
Evaluation of Enzymatic Activities in Living Systems with Small-molecular Fluorescent Substrate Probes
Komatsu, T., & Urano, Y. (2015) · Analytical Sciences · doi:10.2116/analsci.31.257 · Cited by 55
Synthesis and Preclinical Evaluation of Sulfonamido-based [11C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase
Wang, L., Mori, W., Cheng, R., Yui, J., Hatori, A., Ma, L., Zhang, Y., Rotstein, B. H., Fujinaga, M., Shimoda, Y., et al. (2016) · Theranostics · doi:10.7150/thno.15257 · Cited by 56
The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth
Liu, X., Lu, Y., Chen, Z., Liu, X., Hu, W., Zheng, L., Chen, Y., Kurie, J. M., Shi, M., Mustachio, L. M., et al. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0579 · Cited by 55
Oxylipin profiling for clinical research: Current status and future perspectives
Parchem, K., Letsiou, S., Petan, T., Oskolkova, O., Medina, I., Kuda, O., O’Donnell, V. B., Nicolaou, A., Fedorova, M., Bochkov, V., et al. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101276 · Cited by 55
Acetyl-CoA metabolism as a therapeutic target for cancer
Chen, G., Bao, B., Cheng, Y., Tian, M., Song, J., Zheng, L., & Tong, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115741 · Cited by 54
Protein lysine acetylation in cellular function and its role in cancer manifestation
Arif, M., Senapati, P., Shandilya, J., & Kundu, T. K. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.10.002 · Cited by 58
Targeting the endocannabinoid system as a potential anticancer approach
Schwarz, R., Ramer, R., & Hinz, B. (2018) · Drug Metabolism Reviews · doi:10.1080/03602532.2018.1428344 · Cited by 55
Lipid Catabolism and ROS in Cancer: A Bidirectional Liaison
Castelli, S., Falco, P. D., Ciccarone, F., Desideri, E., & Ciriolo, M. R. (2021) · Cancers · doi:10.3390/cancers13215484 · Cited by 57
The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes
Rengachari, S., Bezerra, G. A., Riegler-Berket, L., Gruber, C. C., Sturm, C., Taschler, U., Boeszoermenyi, A., Dreveny, I., Zimmermann, R., Gruber, K. F., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.04.006 · Cited by 54
An Activity‐Based Imaging Probe for the Integral Membrane Hydrolase KIAA1363
Chang, J. W., Moellering, R. E., & Cravatt, B. F. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201107236 · Cited by 53
Self-citation
Role of cystathionine beta synthase in lipid metabolism in ovarian cancer
Chakraborty, P. K., Xiong, X., Mustafi, S. B., Saha, S., Dhanasekaran, D. N., Mandal, N. A., McMeekin, S., Bhattacharya, R., & Mukherjee, P. (2015) · Oncotarget · doi:10.18632/oncotarget.5424 · Cited by 51
N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages
Menga, A., Favia, M., Spera, I., Vegliante, M. C., Gissi, R., Grassi, A., Laera, L., Campanella, A., Gerbino, A., Carrà, G., et al. (2021) · EMBO Reports · doi:10.15252/embr.202051981 · Cited by 57
Hypoxia and Metabolism in Cancer
Bensaad, K., & Harris, A. L. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5915-6_1 · Cited by 49
Deletion of the gene encoding G0/G1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice
El-Assaad, W., El-Kouhen, K., Mohammad, A. H., Yang, J., Morita, M., Gamache, I., Mamer, O., Avizonis, D. Z., Hermance, N. M., Kersten, S., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3429-z · Cited by 54
Phytosterols inhibit the tumor growth and lipoprotein oxidizability induced by a high-fat diet in mice with inherited breast cancer
Llaverı́as, G., Escolá‐Gil, J. C., Lerma, E., Julve, J., Pons, C., Cabré, A., Cofán, M., Ros, E., Sánchez‐Quesada, J. L., & Blanco‐Vaca, F. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.01.007 · Cited by 52
Inositol Phosphate Recycling Regulates Glycolytic and Lipid Metabolism That Drives Cancer Aggressiveness
Benjamin, D. I., Louie, S. M., Mulvihill, M. M., Kohnz, R. A., Li, D. S., Chan, L. G., Sorrentino, A., Bandyopadhyay, S., Cozzo, A. J., Ohiri, A., et al. (2014) · ACS Chemical Biology · doi:10.1021/cb5001907 · Cited by 51
Self-citation
Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer
Sun, H., Jiang, L., Luo, X., Jin, W., He, Q., An, J., Lui, K., Shi, J., Rong, R., Su, W., et al. (2012) · Oncogene · doi:10.1038/onc.2012.34 · Cited by 52
Inhibitors of the Endocannabinoid-Degrading Enzymes, or how to Increase Endocannabinoids Activity by Preventing their Hydrolysis
Feledziak, M., Lambert, D. M., Marchand‐Brynaert, J., & Muccioli, G. G. (2011) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488912798842223 · Cited by 50
