DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

Tu, Weihong, Xu, Xin, Peng, Lisheng, Zhong, Xiaofen, Zhang, Wenfeng, Soundarapandian, Mangala M., Belal, Cherine, Wang, Manqi, Jia, Nali, Zhang, Wen, Lew, Frank, Chan, Sic Lung, Chen, Yanfang, Lu, Youming·2010·Cell

DOI 10.1016/j.cell.2009.12.055

Cited by (495)

Items 101–200 of 495

Excitatory Synaptic Transmission in Ischemic Stroke: A New Outlet for Classical Neuroprotective Strategies
Fan Wang, Xueheng Xie, Xiaoyan Xing, Xiaobo Sun · 2022 · International Journal of Molecular Sciences
Novel Pharmacological Approaches to the Treatment of Depression
Elias Elias, Ariel Y. Zhang, Melissa T. Manners · 2022 · Life
Combining xenon and mild therapeutic hypothermia preserves neurological function after prolonged cardiac arrest in pigs*
Michael Fries, Anne Brücken, Ayşegül Çizen, Maren Westerkamp, Céline Löwer, Jan Deike-Glindemann, Nora Katharina Schnorrenberger, Steffen Rex, Mark Coburn, Kay Wilhelm Nolte et al. · 2012 · Critical Care Medicine
Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation
Xuying Sun, Qing‐zhang Tuo, Zhen‐Yu Liuyang, Ao‐Ji Xie, Xiao-Long Feng, Xiong Yan, Mei Qiu, Li Shen, Xiu-Lian Wang, Fu-Yuan Cao et al. · 2016 · Cell Death and Disease
The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu
M. Huuskonen, Qing-Zhang Tuo, S. Loppi, H. Dhungana, P. Korhonen, Lachlan E. McInnes, P. Donnelly, A. Grubman, S. Wojciechowski, Katarína Lejavová et al. · 2017 · Neurotherapeutics
Epac2-dependent mobilization of intracellular Ca2+by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ɛ knockout mice: Calcium mobilizing properties of exendin-4 in mouse β-cells
Dzhura, Igor, Chepurny, Oleg G., Kelley, Grant G., Leech, Colin A., Roe, Michael W., Dzhura, Elvira, Afshari, Parisa, Malik, Sundeep, Rindler, Michael J., Xu, Xin et al. · 2010 · The Journal of Physiology
Nuclear translocation of annexin 1 following oxygen-glucose deprivation–reperfusion induces apoptosis by regulating Bid expression via p53 binding
Xing Li, Yin Zhao, Qian Xia, Lu Zheng, Lu Liu, Baoming Zhao, Jing Shi · 2016 · Cell Death and Disease
d-Serine, the Shape-Shifting NMDA Receptor Co-agonist
Joseph T. Coyle, Darrick T. Balu, Herman Wolosker · 2020 · Neurochemical Research
NR2B‐NMDA receptor mediated modulation of the tyrosine phosphatase STEP regulates glutamate induced neuronal cell death
Ranjana Poddar, Ishani Deb, Saibal Mukherjee, Surojit Paul · 2010 · Journal of Neurochemistry
Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs
Zhu, Jinwei, Zhou, Qingqing, Shang, Yuan, Li, Hao, Peng, Mengjuan, Ke, Xiao, Weng, Zhuangfeng, Zhang, Rongguang, Huang, Xuhui, Li, Shawn S.C. et al. · 2017 · Cell Reports
The DAP-kinase interactome
Shani Bialik, Adi Kimchi · 2013 · APOPTOSIS
Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage
Dongxu Zhai, Kyle Chin, Min Wang, Fang Liu · 2014 · Molecular Brain
Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice
Chenxi Qiu, Önder Albayram, Asami Kondo, Bin Wang, Na‐Mi Kim, Ken Arai, Cheng-yu Tsai, Mahmoud Adel Bassal, Megan K. Herbert, Kazuo Washida et al. · 2021 · Science Translational Medicine
Post-translational modification of NMDA receptor GluN2B subunit and its roles in chronic pain and memory
Shuang Qiu, Xiang‐Yao Li, Min Zhuo · 2011 · Seminars in Cell and Developmental Biology
