Cited by 50Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingAmino Acid Enzymes and Metabolism

The C‐terminal domains of the NMDA receptor: How intrinsically disordered tails affect signalling, plasticity and disease

Warnet, Xavier L., Bakke Krog, Helle, Sevillano‐Quispe, Oscar G., Poulsen, Hanne, Kjaergaard, Magnus·2021·European Journal of Neuroscience

Abstract

NMDA receptors are part of the ionotropic glutamate receptor family, and are crucial for neurotransmission and memory. At the cellular level, the effects of activating these receptors include long‐term potentiation (LTP) or depression (LTD). The NMDA receptor is a stringently gated cation channel permeable to Ca 2+ , and it shares the molecular architecture of a tetrameric ligand‐gated ion channel with the other family members. Its subunits, however, have uniquely long cytoplasmic C‐terminal domains (CTDs). While the molecular gymnastics of the extracellular domains have been described in exquisite detail, much less is known about the structure and function of these CTDs. The CTDs vary dramatically in length and sequence between receptor subunits, but they all have a composition characteristic of intrinsically disordered proteins. The CTDs affect channel properties, trafficking and downstream signalling output from the receptor, and these functions are regulated by alternative splicing, protein–protein interactions, and post‐translational modifications such as phosphorylation and palmitoylation. Here, we review the roles of the CTDs in synaptic plasticity with a focus on biochemical mechanisms. In total, the CTDs play a multifaceted role as a modifier of channel function, a regulator of cellular location and abundance, and signalling scaffold control the downstream signalling output.

Integrity signals

Registry

Crossref · 10.1111/ejn.14842

Cites

240 of 240 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Warnet, X. L., Bakke Krog, H., Sevillano‐Quispe, O. G., Poulsen, H., & Kjaergaard, M.
Affiliations
  • Aarhus University (DK)
  • Department of Molecular Biology and Genetics Aarhus University Aarhus Denmark
Corresponding author
Poulsen, Hanne
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2020-07-16
Volume
54
Issue
8
Pages
6713-6739
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W3032632587
Cited by
50
References
240
Citations by year
2026: 4 · 2025: 5 · 2024: 10 · 2023: 11 · 2022: 10 · 2021: 9 · 2020: 1
FWCI
1.07
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Danmarks Grundforskningsfond (DNRF133)
  • National Research Foundation (DNRF133)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
NMDA receptor, C-terminal domain, intrinsically disordered proteins, synaptic plasticity, long-term potentiation, long-term depression, alternative splicing, protein phosphorylation, palmitoylation, protein-protein interaction, receptor trafficking, ionotropic glutamate receptors, memory
MeSH terms
Synaptic Transmission, Neuronal Plasticity, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review