Diet and Pancreatic Cancer Prevention
Casari, I., & Falasca, M. (2015) · Cancers · doi:10.3390/cancers7040892 · Cited by 50
Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats
Levine, A. A., Liktor‐Busa, E., Lipinski, A. A., Couture, S. A., Balasubramanian, S., Aicher, S. A., Langlais, P. R., Vanderah, T. W., & Largent‐Milnes, T. M. (2021) · Biology of Sex Differences · doi:10.1186/s13293-021-00402-2 · Cited by 53
Mapping Proteome-Wide Targets of Environmental Chemicals Using Reactivity-Based Chemoproteomic Platforms
Medina-Cleghorn, D., Bateman, L. A., Ford, B., Heslin, A., Fisher, K. J., Dalvie, E. D., & Nomura, D. K. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.09.008 · Cited by 49
Self-citation
Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer
Pardo, J. C. T., de Porras, V. R., Gil, J., Pous, A. F., Puig‐Domingo, M., & Jordà, M. (2022) · Nutrients · doi:10.3390/nu14040851 · Cited by 55
Epithelial-to-mesenchymal transition involves triacylglycerol accumulation in DU145 prostate cancer cells
Dalmau, N., Jaumot, J., Tauler, R., & Bedia, C. (2015) · Molecular BioSystems · doi:10.1039/c5mb00413f · Cited by 49
Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms
Soderstrom, K., Soliman, E., & Dross, R. V. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00720 · Cited by 52
Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a “Tail Switching” Strategy on a Piperazinyl Azetidine Skeleton
Chen, Z., Mori, W., Deng, X., Cheng, R., Ogasawara, D., Zhang, G., Schafroth, M. A., Dahl, K., Fu, H., Hatori, A., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01778 · Cited by 48
Self-citation
Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling
Xie, H., Heier, C., Kien, B., Vesely, P. W., Tang, Z., Sexl, V., Schoiswohl, G., Strießnig-Bina, I., Höefler, G., Zechner, R., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158737 · Cited by 48
Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma
Huang, H., Li, S., Tang, Q., & Zhu, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.680955 · Cited by 49
Molecular targets and pathways involved in liver metastasis of colorectal cancer
Weidle, U. H., Birzele, F., & Krüger, A. (2015) · Clinical & Experimental Metastasis · doi:10.1007/s10585-015-9732-3 · Cited by 51
Pyrimidine metabolic rate limiting enzymes in poorly-differentiated hepatocellular carcinoma are signature genes of cancer stemness and associated with poor prognosis
Yeh, H.-W., Lee, S.-S., Chang, C.-Y., Hu, C., & Jou, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.20774 · Cited by 49
Contribution of adipocytes in the tumor microenvironment to breast cancer metabolism
Lyu, X., Zhang, Q., Fares, H. M., Wang, Y., Han, Y., & Sun, L. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215616 · Cited by 48
Microtargeting cancer metabolism: opening new therapeutic windows based on lipid metabolism
de Cedrón, M. G., & de Molina, A. R. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r061812 · Cited by 49
Lipases and their inhibitors in health and disease
Nomura, D. K., & Casida, J. E. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.04.004 · Cited by 50
Self-citation
Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells
Wu, H., Weidinger, C., Schmidt, F., Keye, J., Friedrich, M., Yerinde, C., Willimsky, G., Qin, Z., Siegmund, B., & Glauben, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-07685-9 · Cited by 48
The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB1 Cannabinoid Receptor
Prüser, J. L., Ramer, R., Wittig, F., Ivanov, I., Merkord, J., & Hinz, B. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0589 · Cited by 50
Lipid Metabolism and Lipidomics Applications in Cancer Research
Pan, M., Qin, C., & Han, X. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6785-2_1 · Cited by 50
Circadian Regulation and Clock-Controlled Mechanisms of Glycerophospholipid Metabolism from Neuronal Cells and Tissues to Fibroblasts
Guido, M. E., Monjes, N. M., Wagner, P. M., & Salvador, G. A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02595-4 · Cited by 46
Targeting cancer-specific metabolic pathways for developing novel cancer therapeutics
Pal, S., Sharma, A. K., Mathew, S. P., & Jaganathan, B. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.955476 · Cited by 50
Lipid droplets provide metabolic flexibility for cancer progression