Tumor suppressor death-associated protein kinase is required for full IL-1β production
Ya-Ting Chuang, Yu‐Chuan Lin, Kuan‐Hung Lin, Ting-Fang Chou, Wen‐Chih Kuo, Kaiting Yang, Pei‐Rung Wu, Ruey‐Hwa Chen, Adi Kimchi, Ming‐Zong Lai · 2010 · Blood
Prolonged Adenosine A1 Receptor Activation in Hypoxia and Pial Vessel Disruption Focal Cortical Ischemia Facilitates Clathrin-Mediated AMPA Receptor Endocytosis and Long-Lasting Synaptic Inhibition in Rat Hippocampal CA3-CA1 Synapses: Differential Regulation of GluA2 and GluA1 Subunits by p38 MAPK and JNK
Zhicheng Chen, Cherry Xiong, Cassandra Pancyr, Jocelyn Stockwell, Wolfgang Walz, Francisco S. Cayabyab · 2014 · Journal of Neuroscience
The GluN1/GluN2B NMDA receptor and metabotropic glutamate receptor 1 negative allosteric modulator has enhanced neuroprotection in a rat subarachnoid hemorrhage model
Zongyong Zhang, Junke Liu, Cundong Fan, Leilei Mao, Rongxia Xie, Suyun Wang, Mingfeng Yang, Hui Yuan, Xiaoyi Yang, Jingyi Sun et al. · 2017 · Experimental Neurology
NMDA receptor signaling: death or survival?
Tong Luo, Wei-Hua Wu, Bo-Shiun Chen · 2011 · Frontiers in Biology
Caffeoylquinic Acids Are Major Constituents with Potent Anti‐Influenza Effects in Brazilian Green Propolis Water Extract
Tomohiko Urushisaki, Tomoaki Takemura, Shigemi Tazawa, Mayuko Fukuoka, Junji Hosokawa‐Muto, Yoko Araki, Kazuo Kuwata · 2011 · Evidence-based Complementary and Alternative Medicine
Tonic NMDA receptor-mediated current in prefrontal cortical pyramidal cells and fast-spiking interneurons
Povysheva, Nadezhda V., Johnson, Jon W. · 2012 · Journal of Neurophysiology
β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain
Gang Chen, Rou‐Gang Xie, Yong‐Jing Gao, Zhen‐Zhong Xu, Lin‐Xia Zhao, Sangsu Bang, Temugin Berta, Chul‐Kyu Park, Mark Lay, Wei Chen et al. · 2016 · Nature Communications
Neuroprotective effect of estrogen: Role of nonsynaptic NR2B-containing NMDA receptors
Shui‐bing Liu, Ming Zhao · 2012 · Brain Research Bulletin
Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death
Mi‐Hyeon You, Byeong Mo Kim, Chun-Hau Chen, Michael J Begley, Lewis C. Cantley, Tae Ho Lee · 2016 · Cell Death and Differentiation
Death-Associated Protein Kinase 1 as a Promising Drug Target in Cancer and Alzheimer’s Disease
Dongmei Chen, Xiao Zhen Zhou, Tae Ho Lee · 2018 · Recent Patents on Anti-Cancer Drug Discovery
CaMKII versus DAPK1 Binding to GluN2B in Ischemic Neuronal Cell Death after Resuscitation from Cardiac Arrest
Olivia R. Buonarati, Sarah G. Cook, Dayton J. Goodell, Nicholas E. Chalmers, Nicole L. Rumian, Jonathan E. Tullis, Susana Restrepo, Steven J. Coultrap, Nidia Quillinan, Paco S. Herson et al. · 2020 · Cell Reports
Melatonin directly binds and inhibits death‐associated protein kinase 1 function in Alzheimer’s disease
Dongmei Chen, Yingxue Mei, Nami Kim, Guihua Lan, Chen‐Ling Gan, Fei Fan, Tao Zhang, Yongfang Xia, Long Wang, Chun Lin et al. · 2020 · Journal of Pineal Research
Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington’s disease
Shiraz Tyebji, Anthony John Hannan · 2017 · Progress in Neurobiology
Honokiol protects brain against ischemia–reperfusion injury in rats through disrupting PSD95–nNOS interaction
