Cravatt, Benjamin F.

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature

Cannabis and Cannabinoid ResearchEicosanoids and Hypertension Pharmacology

Cited by 2,125

Quantitative reactivity profiling predicts functional cysteines in proteomes

Weerapana, E., Wang, C., Simon, G. M., Richter, F., Khare, S., Dillon, M. B. D., Bachovchin, D. A., Mowen, K., Baker, D., & Cravatt, B. F. (2010) · Nature

Redox biology and oxidative stressAdvanced Proteomics Techniques and Applications

Cited by 1,684

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

Cravatt, B. F., Demarest, K., Patricelli, M. P., Bracey, M. H., Giang, D. K., Martin, B. R., & Lichtman, A. H. (2001) · Proceedings of the National Academy of Sciences

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 1,310

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

Cravatt, B. F., Wright, A. T., & Kozarich, J. W. (2008) · Annual Review of Biochemistry

Advanced Proteomics Techniques and ApplicationsClick Chemistry and Applications

Cited by 1,270

A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol

Blankman, J. L., Simon, G. M., & Cravatt, B. F. (2007) · Chemistry & Biology

Cannabis and Cannabinoid ResearchEicosanoids and Hypertension Pharmacology

Cited by 1,177

Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

Nomura, D. K., Long, J. Z., Niessen, S., Hoover, H. S., Ng, S.-W., & Cravatt, B. F. (2010) · Cell

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 1,002

Proteome-wide covalent ligand discovery in native biological systems

Backus, K. M., Correia, B. E., Lum, K. M., Forli, S., Horning, B. D., González-Páez, G. E., Chatterjee, S., Lanning, B. R., Teijaro, J. R., Olson, A. J., et al. (2016) · Nature

Click Chemistry and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 940

How many human proteoforms are there?

Aebersold, R., Agar, J. N., Amster, I. J., Baker, M. S., Bertozzi, C. R., Boja, E. S., Costello, C. E., Cravatt, B. F., Fenselau, C., Garcia, B. A., et al. (2018) · Nature Chemical Biology

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 907

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

Nomura, D. K., Morrison, B. E., Blankman, J. L., Long, J. Z., Kinsey, S. G., Marcondes, M. C. G., Ward, A. M., Hahn, Y. K., Lichtman, A. H., Conti, B., et al. (2011) · Science

Cannabis and Cannabinoid ResearchInflammatory mediators and NSAID effects

Cited by 727

Structure and function of fatty acid amide hydrolase

McKinney, M. K., & Cravatt, B. F. (2005) · Annual Review of Biochemistry

Cannabis and Cannabinoid ResearchEicosanoids and Hypertension Pharmacology

Cited by 680

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

Schlosburg, J. E., Blankman, J. L., Long, J. Z., Nomura, D. K., Pan, B., Kinsey, S. G., Nguyen, P. T., Ramesh, D., Booker, L., Burston, J. J., et al. (2010) · Nature Neuroscience

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 641

Chemical characterization of a family of brain lipids that induce sleep

Cravatt, B. F., Prospero-Garcia, O., Siuzdak, G., Gilula, N. B., Henriksen, S. J., Boger, D. L., & Lerner, R. A. (1995) · Science

Sleep and Wakefulness ResearchCircadian rhythm and melatonin

Cited by 620

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

Ahn, K., McKinney, M. K., & Cravatt, B. F. (2008) · Chemical Reviews

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 529

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

Zhang, X., Crowley, V. M., Wucherpfennig, T. G., Dix, M. M., & Cravatt, B. F. (2019) · Nature Chemical Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 487

Global profiling of lysine reactivity and ligandability in the human proteome

Hacker, S. M., Backus, K. M., Lazear, M. R., Forli, S., Correia, B. E., & Cravatt, B. F. (2017) · Nature Chemistry

Click Chemistry and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 485

Conversion of Acetaminophen to the Bioactive N-Acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System

Högestätt, E. D., Jönsson, B. A. G., Ermund, A., Andersson, D. A., Björk, H., Alexander, J. P., Cravatt, B. F., Basbaum, A. I., & Zygmunt, P. M. (2005) · Journal of Biological Chemistry

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 454

Ligand and Target Discovery by Fragment-Based Screening in Human Cells

Parker, C. G., Galmozzi, A., Wang, Y., Correia, B. E., Sasaki, K., Joslyn, C. M., Kim, A. S., Cavallaro, C. L., Lawrence, R. M., Johnson, S. R., et al. (2017) · Cell

Click Chemistry and ApplicationsComputational Drug Discovery Methods

Cited by 439

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

Ahn, K., Johnson, D. S., Mileni, M., Beidler, D., Long, J. Z., McKinney, M. K., Weerapana, E., Sadagopan, N., Liimatta, M., Smith, S. E., et al. (2009) · Chemistry & Biology

Cannabis and Cannabinoid ResearchEicosanoids and Hypertension Pharmacology

Cited by 439

Strategies for Discovering and Derisking Covalent, Irreversible Enzyme Inhibitors

Johnson, D. S., Weerapana, E., & Cravatt, B. F. (2010) · Future Medicinal Chemistry

Click Chemistry and ApplicationsEnzyme function and inhibition

Cited by 387

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

Vinogradova, E. V., Zhang, X., Remillard, D., Lazar, D. C., Suciu, R. M., Wang, Y., Bianco, G., Yamashita, Y., Crowley, V. M., Schafroth, M. A., et al. (2020) · Cell

Redox biology and oxidative stressGenomics, phytochemicals, and oxidative stress

Cited by 351

Comparative analysis of fatty acid amide hydrolase and cb1 cannabinoid receptor expression in the mouse brain: evidence of a widespread role for fatty acid amide hydrolase in regulation of endocannabinoid signaling

Egertová, M., Cravatt, B. F., & Elphick, M. R. (2003) · Neuroscience

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 347

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

van Esbroeck, A. C. M., Janssen, A. P. A., Cognetta, A. B., Ogasawara, D., Shpak, G., van der Kroeg, M., Kantae, V., Baggelaar, M. P., de Vrij, F. M. S., Deng, H., et al. (2017) · Science

Cannabis and Cannabinoid ResearchComputational Drug Discovery Methods

Cited by 332

Chemical Probes of Endocannabinoid Metabolism

Blankman, J. L., & Cravatt, B. F. (2013) · Pharmacological Reviews

Cannabis and Cannabinoid ResearchEicosanoids and Hypertension Pharmacology

Cited by 327

Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries

Kuljanin, M., Mitchell, D. C., Schweppe, D. K., Gikandi, A. S., Nusinow, D. P., Bulloch, N. J., Vinogradova, E. V., Wilson, D. L., Kool, E. T., Mancias, J. D., et al. (2021) · Nature Biotechnology

Click Chemistry and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 305