Safi, R., Menéndez, P. R., & Pol, A. (2024) · FEBS Letters · doi:10.1002/1873-3468.14820 · Cited by 50
The Role of Monoacylglycerol Lipase (MAGL) in the Cancer Progress
Qin, H., & Ruan, Z. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-014-9899-2 · Cited by 47
Serum Fatty Acid Profiling of Colorectal Cancer by Gas Chromatography/Mass Spectrometry
Kondo, Y., Nishiumi, S., Shinohara, M., Hatano, N., Ikeda, A., Yoshie, T., Kobayashi, T., Shiomi, Y., Irino, Y., Takenawa, T., et al. (2011) · Biomarkers in Medicine · doi:10.2217/bmm.11.41 · Cited by 48
Discovery and Development of Endocannabinoid-Hydrolyzing Enzyme Inhibitors
Minkkilä, A., Saario, S. M., & Nevalainen, T. (2010) · Current Topics in Medicinal Chemistry · doi:10.2174/156802610791164238 · Cited by 46
Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells
Lupien, L. E., Bloch, K. M., Dehairs, J., Traphagen, N. A., Feng, W. W., Davis, W. L., Dennis, T., Swinnen, J. V., Wells, W. A., Smits, N. C., et al. (2019) · Journal of Lipid Research · doi:10.1194/jlr.ra119000327 · Cited by 46
Connecting Metabolic Rewiring With Phenotype Switching in Melanoma
Falletta, P., Goding, C. R., & Vivas, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.930250 · Cited by 46
Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling
Zhai, Y., Zhang, X., Chen, Z., Yan, D., Zhu, L. F., Zhang, Z., Wang, X., Tian, K., Huang, Y. X., Yang, X., et al. (2024) · Nature Chemistry · doi:10.1038/s41557-024-01545-6 · Cited by 53
Stearic acid metabolism in human health and disease
Shen, X., Miao, S., Zhang, Y., Guo, X., Li, W., Mao, X., & Zhang, Q. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.12.012 · Cited by 54
The Synergistic Effect of Chemical Carcinogens Enhances Epstein-Barr Virus Reactivation and Tumor Progression of Nasopharyngeal Carcinoma Cells
Fang, C., Huang, S., Wu, C.-C., Hsu, H.-Y., Chou, S., Tsai, C.-H. A., Chang, Y., Takada, K., & Chen, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044810 · Cited by 45
Analysis of ovarian tumor pathology by Fourier Transform Infrared Spectroscopy
Mehrotra, R., Tyagi, G., Jangir, D. K., Dawar, R., & Gupta, N. (2010) · Journal of Ovarian Research · doi:10.1186/1757-2215-3-27 · Cited by 45
The Role of Metabolic Lipases in the Pathogenesis and Management of Liver Disease
Tardelli, M., Bruschi, F. V., & Trauner, M. A. (2020) · Hepatology · doi:10.1002/hep.31250 · Cited by 45
Chemical modulation of glycerolipid signaling and metabolic pathways
Scott, S., Mathews, T. P., Ivanova, P. T., Lindsley, C. W., & Brown, H. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.01.009 · Cited by 44
Activity-Based Probes for Detection of Active MALT1 Paracaspase in Immune Cells and Lymphomas
Eitelhuber, A. C., Vosyka, O., Nagel, D., Bognar, M., Lenze, D., Lammens, K., Schlauderer, F., Hlahla, D., Hopfner, K., Lenz, G., et al. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.10.021 · Cited by 44
Genetic variants in the inositol phosphate metabolism pathway and risk of different types of cancer
Tan, J., Yu, C., Wang, Z.-H., Chen, H., Guan, J., Chen, Y., & Fang, J. (2015) · Scientific Reports · doi:10.1038/srep08473 · Cited by 44
Staphylococcal Nuclease and Tudor Domain Containing 1 (SND1 Protein) Promotes Hepatocarcinogenesis by Inhibiting Monoglyceride Lipase (MGLL)
Rajasekaran, D., Jariwala, N. H., Mendoza, R. G., Robertson, C. L., Akiel, M., Dozmorov, M. G., Fisher, P. B., & Sarkar, D. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.715359 · Cited by 44
Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors
Bononi, G., Granchi, C., Lapillo, M., Giannotti, M., Nieri, D., Fortunato, S., Boustani, M. E., Caligiuri, I., Poli, G., Carlson, K. E., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.08.038 · Cited by 45
Emerging Role of Metabolomics in Ovarian Cancer Diagnosis
Saorin, A., Gregorio, E. D., Miolo, G., Steffan, A., & Corona, G. (2020) · Metabolites · doi:10.3390/metabo10100419 · Cited by 45
An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)
Bononi, G., Poli, G., Rizzolio, F., Tuccinardi, T., Macchia, M., Minutolo, F., & Granchi, C. (2020) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2021.1841166 · Cited by 45
Integrating human omics data to prioritize candidate genes
Chen, Y., Wu, X., & Jiang, R. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-57 · Cited by 42
Link between obesity and cancer: role of triglyceride/free fatty acid cycling.