Zhenyu Hu, Xiling Bian, Xiaoyan Liu, Yuanjun Zhu, Xiaoyi Zhang, Shizhong Chen, KeWei Wang, Yinye Wang · 2012 · Brain Research
Local and Use-Dependent Effects of β-Amyloid Oligomers on NMDA Receptor Function Revealed by Optical Quantal Analysis
Brooke L. Sinnen, Aaron B. Bowen, Emily S. Gibson, Matthew J. Kennedy · 2016 · Journal of Neuroscience
The differences between GluN2A and GluN2B signaling in the brain
Yongjun Sun, Yingge Xu, Xiaokun Cheng, Xi Chen, Yinghua Xie, Linan Zhang, Long Wang, Jie Hong Hu, Zibin Gao · 2018 · Journal of Neuroscience Research
Modulation of Synaptic Plasticity by Stress Hormone Associates with Plastic Alteration of Synaptic NMDA Receptor in the Adult Hippocampus
Yiu Chung Tse, Rosemary C. Bagot, Juliana A. Hutter, Alice S. Wong, Tak Pan Wong · 2011 · PLoS ONE
Amyloid β / PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer´s disease
Carolina Ortiz-Sanz, Uxue Balantzategi, Tania Quintela‐López, Asier Ruiz, Celia Luchena, Jone Zuazo-Ibarra, Estibaliz Capetillo‐Zarate, Carlos Matute, Jose Luis Zugaza, Elena M Alberdi · 2022 · Cell Death and Disease
Vinpocetine alleviate cerebral ischemia/reperfusion injury by down-regulating TLR4/MyD88/NF-κB signaling
Lirong Wu, Liang Liu, Xiao‐Yi Xiong, Qin Zhang, Fa-Xiang Wang, Chang‐Xiong Gong, Qi Zhong, Yuan‐Rui Yang, Zhaoyou Meng, Qingwu Yang · 2017 · Oncotarget
LncRNA MALAT1 targeting miR‐124‐3p regulates DAPK1 expression contributes to cell apoptosis in Parkinson's Disease
Yi Lu, Zhongying Gong, Xiaojie Jin, Peng Zhao, Yuting Zhang, Zhiyun Wang · 2020 · Journal of Cellular Biochemistry
Regulatory T cells in CNS injury: the simple, the complex and the confused
James T. Walsh, Jonathan Kipnis · 2011 · Trends in Molecular Medicine
Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1
Jamie McQueen, Tomás J. Ryan, Sean McKay, Katie F. M. Marwick, Paul S. Baxter, Sarah M. Carpanini, Thomas M. Wishart, Thomas Henry Gillingwater, Jean C. Manson, David J. A. Wyllie et al. · 2017 · eLife
NMDA Receptors: Distribution, Role, and Insights into Neuropsychiatric Disorders
Marie Beaurain, Anne‐Sophie Salabert, Pierre Payoux, Emmanuel Gras, Franck Talmont · 2024 · Pharmaceuticals
Spreading Depolarization May Link Migraine and Stroke
Katharina Eikermann‐Haerter · 2014 · Headache The Journal of Head and Face Pain
Expression of BC1 Impairs Spatial Learning and Memory in Alzheimer’s Disease Via APP Translation
Zhang, Tongmei, Pang, Pei, Fang, Zemin, Guo, Yu, Li, Hao, Li, Xinyan, Tian, Tian, Yang, Xin, Chen, Wenting, Shu, Shu et al. · 2018 · Molecular Neurobiology
Molecular mechanisms of NMDA receptor-mediated excitotoxicity: Implications for neuroprotective therapeutics for stroke
Wang, YuTian, Li, Victor · 2016 · Neural Regeneration Research
Melatonin Protects MCAO-Induced Neuronal Loss via NR2A Mediated Prosurvival Pathways
Fawad Ali Shah, Gong‐Ping Liu, Lina Tariq Al Kury, Alam Zeb, Phil‐Ok Koh, Muzaffar Abbas, Tao Li, Xifei Yang, Fang Liu, Yuhua Jiang et al. · 2019 · Frontiers in Pharmacology
Long Non-coding RNAs as Promising Therapeutic Approach in Ischemic Stroke: a Comprehensive Review
Marta Wolska, Joanna Jarosz-Popek, Eva Junger, Zofia Wicik, Tahmina Porshoor, Lucia Sharif, Pamela Czajka, Marek A Postula, Dagmara Maria Mirowska-Guzel, Anna Członkowska et al. · 2020 · Molecular Neurobiology
Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats
Gaoshang Chai, Dong-Xiao Duan, Rong-Hong Ma, Jianying Shen, Honglian Li, Zhiwei Ma, Yu Luo, Lu Wang, Xin-Hua Qi, Jian‐Zhi Wang et al. · 2014 · Neuroscience Bulletin
Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein
Byeong Mo Kim, Mi‐Hyeon You, Chun-Hau Chen, Jaehong Suh, Rudolph E. Tanzi, Tae Ho Lee · 2016 · Human Molecular Genetics
Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1
Shu Shu, Houze Zhu, Na Tang, Wenting Chen, Xinyan Li, Hao Li, Lei Pei, Dan Liu, Yangling Mu, Qing Tian et al. · 2016 · Journal of Neuroscience
Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals
Mohamed Elbadawy, Tatsuya Usui, Hideyuki Yamawaki, Kazuaki Sasaki · 2018 · International Journal of Molecular Sciences
The C‐terminal domains of the NMDA receptor: How intrinsically disordered tails affect signalling, plasticity and disease
Warnet, Xavier L., Bakke Krog, Helle, Sevillano‐Quispe, Oscar G., Poulsen, Hanne, Kjaergaard, Magnus · 2021 · European Journal of Neuroscience
Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage
Han-Wei Liu, Li-Na Gong, Ke Lai, Xiafei Yu, Zhen-Qi Liu, Ming‐Xian Li, Xin‐Lu Yin, Min Liang, Hao-Song Shi, Lin‐Hua Jiang et al. · 2023 · Neuron
GluN2A versus GluN2B: twins, but quite different
Xiaomin Zhang, Jianhong Luo · 2013 · Neuroscience Bulletin
Inhibition of death-associated protein kinase 1 attenuates cis P-tau and neurodegeneration in traumatic brain injury
Nami Kim, Bin Wang, Kazuhiro Koikawa, Yutaka Nezu, Chenxi Qiu, Tae Ho Lee, Xiao Zhen Zhou · 2021 · Progress in Neurobiology
Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral palsy
Darcy L. Fehlings, Mehdi Zarrei, Worrawat Engchuan, Neal Sondheimer, Bhooma Thiruvahindrapuram, Jeffrey R. MacDonald, Edward J. Higginbotham, Ritesh Thapa, Tarannum Behlim, Sabrina Aimola et al. · 2024 · Nature Genetics
Migraine Prophylaxis, Ischemic Depolarizations, and Stroke Outcomes in Mice
Katharina Eikermann‐Haerter, Jeong Hyun Lee, Nilufer Yalcin, Esther S. Yu, Ali Daneshmand, Ying Wei, Yi Zhou Zheng, Anil Can, Buse Sengul, Michel Dominique Ferrari et al. · 2014 · Stroke
A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury
Juan Chen, Rong Hu, Huabao Liao, Ya Zhang, Ruixue Lei, Zhifeng Zhang, Yang Zhuang, Yu Wan, Ping Jin, Hua Feng et al. · 2017 · Scientific Reports
Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation
Yung‐Hsuan Wu, Ting-Fang Chou, Leslie Young, Fu‐Yi Hsieh, Hsuan-Yin Pan, Shu-Ting Mo, Shani Bialik Brown, Ruey‐Hwa Chen, Adi Kimchi, Ming‐Zong Lai · 2020 · Cell Death and Disease
Neuroprotective effects of vitexin by inhibition of NMDA receptors in primary cultures of mouse cerebral cortical neurons
Le Yang, Zhi-ming Yang, Nan Zhang, Zhen Tian, Shui‐bing Liu, Ming Zhao · 2013 · Molecular and Cellular Biochemistry
Evaluating DAPK as a therapeutic target
Yide Huang, Ling Chen, Libin Guo, Ted R. Hupp, Yao Lin · 2013 · APOPTOSIS
Kibra Modulates Learning and Memory via Binding to Dendrin
Zeyang Ji, Hao Li, Zhou Yang, Xian Huang, Xiao Ke, Sehui Ma, Zhijie Lin, Youming Lu, Mingjie Zhang · 2019 · Cell Reports
Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke
R. Rama, Julio Cesar Garcia Rodriguez · 2012 · InTech eBooks
Death Associated Protein Kinases: Molecular Structure and Brain Injury
Syam Nair, Henrik Hagberg, Golgodu Krishnamurthy Rajanikant, Claire Thornton, Carina E. Mallard · 2013 · International Journal of Molecular Sciences
A Truncated Fragment of Src Protein Kinase Generated by Calpain-mediated Cleavage Is a Mediator of Neuronal Death in Excitotoxicity
Mohammed Iqbal Hossain, Carli L. Roulston, Mohd Aizuddin Kamaruddin, Percy W.Y. Chu, Dominic C.H. Ng, Gregory James Dusting, Jeffrey D. Bjorge, Nicholas A. Williamson, Donald J. Fujita, Steve Cheung et al. · 2013 · Journal of Biological Chemistry
Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease
Tao Zhang, Yongfang Xia, Li Hu, Dongmei Chen, Chen‐Ling Gan, Long Wang, Yingxue Mei, Guihua Lan, Xindong Shui, Yuan Tian et al. · 2021 · International Journal of Biological Sciences
Protein-protein interactions at the NMDA receptor complex: From synaptic retention to synaptonuclear protein messengers
Fabrizio Gardoni, Mónica Di Luca · 2021 · Neuropharmacology
Death-associated protein kinase 1 as a therapeutic target for Alzheimer's disease
Tao Zhang, Byeong Mo Kim, Tae Ho Lee · 2024 · Translational Neurodegeneration
Extrasynaptic NMDA Receptor in Excitotoxicity
Xianju Zhou, Zhuoyou Chen, Wenwei Yun, Jianhua Ren, Chengwei Li, Hongbing Wang · 2014 · The Neuroscientist
Mechanisms of Neuroprotective Effects of Peptides Derived from Natural Materials and Their Production and Assessment
Seung Yun Lee, Sun Jin Hur · 2019 · Comprehensive Reviews in Food Science and Food Safety
Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)
Huifang Wang, Runhua Zhou, Fushan Xu, Kongjun Yang, Liuhai Zheng, Pan Zhao, Guangwei Shi, Lingyun Dai, Chengchao Xu, Le Yu et al. · 2023 · Biomaterials Research
The role of N-methyl-D-aspartate glutamate receptors in Alzheimer’s disease: From pathophysiology to therapeutic approaches
Wenying Liu, Yan Li, Tan Zhao, Min Gong, Xuechu Wang, Yue Zhang, Lingzhi Xu, Wenwen Li, Yan Li, Jianping Jia · 2023 · Progress in Neurobiology
The Membrane-Active Tri-Block Copolymer Pluronic F-68 Profoundly Rescues Rat Hippocampal Neurons from Oxygen-Glucose Deprivation-Induced Death through Early Inhibition of Apoptosis
Phullara B. Shelat, Leigh D. Plant, J. C. Wang, Elizabeth E.L. Lee, Jeremy D. Marks · 2013 · Journal of Neuroscience
Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure
Sean McKay, C. Peter Bengtson, Hilmar Bading, David J. A. Wyllie, Giles E. Hardingham · 2013 · Neuropharmacology
Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia
Marta Mota Vieira, Jeannette Schmidt, Joana S. Ferreira, Kevin She, Shinichiro Oku, Miranda Mele, Armanda E. Santos, Carlos Bandeira Duarte, Ann Marie Craig, Ana Luı́sa Carvalho · 2015 · Neurobiology of Disease
NMDA receptor C-terminal signaling in development, plasticity, and disease
Giles E. Hardingham · 2019 · F1000Research
DAPK1: a Novel Pathology and Treatment Target for Alzheimer’s Disease
Xu, Ling-zhi, Li, Bing-qiu, Jia, Jian-ping · 2019 · Molecular Neurobiology
Repeated oxytocin prevents central sensitization by regulating synaptic plasticity via oxytocin receptor in a chronic migraine mouse model
Yunfeng Wang, Qi Pan, Ruimin Tian, Qianwen Wen, Guangcheng Qin, Dunke Zhang, Lixue Chen, Yixin Zhang, Jiying Zhou · 2021 · The Journal of Headache and Pain
Interferons, Signal Transduction Pathways, and the Central Nervous System
