DAPK1: a Novel Pathology and Treatment Target for Alzheimer’s Disease

Alzheimer’s Disease

Scheltens, P., Blennow, K., Breteler, M. M. B., de Strooper, B., Frisoni, G. B., Salloway, S., & Van der Flier, W. M. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01124-1 · Cited by 3,125 · see citing works

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

Karran, E., Mercken, M., & Strooper, B. D. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3505 · Cited by 2,188 · see citing works

NMDA receptor subunits: diversity, development and disease

Cull-Candy, S., Brickley, S., & Farrant, M. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00215-4 · Cited by 1,694 · see citing works

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686 · see citing works

The Molecular and Systems Biology of Memory

Kandel, E. R., Dudai, Y., & Mayford, M. R. (2014) · Cell · doi:10.1016/j.cell.2014.03.001 · Cited by 1,134 · see citing works

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

Lai, T. W., Zhang, S., & Wang, Y. T. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.006 · Cited by 1,106 · see citing works

Subunit arrangement and function in NMDA receptors

Furukawa, H., Singh, S. K., Mancusso, R., & Gouaux, E. (2005) · Nature · doi:10.1038/nature04089 · Cited by 787 · see citing works

The cost of Alzheimer's disease in China and re‐estimation of costs worldwide

Jia, J., Wei, C., Chen, S., Li, F., Tang, Y., Qin, W., Zhao, L., Jin, H., Xu, H., Wang, F., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.12.006 · Cited by 752 · see citing works

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

Lu, B., Nagappan, G., Guan, X.-M., Nathan, P. J., & Wren, P. B. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3505 · Cited by 747 · see citing works

Postsynaptic signaling and plasticity mechanisms

Sheng, M., & Kim, M. J. (2002) · Science · doi:10.1126/science.1075333 · Cited by 731 · see citing works

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

Tu, S., Okamoto, S., Lipton, S. A., & Xu, H. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-48 · Cited by 582 · see citing works

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

Tu, W., Xu, X., Peng, L., Zhong, X., Zhang, W., Soundarapandian, M. M., Belal, C., Wang, M., Jia, N., Zhang, W., et al. (2010) · Cell · doi:10.1016/j.cell.2009.12.055 · Cited by 493 · see citing works

The prevalence of dementia in urban and rural areas of China

Jia, J., Wang, F., Wei, C., Zhou, A., Jia, X., Li, F., Tang, M., Chu, L., Zhou, Y.-L., Zhou, C., et al. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.01.012 · Cited by 447 · see citing works

The Death-Associated Protein Kinases: Structure, Function, and Beyond

Bialik, S., & Kimchi, A. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142615 · Cited by 441 · see citing works

Memory and the NMDA Receptors

Li, F. R., & Tsien, J. Z. (2009) · New England Journal of Medicine · doi:10.1056/nejmcibr0902052 · Cited by 363 · see citing works

A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease

Karran, E. H., & Hardy, J. (2014) · Annals of Neurology · doi:10.1002/ana.24188 · Cited by 275 · see citing works

Ultrasound treatment of neurological diseases — current and emerging applications

Leinenga, G., Langton, C. M., Nisbet, R. M., & Götz, J. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.13 · Cited by 271 · see citing works

The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders

Cattaneo, A., Cattane, N., Begni, V, Pariante, C. M., & Riva, M. A. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.214 · Cited by 244 · see citing works

Higher brain <i>BDNF</i> gene expression is associated with slower cognitive decline in older adults

Buchman, A. S., Yu, L., Boyle, P. A., Schneider, J. A., De Jager, P. L., & Bennett, D. A. (2016) · Neurology · doi:10.1212/wnl.0000000000002387 · Cited by 239 · see citing works

Bidirectional signals transduced by DAPK–ERK interaction promote the apoptotic effect of DAPK

Chen, C.-H., Wang, W., Kuo, J., Tsai, H.-C., Lin, J., Chang, Z.-F., & Chen, R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600510 · Cited by 221 · see citing works

Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy

Singh, P., Ravanan, P., & Talwar, P. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00046 · Cited by 215 · see citing works

Stress and trauma: BDNF control of dendritic-spine formation and regression

Bennett, M. R., & Lagopoulos, J. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.005 · Cited by 199 · see citing works

The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese

Jia, J., Zhou, A., Wei, C., Jia, X., Wang, F., Fang, L., Wu, X., Mok, V., Gauthier, S. G., Tang, M., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.09.008 · Cited by 180 · see citing works