Gong, Y., Lj, D., & Liang, J. (2014) · PubMed · Cited by 43
Monoacylglycerol lipase inhibitor JZL184 regulates apoptosis and migration of colorectal cancer cells
Ma, M., Bai, J., LING, Y., Chang, W., Xie, G., Li, R., Wang, G., & Tao, K. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4829 · Cited by 43
Antitumorigenic targets of cannabinoids – current status and implications
Ramer, R., & Hinz, B. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2016.1177512 · Cited by 44
Phyto-, endo- and synthetic cannabinoids: promising chemotherapeutic agents in the treatment of breast and prostate carcinomas
Fraguas‐Sánchez, A. I., Fernández-Carballido, A. M., & Torres‐Suárez, A. I. (2016) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2016.1236913 · Cited by 43
Lipid metabolic reprogramming as an emerging mechanism of resistance to kinase inhibitors in breast cancer
Feng, W. W., & Kurokawa, M. (2019) · Cancer Drug Resistance · doi:10.20517/cdr.2019.100 · Cited by 44
Reprogramming of Lipid Metabolism Mediates Crosstalk, Remodeling, and Intervention of Microenvironment Components in Breast Cancer
Wang, J., Zhang, W.-F., Liu, C., Wang, L., Wu, J., Sun, C.-G., & Wu, Q.-B. (2024) · International Journal on Biological Sciences · doi:10.7150/ijbs.92125 · Cited by 47
Unraveling the intricate relationship between lipid metabolism and oncogenic signaling pathways
Khan, F., Elsori, D. H., Verma, M., Pandey, S., Rab, S. O., Siddiqui, S., Alabdallah, N. M., Saeed, M., & Pandey, P. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1399065 · Cited by 45
Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire
Nasr, M. L., Shi, X., Bowman, A. L., Johnson, M., Zvonok, N., Janero, D. R., Vemuri, K. V., Wales, T. E., Engen, J. R., & Makriyannis, A. (2013) · Protein Science · doi:10.1002/pro.2257 · Cited by 42
Delta9‐tetrahydrocannabinol and cannabidiol as potential curative agents for cancer: A critical examination of the preclinical literature
Fowler, C. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.84 · Cited by 44
Alkylglyceronephosphate Synthase (AGPS) Alters Lipid Signaling Pathways and Supports Chemotherapy Resistance of Glioma and Hepatic Carcinoma Cell Lines
Zhu, Y. T., Liu, X., Yang, P., Zhao, M., Lv, L.-X., Zhang, G., Wang, Q., & Zhang, L. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.7.3219 · Cited by 42
Use of Plasma Metabolomics to Identify Diagnostic Biomarkers for Early Stage Epithelial Ovarian Cancer
Fan, L., Yin, M., Ke, C., Ge, T., Zhang, G., Zhang, W., Zhou, X., Lou, G., & Li, K. (2016) · Journal of Cancer · doi:10.7150/jca.15074 · Cited by 43

Authors: Nomura, D. K., Long, J. Z., Niessen, S., Hoover, H. S., Ng, S.-W., & Cravatt, B. F.
Affiliations: Scripps Research Institute (US)
Brigham and Women's Hospital (US)
Corresponding author: Cravatt, Benjamin F.
ORCID: Nomura, Daniel K.
Long, Jonathan Z.
Hoover, Heather S.
Ng, Shu-Wing
Cravatt, Benjamin F.
Venue: Cell
Publisher: Elsevier BV
Published: 2010-01
Volume: 140
Issue: 1
Pages: 49-61
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2009.11.027
PMC: PMC2885975
OpenAlex: W2127624416
Cited by: 1,002
References: 69
Citations by year: 2026: 40 · 2025: 41 · 2024: 55 · 2023: 46 · 2022: 59 · 2021: 78 · 2020: 69 · 2019: 67 · 2018: 69 · 2017: 60 · 2016: 75 · 2015: 72 · 2014: 70 · 2013: 61 · 2012: 47
FWCI: 15.66
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1293 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA132630, CA-087660, R37CA087660, R01CA087660, CA132630)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Keywords: monoacylglycerol lipase, fatty acid metabolism, lipolysis, tumor cell migration and invasion, tumor growth, MAGL inhibitors, high-fat diet, cancer metabolism
MeSH terms: Animals, Cell Line, Fatty Acids, Female, Humans, Monoacylglycerol Lipases, Neoplasm Transplantation, Ovarian Neoplasms, Transplantation, Heterologous, Tumor Cells, Cultured, Monoglycerides, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks