The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis
Open accessAbstract
Tumor cells display progressive changes in metabolism that correlate with malignancy, including development of a lipogenic phenotype. How stored fats are liberated and remodeled to support cancer pathogenesis, however, remains unknown. Here, we show that the enzyme monoacylglycerol lipase (MAGL) is highly expressed in aggressive human cancer cells and primary tumors, where it regulates a fatty acid network enriched in oncogenic signaling lipids that promotes migration, invasion, survival, and in vivo tumor growth. Overexpression of MAGL in nonaggressive cancer cells recapitulates this fatty acid network and increases their pathogenicity-phenotypes that are reversed by an MAGL inhibitor. Impairments in MAGL-dependent tumor growth are rescued by a high-fat diet, indicating that exogenous sources of fatty acids can contribute to malignancy in cancers lacking MAGL activity. Together, these findings reveal how cancer cells can co-opt a lipolytic enzyme to translate their lipogenic state into an array of protumorigenic signals. PAPERFLICK:
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“An elevated expression of lipoprotein lipase (LPL) and monoacylglycerol lipase (MAGL) across diverse cancer subtypes and correlates with invasiveness”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Nomura et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
Eng, J. K., McCormack, A. L., & Yates, J. R. (1994) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(94)80016-2 · Cited by 6,484
Smith, C. A., Want, E. J., O’Maille, G., Abagyan, R. A., & Siuzdak, G. E. (2006) · Analytical Chemistry · doi:10.1021/ac051437y · Cited by 5,296
Why Do Cancers Have High Aerobic Glycolysis?
Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Calle, E. E., & Kaaks, R. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1408 · Cited by 3,613
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics
Liu, H., Sadygov, R. G., & Yates, J. R. (2004) · Analytical Chemistry · doi:10.1021/ac0498563 · Cited by 2,533
Tumor cell metabolism: cancer's Achilles' heel
Kroemer, G., & Pouyssegur, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.005 · Cited by 2,337
Systematic variation in gene expression patterns in human cancer cell lines
Ross, D. T., Scherf, U., Eisen, M. B., Perou, C. M., Rees, C., Spellman, P., Iyer, V., Jeffrey, S. S., Van de Rijn, M., Waltham, M., et al. (2000) · Nature Genetics · doi:10.1038/73432 · Cited by 2,088
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
PI3K pathway alterations in cancer: variations on a theme
Yuan, T. L., & Cantley, L. C. (2008) · Oncogene · doi:10.1038/onc.2008.245 · Cited by 1,845
The Mitochondrial Carnitine Palmitoyltransferase System — From Concept to Molecular Analysis
McGarry, J. D., & Brown, N. F. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00001.x · Cited by 1,616 · cited 1×
“However, inhibitors of carnitine palmitoyltransferase 1 (CPT1), which catalyzes the ratelimiting step in b-oxidation (McGarry and Brown, 1997), did not affect the migratory activity of cancer cells (shControl, shMAGL, or MAGL-OE) (Figure S5).”
BackgroundTabb, D. L., McDonald, W. H., & Yates, J. R. (2002) · Journal of Proteome Research · doi:10.1021/pr015504q · Cited by 1,369
A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol
Blankman, J. L., Simon, G. M., & Cravatt, B. F. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.11.006 · Cited by 1,177
Self-citationActivity-based protein profiling: The serine hydrolases
Liu, Y., Patricelli, M. P., & Cravatt, B. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14694 · Cited by 1,143
Self-citationThe emerging role of lysophosphatidic acid in cancer
Mills, G. B., & Moolenaar, W. H. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1143 · Cited by 1,116
Tumor suppressors and cell metabolism: a recipe for cancer growth
Jones, R. G., & Thompson, C. B. (2009) · Genes & Development · doi:10.1101/gad.1756509 · Cited by 1,085
Brick by brick: metabolism and tumor cell growth
DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.02.003 · Cited by 1,018
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
Long, J. Z., Li, W., Booker, L., Burston, J. J., Kinsey, S. G., Schlosburg, J. E., Pavón, F. J., Serrano, A., Selley, D. E., Parsons, L. H., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.129 · Cited by 954
Self-citationBuzzai, M., Jones, R. G., Amaravadi, R. K., Lum, J. J., DeBerardinis, R. J., Zhao, F., Viollet, B., & Thompson, C. B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4447 · Cited by 949
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis
Gupta, G. P., Nguyen, D. X., Chiang, A. C., Bos, P. D., Kim, J. Y., Nadal, C., Gomis, R. R., Manova-Todorova, K. O., & Massagué, J. (2007) · Nature · doi:10.1038/nature05760 · Cited by 735
Aspirin and the potential role of prostaglandins in colon cancer.