Shreeram C. Nallar, Dhan V. Kalvakolanu · 2014 · Journal of Interferon & Cytokine Research
GABAA Receptor Endocytosis in the Basolateral Amygdala Is Critical to the Reinstatement of Fear Memory Measured by Fear-Potentiated Startle
Hui‐Ching Lin, Y.-C. Tseng, Sheng-Chun Mao, P.-S. Chen, Po‐Wu Gean · 2011 · Journal of Neuroscience
Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics
Gabriella MacDougall, Ryan S. Anderton, Frank Louis Mastaglia, Neville W. Knuckey, Bruno P. Meloni · 2018 · Neurobiology of Disease
Pathophysiological Ionotropic Glutamate Signalling in Neuroinflammatory Disease as a Therapeutic Target
Richard Fairless, Hilmar Bading, Ricarda Diem · 2021 · Frontiers in Neuroscience
Therapeutic Intervention of Learning and Memory Decays by Salidroside Stimulation of Neurogenesis in Aging
Huijuan Jin, Lei Pei, Xiaogang Shu, Xin Yang, Tianhua Yan, Yan Wu, Na Wei, Honglin Yan, Shan Wang, Chengye Yao et al. · 2014 · Molecular Neurobiology
Quantitative structure–activity relationship studies of dibenzo[a,d]cycloalkenimine derivatives for non-competitive antagonists ofN-methyl- d -aspartate based on density functional theory with electronic and topological descriptors
Samir Chtita, Majdouline Larif, Mounir Ghamali, Mohammed Bouachrıne, Tahar Lakhlifi · 2014 · Journal of Taibah University for Science
GluN2B-containing NMDARs in the mammalian brain: pharmacology, physiology, and pathology
Yang Ge, Yu Tian Wang · 2023 · Frontiers in Molecular Neuroscience
Therapeutic Targets for Cerebral Ischemia Based on the Signaling Pathways of the GluN2B C Terminus
Yongjun Sun, Linan Zhang, You Chen, Liying Zhan, Zibin Gao · 2015 · Stroke
Remote Ischemic Postconditioning for Ischemic Stroke
Jingjing Zhao, Hui Xiao, Wenbo Zhao, Xiao‐Pei Zhang, Yu Xiang, Zengjie Ye, Miao‐Miao Mo, Xueting Peng, Lin Wei · 2018 · Chinese Medical Journal
Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS
Shuangchan Wu, Yuan Yue, Hui Rou Tian, Li Tao, Yuting Wang, Jin Xiang, Shi Wang, Hong Ding · 2014 · Neuropharmacology
A beacon of hope in stroke therapy—Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies
Ashfaqul Hoque, Mohammed Iqbal Hossain, S. Sadia Ameen, Ching‐Seng Ang, Nicholas A. Williamson, Dominic C.H. Ng, Anderly C. Chüeh, Carli L. Roulston, Heung‐Chin Cheng · 2016 · Pharmacology & Therapeutics
Assessment of the Neuroprotective Effects of Arginine-Rich Protamine Peptides, Poly-Arginine Peptides (R12-Cyclic, R22) and Arginine–Tryptophan-Containing Peptides Following In Vitro Excitotoxicity and/or Permanent Middle Cerebral Artery Occlusion in Rats
Bruno P. Meloni, Diego Milani, Jane L. Cross, Vince W. Clark, Adam B. Edwards, Ryan S. Anderton, David Blacker, Neville W. Knuckey · 2017 · NeuroMolecular Medicine
Pseudoginsenoside-F11 Protects against Transient Cerebral Ischemia Injury in Rats Involving Repressing Calcium Overload
Tianyu Zhang, Chunfu Wu, Xiaowei Yang, Yueyang Liu, Hanlin Yang, Linlin Yuan, Yinglu Liu, Shibo Sun, Jingyu Yang · 2019 · Neuroscience
Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase – Design, synthesis and biological evaluation
Chandran Remya, Kalarickal Vijayan Dileep, Eeda Koti Reddy, Kumar Mantosh, Lakshmi Kesavan, Reena Sarah Jacob, Ayyiliath Meleveetil Sajith, E. Jayadevi Variyar, Shaik Anwar, Kam Y. J. Zhang et al. · 2021 · Computational and Structural Biotechnology Journal