G-Protein-Coupled Receptor 30 Mediates Rapid Neuroprotective Effects of Estrogen via Depression of NR2B-Containing NMDA Receptors

Liu, S., Zhang, N., Guo, Y., Zhao, R., Shi, T., Feng, S., Wang, S.-Q., Yang, Q., Li, X., Wu, Y., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5828-11.2012 · Cited by 161 · see citing works

The Pro-apoptotic Function of Death-associated Protein Kinase Is Controlled by a Unique Inhibitory Autophosphorylation-based Mechanism

Shohat-Ophir, G., Spivak-Kroizman, T. R., Cohen, O., Bialik, S., Shani, G., Berissi, H., Eisenstein, M., & Kimchi, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105133200 · Cited by 153 · see citing works

DAPK1 variants are associated with Alzheimer's disease and allele-specific expression

Li, Y., Grupe, A., Rowland, C. M., Nowotny, P., Kauwe, J. S. K., Smemo, S., Hinrichs, A. L., Tacey, K. M., Toombs, T. A., Kwok, S., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl178 · Cited by 128 · see citing works

DAPK1–p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death

Pei, L., Shang, Y., Jin, H., Wang, S., Wei, N., Yan, H., Wu, Y., Yao, C., Wang, X., Zhu, L., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5119-13.2014 · Cited by 122 · see citing works

Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects

Li, S.-X., Han, Y., Xu, L., Yuan, K., Zhang, R.-X., Sun, C.-Y., Xu, D.-F., Yuan, M., Deng, J.-H., Meng, S.-Q., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.85 · Cited by 100 · see citing works

Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function

Kim, B. M., You, M.-H., Chen, C.-H., Lee, S., Hong, Y., Hong, Y., Kimchi, A., Zhou, X. Z., & Lee, T. H. (2014) · Cell Death &amp; Disease · doi:10.1038/cddis.2014.216 · Cited by 98 · see citing works

Ca2+-dependent Phosphorylation of Syntaxin-1A by the Death-associated Protein (DAP) Kinase Regulates Its Interaction with Munc18

Tian, J.-H., Das, S., & Sheng, Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300492200 · Cited by 91 · see citing works

DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific

Goodell, D. J., Zaegel, V., Coultrap, S. J., Hell, J. W., & Bayer, K. U. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.068 · Cited by 88 · see citing works

DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies

Wang, S., Shi, X.-D., Li, H., Pang, P., Pei, L., Shen, H., & Lu, Y. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0008-y · Cited by 83 · see citing works

DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity

Wu, P.-R., Tsai, P.-I., Chen, G., Chou, H.-J., Huang, Y.-P., Chen, Y. H., Lin, M.-Y., Kimchi, A., Chien, C.-T., & Chen, R.-H. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.2 · Cited by 82 · see citing works

Alzheimer’s disease risk variants show association with cerebrospinal fluid amyloid beta

Kauwe, J. S. K., Wang, J., Mayo, K., Morris, J. C., Fagan, A. M., Holtzman, D. M., & Goate, A. M. (2009) · neurogenetics · doi:10.1007/s10048-008-0150-4 · Cited by 82 · see citing works

<i>BDNF</i>Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer’s disease

Lim, Y. Y., Hassenstab, J., Cruchaga, C., Goate, A., Fagan, A. M., Benzinger, T. L. S., Maruff, P., Snyder, P. J., Masters, C. L., Allegri, R., et al. (2016) · Brain · doi:10.1093/brain/aww200 · Cited by 76 · see citing works

A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau

Pei, L., Wang, S., Jin, H., Bi, L., Wei, N., Yan, H., Yang, X., Yao, C., Xu, M., Shu, S., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv096 · Cited by 74 · see citing works

Systematic Analysis of Candidate Genes for Alzheimer's Disease in a French, Genome-Wide Association Study

Laumet, G. O., Chouraki, V. A., Grenier‐Boley, B., Legry, V., Heath, S. C., Zélénika, D., Fiévet, N., Hannequin, D., Délepine, M., Pasquier, F., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100126 · Cited by 71 · see citing works

Assessment of Alzheimer’s disease case–control associations using family-based methods

Schjeide, B. M., McQueen, M. B., Mullin, K., DiVito, J. R., Hogan, M. F., Parkinson, M., Hooli, B. V., Lange, C., Blacker, D., Tanzi, R. E., et al. (2008) · Neurogenetics · doi:10.1007/s10048-008-0151-3 · Cited by 70 · see citing works

BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention

Boots, E. A., Schultz, S. A., Clark, L. R., Racine, A. M., Darst, B. F., Koscik, R. L., Carlsson, C. M., Gallagher, C. L., Hogan, K. J., Bendlin, B. B., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000003980 · Cited by 70 · see citing works

Brain BDNF expression as a biomarker for cognitive reserve against Alzheimer disease progression

Beeri, M. S., & Sonnen, J. A. (2016) · Neurology · doi:10.1212/wnl.0000000000002389 · Cited by 69 · see citing works

Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death

You, M., Kim, B. M., Chen, C.-H., Begley, M. J., Cantley, L. C., & Lee, T. H. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.114 · Cited by 61 · see citing works

Phosphorylation of Tau by Death-Associated Protein Kinase 1 Antagonizes the Kinase-Induced Cell Apoptosis

Duan, D.-X., Chai, G., Ni, Z.-F., Hu, Y., Luo, Y., Cheng, X., Chen, N., Wang, J., & Liu, G. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130377 · Cited by 55 · see citing works

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1

McQueen, J., Ryan, T. J., McKay, S., Marwick, K. F. M., Baxter, P. S., Carpanini, S. M., Wishart, T. M., Gillingwater, T. H., Manson, J. C., Wyllie, D. J. A., et al. (2017) · eLife · doi:10.7554/elife.17161 · Cited by 55 · see citing works

Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein

Kim, B. M., You, M., Chen, C.-H., Suh, J., Tanzi, R. E., & Lee, T. H. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw114 · Cited by 52 · see citing works

Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1

Shu, S., Zhu, H., Tang, N., Chen, W., Li, X., Li, H., Pei, L., Liu, D., Mu, Y., Tian, Q., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2258-16.2016 · Cited by 51 · see citing works

Opportunities and challenges in developing Alzheimer disease therapeutics

Iqbal, K., & Grundke, I. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0878-z · Cited by 47 · see citing works

Intervention of Death-Associated Protein Kinase 1–p53 Interaction Exerts the Therapeutic Effects Against Stroke

Wang, X., Pei, L., Yan, H., Wang, Z., Wei, N., Wang, S., Yang, X., Tian, Q., & Lu, Y. (2014) · Stroke · doi:10.1161/strokeaha.114.006348 · Cited by 39 · see citing works

DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells

Xiong, W., Wu, Y., Xian, W., Song, L., Hu, L., Pan, S., Liu, M., Yao, S., Pei, L., & Shang, Y. (2018) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2018.01.003 · Cited by 37 · see citing works

Deletion of the kinase domain from death-associated protein kinase enhances spatial memory in mice

Yukawa, K., Tanaka, T., Bai, T., Li, L., Tsubota, Y., Owada-Makabe, K., Maeda, M., Hoshino, K., Akira, S., & Iso, H. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.17.5.869 · Cited by 26 · see citing works

Rs4878104 contributes to Alzheimer’s disease risk and regulates DAPK1 gene expression

Hu, Y., Cheng, L., Zhang, Y., Bai, W.-Y., Zhou, W., Wang, T., Han, Z., Zong, J., Jin, S., Zhang, J., et al. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2959-9 · Cited by 26 · see citing works

Association of DAPK1 genetic variations with Alzheimer's disease in Han Chinese

Wu, Z., Zhang, W., Yu, J., Zhang, Q., Tian, Y., Lu, R.-C., Yu, N., Zhao-fu, C., & Tan, L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.12.036 · Cited by 24 · see citing works

Death-associated protein kinase (DAPK1) in cerebral cortex of late-onset Alzheimer's disease patients and aged controls

Hainsworth, A. H., Allsopp, R. C., Jim, A., Potter, J. F., Lowe, J. S., Talbot, C. J., & Prettyman, R. J. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2009.01035.x · Cited by 21 · see citing works

No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer's disease

Minster, R. L., DeKosky, S. T., & Kamboh, M. I. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.01.006 · Cited by 19 · see citing works

DAPK1 is Associated with FTD and not with Alzheimer's Disease

Tedde, A., Piaceri, I., Bagnoli, S., Lucenteforte, E., Piacentini, S., Sorbi, S., & Nacmias, B. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120556 · Cited by 5 · see citing works

Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer’s Disease Multitarget Drug Discovery?: Miniperspective