Marnett, L. J. (1992) · PubMed · Cited by 685
Cell motility through plasma membrane blebbing
Fackler, O., & Grosse, R. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200802081 · Cited by 588
Synthesis and antitumor activity of an inhibitor of fatty acid synthase
Kuhajda, F. P., Pizer, E. S., Li, J. N., Mani, N. S., Frehywot, G. L., & Townsend, C. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3450 · Cited by 568
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
Ahn, K., McKinney, M. K., & Cravatt, B. F. (2008) · Chemical Reviews · doi:10.1021/cr0782067 · Cited by 529
Self-citationTumours with PI3K activation are resistant to dietary restriction
Kalaany, N. Y., & Sabatini, D. M. (2009) · Nature · doi:10.1038/nature07782 · Cited by 468
Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer
Liu, Y. (2006) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4500879 · Cited by 433
Profiling Serine Hydrolase Activities in Complex Proteomes
Kidd, D., Liu, Y., & Cravatt, B. F. (2001) · Biochemistry · doi:10.1021/bi002579j · Cited by 369
Self-citationEnzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness
Jessani, N., Liu, Y., Humphrey, M., & Cravatt, B. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162187599 · Cited by 361
Self-citationBuzzai, M., Bauer, D. E., Jones, R. G., DeBerardinis, R. J., Hatzivassiliou, G., Elstrom, R. L., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208622 · Cited by 357
Glycerolipid Metabolism and Signaling in Health and Disease
Prentki, M., & Madiraju, S. R. M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0007 · Cited by 331
A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation
Dinh, T. P., Freund, T. F., & Piomelli, D. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00150-0 · Cited by 319
Assignment of Endogenous Substrates to Enzymes by Global Metabolite Profiling
Saghatelian, A., Trauger, S. A., Want, E. J., Hawkins, E. G., Siuzdak, G. E., & Cravatt, B. F. (2004) · Biochemistry · doi:10.1021/bi0480335 · Cited by 318
Self-citationLong, J. Z., Nomura, D. K., & Cravatt, B. F. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.05.009 · Cited by 312
Self-citationCannabinoid Receptors and Endocannabinoids: Evidence for New Players
Mackie, K., & Stella, N. (2006) · The AAPS Journal · doi:10.1007/bf02854900 · Cited by 303
Patricelli, M. P., Giang, D. K., Stamp, L. M., & Burbaum, J. J. (2001) · PROTEOMICS · doi:10.1002/1615-9861(200109)1:9 · Cited by 281
Lipolysis: pathway under construction
Zechner, R., Bogner‐Strauß, J. G., Haemmerle, G., Lass, A., & Zimmermann, R. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000169354.20395.1c · Cited by 277
Schrijver, E. D., Brusselmans, K., Heyns, W., Verhoeven, G., & Swinnen, J. V. (2003) · PubMed · Cited by 269
A streamlined platform for high-content functional proteomics of primary human specimens
Jessani, N., Niessen, S., Wei, B. Q., Nicolau, M. M., Humphrey, M., Ji, Y., Han, W., Noh, D., Yates, J. R., Jeffrey, S. S., et al. (2005) · Nature Methods · doi:10.1038/nmeth778 · Cited by 240
Self-citationValidation of Tandem Mass Spectrometry Database Search Results Using DTASelect
Cociorva, D., Tabb, D. L., & Yates, J. R. (2006) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi1304s16 · Cited by 228
Invadopodia: At the cutting edge of tumour invasion
Stylli, S. S., Kaye, A. H., & Lock, P. (2008) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2008.03.003 · Cited by 226
DeBerardinis, R. J., Lum, J. J., & Thompson, C. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608372200 · Cited by 221
Ren, J., Xiao, Y.-J., Singh, L. S., Zhao, X., Zhao, Z., Feng, L., Rose, T. M., Prestwich, G. D., & Xu, Y. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1292 · Cited by 220
Gschwind, A., Prenzel, N., & Ullrich, A. (2002) · PubMed · Cited by 220
Bektas, M., Payne, S. G., Liu, H., Goparaju, S. K., Milstien, S., & Spiegel, S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407123 · Cited by 216
Chiang, K. P., Niessen, S., Saghatelian, A., & Cravatt, B. F. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.08.008 · Cited by 200
Self-citationVázquez‐Martín, A., Colomer, R., Brunet, J., Lupu, R., & Menéndez, J. A. (2008) · Cell Proliferation · doi:10.1111/j.1365-2184.2007.00498.x · Cited by 200