Protective Role for Type 4 Metabotropic Glutamate Receptors against Ischemic Brain Damage
Slavianka Georgieva Moyanova, Federica Mastroiacovo, Lidia Kortenska, Rumiana Mitreva, Erminia Fardone, Ines Santolini, Mónica Sobrado, Giuseppe Battaglia, Valeria Bruno, Ferdinando Nicoletti et al. · 2010 · Journal of Cerebral Blood Flow & Metabolism
Early onset senescence and cognitive impairment in a murine model of repeated mTBI
Schwab, Nicole, Ju, YoungJun, Hazrati, Lili-Naz · 2021 · Acta Neuropathologica Communications
Intervention of Death-Associated Protein Kinase 1–p53 Interaction Exerts the Therapeutic Effects Against Stroke
Xiaoxi Wang, Lei Pei, Honglin Yan, Zhongping Wang, Na Wei, Shan Wang, Xin Yang, Qing Tian, Youming Lu · 2014 · Stroke
A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI
Holger Husi, María Dolores Sánchez-Niño, Christian Delles, William Mullen, Antonia Vlahou, Alberto Ortíz, Harald Mischak · 2013 · BMC Systems Biology
The R18 Polyarginine Peptide Is More Effective Than the TAT-NR2B9c (NA-1) Peptide When Administered 60 Minutes after Permanent Middle Cerebral Artery Occlusion in the Rat
D. Milani, N. Knuckey, Ryan S. Anderton, Jane L. Cross, Bruno P. Meloni · 2016 · Stroke Research and Treatment
The Neuroprotective Peptide Poly-Arginine-12 (R12) Reduces Cell Surface Levels of NMDA NR2B Receptor Subunit in Cortical Neurons; Investigation into the Involvement of Endocytic Mechanisms
Gabriella MacDougall, Ryan S. Anderton, Adam B. Edwards, Neville W. Knuckey, Bruno P. Meloni · 2016 · Journal of Molecular Neuroscience
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1
Julia Pose‐Utrilla, Lucía García‐Guerra, Ana del Puerto, Abraham Martín, Jerónimo Jurado‐Arjona, Noelia S. de León-Reyes, Andrea Gamir-Morralla, Álvaro Sebastián‐Serrano, Mónica Garcı́a-Gallo, Leonor Kremer et al. · 2017 · Nature Communications
Protopanaxadiol ginsenoside Rd protects against NMDA receptor-mediated excitotoxicity by attenuating calcineurin-regulated DAPK1 activity
Chen Zhang, Xuedong Liu, Hui Xu, Gengyao Hu, Xiao Zhang, Zhen Xie, Dongyun Feng, Rui Xin Wu, Gang Zhao, Ming Shi · 2020 · Scientific Reports
The Use of ADSCs as a Treatment for Chronic Stroke
Tzu-Min Chan, Horng‐Jyh Harn, Hui-Ping Lin, Shao‐Chih Chiu, Po‐Cheng Lin, Hsin-I Wang, Li-Ing Ho, Chih‐Pin Chuu, Tzyy‐Wen Chiou, An-Cheng Hsieh et al. · 2014 · Cell Transplantation
Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons
Jiejie Wang, Xinyou Lv, Yu Wu, Tao Xu, Mingfei Jiao, Risheng Yang, Xia Li, Ming Chen, Ying-Gang Yan, Changwan Chen et al. · 2018 · Nature Communications
Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors
Johansen B. Amin, Catherine Lourdes Salussolia, Kelvin Chan, Michael C. Regan, Jian Dai, Huan‐Xiang Zhou, Hiro Furukawa, Mark E. Bowen, Lonnie P. Wollmuth · 2017 · The Journal of General Physiology
Promising targets of cell death signaling of NR2B receptor subunit in stroke pathogenesis
Shu Shu, Lei Pei, Youming Lu · 2014 · Regenerative Medicine Research
NMDA receptor‐driven calcium influx promotes ischemic human cardiomyocyte apoptosis through a p38 MAPK‐mediated mechanism
Zi‐You Liu, Qinwen Zhong, Chengnan Tian, Hou Mou, Junjian Yu, Shuo Hu · 2019 · Journal of Cellular Biochemistry