De Simone, A., Tumiatti, V., Andrisano, V., & Milelli, A. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00931 · Cited by 110 · see citing works

Death-Associated Protein Kinase 1 as a Promising Drug Target in Cancer and Alzheimer’s Disease

Chen, D., Zhou, X. Z., & Lee, T. H. (2018) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/1574892814666181218170257 · Cited by 61 · see citing works

LncRNA MALAT1 targeting miR‐124‐3p regulates DAPK1 expression contributes to cell apoptosis in Parkinson's Disease

Lu, Y., Gong, Z., Jin, X., Zhao, P., Zhang, Y., & Wang, Z. (2020) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29711 · Cited by 56 · see citing works

A brain proteomic signature of incipient Alzheimer’s disease in young <i>APOE</i> ε4 carriers identifies novel drug targets

Roberts, J. A., Varma, V. R., An, Y., Varma, S., Candia, J., Fantoni, G., Tiwari, V., Anerillas, C., Williamson, A., Saito, A., et al. (2021) · Science Advances · doi:10.1126/sciadv.abi8178 · Cited by 49 · see citing works

Born to Protect: Leveraging BDNF Against Cognitive Deficit in Alzheimer’s Disease

Caffino, L., Mottarlini, F., & Fumagalli, F. (2020) · CNS Drugs · doi:10.1007/s40263-020-00705-9 · Cited by 48 · see citing works

Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer’s disease

Coninx, E., Chew, Y. C., Yang, X., Guo, W., Coolkens, A., Baatout, S., Moons, L., Verslegers, M., & Quintens, R. (2020) · Aging · doi:10.18632/aging.104056 · Cited by 45 · see citing works

Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease

Zhang, T., Xia, Y., Hu, L., Chen, D., Gan, C., Wang, L., Mei, Y., Lan, G., Shui, X., Tian, Y., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.66760 · Cited by 46 · see citing works

Stereo-seq of the prefrontal cortex in aging and Alzheimer’s disease

Gong, Y., Haeri, M., Zhang, X., Li, Y., Liu, A., Wu, D., Zhang, Q., Jazwinski, S. M., Zhou, X., Wang, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-54715-y · Cited by 51 · see citing works

Early onset senescence and cognitive impairment in a murine model of repeated mTBI

Schwab, N., Ju, Y., & Hazrati, L.-N. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01190-x · Cited by 39 · see citing works

The impact of DAPK1 and mTORC1 signaling association on autophagy in cancer

Movahhed, P., Saberiyan, M., Safi, A., Arshadi, Z., Kazerouni, F., & Teimori, H. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07154-1 · Cited by 34 · see citing works

Targeting Death-Associated Protein Kinases for Treatment of Human Diseases: Recent Advances and Future Directions

Zhang, L., Luo, B., Lü, Y., & Chen, Y. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01606 · Cited by 30 · see citing works

Role of DAPK1 in neuronal cell death, survival and diseases in the nervous system

Alsaadi, M. S. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.02.003 · Cited by 28 · see citing works

Stability, Hydrogen Bond Occupancy Analysis and Binding Free Energy Calculation from Flavonol Docked in DAPK1 Active Site Using Molecular Dynamic Simulation Approaches

Zikri, A. T., Pranowo, H. D., & Haryadi, W. (2020) · Indonesian Journal of Chemistry · doi:10.22146/ijc.56087 · Cited by 27 · see citing works

Circular RNA circTLK1 regulates dopaminergic neuron injury during Parkinson‘s disease by targeting miR-26a-5p/DAPK1

Chen, W., Hou, C., Wang, Y., Hong, L., Wang, F., & Zhang, J. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136638 · Cited by 26 · see citing works

Pin1 and Alzheimer's disease

Malter, J. S. (2022) · Translational research · doi:10.1016/j.trsl.2022.09.003 · Cited by 22 · see citing works

NMDA Receptor GluN2B Subunit Is Involved in Excitotoxicity Mediated by Death-Associated Protein Kinase 1 in Alzheimer’s Disease

Xu, L., Li, B., Li, F., Li, Y., Qin, W., Zhao, Y., & Jia, J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220747 · Cited by 19 · see citing works

Aerobic exercise mitigates hippocampal neuronal apoptosis by regulating DAPK1 / CDKN2A / REDD1 / FoXO1 / FasL signaling pathway in D‐galactose‐induced aging mice

