The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization
Open accessAbstract
Summary NMDA receptor-dependent synaptic modifications, such as long-term potentiation (LTP) and long-term depression (LTD), are essential for brain development and function. LTD occurs mainly by the removal of AMPA receptors from the postsynaptic membrane, but the underlying molecular mechanisms remain unclear. Here we show that activation of caspase-3 via mitochondria is required for LTD and AMPA receptor internalization in hippocampal neurons. LTD and AMPA receptor internalization are blocked by peptide inhibitors of caspase-3 and -9. In hippocampal slices from caspase-3 knockout mice, LTD is abolished whereas LTP remains normal. LTD is also prevented by overexpression of the anti-apoptotic proteins XIAP or Bcl-xL, and by a mutant Akt1 protein that is resistant to caspase-3 proteolysis. NMDA receptor stimulation that induces LTD transiently activates caspase-3 in dendrites, without causing cell death. These data indicate an unexpected causal link between the molecular mechanisms of apoptosis and LTD.
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Metadata
- Authors
- Li, Z., Jo, J., Jia, J.-M., Lo, S.-C., Whitcomb, D. J., Jiao, S., Cho, K., & Sheng, M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 141
- Issue
- 5
- Pages
- 859-871
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2113455273
- Cited by
- 532
- References
- 57
- FWCI
- 18.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, Z., Jo, J., Jia, J.-M., Lo, S.-C., Whitcomb, D. J., Jiao, S., Cho, K., & Sheng, M. (2010). Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization. Cell. https://doi.org/10.1016/j.cell.2010.03.053
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