Welch, D. R., Bisi, J., Miller, B. E., Conaway, D. H., Seftor, E. A., Yohem, K. H., Gilmore, L. B., Seftor, R. E. B., Nakajima, M., & Hendrix, M. J. C. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910470211 · Cited by 190
Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo
Jessani, N., Humphrey, M., McDonald, W. H., Niessen, S., Masuda, K. R., Gangadharan, B., Yates, J. R., Mueller, B. M., & Cravatt, B. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404727101 · Cited by 184
Self-citationSpatiotemporal Analysis of Differential Akt Regulation in Plasma Membrane Microdomains
Gao, X., & Zhang, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0449 · Cited by 173
Roca, H., Varsos, Z. S., & Pienta, K. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801073200 · Cited by 168
Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
Wang, D., Wang, H., Wei, N., Backlund, M. G., Dey, S. K., & DuBois, R. N. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0896 · Cited by 166
Molecular determinants of human uveal melanoma invasion and metastasis
Seftor, E. A., Meltzer, P. S., Kirschmann, D. A., Pe’er, J., Maniotis, A. J., Trent, J. M., Folberg, R., & Hendrix, M. J. C. (2002) · Clinical & Experimental Metastasis · doi:10.1023/a:1015591624171 · Cited by 165
Zhou, W., Han, W. F., Landree, L. E., Thupari, J. N., Pinn, M. L., Bililign, T., Kim, E. K., Vadlamudi, A., Medghalchi, S. M., Meskini, R. E., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3439 · Cited by 157
Cannabinoid Receptors and Endocannabinoids: Evidence for New Players
Mackie, K., & Stella, N. (2006) · The AAPS Journal · doi:10.1208/aapsj080234 · Cited by 149
The Plasminogen Activator System and Cancer
McMahon, B. J., & Kwaan, H. C. (2007) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000175156 · Cited by 148
Sarnataro, D., Pisanti, S., Santoro, A., Gazzerro, P., Malfitano, A. M., Laezza, C., & Bifulco, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.025601 · Cited by 134
Siddiqui, R. A., Zérouga, M., Wu, M., Castillo, A., Harvey, K. A., Zaloga, G. P., & Stillwell, W. H. (2005) · Breast Cancer Research · doi:10.1186/bcr1036 · Cited by 126
Activation of the endocannabinoid system by organophosphorus nerve agents
Nomura, D. K., Blankman, J. L., Simon, G. M., Fujioka, K., Issa, R. S., Ward, A. M., Cravatt, B. F., & Casida, J. E. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.86 · Cited by 112
Self-citationPuustinen, P., Junttila, M. R., Vanhatupa, S., Sablina, A. A., Hector-Greene, M., Teittinen, K. J., Raheem, O., Ketola, K., Lin, S., Kast, J., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2760 · Cited by 98
Discovery of Drug-Resistant and Drug-Sensitizing Mutations in the Oncogenic PI3K Isoform p110α
Zunder, E. R., Knight, Z. A., Houseman, B. T., Apsel, B., & Shokat, K. M. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.06.014 · Cited by 96
Exon–intron organization and chromosomal localization of the mouse monoglyceride lipase gene
Karlsson, M., Reue, K., Xia, Y.-R., Lusis, A. J., Langin, D., Tornqvist, H. E., & Holm, C. (2001) · Gene · doi:10.1016/s0378-1119(01)00559-5 · Cited by 87
Przybytkowski, E., Joly, E. C., Nolan, C. J., Hardy, S., Francoeur, A.-M., Langelier, Y., & Prentki, M. (2007) · Biochemistry and Cell Biology · doi:10.1139/o07-001 · Cited by 60
Endsley, M. P., Aggarwal, N. T., Isbell, M. A., Wheelock, C. E., Hammock, B. D., Falck, J. R., Campbell, W. B., & Nithipatikom, K. (2007) · International Journal of Cancer · doi:10.1002/ijc.22761 · Cited by 52
Gjerstorff, M. F., Benoit, V. M., Lænkholm, A., Nielsen, O., Johansen, L. E., & Ditzel, H. J. (2006) · International Journal of Oncology · doi:10.3892/ijo.28.6.1327 · Cited by 36
Zhao, Q. J., He, Z., Chen, N., Cho, Y., Zhu, F., Lu, C., Ma, W., Bode, A. M., & Dong, Z. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412828200 · Cited by 28
Research works printed but not linked: 6
- Cociorva, D., and Yates, J.R. (2006). DTASelect 2.0: improving the confidence of peptide and protein identifications. Proceedings of the 54th Annual ASMS Meeting, American Society for Mass Spectrometry, Sante Fe, New Mexico.