Liu, Y., Guo, W., & Hong, S. (2023) · The FASEB Journal · doi:10.1096/fj.202300847rr · Cited by 19 · see citing works

The Role of Death-Associated Protein Kinase-1 in Cell Homeostasis-Related Processes

Makgoo, L., Mosebi, S., & Mbita, Z. (2023) · Genes · doi:10.3390/genes14061274 · Cited by 17 · see citing works

MicroRNA-124/Death-Associated Protein Kinase 1 Signaling Regulates Neuronal Apoptosis in Traumatic Brain Injury via Phosphorylating NR2B

Shi, Y., Cui, W., Wang, Q., Zhou, J., Wu, X., Wang, J., Zhang, S., Hu, Q., Han, L., Du, Y. F., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.892197 · Cited by 15 · see citing works

Chronic Fluoxetine Treatment Induces Maturation-Compatible Changes in the Dendritic Arbor and in Synaptic Responses in the Auditory Cortex

Ampuero, E., Cerda, M., Härtel, S., Rubio, F. J., Massa, S., Cubillos, P., Abarzúa-Catalán, L., Sandoval, R., Galaburda, A. M., & Wyneken, Ú. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00804 · Cited by 15 · see citing works

Design of Multi-Target drugs of HDACs and other Anti-Alzheimer related Targets: Current strategies and future prospects in Alzheimer’s diseases therapy

Soltan, O. M., Abdelrahman, K. S., Bass, A. K. A., Takizawa, K., Narumi, A., & Konno, H. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107651 · Cited by 14 · see citing works

Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage

Zeng, P. H., Wang, X., Su, H.-F., Zhang, T., Ning, L., Shi, Y., Yang, S., Li, L., & Tian, Q. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153630 · Cited by 13 · see citing works

Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke

Noori, T., Shirooie, S., Sureda, A., Sobarzo‐Sánchez, E., Dehpour, A. R., Saldías, M., & Akkol, E. K. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03628-7 · Cited by 13 · see citing works

Resveratrol Upregulates miR ‐124‐3p Expression to Target DAPK1 , Regulating the NLRP3 /Caspase‐1/ GSDMD Pathway to Inhibit Pyroptosis and Alleviate Spinal Cord Injury

Li, D., Dai, Y., Li, Z., Bi, H., Li, H., Wang, Y., Liu, Y., Tian, X., & Chen, L. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70338 · Cited by 13 · see citing works

Identification of potential death-associated protein kinase-1 (DAPK1) inhibitors by an integrated ligand-based and structure-based computational drug design approach

Ghosh, P., Singh, R., Ganeshpurkar, A., Swetha, R., Kumar, D., Singh, S. K., & Kumar, A. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2158935 · Cited by 12 · see citing works

Ablation of Death-Associated Protein Kinase 1 Changes the Transcriptomic Profile and Alters Neural-Related Pathways in the Brain

Li, R., Zhi, S., Lan, G., Chen, X., Zheng, X., Hu, L., Wang, L., Zhang, T., Lee, T. H., Rao, S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076542 · Cited by 11 · see citing works

Smoothed quantile regression for partially functional linear models in high dimensions

Wang, Z., Bai, Y., Härdle, W. K., & Tian, M. (2023) · Biometrical Journal · doi:10.1002/bimj.202200060 · Cited by 9 · see citing works

In Silico Prediction of Quercetin Analogs for Targeting Death-Associated Protein Kinase 1 (DAPK1) Against Alzheimer’s Disease

Sun, Y., Zhao, J. W., Lu, Y., Ngo, F. Y., Shuai, B., Zhang, Z., Feng, Y., & Rong, J. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240515090434 · Cited by 8 · see citing works

Mechanism of cAMP Response Element-binding Protein 1/Death-associated Protein Kinase 1 Axis-mediated Hippocampal Neuron Apoptosis in Rat Brain Injury After Cardiopulmonary Resuscitation

Zhou, Y., Zhang, X., Yang, H., Chu, B., Zhen, M., Zhang, J., & Yang, L. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.06.024 · Cited by 6 · see citing works

Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus

Cai, S., Ding, R., Zhang, H., Chen, Q., Yu, F., Xia, Y., Chen, Q., Miao, X., Zhou, B., Chen, J., et al. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101323 · Cited by 4 · see citing works

PROTACs for central nervous system disorders: challenges and opportunities

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Diagnosis of Alzheimer’s disease using FusionNet with improved secretary bird optimization algorithm for optimal MK-SVM based on imaging genetic data

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