- Jessani, N., Liu, Y., Humphrey, M., and Cravatt, B.F. (2002). Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proc. Natl. Acad. Sci. USA 99, 10335-10340. · DOI
- Jessani, N., Humphrey, M., McDonald, W.H., Niessen, S., Masuda, K., Gangadharan, B., Yates, J.R., 3rd, Mueller, B.M., and Cravatt, B.F. (2004). Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo. Proc. Natl. Acad. Sci. USA 101, 13756-13761. · DOI
- Jessani, N., Niessen, S., Wei, B.Q., Nicolau, M., Humphrey, M., Ji, Y., Han, W., Noh, D.Y., Yates, J.R., 3rd, Jeffrey, S.S., et al. (2005). A streamlined platform for high-content functional proteomics of primary human specimens. Nat. Methods 2, 691-697. · DOI
- Liu, H., Sadygov, R.G., and Yates, J.R., III. (2004). A model for random sampling and estimation of relative protein abundance in shotgun proteomics. Anal. Chem. 76, 4193-4201. · DOI
- Seftor, E.A., Meltzer, P.S., Kirschmann, D.A., Pe'er, J., Maniotis, A.J., Trent, J.M., Folberg, R., and Hendrix, M.J. (2002). Molecular determinants of human uveal melanoma invasion and metastasis. Clin. Exp. Metastasis 19, 233-246. · DOI
Cited by
Sorted by citations
The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926
Cellular Fatty Acid Metabolism and Cancer
Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.017 · Cited by 2,123
Targeting cancer metabolism: a therapeutic window opens
Heiden, M. G. V. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3504 · Cited by 1,443
Santos, C. R., & Schulze, A. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08644.x · Cited by 1,371
XCMS Online: A Web-Based Platform to Process Untargeted Metabolomic Data
Tautenhahn, R., Patti, G. J., Rinehart, D., & Siuzdak, G. E. (2012) · Analytical Chemistry · doi:10.1021/ac300698c · Cited by 1,323
Metadata
- Authors
- Nomura, D. K., Long, J. Z., Niessen, S., Hoover, H. S., Ng, S.-W., & Cravatt, B. F.
- Affiliations
- Scripps Research Institute (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Cravatt, Benjamin F.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 140
- Issue
- 1
- Pages
- 49-61
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2885975
- OpenAlex
- W2127624416
- Cited by
- 1,002
- References
- 69
- Citations by year
- 2026: 40 · 2025: 41 · 2024: 55 · 2023: 46 · 2022: 59 · 2021: 78 · 2020: 69 · 2019: 67 · 2018: 69 · 2017: 60 · 2016: 75 · 2015: 72 · 2014: 70 · 2013: 61 · 2012: 47
- FWCI
- 15.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1293 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA132630, CA-087660, R37CA087660, R01CA087660, CA132630)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Keywords
- monoacylglycerol lipase, fatty acid metabolism, lipolysis, tumor cell migration and invasion, tumor growth, MAGL inhibitors, high-fat diet, cancer metabolism
- MeSH terms
- Animals, Cell Line, Fatty Acids, Female, Humans, Monoacylglycerol Lipases, Neoplasm Transplantation, Ovarian Neoplasms, Transplantation, Heterologous, Tumor Cells, Cultured, Monoglycerides, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
